Regional Studies in Marine Science, Journal Year: 2024, Volume and Issue: unknown, P. 104003 - 104003
Published: Dec. 1, 2024
Language: Английский
Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107289 - 107289
Published: July 1, 2024
Atherosclerosis is a chronic inflammatory vascular disease characterized by lipid metabolism disorder and accumulation. Equisetin (EQST) hemiterpene compound isolated from fungus of marine sponge origin, which has antibacterial, anti-inflammatory, lipid-lowering, weight loss effects. Whether EQST anti-atherosclerotic activity not been reported. In this study, we revealed that displayed anti- atherosclerosis effects through inhibiting macrophage response, uptake foam cell formation in vitro, finally ameliorated high-fat diet (HFD)-induced AopE
Language: Английский
Citations
6
Published: March 13, 2025
Citations
0
Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 190, P. 110044 - 110044
Published: March 22, 2025
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1632 - 1632
Published: April 6, 2025
One pair of novel enantiomers, gigantdioxin A (+)-1 and B (−)-1, with a skeleton benzo[d][1,3]dioxin; new acetophenone gigantone (3); known 3-chlorogentisyl alcohol (2), which is the bioprecursor 1; (4); chromone derivative (5) were obtained from sponge-associated fungus Aspergillus giganteus MA46-5. Their structures established by extensive in-depth spectral analysis, such as UV, 1D 2D NMR, HRESIMS. The absolute configurations (±)-1 deduced ORD, chiral separation, experimental computational ECD. Meanwhile, we proposed possible biosynthetic pathway (±)-1. Fortunately, was proved biomimetic synthesis through 2, bioprecursor, reacted n-butyraldehyde. Myocardial protection assays showed that 3 4 possessed stronger protective effects than positive control against myocardial cell H9c2 ischemia–reperfusion injury in low concentrations, effect (−)-1 almost equal to control. Further, explored mechanism network pharmacology. Adenosine A2a receptor (ADORA2A) serum albumin (ALB) represent potential targets for associated 4, respectively. Based on pharmacology, docked predicted proteins bioactive compounds using Autodock Vina.
Language: Английский
Citations
0
Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
ABSTRACT In recent decades, the potentiality of marine natural products (MNPs) in medical field has been increasingly recognized. Natural compounds derived from microorganisms, algae, and invertebrates have shown significant promise for treating inflammation‐related diseases. this review, we cover three primary sources MNPs their diverse unique chemical structures bioactivities. This review aims to summarize progress combating Moreover, functions mechanisms diseases, highlighting regulating inflammatory signaling pathways, cellular stress responses, gut microbiota, among others. Meanwhile, focus on key technologies scientific methods address current limitations challenges MNPs.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4264 - 4264
Published: April 30, 2025
Cardiovascular diseases (CVDs), including heart failure (HF), hypertension, myocardial infarction (MI), and atherosclerosis, are increasingly linked to gut microbiota dysbiosis its metabolic byproducts. HF, affecting over 64 million individuals globally, is associated with systemic inflammation barrier dysfunction, exacerbating disease progression. Similarly, hypertension MI correlate reduced microbial diversity an abundance of pro-inflammatory bacteria, contributing vascular increased cardiovascular risk. Atherosclerosis also influenced by dysbiosis, key metabolites such as trimethylamine-N-oxide (TMAO) short-chain fatty acids (SCFAs) playing crucial roles in pathogenesis. Emerging evidence highlights the therapeutic potential natural compounds, flavonoids, omega-3 acids, resveratrol, curcumin, marine-derived bioactives, which modulate confer cardioprotective effects. These insights underscore a critical regulator health, suggesting that targeting may offer novel preventive strategies. Further research needed elucidate underlying mechanisms optimize microbiome-based interventions for improved outcomes.
Language: Английский
Citations
0
Journal of Biosciences, Journal Year: 2025, Volume and Issue: 50(2)
Published: May 5, 2025
Language: Английский
Citations
0
Marine Drugs, Journal Year: 2024, Volume and Issue: 22(5), P. 210 - 210
Published: May 3, 2024
Ageing represents a main risk factor for several pathologies. Among them, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) are predominant in the elderly population often require prolonged use of multiple drugs due to their chronic nature high proportion co-morbidities. Hence, research is constantly looking novel, effective molecules treat CVD T2DM with minimal side effects. Marine active compounds, holding great diversity chemical structures biological properties, represent interesting therapeutic candidates these age-related diseases. This review summarizes current state on marine compounds treatment T2DM, from pre-clinical studies clinical investigations approved drugs, highlighting potential development new therapies, together limitations translating results into human application.
Language: Английский
Citations
2
Marine Drugs, Journal Year: 2023, Volume and Issue: 21(11), P. 549 - 549
Published: Oct. 24, 2023
Cardiovascular diseases (CVD) remain the leading cause of death across globe, hence, establishing strategies to counteract CVD are imperative reduce mortality and burden on health systems. Dietary modification is an effective primary prevention strategy against CVD. Research regarding dietary supplementation has become increasingly popular. This review focuses current in vivo, vitro, epidemiological studies associated with that omega-3 polyunsaturated fatty acids (n-3 PUFAs) polar lipids (PLs) how they play a role Furthermore, this results several major clinical trials examining n-3 PUFAs both secondary Notably, we place lens REDUCE-IT STRENGTH trials. Finally, PLs recently been suggested as potential alternative avenue for reduction incidence versus neutral forms PUFAs. However, evidence argument currently rather limited. Therefore, draw literature suggest future PL supplementation. We conclude despite conflicting evidence, human must be completed confirm whether may more than PUFA cardiovascular risk.
Language: Английский
Citations
6
Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107173 - 107173
Published: April 3, 2024
Our recent multi-omics studies have revealed rich sources of novel bioactive proteins and polypeptides from marine organisms including cnidarians. In the present study, we initially conducted a transcriptomic analysis to review composition profile Zoanthus sociatus. Then, newly discovered NPY-like polypeptide-ZoaNPY was selected for further in silico structural, binding virtually pharmacological studies. To evaluate pro-angiogenic effects ZoaNPY, employed an vitro HUVECs model vivo zebrafish model. results indicate that at 1-100 pmol, enhances cell survival, migration tube formation endothelial cells. Besides, treatment with ZoaNPY could restore chemically-induced vascular insufficiency embryos. Western blot demonstrated application increase phosphorylation related angiogenesis signaling PKC, PLC, FAK, Src, Akt, mTOR, MEK, ERK1/2. Furthermore, through molecular docking surface plasmon resonance (SPR) verification, shown directly physically interact NPY Y2 receptor. view this, all evidence showed involve activation receptor, thereby activating Akt/mTOR, PLC/PKC, ERK/MEK Src- FAK-dependent pathways. excision wound model, accelerate healing process mice. findings provide new insights into discovery development drugs derived future.
Language: Английский
Citations
1