Journal of Industrial Microbiology & Biotechnology,
Journal Year:
2021,
Volume and Issue:
48(3-4)
Published: Jan. 1, 2021
Abstract
Actinomycetes
are
a
rich
source
of
bioactive
natural
products
important
for
novel
drug
leads.
Recent
genome
mining
approaches
have
revealed
an
enormous
number
secondary
metabolite
biosynthetic
gene
clusters
(smBGCs)
in
actinomycetes.
However,
under
standard
laboratory
culture
conditions,
many
smBGCs
silent
or
cryptic.
To
activate
these
dormant
smBGCs,
several
approaches,
including
culture-based
genetic
engineering-based
strategies,
been
developed.
Above
all,
coculture
is
promising
approach
to
induce
production
from
actinomycetes
by
mimicking
ecological
habitat
where
cryptic
may
be
activated.
In
this
review,
we
introduce
studies
that
aim
expand
the
chemical
diversity
actinomycetes,
categorizing
cases
type
partner.
Furthermore,
discuss
current
challenges
need
overcome
support
elicitation
compounds
Journal of Medical Microbiology,
Journal Year:
2020,
Volume and Issue:
69(8), P. 1040 - 1048
Published: July 21, 2020
Given
the
increased
reporting
of
multi-resistant
bacteria
and
shortage
newly
approved
medicines,
researchers
have
been
looking
towards
extreme
unusual
environments
as
a
new
source
antibiotics.
Frontiers in Chemistry,
Journal Year:
2020,
Volume and Issue:
8
Published: May 8, 2020
The
growing
concern
over
the
harmful
effects
of
synthetic
colorants
on
both
consumer
and
environment
has
raised
a
strong
interest
in
natural
colouring
alternatives.
As
result
worldwide
demand
for
colourants
origin
is
rapidly
increasing
food,
cosmetic
textile
sectors.
Natural
have
capacity
to
be
used
variety
industrial
applications,
instance,
as
dyes
non-textile
substrates
such
leather,
paper,
within
paints
coatings,
cosmetics,
food
additives.
Currently,
pigments
produced
through
plants
microbes
are
primary
source
exploited
by
modern
industries.
Among
other
non-conventional
sources,
filamentous
fungi
particularly
ascomycetous
basidiomycetous
(mushrooms),
lichens
(symbiotic
association
fungus
with
green
alga
or
cyanobacterium)
known
produce
an
extraordinary
range
colours
including
several
chemical
classes
melanins,
azaphilones,
flavins,
phenazines,
quinines.
This
review
seeks
emphasise
opportunity
afforded
naturally
found
viable
alternative
current
sources.
presents
comprehensive
discussion
fungal
resources
endophytes,
halophytes,
obtained
from
sources
soil,
sediments,
mangroves
marine
environments.
A
key
driver
stems
environmental
factors
here
will
extend
advancement
greener
extraction
techniques
intracellular
extracellular
pigments.
search
compounds
requires
multidisciplinary
approach
metabolomics,
metabolic
engineering
biotechnological
approaches
that
potential
deal
various
challenges
faced
pigment
industry
Frontiers in Marine Science,
Journal Year:
2021,
Volume and Issue:
8
Published: March 16, 2021
Coastal
countries
have
traditionally
relied
on
the
existing
marine
resources
(e.g.,
fishing,
food,
transport,
recreation,
and
tourism)
as
well
tried
to
support
new
economic
endeavors
(ocean
energy,
desalination
for
water
supply,
seabed
mining).
Modern
societies
lifestyle
resulted
in
an
increased
demand
dietary
diversity,
better
health
well-being,
biomedicines,
natural
cosmeceuticals,
environmental
conservation,
sustainable
energy
sources.
These
societal
needs
stimulated
interest
of
researchers
diverse
underexplored
environments
promising
sources
biomolecules
biomass,
they
are
addressed
by
emerging
field
(blue)
biotechnology.
Blue
biotechnology
provides
opportunities
a
wide
range
initiatives
commercial
pharmaceutical,
biomedical,
cosmetic,
nutraceutical,
feed,
agricultural,
related
industries.
This
article
synthesizes
essence,
opportunities,
responsibilities,
challenges
encountered
outlines
attainment
valorization
directly
derived
or
bio-inspired
products
from
organisms.
First,
concept
bioeconomy
is
introduced.
Then,
diversity
bioresources
including
overview
most
prominent
organisms
their
potential
biotechnological
uses
described.
followed
introducing
methodologies
exploration
these
main
use
case
scenarios
food
agronomy,
bioremediation
climate
change,
materials,
healthcare,
well-being
sectors.
The
key
aspects
fields
legislation
funding
provided,
with
emphasis
importance
communication
stakeholder
engagement
at
all
levels
development.
Finally,
vital
overarching
concepts,
such
quadruple
helix
Responsible
Research
Innovation
principle
highlighted
important
follow
within
field.
authors
this
review
collaborating
under
European
Commission-funded
Cooperation
Science
Technology
(COST)
Action
Ocean4Biotech
–
transdisciplinary
networking
platform
focus
study
state
affairs.
Microorganisms,
Journal Year:
2021,
Volume and Issue:
9(1), P. 197 - 197
Published: Jan. 19, 2021
Fungal
endophytes
are
well-established
sources
of
biologically
active
natural
compounds
with
many
producing
pharmacologically
valuable
specific
plant-derived
products.
This
review
details
typical
medicinal
several
classes,
including
alkaloids,
coumarins,
flavonoids,
glycosides,
lignans,
phenylpropanoids,
quinones,
saponins,
terpenoids,
and
xanthones
that
produced
by
endophytic
fungi.
covers
the
studies
carried
out
since
first
report
taxol
biosynthesis
Taxomyces
andreanae
in
1993
up
to
mid-2020.
The
article
also
highlights
prospects
endophyte-dependent
such
bottlenecks
commercialization
this
novel
approach
area
drug
discovery.
After
recent
updates
field
'omics'
'one
strain
compounds'
(OSMAC)
approach,
fungal
have
emerged
as
strong
unconventional
source
prized
Molecules,
Journal Year:
2023,
Volume and Issue:
28(15), P. 5915 - 5915
Published: Aug. 6, 2023
Actinomycetes
inhabit
both
terrestrial
and
marine
ecosystems
are
highly
proficient
in
producing
a
wide
range
of
natural
products
with
diverse
biological
functions,
including
antitumor,
immunosuppressive,
antimicrobial,
antiviral
activities.
In
this
review,
we
delve
into
the
life
cycle,
ecology,
taxonomy,
classification
actinomycetes,
as
well
their
varied
bioactive
metabolites
recently
discovered
between
2015
2023.
Additionally,
explore
promising
strategies
to
unveil
investigate
new
metabolites,
encompassing
genome
mining,
activation
silent
genes
through
signal
molecules,
co-cultivation
approaches.
By
presenting
comprehensive
up-to-date
hope
offer
potential
solution
uncover
novel
compounds
essential
Agronomy,
Journal Year:
2020,
Volume and Issue:
10(9), P. 1424 - 1424
Published: Sept. 19, 2020
Sprouts
and
microgreens
have
attracted
tremendous
interest
across
multiple
disciplines
in
recent
years.
Here,
we
critically
review
the
most
advances
to
underscore
research
prospects
niches,
related
challenges,
not
yet
addressed
or
fully
pursued.
In
particular,
report
a
number
of
themes
that
merit
special
attention
as
result
their
relevance
plant
science,
nutrition,
health,
zootechnics:
(1)
species
inadequately
investigated,
such
wild
plants,
fruit
tree
strains;
(2)
abiotic
biotic
factors,
biostimulants,
for
elicitation
strategies
metabolic
engineering;
(3)
sanitization
processing
technologies
obtain
high-quality
products;
(4)
digestive
fate
impact
bioactive
elements,
antinutrients,
allergens
on
human
nutrition;
(5)
experimental
challenges
researching
health
benefits;
(6)
opportunity
generate
natural
product
libraries
drug
discovery;
(7)
sprouts
animal
feeding
improve
both
nutritional
value
products
diet.
The
convergence
different
involving
interdisciplinary
competencies
advocate
fascinating
pursuits,
example,
variants
collections
identification
selection
chemicals
with
role
nutraceuticals,
key
constituents
functional
foods,
interactive
partners
specific
drugs.
