PROSPECTS ON TITANIUM BIOMATERIALS DOI Creative Commons
Mădălina Simona Bălţatu, Petrică Vizureanu, Andrei Victor Sandu

et al.

European Journal of Materials Science and Engineering, Journal Year: 2023, Volume and Issue: 8(4), P. 201 - 212

Published: Dec. 20, 2023

Biomaterials are substances that have been engineered to interact with biological systems for a medical purpose, either therapeutic or diagnostic one. rich history of evolution, as they continuously transformed from simple inert complex, interactive materials, designed communicate and promote tissue regeneration healing. Titanium, due its excellent biocompatibility, corrosion resistance, mechanical properties, has established place one the most used biomaterials, particularly in orthopedics dental applications. This article provides an overview titanium biomaterial, highlighting applications, recent advancements.

Language: Английский

3D printing metal implants in orthopedic surgery: Methods, applications and future prospects DOI Creative Commons
Meng Meng, Jinzuo Wang,

Huagui Huang

et al.

Journal of Orthopaedic Translation, Journal Year: 2023, Volume and Issue: 42, P. 94 - 112

Published: Sept. 1, 2023

Currently, metal implants are widely used in orthopedic surgeries, including fracture fixation, spinal fusion, joint replacement, and bone tumor defect repair. However, conventional difficult to be customized according the recipient's skeletal anatomy characteristics, leading difficulties meeting individual needs of patients. Additive manufacturing (AM) or three-dimensional (3D) printing technology, an advanced digital fabrication technique capable producing components with complex precise structures, offers opportunities for personalization. We systematically reviewed literature on 3D over past 10 years. Relevant animal, cellular, clinical studies were searched PubMed Web Science. In this paper, we introduce method characteristics biometals summarize properties their applications surgery. On basis, discuss potential possibilities further generalization improvement. technology has facilitated use different procedures. By combining medical images from techniques such as CT MRI, allows based injured tissue. Such patient-specific not only reduce excessive mechanical strength eliminate stress-shielding effects, but also improve biocompatibility functionality, increase cell nutrient permeability, promote angiogenesis growth. addition, advantages low cost, fast cycles, high reproducibility, which can shorten patients' surgery hospitalization time. Many trials have been conducted using implants. modeling software, operation equipment, demand implant materials, lack guidance relevant laws regulations limited its application. There personalization, promotion osseointegration, short production cycle, material utilization. With continuous learning software by surgeons, improvement development materials that better meet needs, regulations, applied more surgeries. Precision, intelligence, personalization future direction orthopedics. It is reasonable believe will deeply integrated artificial 4D printing, big data play a greater role eventually become important part economy. aim latest developments engineers surgeons design closely mimic morphology function native bone.

Language: Английский

Citations

103
Application of collagen in bone regeneration DOI Creative Commons

Rebecca H. Li,

Shiqing Xu, Yan Guo

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. 129 - 143

Published: Jan. 1, 2025

At present, there is a significant population of individuals experiencing bone deficiencies caused by injuries, ailments affecting the bones, congenital abnormalities, and cancer. The management substantial defects global orthopedic challenge due to intricacies involved in promoting restoring growth fresh osseous tissue. Autografts are widely regarded as "gold standard" for repairing because their superior tissue acceptance ability control osteogenesis. However, patients undergoing autografts may encounter various challenges, including but not limited hernia, bleeding, nerve impairment, death. Therefore, researchers regenerative medicine striving find alternatives. Collagen most abundant protein human body, its triple helix structure gives it unique characteristics that contribute strength functionality tissues. commonly processed into forms such scaffolds, sponges, membranes, hydrogels, composite materials, compatibility with affinity water, minimal potential immune reactions, adaptability, transport nutrients or drugs. As an alternative material field regeneration, collagen becoming increasingly important. objective this review provide comprehensive analysis primary types sources collagen, processes synthesis degradation, well advancements made regeneration research applications. A investigation role undertaken, providing valuable points reference more profound comprehension applications field. concluding section provides overview prospective avenues research, underscoring promising future highlighting regeneration. Translational Potential Article. exploration diverse functions translational demonstrated review, these findings underscore treatment option clinical implications, thus paving way innovative efficacious therapeutic strategies domain.

Language: Английский

Citations

5
Recent Advancements in the Surface Modification of Additively Manufactured Metallic Bone Implants DOI Creative Commons

Jianhui Li,

Haitao Fan,

Hui Qiang Li

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown, P. 200195 - 200195

Published: Jan. 1, 2025

Language: Английский

Citations

3
The corrosion and biological behavior of 3D-printed polycaprolactone/chitosan scaffolds as protective coating for Mg alloy implants DOI
Negin Khoshnood, John P. Frampton, S. R. Alavi Zaree

et al.

Surface and Coatings Technology, Journal Year: 2024, Volume and Issue: 477, P. 130368 - 130368

Published: Jan. 5, 2024

Language: Английский

Citations

12
Polyaryletherketones: Properties and applications in modern medicine DOI Creative Commons
Gregory Sacks, Veer Shah,

Lilian Yao

et al.

Biomedical Technology, Journal Year: 2024, Volume and Issue: 6, P. 75 - 89

Published: Jan. 9, 2024

Polyaryletherketones (PAEKs) are a family of durable, multifunctional, thermoplastic biopolymers. This article first provides necessary context and thorough information regarding the mechanical, physical, chemical, crystalline, shape memory properties PAEKs as well critical details manufacturing. Additionally, it an update on clinical biomedical uses by summarizing most recent groundbreaking applications these thermopolymers. have been used clinically in fields including orthopedics, craniofacial cardiothoracic surgery, cardiovascular dental medicine. Other include tissue engineering, post-surgical antibiotic delivery, antimicrobial applications, anti-cancer drug 3D printing. Of importance, comparable mechanical strength elastic modulus to human bone, which enable serve viable alternative metal-based implants. Given their remarkable properties, ability be specifically rapidly manufactured through printing, will continue subject research vital role medical applications.

Language: Английский

Citations

12
Targeting Macrophage Polarization for Reinstating Homeostasis following Tissue Damage DOI Open Access
Qiran Du, Anna Dickinson,

Pruthvi Nakuleswaran

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7278 - 7278

Published: July 2, 2024

Tissue regeneration and remodeling involve many complex stages. Macrophages are critical in maintaining micro-environmental homeostasis by regulating inflammation orchestrating wound healing. They display high plasticity response to various stimuli, showing a spectrum of functional phenotypes that vary from M1 (pro-inflammatory) M2 (anti-inflammatory) macrophages. While transient is an essential trigger for tissue healing following injury, sustained (e.g., foreign body implants, diabetes or inflammatory diseases) can hinder cause damage. Modulating macrophage polarization has emerged as effective strategy enhancing immune-mediated promoting better integration implantable materials the host. This article provides overview macrophages' properties followed discussing different strategies modulating polarization. Advances use synthetic natural biomaterials fabricate immune-modulatory highlighted. reveals development clinical application more immunomodulatory systems targeting under pathological conditions will be driven detailed understanding factors regulate biological function order optimize existing methods generate novel control cell phenotype.

Language: Английский

Citations

10
Cardiac tissue engineering: an emerging approach to the treatment of heart failure DOI Creative Commons
Hossein Rayat Pisheh,

Fatemeh Sadat Nojabaei,

Ahmad Darvishi

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 15, 2024

Heart failure is a major health problem in which the heart unable to pump enough blood meet body’s needs. It progressive disease that becomes more severe over time and can be caused by variety of factors, including attack, cardiomyopathy valve disease. There are various methods cure this disease, has many complications risks. The advancement knowledge technology proposed new for diseases. One promising treatments tissue engineering. Tissue engineering field research aims create living tissues organs replace damaged or diseased tissue. goal improve cardiac function reduce need transplantation. This done using three important principles cells, biomaterials signals techniques cells such as electrospinning, hydrogel synthesis, decellularization, etc. diverse. Treating through still under development research, but it hoped there will no transplants invasive surgeries near future. In study, based on most recent years, we examine power treatment failure.

Language: Английский

Citations

5
Improved Tribological Performance of Nitride-Reinforced Biocompatible Titanium–Niobium–Zirconium–Tantalum (TNZT) Alloys for Advanced Orthopedic Applications DOI Creative Commons
Satyavan Digole,

Jay Desai,

C. M. Baker Christopher

et al.

Metals, Journal Year: 2024, Volume and Issue: 14(1), P. 122 - 122

Published: Jan. 20, 2024

β-titanium (β-Ti) alloys are used in various biomedical applications, especially for orthopedic implants, due to their superior biocompatibility, excellent corrosion resistance, and enhanced mechanical properties. However, the inferior tribological properties of β-Ti lead fretting wear a strong tendency seize, which is major concern applications involving continuous friction. This work aims address this issue by incorporating biocompatible nitrides Ti-Nb-Zr-Ta (TNZT) alloys. TNZT composites comprising 2 wt.% (TiN, NbN, ZrN, TaN) were prepared using high-energy ball milling followed spark plasma sintering. All improved hardness resistance showed biocompatibility. TNZT-2 TiN average highest 311.8 HV lowest coefficient friction 0.659, suggesting efficiency improving performance The underlying mechanisms behind nitride-reinforced discussed detail. effect concentration was also studied preparing with 5 10 TiN, showcased higher 388.5 444.3 HV, respectively. will aid producing advanced applications.

Language: Английский

Citations

4
Investigating a nanocomposite coating of cerium oxide/merwinite via PEO/EPD for enhanced biocorrosion resistance, bioactivity and antibacterial activity of magnesium-based implants DOI

Nasim kojouri Naftchali,

Rouhollah Mehdinavaz Aghdam,

Aryan Najjari

et al.

Ceramics International, Journal Year: 2024, Volume and Issue: 50(21), P. 42766 - 42779

Published: Aug. 8, 2024

Language: Английский

Citations

4
Understanding the Influence of Serum Proteins Adsorption on the Mechano‐Bactericidal Efficacy and Immunomodulation of Nanostructured Titanium DOI Creative Commons
Karolinne Martins de Sousa, Denver P. Linklater, Vladimir A. Baulin

et al.

Advanced Materials Interfaces, Journal Year: 2024, Volume and Issue: 11(17)

Published: March 14, 2024

Abstract Nanostructured surfaces are effective at physically killing bacterial cells, highlighting their prospective application as biomaterials. The benefits of mechano‐bactericidal nanostructures an alternative to chemical functionalisation well documented, however, the effects protein adsorption not understood. In this work, theoretical and experimental analyses conducted by studying human serum proteins (HSP) nanosheet titanium (Ti) its subsequent effect on efficacy toward Staphylococcus aureus Pseudomonas aeruginosa cells. pattern exhibits enhanced antibiofouling behaviour mantaining high bactericidal efficiency both Gram‐negative Gram‐positive cells in presence adsorbed HSP. To ascertain immunomodulatory response, S. introduced protein‐conditioned Ti prior introducing RAW 264.7 macrophages. On pre‐infected nanostructured surfaces, macrophages exhibit wound healing with superior activation M2‐like macrophage polarization secretion anti‐inflammatory cytokines. By contrast, attached infected smooth activated M1‐like polarized phenotype via expression pro‐inflammatory cytokines, indicating persistent inflammation. outcomes work demonstrate suitability nanosheets a potential biomaterial surface whereby activity is compromised HSP and, furthermore, positively influenced immune response.

Language: Английский

Citations

3