As
a
key
member
of
the
neurotrophin
family
in
central
nervous
system,
brain-derived
neurotrophic
factor
(BDNF)
plays
critical
role
maintenance
and
plasticity
system.
Its
innate
neuroprotective
advantage
can
also
be
shared
with
brain
when
normal
aging-dependent
processes
challenge
neural
circuits.
The
intricate
relationship
between
BDNF
resilience
during
aging
process
signifies
molecular
mechanisms
that
underlie
protection
function,
such
as
cognition,
movement
psychological
well-being.
is
crucial
for
neuronal
growth
survival,
it
promote
against
age-related
functional
decline
frailty,
even
if
fails
to
entirely
prevent
ageing-related
decline.
In
present
review,
we
discuss
function
from
perspective
how
may
aging.
We
emphasize
briefly
principal,
well-known
cellular
hallmarks
restrict
disabling
dynamics
enhance
overall
Insight
into
pathways
through
which
reduces
dysfunctions
and/or
improves
resilience,
provide
foundation
developing
targeted
interventions
mental
well-being
an
population.
Cells,
Journal Year:
2023,
Volume and Issue:
12(4), P. 655 - 655
Published: Feb. 17, 2023
Background
and
Methods:
Severe
COVID-19
is
known
to
induce
neurological
damage
(NeuroCOVID),
mostly
in
aged
individuals,
by
affecting
brain-derived
neurotrophic
factor
(BDNF),
matrix
metalloproteinases
(MMP)
2
9
the
neurofilament
light
chain
(NFL)
pathways.
Thus,
aim
of
this
pilot
study
was
investigate
BDNF,
MMP-2,
MMP-9,
NFL
serum
men
affected
at
beginning
hospitalization
period
characterized
different
outcomes,
i.e.,
attending
a
hospital
ward
or
an
intensive
care
unit
(ICU)
with
fatal
outcome.
As
control
group,
we
used
novelty
study,
unexposed
age-matched
men.
We
also
correlated
these
findings
routine
blood
parameters
recruited
individuals.
Results:
found
individuals
severe
lethal
outcomes
disrupted
NFL,
MMP-2
presence
gross
changes
ALT,
GGT,
LDH,
IL-6,
ferritin,
CRP.
confirmed
extended
previous
data,
using
ROC
analyses,
showing
that
ratio
MMPs
(2
9)
versus
BDNF
might
be
useful
tool
predict
Conclusions:
Serum
and/or
their
ratios
MMP-9
could
represent
early
predictors
NeuroCOVID
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 161 - 161
Published: Feb. 4, 2025
Background
Hitherto,
BDNF
levels
in
humans
have
been
primarily
measured
serum
and/or
plasma
where
these
are
readily
measurable,
but
reflect
the
content
of
blood
platelets.
By
contrast,
previous
attempts
to
measure
accessible
human
body
fluids
such
as
saliva
complicated
by
a
lack
sensitivity
specificity
ELISAs
(see
Discussion).
Recently,
suitability
highly
sensitive
ELISA
assay
was
validated
using
mouse
and
conventional
fail
detect
BDNF.
In
this
report,
we
demonstrate
that
extremely
low,
low
pg/mL
range,
yet
detectable
all
samples
tested.
Methods
Saliva
were
collected
from
healthy
volunteers
passive
drool
method.
All
aliquoted
immediately
frozen
keep
at
-80°C
until
use.
At
time
use,
thawed,
centrifuged
remove
any
remaining
particles
measurement
conducted
previously
below).
Recombinant
mature
used
reference.
Results
The
intra-assay
variability
range
CV
=
1.8
4.9%.
could
be
kept
for
2
months
use
measurements,
more
than
4
freeze
thaw
cycles
caused
losses
presumably
due
structural
change
antigen.
measurements
not
affected
method
collection
provided
diluted
least
2-fold.
Conclusions
results
indicate
non-invasive
fashion
can
source
material
try
correlate
with
conditions
interest.
These
also
confirm
those
an
independent
study
published
recently
same
kit
samples.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(15), P. 12438 - 12438
Published: Aug. 4, 2023
Orofacial
pain
represents
a
multidisciplinary
biomedical
challenge
involving
basic
and
clinical
research
for
which
no
satisfactory
solution
has
been
found.
In
this
regard,
trigeminal
is
described
as
one
of
the
worst
pains
perceived,
leaving
patient
with
hope
future.
The
aim
review
to
evaluate
latest
discoveries
on
involvement
neurotrophins
in
orofacial
nociception,
describing
their
role
expression
peripheral
tissues,
ganglion,
nucleus
considering
double
nature
“supporters”
nervous
system
“promoters”
nociceptive
transmission.
order
scan
recent
literature
(last
ten
years),
three
independent
researchers
referred
databases
PubMed,
Embase,
Google
Scholar,
Scopus,
Web
Science
find
original
articles
trials.
selected
33
papers:
29
4
results
obtained
by
screening
show
an
interesting
trend,
precise
modulation
neurotrophin
signaling
could
switch
from
being
“promoter”
beneficial
neurotrophic
supporting
nerves
recovery,
especially
when
structural
alteration
present,
neuropathic
pain.
conclusion,
be
targets
but
more
studies
are
necessary
clarify
future
application
practice.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(40)
Published: Aug. 8, 2024
Abstract
The
first
approved
vaccines
for
human
use
against
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2)
are
nanotechnology‐based.
Although
they
modular,
rapidly
produced,
and
can
reduce
disease
severity,
the
currently
available
restricted
in
preventing
infection,
stressing
global
demand
novel
preventive
vaccine
technologies.
Bearing
this
mind,
we
set
out
to
develop
a
flexible
nanovaccine
platform
nasal
administration
induce
mucosal
immunity,
which
is
fundamental
optimal
protection
virus
infection.
next‐generation
multiepitope
nanovaccines
co‐deliver
immunogenic
peptides,
selected
by
an
immunoinformatic
workflow,
along
with
adjuvants
regulators
of
PD‐L1
expression.
As
case
study,
focused
on
SARS‐CoV‐2
peptides
as
relevant
antigens
validate
approach.
This
evoke
both
local
systemic
cellular‐
humoral‐specific
responses
SARS‐CoV‐2.
led
secretion
immunoglobulin
A
(IgA),
capable
neutralizing
SARS‐CoV‐2,
including
variants
concern,
following
heterologous
immunization
strategy.
Considering
limitations
required
cold
chain
distribution
current
nanotechnology‐based
vaccines,
it
shown
that
lyophilized
stable
long‐term
at
room
temperature
retains
its
vivo
efficacy
upon
reconstitution.
makes
particularly
developing
countries
offers
modular
system
adaptable
future
viral
threats.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
As
a
key
member
of
the
neurotrophin
family
in
central
nervous
system,
brain-derived
neurotrophic
factor
(BDNF)
plays
critical
role
maintenance
and
plasticity
system.
Its
innate
neuroprotective
advantage
can
also
be
shared
with
brain
when
normal
aging-dependent
processes
challenge
neural
circuits.
The
intricate
relationship
between
BDNF
resilience
during
aging
process
signifies
molecular
mechanisms
that
underlie
protection
function,
such
as
cognition,
movement
psychological
well-being.
is
crucial
for
neuronal
growth
survival,
it
promote
against
age-related
functional
decline
frailty,
even
if
fails
to
entirely
prevent
aging-related
decline.
In
present
review,
we
discuss
function
from
perspective
how
may
aging.
We
emphasize
briefly
principal,
well-known
cellular
hallmarks
restrict
disabling
dynamics
enhance
overall
Insight
into
pathways
through
which
reduces
dysfunctions
and/or
improves
resilience,
provides
foundation
developing
targeted
interventions
mental
well-being
an
population.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(11), P. 1585 - 1585
Published: Oct. 27, 2023
COVID-19
patients
can
exhibit
a
wide
range
of
clinical
manifestations
affecting
various
organs
and
systems.
Neurological
symptoms
have
been
reported
in
patients,
both
during
the
acute
phase
illness
cases
long-term
COVID.
Moderate
include
ageusia,
anosmia,
altered
mental
status,
cognitive
impairment,
more
severe
manifest
as
ischemic
cerebrovascular
disease
encephalitis.
In
this
narrative
review,
we
delve
into
neurological
associated
with
COVID-19,
well
underlying
mechanisms
contributing
to
them.
These
direct
damage
neurons,
inflammation,
oxidative
stress,
protein
misfolding.
We
further
investigate
potential
small
molecules
from
natural
products
offer
neuroprotection
models
neurodegenerative
diseases.
Through
our
analysis,
discovered
that
flavonoids,
alkaloids,
terpenoids,
other
compounds
neuroprotective
effects
by
modulating
signaling
pathways
known
be
impacted
COVID-19.
Some
these
also
directly
target
SARS-CoV-2
viral
replication.
Therefore,
origin
show
promise
agents
prevent
or
mitigate
nervous
system
patients.
Further
research
evaluation
different
stages
are
warranted
explore
their
benefits.
Diseases,
Journal Year:
2024,
Volume and Issue:
12(2), P. 37 - 37
Published: Feb. 9, 2024
Introduction:
This
is
a
case
report
of
patient
with
neuropathic
corneal
pain
after
coronavirus
disease
2019
(COVID-19)
infection.
Methods:
A
previously
healthy
27-year-old
female
presented
bilateral
eye
accompanied
by
increased
light
sensitivity
5
months
COVID-19
She
was
diagnosed
based
on
clear
corneas
without
fluorescein
staining,
alongside
the
presence
microneuromas,
dendritic
cells,
and
activated
stromal
keratocytes
identified
bilaterally
in
vivo
confocal
microscopy.
Results:
The
patient’s
tear
nerve
growth
factor,
substance
P,
calcitonin
gene-related
peptide
levels
were
5.9
pg/mL,
2978.7
1.1
ng/mL,
respectively,
for
right
23.1
4798.7
1.2
left
eye,
suggesting
neuroinflammatory
status.
After
6
weeks
topical
0.1%
flurometholone
treatment,
decreased
microneuroma
size,
less
extensive
reduced
factor
P
observed.
scores
Ocular
Pain
Assessment
Survey
showed
an
improvement
burning
sensation
sensitivity,
decreasing
from
80%
70%
to
50%
both.
Conclusions:
Neuropathic
potential
post-COVID-19
complication
that
warrants
ophthalmologists’
neurologists’
attention.
Genes and Cells,
Journal Year:
2024,
Volume and Issue:
19(1), P. 61 - 84
Published: Feb. 26, 2024
The
brain-derived
neurotrophic
factor
(BDNF)
is
a
key
modulator
of
neurogenesis,
synaptogenesis,
neuroregeneration,
and
cell
differentiation
in
the
nervous
system.
Impaired
BDNF
functioning
characteristic
various
neurological
diseases,
such
as
Alzheimer’s
disease,
multiple
sclerosis,
depressive
disorders.
There
recent
evidence
that
patients
with
COVID-19
have
reduced
levels
blood
plasma.
Furthermore,
exogenous
its
mimetics
demonstrated
therapeutic
potential.
In
this
review,
we
systematized
data
gene
structure,
epigenetic
microRNA-mediated
regulation
expression,
transcriptional
variants
BDNF,
effects
on
neuronal
oligodendroglial
differentiation.
Further,
point
out
gaps
current
knowledge
about
propose
experiments
can
expand
range
possibilities
for
using
biomedicine.
These
include
determining
expression
pattern
all
transcripts
at
different
stages
subpopulations
studying
role
receptor-independent
signaling,
circadian
fluctuations
levels,
their
physiological
pathophysiological
conditions.
Finally,
translational
medicine,
evaluating
effect
(including
those
immobilized
three-dimensional
scaffolds
tissue
engineering)
pluripotent
polypotent
cells
identifying
molecular
regulators
transcription,
including
small
molecules
microRNAs
capable
regulating
are
crucial.
Biology,
Journal Year:
2024,
Volume and Issue:
13(11), P. 907 - 907
Published: Nov. 7, 2024
Neurotrophins
(NTs)
constitute
a
family
of
small
protein
messengers
that
play
fundamental
role
in
both
the
central
and
peripheral
nervous
systems.
In
particular,
nerve
growth
factor
(NGF)
brain-derived
neurotrophic
(BDNF)
subtle
survival,
differentiation,
functioning
neuronal
populations,
as
well
fine
regulation
immune
functions.
The
SARS-CoV-2
infection
was
characterized
by
sequela
symptoms
(serious
respiratory
pathology,
inflammatory
storm,
neurological
discomfort,
up
to
less
serious
flu-like
symptoms),
which
caused,
at
end
2023,
more
than
7
million
deaths
worldwide.
Despite
official
pandemic,
physical
psychological
consequences
are
currently
object
scientific
research,
acute
chronic/long-lasting
(Long-COVID-19).
Given
multifactorial
nature
outcomes
adults
children,
several
studies
have
investigated
potential
involvement
NGF
BDNF
systems
pathology.
This
narrative
review
aims
summarize
most
recent
evidence
on
this
crucial
topic.
