Multifunctional Carbon-Based Nanoparticles: Theranostic Applications in Cancer Therapy and Diagnosis

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(4), P. 1323 - 1338

Published: March 15, 2023

Cancer diagnosis and treatment are the most critical challenges in modern medicine. Conventional cancer treatments no longer meet needs of health field due to high rate mutations epigenetic factors that have caused drug resistance tumor cells. Hence, search for unique methods is quickly expanding. The development nanotechnology medicine a system integrate achieve an effective approach overcome known limitations conventional led emergence theranostic nanoparticles nanosystems based on these nanoparticles. An influential group carbon-based These received significant attention their properties, such as electrical conductivity, strength, excellent surface chemistry, wide range structural diversity (graphene, nanodiamond, carbon quantum dots, fullerenes, nanotubes, nanohorns). were widely used various fields, tissue engineering, delivery, imaging, biosensors. In this review, we discuss detail recent features advances advanced diverse strategies treat diseases with

Language: Английский

---

Microwave-Assisted Functionalization of Multi-Walled Carbon Nanotubes for Biosensor and Drug Delivery Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 335 - 335

Published: Jan. 19, 2023

Microwave-assisted synthetic methods have emerged as a popular technique for surface modification and the functionalization of multi-walled carbon nanotubes (MWCNTs) diverse drug delivery applications. Microwave-induced MWCNTs provides high requires less time than conventional techniques. Microwave are simple, fast, effective covalent noncovalent conjugation with various biomolecules polymers. The present review focuses on applications microwave irradiation techniques (MITs) MWCNTs, using amino acids other molecular frameworks containing groups, vitamins, proteins, epoxy moieties, metal nanoparticles,

Language: Английский

---

Recent advances in synergistic use of GQD-based hydrogels for bioimaging and drug delivery in cancer treatment

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(21), P. 5039 - 5060

Published: Jan. 1, 2024

Hydrogel loaded GQDs can be used for targeted bioimaging in specific diseases, including cancer, due to their small size and biocompatibility. have potential application cancer therapy ability absorb radiation make them suitable photothermal photodynamic therapies.

Language: Английский

---

Comprehensive Insights into Oral Squamous Cell Carcinoma: Diagnosis, Pathogenesis, and Therapeutic Advances

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 261, P. 155489 - 155489

Published: July 27, 2024

Language: Английский

---

Beyond traditional hydrogels: The emergence of graphene oxide-based hydrogels in drug delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 94, P. 105506 - 105506

Published: March 1, 2024

Language: Английский

---

Innovative Graphene-Based Nanocomposites for Improvement of Electrochemical Sensors: Synthesis, Characterization, and Applications

Critical Reviews in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: April 24, 2024

Graphene, renowned for its exceptional physicochemical attributes, has emerged as a favored substrate integrating wide array of inorganic and organic materials in scientific endeavors innovations. Electrochemical graphene-based nanocomposite sensors have been developed by incorporating diverse nanoparticles into graphene, effectively immobilized onto electrodes through various techniques. These detected quantified electroactive species samples. This review delves using graphene nanocomposites to fabricate electrochemical sensors, leveraging the electrical, mechanical, thermal properties inherent derivatives. showcase electrocatalytic activity, substantial surface area, superior electrical conductivity, adsorption capabilities, notable porosity, which are highly advantageous sensing applications. A myriad characterization techniques, including Raman spectroscopy, scanning electron microscopy (SEM), transmission (TEM), BET area analysis, X-ray diffraction (XRD), proven effective exploring validating adjustable formation these nanomaterials with graphene. The applicability across matrices, encompassing environmental, food, biological domains, evaluated measurements, such cyclic voltammetry (CV), impedance spectroscopy (EIS), differential pulse (DPV). provides comprehensive overview synthesis methods, sensor applications pertinent nanocomposites. Furthermore, it deliberates on challenges future prospects within this burgeoning field.

Language: Английский

---

Graphene-Based Photodynamic Therapy and Overcoming Cancer Resistance Mechanisms: A Comprehensive Review

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5637 - 5680

Published: June 1, 2024

Abstract: Photodynamic therapy (PDT) is a non-invasive that has made significant progress in treating different diseases, including cancer, by utilizing new nanotechnology products such as graphene and its derivatives. Graphene-based materials have large surface area photothermal effects thereby making them suitable candidates for PDT or photo-active drug carriers. The remarkable photophysical properties of derivates facilitate the efficient generation reactive oxygen species (ROS) upon light irradiation, which destroys cancer cells. Surface functionalization can also enhance their biocompatibility anticancer activity. paper delves into distinct roles played graphene-based photosensitizers (PS) carriers while at same time considers how these could be used to circumvent resistance. This will provide readers with an extensive discussion various pathways contributing inefficiency. Consequently, this comprehensive review underscores vital derivatives may play emerging strategies treatment other medical purposes. With better comprehension current state research existing challenges, integration holds great promise developing targeted, effective, personalized treatments. Keywords: quantum dots, oxide, research, photosensitizers, delivery

Language: Английский

---

Advances in erlotinib delivery systems: Addressing challenges and exploring opportunities in EGFR-targeted cancer therapies

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 161, P. 112114 - 112114

Published: Jan. 22, 2024

Language: Английский

---

Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity

Nanotechnology Reviews, Journal Year: 2021, Volume and Issue: 10(1), P. 1493 - 1559

Published: Jan. 1, 2021

Abstract This review focuses on nano-structured delivery devices prepared from biodegradable and biocompatible natural synthetic polymers, organic raw materials, metals, metal oxides, their other compounds that culminated in the preparation of various nano-entities depending preparative techniques, starting materials’ utilizations. Many nanoparticles (NPs) made polymeric, metallic, magnetic, non-magnetic origins, liposomes, hydrogels, dendrimers, carbon-based have been produced. Developments nanomaterial substrate end products’ design, structural specifications, strategies, chemo-biological interfacing to involve biosystems interactions, surface functionalization, on-site biomolecular physiology-mediated target-specific concepts, examples, applications are outlined. The inherent toxicity, safety design concepts preparation, biomedical fields, especially organs, cellular sub-cellular deliveries deliberated. Bioapplications, therapeutic modules’ pharmacokinetics medicinal values, nanopharmaceutical designs, contributions as healthcare biotechnology drug domains also discussed. importance site-specific triggers nano-scale deliveries, induced specifications numerous entities belonging NPs, composites, nano-conjugates, nano-devices inorganic near biological systems detailed. Modifications provide nano-deliveries intrinsic actions, through physicochemical characteristics modifications, proven success nano-delivery currently available commercial nanomedicinal products provided.

Language: Английский

---

Advanced Computational Methodologies Used in the Discovery of New Natural Anticancer Compounds

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 17, 2021

Natural chemical compounds have been widely investigated for their programmed necrosis causing characteristics. One of the conventional methods screening such is use concentrated plant extracts without isolation active moieties understanding pharmacological activity. For last two decades, modern medicine has relied mainly on and purification one or complicated isomeric compounds. The idea multi-target drugs advanced rapidly impressively from an innovative model when first proposed in early 2000s to popular trends drug development 2021. Alternatively, fragment-based discovery also explored identifying target-based potent natural anticancer agents which based well-defined fragments opposite naturally occurring mixtures. This review summarizes current key advancements compounds; computer-assisted/fragment-based structural elucidation a approach exploration

Language: Английский

---