Phytoene and phytoene-rich microalgae extracts extend lifespan in C. elegans and protect against amyloid-beta toxicity in an Alzheimers disease model DOI Open Access
Ángeles Morón-Ortiz,

Antonis A. Karamalegkos,

Paula Mapelli‐Brahm

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Abstract The role of foods is shifting from focusing on the provision energy and basic nutrients to also include bioactive compounds that prevent development chronic age-related diseases. Microalgae offer a source nutritional with important health effects, have potential for production health-promoting products, without increasing agricultural land use negatively impacting environment. Here we investigate effects microalgal extracts high levels colourless carotenoid phytoene. Phytoene widely available dietary sources can be detected across different tissues in human body. However, it usually regarded as precursor synthesis other carotenoids, rather than molecule. We utilised model organism C. elegans show phytoene-rich Chlorella sorokiniana Dunaliella bardawil anti-ageing properties. protect against oxidative damage amyloid-β 42 proteotoxicity (a major pathology Alzheimer’s disease), extends lifespan. pure phytoene has these suggesting molecule positive ageing longevity.

Language: Английский

Antioxidants from microalgae and their potential impact on human well-being DOI Creative Commons
Leonel Pereira, João Cotas, Ana Valado

et al.

Published: May 31, 2024

In recent times, there has been a revolutionary surge in antioxidant research, with focus on harnessing microalgae to enhance wellness and extend human longevity. Microalgae, diverse group of unicellular photosynthetic organisms, have emerged as promising sources natural antioxidants due their ability synthesize various bioactive compounds, including carotenoids, polyphenols, tocopherols. These play pivotal role scavenging free radicals reducing oxidative stress, known contributors aging chronic diseases. This review provides an over-view advancements understanding microalgae’s potential, covering biochemical composition, extraction techniques, purification methods. Moreover, it delves into compelling vitro vivo studies showcasing microalgae-derived antioxidants’ protective effects against damage, inflammation, cardiovascular diseases, neurodegenerative disorders. The sustainable cultivation controlled environments further supports the potential for large-scale production commercialization compounds. As continue revolutionize they hold immense promise developing novel preventive therapeutic strategies promote health wellbeing.

Language: Английский

Citations

11
Ketocarotenoids adonirubin and adonixanthin: Properties, health benefits, current technologies, and emerging challenges DOI
Cassamo U. Mussagy, Fabiane Oliveira Farias, Alessia Tropea

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 443, P. 138610 - 138610

Published: Jan. 28, 2024

Language: Английский

Citations

6
Current perspectives on industrial application of microbial carotenoid as an alternative to synthetic pigments DOI

Priya Sundararajan,

Shanmuga Priya Ramasamy

Sustainable Chemistry and Pharmacy, Journal Year: 2023, Volume and Issue: 37, P. 101353 - 101353

Published: Nov. 24, 2023

Language: Английский

Citations

14
Important carotenoids derived from marine biomass: Extraction, stabilization, and potentiality in food, cosmetics, and pharmaceutical application DOI
Vikash Chandra Roy, Monjurul Haq, Truc Cong Ho

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104421 - 104421

Published: May 27, 2024

Language: Английский

Citations

5
Production of Fucoxanthin from Microalgae Isochrysis galbana of Djibouti: Optimization, Correlation with Antioxidant Potential, and Bioinformatics Approaches DOI Creative Commons
Fatouma Mohamed Abdoul‐Latif, Ayoub Ainane,

Laila Achenani

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(8), P. 358 - 358

Published: Aug. 6, 2024

Fucoxanthin, a carotenoid with remarkable antioxidant properties, has considerable potential for high-value biotechnological applications in the pharmaceutical, nutraceutical, and cosmeceutical fields. However, conventional extraction methods of this molecule from microalgae are limited terms cost-effectiveness. This study focused on optimizing biomass fucoxanthin production

Language: Английский

Citations

5
A New Method for Selective Extraction of Torularhodin from Red Yeast Using CO2-SFE Technique DOI Creative Commons
A. Ambrico, Vincenzo Larocca, Mario Trupo

et al.

Applied Biochemistry and Biotechnology, Journal Year: 2024, Volume and Issue: 196(9), P. 6473 - 6491

Published: Feb. 22, 2024

Abstract Torularhodin is a dark pink colored carotenoid belonging to the xanthophylls group that can be biologically synthesized by red yeasts, especially Rhodotorula and Sporobolomyces genera. The growing interest in this molecule due its biological activities such as antioxidant, anticholesterolemic, anti-inflammatory, antimicrobial, anticancer. To satisfy potential commercial markets, numerous methods have been proposed develop cost-effective environmentally friendly downstream process for purification of torularhodin. However, obtaining high purity products without resorting use toxic solvents, which leave residues final preparations, remains major challenge. In context, present study aimed new efficient method isolation torularhodin from yeast strain ELP2022 applying extraction technique with supercritical CO 2 (CO -SFE) two sequential steps. particular, first step, dried lysed biomass was subjected action conditions SC) sole solvent apolar carotenoids. second residual SC using ethanol polar co-solvent Both steps were carried out at different operating parameters temperature (40 60 °C) pressure (from 300 500 bar) constant flow 6 L min −1 . Regardless used, allowed obtain an orange-colored oily extract red-colored after respectively. all trials, represented no less than 95.2% ± 0.70 total carotenoids extracts obtained step. best results performing both 40 °C bar, maximum percentage achieved 97.9% 0.88. Since there are data on selective recovery SFE technique, may good starting point optimize support development industrial production microbial synthesis. This significantly reduce environmental impact considered innovation Italian patent application has filed. circular bioeconomy approach, will validated up pilot scale, culturing spp. low-cost media derived agri-food wastes. Graphical

Language: Английский

Citations

4
Improving Undernutrition with Microalgae DOI Open Access
Sunil K. Panchal, Kirsten Heimann, Lindsay Brown

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3223 - 3223

Published: Sept. 23, 2024

Undernutrition is an important global health problem, especially in children and older adults. Both reversal of maternal child undernutrition heathy ageing have become United Nations-supported initiatives, leading to increased attention nutritional interventions targeting undernutrition. One feasible option microalgae, the precursor all terrestrial plants. Most commercially farmed microalgae are photosynthetic single-celled organisms producing organic carbon compounds oxygen. This review will discuss commercial opportunities grow microalgae. Microalgae produce lipids (including omega-3 fatty acids), proteins, carbohydrates, pigments micronutrients so can provide a suitable underutilised alternative for addressing The benefits nutrients derived from been identified, thus they candidates issues globally. potential microalgae-derived be converted into food products. advantages cultivation include that it does not need arable land or pesticides. Additionally, most species still unexplored, presenting options further development. Further, usefulness other purposes such as bioremediation biofuels increase knowledge these microorganisms, allowing development more efficient production interventions.

Language: Английский

Citations

4
Bioactive Compounds Extraction from Marine Microorganisms by Fermentation DOI
Laura Aracely Contreras-Angulo, Nayely Leyva‐López,

Emilia Saraí Rodríguez-Miranda

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multi-omic stock of surface ocean microbiome built by monthly, weekly and daily sampling in Dapeng Bay, China DOI Creative Commons
Yanwei Chen,

Siruo Chen,

Jianchang Tao

et al.

Scientific Data, Journal Year: 2025, Volume and Issue: 12(1)

Published: March 4, 2025

The coastal ocean is the dynamic interface where terrestrial, atmospheric, and marine systems converge, acting as a hotspot for microbial activity, which underpins intricate web of carbon nitrogen cycling. Dapeng Bay, typical semi-enclosed bay along southern coastline China, strongly influenced by monsoon climates human activities. Despite its ecological importance, long-term observations investigations into community structure in this region are notably lacking. To address gap, we conducted two-year continuous sampling from May 2021 to June 2023 explore shifts nearshore surface communities assess effects environmental stressors. This study presents comprehensive amplicon, metagenomic, metatranscriptomic information. We identified 3,600 amplicon sequence variants recovered 1,216 high-quality metagenome-assembled MAGs, representing 17 bacterial 3 archaeal phyla. Additionally, 587 MAGs were correlated with transcriptional comprising 539 48 populations. dataset anticipated provide multi-dimensional perspective, enhancing our understanding complexity, dynamics, adaptability environments.

Language: Английский

Citations

0
Isolation and Cultivation of Carotenoid-Producing Strains from Tidal Flat Sediment and Proposal of Croceibacterium aestuarii sp. nov., a Novel Carotenoid-Producing Species in the Family Erythrobacteraceae DOI Creative Commons
Xiaoyan Sun, Han Dong, Yu Zhang

et al.

Journal of Marine Science and Engineering, Journal Year: 2024, Volume and Issue: 12(1), P. 99 - 99

Published: Jan. 3, 2024

Carotenoids are extensively used in drugs, cosmetics, nutrients, and foods, owing to their antioxidant anti-inflammatory characteristics. Diverse marine heterotrophic prokaryotes can accumulate carotenoids become promising alternatives for the advancement of production. In this research, 55 strains were isolated cultivated from tidal flat sediment Zhoushan classified into phyla Pseudomonadota (n = 24), Bacillota 18), Bacteroidota 9), Actinomycetota 4). Nine them accumulated carotenoids, most belonged families Flavobacteriaceae 4) Erythrobacteraceae Among those carotenoid-producing strains, one strain, designated as D39T, was proposed novel species belonging genus Croceibacterium through polyphasic taxonomy approaches. Genomic annotations carotenoid compound determinations revealed that strain D39T encoded crtEBIYZG genes mainly zeaxanthin major carotenoids. Furthermore, biosynthesis pathway majority identical with implying members be sources producing zeaxanthin. This study enhances knowledge microbial biodiversity flats, proposes a species, elucidates Croceibacterium, which contribute enriching promoting comprehensive insight genomic contents them.

Language: Английский

Citations

3