Journal of Applied Phycology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 3, 2024
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2550 - 2550
Published: Aug. 3, 2024
Polyphenols are natural compounds which plant-based bioactive molecules, and have been the subject of growing interest in recent years. Characterized by multiple varieties, polyphenols mostly found fruits vegetables. Currently, many diseases waiting for a cure or solution to reduce their symptoms. However, drug other chemical strategies limitations using treatment agent still detection tool diseases, thus researchers need investigate preventive improving treatment. Therefore, it is elucidate polyphenols, bioactivity effects, supplementation, consumption. The disadvantage that they limited bioavailability, although beneficial outcomes with roles. In this context, several different developed improve particularly liposomal nanoparticles. As nutrition one most important factors health, inclusion molecules daily diet significant continues be enthusiastically researched. Nutrition, individuals all ages, key polyphenols.
Language: Английский
Citations
21
Life, Journal Year: 2023, Volume and Issue: 13(9), P. 1831 - 1831
Published: Aug. 29, 2023
Diabetes poses a significant global health challenge, necessitating innovative therapeutic strategies. Natural products and their derivatives have emerged as promising candidates for diabetes management due to diverse compositions pharmacological effects. Algae, in particular, garnered attention potential source of bioactive compounds with anti-diabetic properties. This review offers comprehensive overview algae-derived natural management, highlighting recent developments future prospects. It underscores the pivotal role care delves into diversity algae, constituents, underlying mechanisms efficacy. Noteworthy algal substantial are briefly elucidated, along specific contributions addressing distinct aspects diabetes. The challenges limitations inherent utilizing algae interventions examined, accompanied by strategic recommendations optimizing effectiveness. By these considerations, this aims chart course research refining algae-based approaches. Leveraging multifaceted activities chemical components holds promise pursuit novel antidiabetic treatments. Through continued fine-tuning interventions, burden could be mitigated, ultimately leading enhanced patient outcomes.
Language: Английский
Citations
18
Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(3)
Published: Jan. 22, 2024
Abstract In this investigation, the study focused on chemical constitution and antioxidative as well anti‐inflammatory characteristics of oils pulpy variants (Imatchan (IM), Harmocha (HA), Aknari (AK)) sourced from O. dillenii . This inquiry encompassed both in vitro silico analyses. High‐performance liquid chromatography (HPLC) was employed to ascertain phenolic constituents, while gas chromatography‐mass spectrometry (GC‐MS) methodologies. were applied discern volatile makeup. The appraisal antioxidant potential conducted via deployment assays such 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), ferric reducing power (FRAP), ion chelating (FIC) techniques. activity examined using BSA LOX. Molecular docking methods assessed properties. According HPLC findings, most abundant compounds detected AKO IMO cultivars quercetin 3‐ O ‐β‐D‐glucoside followed by vanillic acid, ferulic acid tyrolsol. Concerning headspace GC‐MS analysis E‐11‐hexadecenal (E)‐2‐undecenal contribute major Opuntia HA, IM, AK pulp oil. DPPH IC 50 for AK, HA IM 38.41±1.54, 42.24±0.29 15.17±1.28 mg/mL, respectively. FRAP capacity determined be 30.23±0.6, 55.96±0.08 23.41±1.83 displayed significant FIC activity, with values 42.75±0.63, 39.54±0.59 35.31±1.38 effective their activity. determine possible targeted proteins ’s compounds. Overall, these fruits demonstrated new ingredients culinary or pharmaceutical applications, providing value natural species that can flourish arid conditions.
Language: Английский
Citations
6
Marine Drugs, Journal Year: 2024, Volume and Issue: 22(6), P. 240 - 240
Published: May 25, 2024
In this research, the chemical compositions of various extracts obtained from Ulva lactuca, a type green seaweed collected Nador lagoon in northern region Morocco, were compared. Their antioxidant and anti-diabetic properties also studied. Using GC–MS technology, fatty acid content samples was analyzed, revealing that palmitic acid, eicosenoic linoleic most abundant unsaturated acids present all samples. The HPLC analysis indicated sinapic naringin, rutin, quercetin, cinnamic salicylic apigenin, flavone, flavanone prevalent phenolic compounds. aqueous extract by maceration showed high levels polyphenols flavonoids, with values 379.67 ± 0.09 mg GAE/g 212.11 0.11 QE/g, respectively. This exhibited an impressive ability to scavenge DPPH radicals, as its IC50 value 0.095 0.12 mg/mL. Additionally, methanolic using Soxhlet method demonstrated preventing β-carotene discoloration, 0.087 0.14 Results in-vitro studies U. lactuca able significantly inhibit enzymatic activity α-amylase α-glucosidase. Among extracts, (S) has been identified potent inhibitor, exhibiting statistically similar effect acarbose. Furthermore, molecular docking models used evaluate interaction between primary phytochemicals found these human pancreatic α-glucosidase enzymes. These findings suggest contain bioactive substances are capable reducing enzyme more effectively than commercially available drug,
Language: Английский
Citations
5
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 786 - 786
Published: June 15, 2024
Crataegus monogyna (C. monogyna) is a prominent plant used in Moroccan traditional medicine. This study investigated the phenolic composition and anti-inflammatory, hepatoprotective, anticancer activities of hydroethanolic extract C. leaves stems. Ultra-high-performance liquid chromatography identified profile. The vitro activity was evaluated using MTT assay on HL-60 K-562 myeloleukemia cells liver (Huh-7) cell lines. anti-inflammatory effect assessed vivo carrageenan-induced paw edema rats. hepatoprotective at 300 1000 mg/kg doses against acetaminophen-induced hepatotoxicity rats studied for seven days. Additionally, molecular docking simulations were performed to evaluate extract’s inhibitory potential key targets: lipoxygenase, cytochrome P450, tyrosine kinase, TRADD. exhibited significant cytotoxic cells, but not lung cancer (Huh-7 line). dose demonstrated most potent effect, inhibiting by 99.10% after 6 h. displayed promising properties. Procyanidin (−7.27 kcal/mol), quercetin (−8.102 catechin (−9.037 kcal/mol) as active molecules respectively. These findings highlight untapped further exploration treating damage, inflammation, leukemia.
Language: Английский
Citations
4
Separations, Journal Year: 2024, Volume and Issue: 11(7), P. 209 - 209
Published: July 5, 2024
This study focused on developing an innovative, straightforward, and economical method utilizing a mixture of readily available solvents to extract arborescin (C2OH2OO8) crystals from Artemisia absinthium L. (A. absinthium). The structural elucidation characterization were conducted using suite techniques including IR spectroscopy, CNHSO elemental analysis, scanning electron microscopy energy dispersive X-ray spectroscopy (SEM-EDS), mass (MS). Density functional theory (DFT) calculations employed determine the molecular properties. Antioxidant activity was measured DPPH radical scavenging assay β-carotene bleaching test. Antimicrobial efficacy assessed against four bacterial strains three fungal strains. docking approach predict probable binding patterns affinities with specific target biomolecules. Employing array analytical techniques, examination isolated crystal A. absinthium. led its comprehensive elucidation. revealed presence distinctive groups, carbonyl group within γ-lactone epoxy group. analysis verified that contained only carbon, hydrogen, oxygen, finding corroborated by SEM-EDS consistent structure arborescin. Additionally, spectrometry confirmed identity compound as arborescin, ion m/z = 248. Quantum-Chemical Descriptors is resistant elementary decomposition under standard conditions. Although demonstrates relatively low antioxidant capacity, IC50 5.04 ± 0.12 mg/mL in assay, test found be 3.64%. Remarkably, effectively inhibits growth Staphylococcus aureus Listeria innocua at concentrations (MIC 166 µg/mL). it exhibits significant antifungal Candida glabrata, minimum inhibitory concentration (MIC) fungicidal (MFC) 83 µg/mL µg/mL, respectively. In this study, exhibited robust score −8.1 kcal/mol, indicating higher affinity compared ciprofloxacin. suggests has potential potent antibacterial agent.
Language: Английский
Citations
4
Saudi Pharmaceutical Journal, Journal Year: 2024, Volume and Issue: 32(10), P. 102167 - 102167
Published: Aug. 30, 2024
Opuntia (Cactaceae) species are native to arid and semi-arid regions of Mexico the southern United States grow in various climatic zones.
Language: Английский
Citations
4
Journal of Applied Phycology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 10, 2025
Background The increasing demand for natural alternatives in diabetes treatment has driven research into plant-derived metabolites, particularly essential oils (EOs) with bioactive properties. This study aims to optimize an EO mixture inhibiting two key enzymes involved glucose digestion: pancreatic α-amylase and intestinal α-glucosidase. Methods Essential were extracted from three Moroccan medicinal plants: false yellowhead ( Inula viscosa L.), rose geranium Pelargonium graveolens L'Hér.), lemongrass Cymbopogon citratus (DC.) Stapf.). Gas chromatography-mass spectrometry (GC-MS) analysis identified metabolites each EO. A statistical design was employed evaluate different ratios their inhibitory effects on Additionally, density functional theory (DFT) calculations molecular docking simulations conducted assess the metabolites' electronic properties interaction potential target enzymes. Results GC-MS 32 P . , citronellol (18.67%), eucalyptol (13.30%), 2-octen-1-ol (8.12%) as major components. I contained 18 dominated by 2-camphanol acetate (51.12%) camphol (19.32%), while C. had 23 α-citral (24.70%) 2-isopropenyl-5-methylhex-4-enal (29.25%) constituents. optimal formulation α-glucosidase inhibition a binary of 73% 27% P. In contrast, best blend consisted 56% 44% I. DFT confirmed electrophilic nature supporting enzyme interaction. Molecular suggested that these phytochemicals could exhibit stronger than acarbose, widely used antidiabetic drug. Conclusion These findings highlight optimized formulations managing hyperglycemia developing novel therapies.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 5, 2025
Figs are delectable, beneficial, nutritious, and seasonal; nevertheless, they deteriorate quickly, making processing the optimal method for preservation. Drying figs is most practical efficient way to preserve them. Paste another possibility. The present study emphasizes nutritional value of two fig pastes, as well their antioxidant antimicrobial properties. Ghoudane (GD) Chetoui (CH) pastes high in sugars, fiber, minerals, antioxidants, them nutritious. HPLC-UV-MS/MS analysis identified bioactive compounds under investigation. CH paste was found mainly contain gallic acid, quercetin, 3'-methyl ether, neochlorogenic acid. Similarly, GD notably comprises catechin, has more polyphenols (374.6 ± 4.57 mg GAE/100 g) flavonoids (102.5 2.16 QE/100 than paste. shown a strong antioxidant, by its DPPH IC50 5.62 0.02 mg/mL TAC 80.16 0.83 µg AAE /mg extract. Also, it revealed correlation between contents activities. Furthermore, hydroethanol extracts have antibacterial fungal activity. In silico showed that chemicals both demonstrated different levels inhibition against targeted proteins. quercetin 3-methyl ether highest efficacy blocking NADPH oxidase, with glide gscore -6.307 K/mol. On other hand, acid exhibited inhibiting activity enzymes: diphosphate kinase from Staphylococcus aureus (-10.493 kcal/mol) β-ketoacyl-[acyl carrier protein] synthase Escherichia coli (-7.357 kcal/mol). Catechin highly potent pathogenic fungus Candida albicans targeting sterol 14-α demethylase (CYP51) -7.638 kcal/mol. an important source nutrients biologically active substances can be used several fields, such food phytopharmaceuticals. This confirms importance process increasing fruit, enhancing utility, thereby reputation appreciation.
Language: Английский
Citations
0