The Influence of Oxidative Stress Markers in Patients with Ischemic Stroke

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1130 - 1130

Published: Sept. 6, 2024

Stroke is the second leading cause of death worldwide, and its incidence rising rapidly. Acute ischemic stroke a subtype that accounts for majority cases has high mortality rate. An effective treatment to minimize damage brain's neural tissue by restoring blood flow decreased perfusion areas brain. Many reports have concluded both oxidative stress excitotoxicity are main pathological processes associated with stroke. Current measures protect brain against serious caused insufficient. For this reason, it important investigate antioxidant strategies reduce damage. This review focuses on studies assessing concentration biomarkers level antioxidants (enzymatic non-enzymatic) their impact clinical prognosis patients after Mechanisms related production ROS/RNS role in pathogenesis presented, as well new therapeutic aimed at reducing effects ischemia reperfusion.

Language: Английский

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Inappropriate Sinus Tachycardia in Athletes: Could Nutraceuticals Play a Role?

Journal of Cardiovascular Development and Disease, Journal Year: 2025, Volume and Issue: 12(2), P. 73 - 73

Published: Feb. 15, 2025

Introduction: Inappropriate sinus tachycardia (IST) is a syndrome characterized by unexpectedly fast and prolonged rates at rest or with minimal physical activity. Epidemiologic characteristics are uncertain, but most patients young female. When IST occurs in athletes, its management (controlling symptoms reducing heart rate) can present additional challenges. We designed an observational pilot study to investigate whether food supplement be useful the treatment of when standard therapy refused. Methods: enrolled 50 consecutive recreational athletes affected frequent recurrences IST. Twelve-lead ECG Holter parameters were recorded enrollment (T0) after 6-month (T1) supplement. Symptoms quality life also evaluated through specific questionnaires. The population was compared historical control group 25 receiving ivabradine as for same clinical condition. Results: resting rate 88.7 ± 12.4 bpm 73.6 6.6 (p < 0.00001); average 88.4 3.3 74.9 4.8 0.0001). maximum 147.1 16.7 139.2 16.8 = 0.06); minimum 49.9 6.5 50.5 6.9 0.33). Finally, number sustained episodes decreased from 1.7 0.8 0.00001). following variations ASTA scores observed: symptom scale (range: 0-27) 14.9 2.1 5.8 1.4 0.00001), while HR QoL 0-39) 24.1 10.8 2.3 Conclusions: findings our suggest that this could play beneficial role managing improving who refuse medical therapy. These effects appear correlate significant improvements some parameters.

Language: Английский

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Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(20), P. 6072 - 6072

Published: Oct. 11, 2024

The safety, feasibility, and potential functional improvement following the intravenous infusion of mesenchymal stem cells (MSCs) were investigated in patients with chronic severe spinal cord injury (SCI).

Language: Английский

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Enhancing performance through biochemical monitoring and nutritional support in female weightlifters during pre-competition weight reduction: a randomized trial

Journal of the International Society of Sports Nutrition, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 28, 2024

Objective Weight reduction is a common practice among female weightlifters before competitions to qualify for specific weight classes. However, this process can adversely affect their physical performance and health. This study aimed investigate the impact of physiological biochemical monitoring nutritional support on competitive state during pre-competition period.

Language: Английский

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Neuroimaging Correlates of Post-COVID-19 Symptoms: A Functional MRI Approach

Diagnostics, Journal Year: 2024, Volume and Issue: 14(19), P. 2180 - 2180

Published: Sept. 29, 2024

Backgrounds and Purpose: Post-COVID syndrome is characterized by persistent symptoms, including fatigue cognitive impairment. These symptoms may be experienced up to 80% of patients. We aimed identify possible patterns brain activation underlying post-COVID fatigue. Methods: The study used functional MRI (Siemens MAGNETOM Prisma 3T scanner with a specially created protocol) the in 30 patients 20 healthy volunteers. Task (fMRI) was performed using paradigm (modified Stroop test). Eligible included adults aged 18–50 years >12 weeks before enrolment (less than 12 months) prior history documented COVID-19 not attributable any other cause, MFI-20 score > MoCA at first visit. Healthy control participants had no negative tests for severe acute coronavirus respiratory < fMRI data were processed SPM12 software package based on MATLAB R2022a. Results: Cognitive task analysis showed significantly higher group versus volunteers’ group. Between-group significant differences. Using threshold T 3 we identified eight clusters statistically activation: supramarginal gyri, posterior cingulate cortex, opercular parts precentral gyri cerebellum lobe bilaterally. Conclusions: associated subjective impairment could show changes activity areas connected information processing speed quality.

Language: Английский

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Long-Term Quality of Life Among Patients Undergoing Endoscopic Pituitary Gland Surgery

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(21), P. 6371 - 6371

Published: Oct. 24, 2024

The endoscopic approach to skull base lesions is widely regarded as less invasive and associated with reduced morbidity, offering favorable outcomes, particularly in terms of short-term quality life (QOL). However, date, long-term assessments both nasal function tumor-related QOL remain limited. To evaluate patients' nasal- after endonasal resection pituitary tumors detect predictors for poor postoperative QOL. Study Design: This study was a prospective cohort study.

Language: Английский

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Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

ABSTRACT Obstructive sleep apnea (OSA) is a multifactorial disorder characterized by strong genetic basis. Excessive daytime sleepiness (EDS) symptom that reported subset of OSA patients, persisting even after treatment with continuous positive airway pressure (CPAP). It recognized as clinical subtype underlying carrying alarming heightened cardiovascular risk. Thus, conceptualizing EDS an exposure variable, we sought to investigate EDS’s influence on variation linked apnea-hypopnea index (AHI), diagnostic measure severity. This study serves the first large-scale genome-wide gene x environment interaction analysis for AHI, investigating interplay between its markers and across within specific sex. Our work pools together whole genome sequencing data from seven cohorts, enabling diverse dataset (four population backgrounds) over 11,500 samples. Among total 16 discovered targets evidence EDS, eight are previously unreported OSA, including CCDC3 , MARCHF1 MED31 identified in all sexes; TMEM26 CPSF4L PI4K2B males; RAP1GAP YY1 females. We discuss connections insulin resistance, thiamine deficiency, resveratrol use may be worthy therapeutic consideration excessively sleepy patients.

Language: Английский

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Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Obstructive sleep apnea (OSA) is a multifactorial disorder characterized by strong genetic basis. Excessive daytime sleepiness (EDS) symptom that reported subset of OSA patients, persisting even after treatment with continuous positive airway pressure (CPAP). It recognized as clinical subtype underlying carrying alarming heightened cardiovascular risk. Thus, conceptualizing EDS an exposure variable, we sought to investigate EDS’s influence on variation linked apnea-hypopnea index (AHI), diagnostic measure severity. This study serves the first large-scale genome-wide gene x environment interaction analysis for AHI, investigating interplay between its markers and across within specific sex. Our work pools together whole genome sequencing data from seven cohorts, enabling diverse dataset (four population backgrounds) over 11,500 samples. Among total 16 discovered targets evidence EDS, eight are previously unreported OSA, including CCDC3, MARCHF1, MED31 identified in all sexes; TMEM26, CPSF4L, PI4K2B males; RAP1GAP YY1 females. We discuss connections insulin resistance, thiamine deficiency, resveratrol use may be worthy therapeutic consideration excessively sleepy patients.

Language: Английский

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Using the Complex Network Model to Associate Nutritional, Psychological, and Physical Parameters and Aspects of Sleep with Depression Symptoms

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6743 - 6743

Published: Nov. 9, 2024

: Major depressive disorder is a significant public health concern linked to factors such as low-quality diet, sedentary lifestyle, and poor sleep quality, all of which contribute its development; nevertheless, the existing literature lacks comprehensive framework effectively integrate these interrelated influences.

Language: Английский

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Longitudinal Metabolomics Reveals Metabolic Dysregulation Dynamics in Patients with Severe COVID-19

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 656 - 656

Published: Nov. 25, 2024

Background/Objective: A dysregulated metabolism has been studied as a key aspect of the COVID-19 pathophysiology, but its longitudinal progression in severe cases remains unclear. In this study, we aimed to investigate metabolic dysregulation over time patients with requiring mechanical ventilation (MV). Methods: single-center, prospective, observational obtained 236 serum samples from 118 adult on MV an ICU. The metabolite measurements were performed using capillary electrophoresis Fourier transform mass spectrometry, and categorized sampling points into three zones align them disease progression: zone 1 (T1) (the hyperacute phase, days 1–3 post-MV initiation), T2 acute 4–14), T3 chronic 15–30). Using volcano plots enrichment pathway analyses, identified differential metabolites (DMs) enriched pathways (EPs) between survivors non-survivors for each zone. DMs EPs further grouped early-stage, late-stage, consistent groups based which they detected. Results: With 566 annotated metabolites, 38 17 early-stage group, indicated enhanced energy production glucose, amino acid, fatty acid metabolisms non-survivors. As late-stage 84 10 showed upregulated sphingolipid, taurine, tryptophan–kynurenine downregulated steroid hormone synthesis Three 23 group more pronounced dopamine arachidonic across all Conclusions: This study elucidated temporal differences COVID-19, offering insights mechanisms.

Language: Английский

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