Deregulation of Plasma microRNA Expression in a TARDBP-ALS Family DOI Creative Commons
Paola Ruffo, Stefania Catalano, Vincenzo La Bella

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(4), P. 706 - 706

Published: April 21, 2023

TDP-43 intracellular aggregates are a pathogenic sign of most amyotrophic lateral sclerosis (ALS) cases. Familial ALS, brought on by TARDBP gene mutations, emphasizes the relevance this altered protein in pathophysiology. Growing evidence suggests role for dysregulated microRNA (miRNA) ALS disease. Furthermore, several studies showed that miRNAs highly stable various biological fluids (CSF, blood, plasma, and serum), they expressed differentially comparing patients controls. In 2011, our research group discovered rare mutation (G376D) large Apulian family with affected members exhibiting rapidly progressing To identify potential non-invasive biomarkers preclinical clinical progression TARDBP-ALS family, we assessed expression levels plasma microRNAs (n = 7) asymptomatic carriers compared healthy controls 13). Applying qPCR, investigate 10 bind vitro during their biogenesis or mature form, other nine known to be deregulated We highlight miR-132-5p, miR-132-3p, miR-124-3p, miR-133a-3p as G376D-TARDBP-associated ALS. Our strongly supports performing predictive diagnostics identifying new therapeutic targets.

Language: Английский

MiRNAs as major players in brain health and disease: current knowledge and future perspectives DOI Creative Commons

Sarika V. Kapplingattu,

Sujata Bhattacharya, Yogita K. Adlakha

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 13, 2025

Abstract MicroRNAs are regulators of gene expression and their dysregulation can lead to various diseases. MicroRNA-135 (MiR-135) exhibits brain-specific expression, performs functions such as neuronal morphology, neural induction, synaptic function in the human brain. Dysfunction miR-135 has been reported brain tumors, neurodegenerative neurodevelopmental disorders. Several reports show downregulation glioblastoma, indicating its tumor suppressor role pathogenesis tumors. In this review, by performing silico analysis molecular targets miR-135, we reveal significant pathways processes modulated miR-135. We summarize biological significance, roles, signaling miRNAs general, with a focus on different neurological diseases including also discuss methods, limitations, potential glioblastoma organoids recapitulating disease initiation progression. highlight promising therapeutic antitumor agents for aggressive tumors glioblastoma.

Language: Английский

Citations

2
Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Alzheimer’s disease DOI
Nourhan M. Abdelmaksoud, Al-Aliaa M. Sallam, Ahmed I. Abulsoud

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 155007 - 155007

Published: Dec. 4, 2023

Language: Английский

Citations

23
Non-Coding RNAs in Neurological and Neuropsychiatric Disorders: Unraveling the Hidden Players in Disease Pathogenesis DOI Creative Commons
Mirolyuba Ilieva

Cells, Journal Year: 2024, Volume and Issue: 13(12), P. 1063 - 1063

Published: June 19, 2024

Neurological and neuropsychiatric disorders pose substantial challenges to public health, necessitating a comprehensive understanding of the molecular mechanisms underlying their pathogenesis. In recent years, focus has shifted toward intricate world non-coding RNAs (ncRNAs), class RNA molecules that do not encode proteins but play pivotal roles in gene regulation cellular processes. This review explores emerging significance ncRNAs context neurological disorders, shedding light on diverse functions regulatory mechanisms. The dysregulation various ncRNAs, including microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), been implicated pathophysiology conditions such as Alzheimer’s disease, Parkinson’s schizophrenia, mood disorders. delves into specific these modulating key processes, synaptic plasticity, neuroinflammation, apoptosis, providing nuanced impact disease progression. Furthermore, it discusses potential diagnostic therapeutic implications targeting identification ncRNA signatures holds promise for development novel biomarkers early detection, while manipulation expression offers innovative avenues. Challenges future directions field are also considered, highlighting need continued research unravel complexities ncRNA-mediated networks aims provide overview current state knowledge stimulate further exploration fascinating realm brain’s landscape.

Language: Английский

Citations

10
A Review of Nanotechnology in microRNA Detection and Drug Delivery DOI Creative Commons
Hsiuying Wang

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1277 - 1277

Published: July 30, 2024

MicroRNAs (miRNAs) are small, non-coding RNAs that play a crucial role in regulating gene expression. Dysfunction miRNAs can lead to various diseases, including cancers, neurological disorders, and cardiovascular conditions. To date, approximately 2000 have been identified humans. These small molecules shown promise as disease biomarkers potential therapeutic targets. Therefore, identifying miRNA for diseases developing effective drug delivery systems essential. Nanotechnology offers promising new approaches addressing scientific medical challenges. Traditional detection methods include next-generation sequencing, microarrays, Northern blotting, reverse transcription-quantitative polymerase chain reaction (RT-qPCR). serve an alternative blotting RT-qPCR detection. Moreover, nanomaterials exhibit unique properties differ from larger counterparts, enabling therapeutics more effectively enter target cells, reduce degradation the bloodstream, be released specific tissues or cells. This paper reviews application of nanotechnology systems. Given still stages, holds great accelerating development.

Language: Английский

Citations

10
Molecular Mechanisms Linking Osteoarthritis and Alzheimer’s Disease: Shared Pathways, Mechanisms and Breakthrough Prospects DOI Open Access

Idiongo Okon Umoh,

Helton José Reis, Antônio Carlos Pinheiro de Oliveira

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 3044 - 3044

Published: March 6, 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative mostly affecting the elderly population. It characterized by cognitive decline that occurs due to impaired neurotransmission and neuronal death. Even though deposition of amyloid beta (Aβ) peptides aggregation hyperphosphorylated TAU have been established as major pathological hallmarks disease, other factors such interaction genetic environmental are believed contribute development progression AD. In general, patients initially present mild forgetfulness difficulty in forming new memories. As it progresses, there significant impairments problem solving, social interaction, speech overall function affected individual. Osteoarthritis (OA) most recurrent form arthritis widely acknowledged whole-joint distinguished degeneration erosion joint cartilage accompanying synovitis subchondral bone changes can prompt peripheral inflammatory responses. Also predominantly elderly, OA frequently embroils weight-bearing joints knees, spine hips leading pains, stiffness diminished mobility, which turn significantly impacts patient’s standard life. Both infirmities co-occur older adults result independent factors, multiple health conditions common old age. Additionally, risk genetics, lifestyle changes, age chronic inflammation may both some individuals. Besides localized low-grade inflammation, notable systemic prompted play role AD pathogenesis. Studies explored relationships between inflammatory-associated diseases like obesity, hypertension, dyslipidemia, diabetes mellitus Given dementia shares similar with OA—both being age-related diseases, indeed serve factor for This work aims review literature on molecular mechanisms linking pathologies, explore potential connections these alongside future prospects innovative treatments.

Language: Английский

Citations

9
Advancing personalized medicine in neurodegenerative diseases: The role of epigenetics and pharmacoepigenomics in pharmacotherapy DOI Creative Commons
Christian Griñán‐Ferré, Aina Bellver‐Sanchís, Ana Guerrero

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 205, P. 107247 - 107247

Published: June 2, 2024

About 80% of brain disorders have a genetic basis. The pathogenesis most neurodegenerative diseases is associated with myriad defects, epigenetic alterations (DNA methylation, histone/chromatin remodeling, miRNA dysregulation), and environmental factors. emergence new sequencing technologies tools to study the epigenome has led identifying predictive biomarkers for earlier diagnosis, opening up possibility prophylactical interventions. As result, advances in pharmacogenetics pharmacoepigenomics now allow personalized treatments based on profile each patient specific mechanisms involved. This Review highlights complexity variability responses pharmacotherapy, emphasizing influence polymorphisms pharmacokinetics pharmacodynamics drugs used treat those conditions. We specifically discuss potential modulatory effect several an increased risk developing different diseases. explore genomic analyzing individual-specific drug metabolism predict response clinical outcomes. also provide insights into mechanism action under investigation their impact disease-modifying pathways. Finally, underscores great this field enhance effectiveness safety through medicine.

Language: Английский

Citations

9
Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases DOI Creative Commons

FrancescaLuisa Conforti,

Paola Ruffo, Francesca De Amicis

et al.

Neural Regeneration Research, Journal Year: 2022, Volume and Issue: 18(6), P. 1243 - 1243

Published: Oct. 14, 2022

The growing and rapid development of high-throughput sequencing technologies have allowed a greater understanding the mechanisms underlying gene expression regulation. Editing epigenome epitranscriptome directs fate transcript influencing functional outcome each mRNA. In this context, non-coding RNAs play decisive role in addressing regulation at chromosomal levels. Long-noncoding RNAs, consisting more than 200 nucleotides, been shown to act as epigenetic regulators several key molecular processes involving neurodegenerative disorders, such Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis Huntington's disease. are abundantly expressed central nervous system, suggesting that their deregulation could trigger neuronal degeneration through RNA modifications. evaluation diagnostic significance therapeutic potential lead new treatments for these diseases which there is no cure.

Language: Английский

Citations

34
The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review DOI Open Access

Bombonica Gabriela Dogaru,

Constantin Munteanu

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12555 - 12555

Published: Aug. 8, 2023

This review explores the emerging role of hydrogen sulfide (H

Language: Английский

Citations

20
The role of miRNAs in multiple sclerosis pathogenesis, diagnosis, and therapeutic resistance DOI
Ahmed S. Doghish, Ola Elazazy, Hend H. Mohamed

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 251, P. 154880 - 154880

Published: Oct. 11, 2023

Language: Английский

Citations

16
The molecular mechanism of ferroptosis and its relationship with Parkinson's disease DOI Creative Commons

Yan Su,

Yue Jiao,

Sheng Cai

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 213, P. 110991 - 110991

Published: May 31, 2024

Neurodegenerative diseases such as Parkinson's disease (PD) have complex pathogenetic mechanisms. Genetic, age, and environmental factors are all related to PD. Due the unclear pathogenesis of PD lack effective cure methods, it is urgent find new targets for treating patients. Ferroptosis a form cell death that reliant on iron exhibits distinct morphological mechanistic characteristics compared other types death. It encompasses range biological processes, including iron/lipid metabolism oxidative stress. In recent years, research has found ferroptosis plays crucial role in pathophysiological processes neurodegenerative stroke. Therefore, also closely PD, This article reviews core mechanisms elucidates correlation between ferroptosis. addition, compounds emerged years exert anti effects by inhibiting signaling pathway were summarized. I hope further elaborate relationship through review this article, provide strategies developing treatments targeting

Language: Английский

Citations

7