Immunomodulatory Compounds from the Sea: From the Origins to a Modern Marine Pharmacopoeia
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(7), P. 304 - 304
Published: June 28, 2024
From
sea
shores
to
the
abysses
of
deep
ocean,
marine
ecosystems
have
provided
humanity
with
valuable
medicinal
resources.
The
use
organisms
is
discussed
in
ancient
pharmacopoeias
different
times
and
geographic
regions
still
deeply
rooted
traditional
medicine.
Thanks
present-day,
large-scale
bioprospecting
rigorous
screening
for
bioactive
metabolites,
ocean
coming
back
as
an
untapped
resource
natural
compounds
therapeutic
potential.
This
renewed
interest
drugs
propelled
by
a
burgeoning
research
field
investigating
molecular
mechanisms
which
newly
identified
intervene
pathophysiology
human
diseases.
Of
great
clinical
relevance
are
molecules
endowed
anti-inflammatory
immunomodulatory
properties
emerging
applications
management
chronic
inflammatory
disorders,
autoimmune
diseases,
cancer.
Here,
we
review
historical
development
pharmacology
Eastern
Western
worlds
describe
status
drug
discovery.
Finally,
discuss
importance
conducting
sustainable
exploitation
resources
through
biotechnology.
Language: Английский
Improving Undernutrition with Microalgae
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(18), P. 3223 - 3223
Published: Sept. 23, 2024
Undernutrition
is
an
important
global
health
problem,
especially
in
children
and
older
adults.
Both
reversal
of
maternal
child
undernutrition
heathy
ageing
have
become
United
Nations-supported
initiatives,
leading
to
increased
attention
nutritional
interventions
targeting
undernutrition.
One
feasible
option
microalgae,
the
precursor
all
terrestrial
plants.
Most
commercially
farmed
microalgae
are
photosynthetic
single-celled
organisms
producing
organic
carbon
compounds
oxygen.
This
review
will
discuss
commercial
opportunities
grow
microalgae.
Microalgae
produce
lipids
(including
omega-3
fatty
acids),
proteins,
carbohydrates,
pigments
micronutrients
so
can
provide
a
suitable
underutilised
alternative
for
addressing
The
benefits
nutrients
derived
from
been
identified,
thus
they
candidates
issues
globally.
potential
microalgae-derived
be
converted
into
food
products.
advantages
cultivation
include
that
it
does
not
need
arable
land
or
pesticides.
Additionally,
most
species
still
unexplored,
presenting
options
further
development.
Further,
usefulness
other
purposes
such
as
bioremediation
biofuels
increase
knowledge
these
microorganisms,
allowing
development
more
efficient
production
interventions.
Language: Английский
Marine Phytoplankton Bioactive Lipids and Their Perspectives in Clinical Inflammation
Marine Drugs,
Journal Year:
2025,
Volume and Issue:
23(2), P. 86 - 86
Published: Feb. 17, 2025
Marine
phytoplankton
is
an
emerging
source
of
immunomodulatory
bioactive
lipids
(BLs).
Under
physiological
growth
conditions
and
upon
stress
challenges,
several
eukaryotic
microalgal
species
accumulate
lipid
metabolites
that
resemble
the
precursors
animal
mediators
inflammation:
eicosanoids
prostaglandins.
Therefore,
marine
could
serve
as
a
biotechnological
platform
to
produce
functional
BLs
with
therapeutic
applications
in
management
chronic
inflammatory
diseases
other
clinical
conditions.
However,
be
commercially
competitive,
lipidic
precursor
yields
should
enhanced.
Beside
tailoring
cultivation
native
producers,
genetic
engineering
feasible
strategy
accrue
production
introduce
heterologous
biosynthetic
pathways
hosts.
Here,
we
present
state-of-the-art
research
on
from
discuss
synthetic
biology
approaches
boost
their
light-driven
biosynthesis.
Language: Английский
A Review of Application of Paramylon (β-1, 3-Glucan) in Plant Growth and Production
Limenew Abate Worku,
No information about this author
Rakesh Kumar Bachheti,
No information about this author
Woinshet Kassie Alemu
No information about this author
et al.
Natural Product Communications,
Journal Year:
2025,
Volume and Issue:
20(4)
Published: April 1, 2025
Paramylon,
a
β-1,3-glucan
polysaccharide
found
in
microalgae
like
Euglena
gracilis
,
has
attracted
significant
interest
nutrition,
health,
and
agriculture
due
to
its
diverse
applications.
It
is
highly
adaptable,
utilizing
nutrients
from
wastewater,
CO
2
vaporization,
or
food
waste,
with
waste-based
cultivation
yielding
1.77
g/L/day.
Paramylon
influences
plant
physiology,
enhancing
hormone
content,
photosynthetic
efficiency,
dehydration
tolerance.
For
example,
during
paramylon
treatment,
the
efficiency
of
Solanum
lycopersicum
increased
75%,
compared
50%
controls,
while
drought
resistance
rose
80%,
significantly
higher
than
60%
observed
untreated
plants.
also
improves
water-use
regulates
diffusion,
offering
protection
against
abiotic
stresses
such
as
drought,
salinity,
nutrient
deficiencies,
extreme
temperatures.
As
sustainable
alternative
traditional
fertilizers,
functions
effectively
biostimulant,
crop
yield
quality
increasing
tolerance
environmental
stress.
Despite
promising
potential,
precise
molecular
mechanisms
long-term
effects
on
different
crops
soil
ecosystems
remain
underexplored.
Future
research
should
focus
optimizing
formulations
enhance
bioavailability,
exploring
synergistic
other
biostimulants,
assessing
economic
feasibility
scalability
for
commercial
adoption.
Additionally,
studying
impact
microbiota
plant-microbe
interactions
could
reveal
broader
ecological
benefits.
This
review
highlights
paramylon's
potential
fertilizer
improve
agricultural
productivity
quality.
While
current
findings
are
promising,
further
interdisciplinary
essential
unlock
full
modern
systems.
Language: Английский
Tetrahedral Framework Nucleic Acid‐Based Delivery of Astaxanthin Suppresses Chondrocyte Pyroptosis and Modulates Oxidative Stress for the Treatment of Osteoarthritis
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(28)
Published: June 24, 2024
Worldwide,
osteoarthritis
(OA)
is
regarded
as
the
most
widespread,
distressing,
and
limiting
chronic
disease
that
affects
degenerative
joints.
Currently,
there
no
treatment
available
to
modify
progression
of
OA.
The
pathogenesis
OA
significantly
linked
with
oxidative
stress
pyroptosis.
Astaxanthin
(Ast)
a
natural
ketocarotenoid
pigment
potent
antioxidant
activity
shown
effectively
alleviate
cartilage
damage
in
However,
its
bioavailability
greatly
limited
due
poor
water
solubility,
high
sensitivity
light,
temperature,
pH.
In
this
study,
Ast-loaded
tetrahedral
framework
nucleic
acids
(tFNAs)
or
tFNA/Ast
complexes
(TAC)
for
Ast
delivery
are
developed.
Compared
free
tFNA
alone,
TAC
exhibits
improved
drug
stability
cellular
uptake.
Most
importantly,
protects
chondrocytes
against
stress-induced
pyroptosis
while
promoting
extracellular
matrix
anabolism
by
chondrocytes,
ultimately
alleviates
mouse
destabilization
medial
meniscus
(DMM)
model.
Thus,
holds
great
promise
patients.
Language: Английский
Harnessing systems biology approach for characterization of carotenoid biosynthesis pathways in microalgae
Biochemistry and Biophysics Reports,
Journal Year:
2024,
Volume and Issue:
39, P. 101759 - 101759
Published: June 21, 2024
Systems
biology
is
an
interdisciplinary
field
that
aims
to
understand
complex
biological
processes
at
the
system
level.
The
data,
driven
by
high-throughput
omics
technologies,
can
be
used
study
underpinning
mechanisms
of
metabolite
production
under
different
conditions
harness
this
knowledge
for
construction
regulatory
networks,
protein
metabolic
models,
and
engineering
strains
with
enhanced
target
in
microalgae.
In
current
study,
we
comprehensively
reviewed
recent
progress
application
these
technologies
characterization
carotenoid
biosynthesis
pathways
Moreover,
harnessing
integrated
approaches
such
as
network
analysis,
meta-analysis,
machine
learning
models
deciphering
complexity
were
discussed.
Language: Английский