Wound Repair and Regeneration,
Journal Year:
2024,
Volume and Issue:
32(3), P. 301 - 313
Published: Feb. 3, 2024
Abstract
Bacterial
wound
infection
has
emerged
as
a
pivotal
threat
to
human
health
worldwide,
and
the
situation
worsened
owing
gradual
increase
in
antibiotic‐resistant
bacteria
caused
by
improper
use
of
antibiotics.
To
reduce
antibiotics
avoid
bacteria,
researchers
are
increasingly
paying
attention
photodynamic
therapy,
which
uses
light
produce
reactive
oxygen
species
kill
bacteria.
Treating
bacteria‐infected
wounds
therapy
requires
fixing
photosensitizer
(PS)
at
site
maintaining
certain
level
humidity.
Hydrogels
materials
with
high
water
content
well
suited
for
PSs
sites
antibacterial
therapy.
Therefore,
hydrogels
often
loaded
treating
via
In
this
review,
we
systematically
summarised
mechanisms
applications
PS‐loaded
addition,
recent
studies
research
status
progresses
novel
discussed.
Finally,
challenges
future
prospects
reviewed.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
28, P. 511 - 536
Published: June 27, 2023
Bioinks
are
formulations
of
biomaterials
and
living
cells,
sometimes
with
growth
factors
or
other
biomolecules,
while
extrusion
bioprinting
is
an
emerging
technique
to
apply
deposit
these
bioinks
biomaterial
solutions
create
three-dimensional
(3D)
constructs
architectures
mechanical/biological
properties
that
mimic
those
native
human
tissue
organs.
Printed
have
found
wide
applications
in
engineering
for
repairing
treating
tissue/organ
injuries,
as
well
vitro
modelling
testing
validating
newly
developed
therapeutics
vaccines
prior
their
use
humans.
Successful
printing
subsequent
rely
on
the
formulated
bioinks,
including
rheological,
mechanical,
biological
properties,
process.
This
article
critically
reviews
latest
developments
bioprinting,
focusing
bioink
synthesis
characterization,
influence
Key
issues
challenges
also
discussed
along
recommendations
future
research.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(17), P. 6191 - 6220
Published: Jan. 1, 2023
This
review
highlights
the
recent
progress
in
piezoelectric
gels
(also
known
as
PiezoGels)
comprised
of
polymers,
ceramic
oxides
and
supramolecular
materials
used
for
energy
harvesting,
sensing
wound
dressing.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(11), P. 2334 - 2366
Published: Jan. 1, 2023
In
recent
years,
titanium(
iv
)
dioxide
nanoparticles
(TiO
2
NPs)
have
shown
promising
potential
in
various
biological
applications
such
as
antimicrobials,
drug
delivery,
photodynamic
therapy,
biosensors,
and
tissue
engineering.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1370 - 1370
Published: Jan. 23, 2024
The
mannose
receptor
(MR,
CD
206)
is
an
endocytic
primarily
expressed
by
macrophages
and
dendritic
cells,
which
plays
a
critical
role
in
both
endocytosis
antigen
processing
presentation.
MR
carbohydrate
recognition
domains
(CRDs)
exhibit
high
binding
affinity
for
branched
linear
oligosaccharides.
Furthermore,
multivalent
presentation
on
the
various
templates
like
peptides,
proteins,
polymers,
micelles,
dendrimers
was
proven
to
be
valuable
approach
selective
efficient
delivery
of
therapeutically
active
agents
MR.
This
review
provides
detailed
account
most
relevant
recent
aspects
synthesis
application
mannosylated
bioactive
formulations
MR-mediated
treatments
cancer
other
infectious
diseases.
It
further
highlights
findings
related
necessary
structural
features
mannose-containing
ligands
successful
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(26)
Published: April 11, 2024
Drug
delivery
is
a
key
component
of
nanomedicine,
and
conventional
relies
on
the
adsorption
or
encapsulation
drug
molecules
to
nanomaterial.
Many
vehicles
contain
metal
ions,
such
as
metal-organic
frameworks,
oxides,
transition
dichalcogenides,
MXene,
noble
nanoparticles.
These
materials
have
high
content
pose
potential
long-term
toxicity
concerns
leading
difficulties
for
clinical
approval.
In
this
review,
recent
developments
are
summarized
in
use
ligands
coordination
forming
various
nanomaterials
soft
materials.
these
cases,
drug-to-metal
ratio
much
higher
than
adsorption-based
strategies.
The
divided
into
small-molecule
drugs,
nucleic
acids,
proteins.
formed
hybrid
mainly
include
nanoparticles
hydrogels,
upon
which
targeting
can
be
grafted
improve
efficacy
further
decrease
toxicity.
application
addressing
cancer,
viral
infection,
bacterial
infection
inflammatory
bowel
disease,
bone
diseases
reviewed.
end,
some
future
directions
discussed
from
fundamental
research,
science,
medicine.
The Microbe,
Journal Year:
2024,
Volume and Issue:
2, P. 100051 - 100051
Published: Feb. 29, 2024
Antimicrobial
peptides
(AMPs)
are
low-molecular-weight
that
demonstrate
a
broad
range
of
antimicrobial
and
immunomodulatory
effects
against
bacteria,
viruses,
yeasts,
fungi,
cytotoxic
cancer
cells.
Natural
AMPs
typically
have
positive
charge
contain
fewer
than
100
amino
acids,
along
with
amphipathic
properties.
obtained
from
numerous
sources,
like
humans,
animals,
plants,
etc.,
where
they
act
as
significant
part
the
innate
immune
system
provide
first-line
protection
pathogenic
microorganisms.
As
result,
since
separate
mechanisms
conventional
antibiotics,
can
be
best
choice
for
drug-resistant
microbial
treatment.
The
tablet,
capsule,
solution
inconvenient
when
given
orally
due
to
peptide
degradation
lower
absorption
in
gastrointestinal
tract.
Novel
drug
delivery
systems
formulations
been
developed
showed
increased
activity
compared
single
AMP.
Special
nanocarriers,
hydrogels,
cubosomes,
wafers,
dry
powder
inhalers,
creams,
mouth
rinse
established
help
prevent
some
major
barriers
clinical
applications,
such
cytotoxicity,
bioavailability,
stability.
In
our
review
studies,
we
discussing
formulation
by
classification,
different
benefits
limitations
various
methods,
their
applications.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(4), P. 3551 - 3570
Published: Jan. 20, 2023
Owing
to
their
properties
such
as
biocompatibility,
tunable
mechanical
properties,
permeability
toward
oxygen,
nutrients,
and
the
ability
hold
a
significant
amount
of
water,
hydrogels
have
wide
applications
in
biomedical
research.
They
been
engaged
drug
delivery
systems,
3D
cell
culture,
imaging,
extracellular
matrix
(ECM)
mimetics.
Injectable
represent
major
subset
possessing
advantages
site-specific
conformation
with
minimal
invasive
techniques.
It
preserves
inherent
drug/biomolecules
is
devoid
any
side
effects
associated
surgery.
Various
polymeric
materials
utilized
developing
injectable
are
limitations
toxicity,
immunogenicity,
tedious
manufacturing
processes,
lack
easy
synthetic
tunability.
Peptides
an
important
class
biomaterials
that
interesting
stimuli
responsiveness,
shear
thinning,
self-healing,
biosignaling.
immunogenicity
toxicity.
Therefore,
numerous
peptide-based
explored
past,
few
them
reached
market.
In
recent
years,
minimalistic
dipeptides
shown
form
stable
through
cooperative
noncovalent
interactions.
addition
lengthy
hydrogels,
unique
low
production
cost,
high
accessibility,
higher
stability.
Given
instances
expanding
significance
peptide
research
emerging
trend
dipeptide-based
timely
review
on
shall
highlight
various
aspects
this
biomaterials.
This
concise
focuses
dipeptide
hydrogel
may
stimulate
current
trends
biomaterial
translate
its
products
for
applications.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(10), P. 8960 - 8976
Published: Feb. 28, 2023
Since
the
first
report
on
pharmacological
activity
of
curcumin
in
1949,
enormous
amounts
research
have
reported
diverse
activities
for
this
natural
polyphenol
found
dietary
spice
turmeric.
However,
has
not
yet
been
used
human
application
as
an
approved
drug.
The
clinical
translation
hampered
due
to
its
low
solubility
and
bioavailability.
improvement
bioavailability
can
be
achieved
by
formulation
using
drug
delivery
systems.
Hydrogels
with
their
biocompatibility
toxicity
effects
shown
a
substantial
impact
successful
hydrophobic
drugs
trials.
This
review
focuses
hydrogel-based
systems
describes
applications
anti-cancer
well
wound
healing
agents.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1068 - 1068
Published: Feb. 21, 2023
The
development
of
peptide-based
materials
has
emerged
as
one
the
most
challenging
aspects
biomaterials
in
recent
years.
It
been
widely
acknowledged
that
can
be
used
a
broad
range
biomedical
applications,
particularly
tissue
engineering.
Among
them,
hydrogels
have
attracting
considerable
interest
engineering
because
they
mimic
formation
conditions
by
providing
three-dimensional
environment
and
high
water
content.
found
received
more
attention
due
to
mimicking
proteins,
extracellular
matrix
well
wide
variety
applications
are
capable
serving.
is
without
doubt
become
leading
today
owing
their
tunable
mechanical
stability,
content,
biocompatibility.
Here,
we
discuss
detail
various
types
materials,
emphasizing
hydrogels,
then
examine
how
formed,
paying
particular
peptide
structures
incorporated
into
final
structure.
Following
that,
self-assembly
under
conditions,
parameters
considered
critical
factors,
which
include
pH,
amino
acid
composi-
tion
within
sequence,
cross-linking
techniques.
Further,
studies
on
reviewed.
Cancer
immunotherapy
has
achieved
tremendous
successful
clinical
results
and
obtained
historic
victories
in
tumor
treatments.
However,
great
limitations
associated
with
feeble
immune
responses
serious
adverse
effects
still
cannot
be
neglected
due
to
the
complicated
multifactorial
etiology
pathologic
microenvironment
tumors.
The
rapid
development
of
nanomedical
science
material
facilitated
advanced
progress
engineering
biomaterials
tackle
critical
issues.
supramolecular
flexible
modular
structures
have
exhibited
unparalleled
advantages
high
cargo-loading
efficiency,
excellent
biocompatibility,
diversiform
immunomodulatory
activity,
thereby
providing
a
powerful
weapon
for
cancer
immunotherapy.
In
past
decades,
were
extensively
explored
as
versatile
delivery
platforms
immunotherapeutic
agents
or
designed
interact
key
moleculars
system
precise
controllable
manner.
this
review,
we
focused
on
crucial
role
modulation
pivotal
steps
during
immunotherapy,
including
antigen
presentation,
T
lymphocyte
activation,
tumor-associated
macrophage
elimination
repolarization,
myeloid-derived
suppressor
cell
depletion.
Based
extensive
research,
current
prospects
