Role of Oxidative Stress and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Nonalcoholic Fatty Liver Disease DOI Open Access

Plator Memaj,

Zayd Ouzerara,

François R. Jornayvaz

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11271 - 11271

Published: July 10, 2023

Nonalcoholic fatty liver disease (NAFLD) has become a widely studied subject due to its increasing prevalence and links diseases such as type 2 diabetes obesity. It severe complications, including nonalcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma, portal hypertension that can lead transplantation in some cases. To better prevent treat this pathology, it is important understand underlying physiology. Here, we identify two main factors play crucial role the pathophysiology of NAFLD: oxidative stress key carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). We discuss linking these NAFLD pathophysiology.

Language: Английский

The association between telomere length and non-alcoholic fatty liver disease: a prospective study DOI Creative Commons
Linxi Tang,

Dankang Li,

Yudiyang Ma

et al.

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 9, 2023

Abstract Background Research on the association between telomere length (TL) and incident non-alcoholic fatty liver disease (NAFLD) is limited. This study examined this further assessed how TL contributes to of NAFLD with its known risk factors. Methods Quantitative PCR (polymerase chain reaction) was employed assess leucocyte length. Polygenic score (PRS) for NAFLD, air pollution score, lifestyle index were constructed. Cox proportional hazard models conducted estimate ratios (HRs) 95% confidence intervals. Results Among 467,848 participants in UK Biobank, we identified 4809 cases over a median follow-up 12.83 years. We found that long associated decreased as each interquartile range increase resulted an HR 0.93 (95% CI 0.89, 0.96). partly mediated age (proportion mediated: 15.52%). When assessing joint effects other factors, highest low old age, high unfavorable lifestyle, PRS, compared reference group. A positive addictive interaction observed PRS TL, accounting 14.57% (2.51%, 27.14%) genetic susceptibility. Conclusions Long incidence. Telomere played important role NAFLD. Graphical

Language: Английский

Citations

11
Mechanistic Insights into the Biological Effects and Antioxidant Activity of Walnut (Juglans regia L.) Ellagitannins: A Systematic Review DOI Creative Commons
Letiția Mateș, Roxana Banc,

Flaviu Andrei Zaharie

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 974 - 974

Published: Aug. 10, 2024

Walnuts (

Language: Английский

Citations

4
Chemical Characterization and Differential Lipid-Modulating Effects of Selected Plant Extracts from Côa Valley (Portugal) in a Cell Model for Liver Steatosis DOI Creative Commons
Ricardo Amorim, Mário Pedro Marques, Catarina Melim

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 39 - 39

Published: Jan. 1, 2025

Background/Objectives: Côa Valley, located in the northeast of Portugal, harbors more than 500 medicinal plant species. Among them, four species stand out due to their traditional uses: Equisetum ramosissimum Desf. (hemorrhages, urethritis, hepatitis), Rumex scutatus L. subsp. induratus (Boiss. and Reut.) Malag. (inflammation, constipation), Geranium purpureum Vill., lucidum (pain relief, gastric issues). Given rich ethnomedicinal history, we evaluated protective effects on an vitro model metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: Decoction (D) hydroalcoholic (EtOH80%) extracts were prepared chemically characterized. Their safety profile lipid accumulation assessed palmitic acid (PA)-treated HepG2 cells using resazurin, sulforhodamine B, Nile Red assays. Results: Chemical analysis revealed diverse phenolic compounds, particularly kaempferol derivatives E. ramosissimum. All showed minimal cytotoxicity at 25–50 µg/mL. At 100 µg/mL, only maintained high cell viability. In lipotoxicity model, decoction demonstrated most potent effect, significantly reducing PA-induced neutral a dose-dependent manner, while other varying degrees activity. Conclusions: These findings highlight ramosissimum’s decoction, derivatives, as effective this MASLD also providing comprehensive characterization traditionally used plants from Valley region.

Language: Английский

Citations

0
Exploring the mechanism and crosstalk between IL-6 and IL- 1β on M2 macrophages under metabolic stress conditions DOI

Shawna Yadav,

Anusha Prasannan,

Kaliyamurthi Venkatachalam

et al.

Cytokine, Journal Year: 2025, Volume and Issue: 186, P. 156852 - 156852

Published: Jan. 6, 2025

Language: Английский

Citations

0
Unlocking the therapeutic potential of canagliflozin in NAFLD: Insights into AMPK/SIRT1-mediated lipophagy DOI

Nahla E. El‐Ashmawy,

Ghada M. Al‐Ashmawy, Asmaa A. Kamel

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(3), P. 167666 - 167666

Published: Jan. 20, 2025

Language: Английский

Citations

0
Coagulation Dysfunctions in Non-Alcoholic Fatty Liver Disease—Oxidative Stress and Inflammation Relevance DOI Creative Commons
Madalina Andreea Robea, Ioana-Miruna Balmuș, Irina Gîrleanu

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(9), P. 1614 - 1614

Published: Sept. 7, 2023

Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases. Its incidence progressively rising and it possibly becoming a worldwide epidemic. NAFLD encompasses spectrum diseases accounting for chronic accumulation fat within hepatocytes due to various causes, excluding excessive alcohol consumption. In this study, we aimed focus on finding evidence regarding implications oxidative stress inflammatory processes that form multifaceted pathophysiological tableau in relation thrombotic events co-occur associated Recent pathophysiology suggests complex pattern multidirectional components, such as prooxidative, proinflammatory, prothrombotic better explains multiple factors promote mechanisms underlying acid excess subsequent processes. As there extensive multi-component nature pathophysiology, further studies could address interactions underlie development progression disease. Therefore, study describe possible connecting molecular impairments with clinical manifestations, focusing especially among stress, inflammation, coagulation dysfunctions. Thus, described bidirectional modulation homeostasis, inflammation occurs stages NAFLD.

Language: Английский

Citations

10
Mulberry leaf extract inhibits obesity and protects against diethylnitrosamine-induced hepatocellular carcinoma in rats DOI Creative Commons

Yun‐Ching Chang,

Meng-Hsun Yu,

Hui‐Pei Huang

et al.

Journal of Traditional and Complementary Medicine, Journal Year: 2024, Volume and Issue: 14(3), P. 266 - 275

Published: Jan. 22, 2024

Mulberry leaf has been recognized as a traditional Chinese medicinal plant, which was distributed throughout the Asia. The aqueous extract of mulberry (MLE) various biologically active components such polyphenols and flavonoids. However, inhibitory effect MLE in hepatocarcinogenesis is poorly understood. In this study, we determined role supplementation preventing carcinogen-initiated high-fat diet (HFD)-promoted Sprague-Dawley (SD) rat model. rats were fed an HFD to induce obesity spontaneous hepatomas by administering 0.01% diethylnitrosamine (DEN) their drinking water for 12 weeks (HD group), also through oral ingestion at daily doses 0.5%, 1%, or 2%. At end 12-week experimental period, liver tumors analyzed identify markers oxidative stress antioxidant enzyme activities, serum determine nutritional status function. Histopathological analysis revealed that significantly suppressed severity incidence hepatic tumors. Furthermore, compared with + DEN groups, expression protein kinase C (PKC)-α Rac family small GTPase 1 (Rac1) lower groups. These findings suggest prevents obesity-enhanced, carcinogen-induced hepatocellular carcinoma development, potentially (PKC)α/Rac1 signaling pathway. might be effective chemoprevention modality nonalcoholic fatty disease (NAFLD)/nonalcoholic steatohepatitis (NASH)-related hepatocarcinogenesis.

Language: Английский

Citations

3
Emerging Perspectives of Copper-Mediated Transcriptional Regulation in Mammalian Cell Development DOI Creative Commons
Fa’alataitaua M. Fitisemanu, Teresita Padilla‐Benavides

Metallomics, Journal Year: 2024, Volume and Issue: 16(10)

Published: Oct. 1, 2024

Copper (Cu) is a vital micronutrient necessary for proper development and function of mammalian cells tissues. Cu mediates the redox active enzymes that facilitate metabolic processes signaling pathways. levels are tightly regulated by network Cu-binding transporters, chaperones, small molecule ligands. Extensive research has focused on homeostasis (cuprostasis) pathologies, which result from mutations perturbations. There roles proteins as transcription factors (Cu-TFs) regulators mediate metal through activation or repression genes associated with handling. Emerging evidence suggests some Cu-TFs may be involved in regulation targets related to development-expanding biological proteins. implicated embryonic tissue-specific alongside mediation cellular response oxidative stress hypoxia. also neurological disorders, providing new biomarkers therapeutic diseases such Parkinson's disease, prion Friedreich's ataxia. This review provides critical analysis current understanding role cuproproteins transcriptional regulation.

Language: Английский

Citations

3
Orthosiphon aristatus (Blume) Miq Alleviates Non-Alcoholic Fatty Liver Disease via Antioxidant Activities in C57BL/6 Obese Mice and Palmitic–Oleic Acid-Induced Steatosis in HepG2 Cells DOI Creative Commons
Salah Abdalrazak Alshehade,

Raghdaa Hamdan Al Zarzour,

Michael L. Mathai

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(1), P. 109 - 109

Published: Jan. 11, 2023

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of disease. Orthosiphon aristatus (Blume) Miq, a traditional plant in South Asia, has previously been shown to attenuate obesity and hyperglycaemic conditions. Eight weeks feeding C57BL/6 mice with standardized O. extract (400 mg/kg) inhibited progression NAFLD. Liver enzymes including alanine aminotransferase aspartate transaminase were significantly reduced treated by 74.2% ± 7.69 52.8% 7.83, respectively. Furthermore, showed reduction serum levels glucose (50% 5.71), insulin (70.2% 12.09), total cholesterol (27.5% 15.93), triglycerides (63.2% 16.5), low-density lipoprotein (62.5% 4.93) atherogenic risk index relative negative control. Histologically, reversed hepatic fat accumulation NAFLD severity. Notably, our results antioxidant activity via increased superoxide dismutase malondialdehyde levels. In addition, pro-inflammatory mediators (IL-6 TNFα) decreased, indicating anti-inflammatory activity. The aqueous, hydroethanolic ethanolic fractions intracellular HepG2 cells that palmitic-oleic acid. Together, these findings suggest activities are primary mechanism action underlying anti-NAFLD effects.

Language: Английский

Citations

8
Cold-Pressed Sacha Inchi Oil: High in Omega-3 and Prevents Fat Accumulation in the Liver DOI Creative Commons

Tepparit Samrit,

Supawadee Osotprasit,

Athit Chaiwichien

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(2), P. 220 - 220

Published: Feb. 7, 2024

The ability of oil supplementation to inhibit various metabolic syndromes has been recognized. However, there are currently no studies determining the effects supplements on healthy conditions. Plukenetia volubilis L., also known as Sacha inchi, is a seed rich in essential unsaturated fatty acids that improves syndrome diseases, such obesity and nonalcoholic liver. health benefits inchi (SIO) remain unclear. This study aims evaluate chemical properties oil. results compound analysis showed an abundant source ω-3 acids, with content 44.73%, exhibits scavenging activity 240.53 ± 11.74 272.41 6.95 µg Trolox/g, determined via DPPH ABTS assays, respectively, while both olive lard oils exhibited lower activities compared inchi. Regarding liver histology, rats given TG accumulation fat droplet distribution than those supplements, areas approximately 14.19 6.49% 8.15 2.40%, respectively. In conclusion, our findings suggest plant antioxidants does not induce pathology kidney, pancreas, spleen. Therefore, it potential be used dietary supplement improve diseases.

Language: Английский

Citations

2