Molecules,
Journal Year:
2024,
Volume and Issue:
29(23), P. 5654 - 5654
Published: Nov. 29, 2024
The
bioavailability,
release,
and
stability
of
pharmaceuticals
under
physicochemical
conditions
is
the
major
cause
drug
candidates
failing
during
their
clinical
trials.
Therefore,
extensive
efforts
have
been
invested
in
development
novel
delivery
systems
that
are
able
to
transport
drugs
a
desired
site
improve
bioavailability.
Hydrogels,
peptide
hydrogels
particular,
extensively
investigated
due
excellent
biocompatibility
biodegradability
properties.
However,
often
weak
mechanical
strength,
which
limits
therapeutic
efficacy.
number
methods
for
improving
rheological
properties
established.
This
review
will
cover
broad
area
delivery,
focusing
on
recent
developments
this
research
field.
We
discuss
variety
different
types
nanocarrier
then,
more
specifically,
significance
perspectives
peptide-based
hydrogels.
In
interplay
intermolecular
forces
govern
self-assembly
hydrogels,
progress
made
understanding
distinct
morphologies
applications
non-canonical
amino
acids
hydrogel
design
be
discussed
detail.
The Microbe,
Journal Year:
2024,
Volume and Issue:
2, P. 100051 - 100051
Published: Feb. 29, 2024
Antimicrobial
peptides
(AMPs)
are
low-molecular-weight
that
demonstrate
a
broad
range
of
antimicrobial
and
immunomodulatory
effects
against
bacteria,
viruses,
yeasts,
fungi,
cytotoxic
cancer
cells.
Natural
AMPs
typically
have
positive
charge
contain
fewer
than
100
amino
acids,
along
with
amphipathic
properties.
obtained
from
numerous
sources,
like
humans,
animals,
plants,
etc.,
where
they
act
as
significant
part
the
innate
immune
system
provide
first-line
protection
pathogenic
microorganisms.
As
result,
since
separate
mechanisms
conventional
antibiotics,
can
be
best
choice
for
drug-resistant
microbial
treatment.
The
tablet,
capsule,
solution
inconvenient
when
given
orally
due
to
peptide
degradation
lower
absorption
in
gastrointestinal
tract.
Novel
drug
delivery
systems
formulations
been
developed
showed
increased
activity
compared
single
AMP.
Special
nanocarriers,
hydrogels,
cubosomes,
wafers,
dry
powder
inhalers,
creams,
mouth
rinse
established
help
prevent
some
major
barriers
clinical
applications,
such
cytotoxicity,
bioavailability,
stability.
In
our
review
studies,
we
discussing
formulation
by
classification,
different
benefits
limitations
various
methods,
their
applications.
The International Journal of Lower Extremity Wounds,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 15, 2024
Nanohydrogel
wound
healing
refers
to
the
use
of
nanotechnology-based
hydrogel
materials
promote
wounds.
Hydrogel
dressings
are
made
up
a
three-dimensional
network
hydrophilic
polymers
that
can
absorb
and
retain
large
amounts
water
or
other
fluids.
Nanohydrogels
take
this
concept
further
by
incorporating
nanoscale
particles
structures
into
matrix.
These
nanoparticles
be
various
materials,
such
as
silver,
zinc
oxide,
derived
from
natural
substances
like
chitosan.
The
inclusion
provide
additional
properties
benefits
dressings.
designed
release
bioactive
substances,
growth
factors
drugs,
in
controlled
manner.
This
allows
for
targeted
delivery
therapeutics
site,
promoting
reducing
inflammation.
Nanoparticles
reinforce
structure
hydrogels,
improving
their
mechanical
strength
stability.
often
incorporate
antimicrobial
nanoparticles,
silver
oxide.
have
shown
effective
activity
against
wide
range
bacteria,
fungi,
pathogens.
By
them
dressings,
nanohydrogels
help
prevent
reduce
risk
infection
encapsulate
factors,
peptides,
sustained
therapeutic
agents
promotes
facilitating
cell
proliferation,
inflammation,
supporting
tissue
regeneration.
unique
nanohydrogels,
including
ability
maintain
moist
environment
deliver
agents,
accelerate
process.
creating
an
optimal
repair,
faster
more
efficient
Biology,
Journal Year:
2023,
Volume and Issue:
13(1), P. 21 - 21
Published: Dec. 29, 2023
Traumatic
brain
injury
(TBI)
is
a
leading
cause
of
mortality
and
long-term
impairment
globally.
TBI
has
dynamic
pathology,
encompassing
variety
metabolic
molecular
events
that
occur
in
two
phases:
primary
secondary.
A
forceful
external
blow
to
the
initiates
phase,
followed
by
secondary
phase
involves
release
calcium
ions
(Ca2+)
initiation
cascade
inflammatory
processes,
including
mitochondrial
dysfunction,
rise
oxidative
stress,
activation
glial
cells,
damage
blood–brain
barrier
(BBB),
resulting
paracellular
leakage.
Currently,
there
are
no
FDA-approved
drugs
for
TBI,
but
existing
approaches
rely
on
delivering
micro-
macromolecular
treatments,
which
constrained
BBB,
poor
retention,
off-target
toxicity,
complex
pathology
TBI.
Therefore,
demand
innovative
alternative
therapeutics
with
effective
delivery
tactics
diagnosis
treatment
Tissue
engineering,
includes
use
biomaterials,
one
such
approach.
Biomaterials,
as
hydrogels,
self-assembling
peptides
electrospun
nanofibers,
can
be
used
alone
or
combination
neuronal
stem
cells
induce
neurite
outgrowth,
differentiation
human
neural
nerve
gap
bridging
This
review
examines
inclusion
biomaterials
potential
treatments
their
types,
synthesis,
mechanisms
action.
also
discusses
challenges
faced
development
biodegradable,
biocompatible,
mechanically
flexible
and,
if
combined
survival
rate
transplanted
cells.
better
understanding
drawbacks
these
novel
therapeutic
will
help
guide
design
future
therapies.
Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
24(6)
Published: March 28, 2024
Abstract
Spinal
cord
injury,
traumatic
brain
and
neurosurgery
procedures
usually
lead
to
neural
tissue
damage.
Self‐assembled
peptide
(SAP)
hydrogels,
a
type
of
innovative
hierarchical
nanofiber‐forming
sequences
serving
as
hydrogelators,
have
emerged
promising
solution
for
repairing
defects
promoting
regeneration.
SAPs
possess
numerous
features,
such
adaptable
morphologies,
biocompatibility,
injectability,
tunable
mechanical
stability,
mimicking
the
native
extracellular
matrix.
This
review
explores
capacity
cell
regeneration
examines
critical
aspects
in
neuroregeneration,
including
their
biochemical
composition,
topology,
behavior,
conductivity,
degradability.
Additionally,
it
delves
into
latest
strategies
involving
central
or
peripheral
engineering.
Finally,
prospects
SAP
hydrogel
design
development
realm
neuroregeneration
are
discussed.
Soft Matter,
Journal Year:
2024,
Volume and Issue:
20(12), P. 2720 - 2729
Published: Jan. 1, 2024
Heating
and
sonication
of
peptide
conjugate
C
14
-FH(Trt)-OH
self-assembles
into
a
supramolecular
hydrogel,
that
forms
weaker
more
porous
gel
state
with
the
addition
divalent
metal
ions.
