The porcine corpus luteum as a model for studying the effects of nanoplastics DOI Creative Commons
Giuseppina Basini, Simone Bertini,

Simona Bussolati

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 110, P. 104503 - 104503

Published: July 24, 2024

Nanoplastics (NPs) affect fertility. We evaluated the effects of NPs treatment on luteal and endothelial cells. examined crucial markers growth redox status. did not induce changes in ATP levels cells, while it increased (p< 0.05) their proliferation. In no change proliferation was detected, an increase (p<0.05) observed. The reactive oxygen species, superoxide anion nitric oxide (p<0.001) detected both cell types, which also showed dismutase enzyme activity as well non-enzymatic antioxidant power (p<0.05). A decrease progesterone production vascular factor were addition, a dose-dependent accumulation cells shown, that likely occurred through adhesion internalization. Results underline potential risk for corpus luteum functionality.

Language: Английский

Atherosclerosis and Bidirectional Relationship between Cancer and Cardiovascular Disease: From Bench to Bedside—Part 1 DOI Open Access

Giuseppina Gallucci,

Fabio Maria Turazza, Alessandro Inno

et al.

Published: March 20, 2024

Atherosclerosis, a complex metabolic-immune disease characterized by chronic inflammation driven the buildup of lipid-rich plaques within arterial walls, has emerged as pivotal factor in intricate interplay between cancer and cardiovascular disease. This bidirectional relationship, marked shared risk factors pathophysiological mechanisms, underscores need for comprehensive understanding how these two formidable health challenges intersect influence each other. Cancer its treatments can contribute to progression atherosclerosis while with inflammatory microenvironment exert profound effects on development outcomes. Both involve interactions general personal exposomes. In this review we want summarize state-of-the-art translational data try show oncologic studies cardiotoxicity broaden our knowledge crucial pathways biology positive impact precision cardiology cardioncology.

Language: Английский

Citations

4
Atherosclerosis and the Bidirectional Relationship between Cancer and Cardiovascular Disease: From Bench to Bedside—Part 1 DOI Open Access

Giuseppina Gallucci,

Fabio Maria Turazza, Alessandro Inno

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4232 - 4232

Published: April 11, 2024

Atherosclerosis, a complex metabolic-immune disease characterized by chronic inflammation driven the buildup of lipid-rich plaques within arterial walls, has emerged as pivotal factor in intricate interplay between cancer and cardiovascular disease. This bidirectional relationship, marked shared risk factors pathophysiological mechanisms, underscores need for comprehensive understanding how these two formidable health challenges intersect influence each other. Cancer its treatments can contribute to progression atherosclerosis, while with inflammatory microenvironment, exert profound effects on development outcomes. Both involve interactions general personal exposomes. In this review, we aim summarize state art translational data try show oncologic studies cardiotoxicity broaden our knowledge crucial pathways biology positive impact precision cardiology cardio-oncology.

Language: Английский

Citations

4
Co-Existing Nanoplastics Further Exacerbates the Effects of Triclosan on the Physiological Functions of Human Serum Albumin DOI Creative Commons
Yan Bao, Yaoyao Wang, Hongbin Liu

et al.

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 112 - 112

Published: Jan. 16, 2025

The potential health risks posed by the coexistence of nanoplastics (NPs) and triclosan (TCS) have garnered significant attention. However, effects underlying mechanisms NPs TCS on key functional proteins at molecular level remain poorly understood. This study reports effect polystyrene (PSNPs) binding to human serum albumin (HSA) using multispectral methods simulation systems. experimental results show that significantly inhibits HSA esterase activity, with exacerbating inhibition in presence PSNPs, which is attributed alteration conformation microenvironment amino acid residues induced PSNPs. Molecular docking site marker competitive studies indicate predominantly binds I subdomain Sudlow II PSNPs does not affect sites. Spectra analyses quenching mechanism between belongs static type change fluorescence type. conformational alterations are further enhanced indicating enhance making more accessible provides valuable information about toxicity case co-exposure.

Language: Английский

Citations

0
Absorption of Toxicants from the Ocular Surface: Potential Applications in Toxicology DOI Creative Commons
Ivan Šoša,

Manuela Perković,

Ivan Šoša

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 645 - 645

Published: March 6, 2025

In relation to the eye, body can absorb substances from ocular surface fluid (OSF) in a few ways: directly through conjunctival sac, nasal mucosa as drains into nose, or ingestion. Regardless of absorption method, sac should be used toxicological matrix, even though only small quantities are needed. Contemporary analytical techniques make it suitable matrix for research. Analyzing and nano-quantities analyte requires high-cost, sophisticated tools, which is particularly relevant high-throughput environment new drug cosmetics testing. Environmental toxicology also presents challenge, many pollutants enter system using same route. A review existing literature was conducted assess potential applications clinical forensic related toxicants surface. The selection studies this aimed identify new, more efficient, cost-effective technology diagnostic methods.

Language: Английский

Citations

0
Association Between Blood Microplastic Levels and Severity of Extracranial Artery Stenosis DOI Creative Commons

Hongxiang Yu,

Hongxia Li, C. X. Cui

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136211 - 136211

Published: Oct. 18, 2024

Language: Английский

Citations

3
Nanoplastics as emerging cardiovascular hazards: a narrative review of current evidence DOI Creative Commons
Gbolahan Olatunji, Emmanuel Kokori, Ikponmwosa Jude Ogieuhi

et al.

The Egyptian Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 36(1)

Published: June 12, 2024

Abstract Background Nanoplastics (NPs) have emerged as significant environmental pollutants, raising concerns due to their ubiquitous presence and potential adverse effects on human health. The migration fate of NPs in the environment are subjects intense study, with exposure pathways expanding through ingestion, inhalation, dermal contact. Body Studies indicate that can infiltrate cardiovascular system, potentially causing effects. Mechanistic insights from vitro animal studies suggest oxidative stress, inflammation, apoptosis, mitochondrial dysfunction contribute nanoplastic-induced toxicity. Animal models demonstrate altered heart rate, myocardial fibrosis, following exposure, specific observed cardiac valves structure. Clinical provide further evidence accumulation tissues, implications for pathologies such atherosclerosis infarction. Notably, patients higher levels nanoplastics carotid plaque exhibit an increased risk outcomes. Conclusion However, challenges studying persist, including methodological limitations, ethical considerations, need standardized detection methods. Addressing these requires interdisciplinary collaboration, innovative research approaches, robust regulatory measures mitigate pollution protect

Language: Английский

Citations

1
The porcine corpus luteum as a model for studying the effects of nanoplastics DOI Creative Commons
Giuseppina Basini, Simone Bertini,

Simona Bussolati

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 110, P. 104503 - 104503

Published: July 24, 2024

Nanoplastics (NPs) affect fertility. We evaluated the effects of NPs treatment on luteal and endothelial cells. examined crucial markers growth redox status. did not induce changes in ATP levels cells, while it increased (p< 0.05) their proliferation. In no change proliferation was detected, an increase (p<0.05) observed. The reactive oxygen species, superoxide anion nitric oxide (p<0.001) detected both cell types, which also showed dismutase enzyme activity as well non-enzymatic antioxidant power (p<0.05). A decrease progesterone production vascular factor were addition, a dose-dependent accumulation cells shown, that likely occurred through adhesion internalization. Results underline potential risk for corpus luteum functionality.

Language: Английский

Citations

0