Bacillus megaterium Renuspore® as a potential probiotic for gut health and detoxification of unwanted dietary contaminants DOI Creative Commons

Annie Simon,

Joan Colom, Shahneela Mazhar

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: April 11, 2023

Exposure to diverse environmental pollutants and food contaminants is ever-increasing. The risks related the bioaccumulation of such xenobiotics in air chain have exerted negative effects on human health, as inflammation, oxidative stress, DNA damage, gastrointestinal disorders, chronic diseases. use probiotics considered an economical versatile tool for detoxification hazardous chemicals that are persistent environment chain, potentially scavenging unwanted gut. In this study, Bacillus megaterium MIT411 (Renuspore®) was characterized general probiotic properties including antimicrobial activity, dietary metabolism, antioxidant capacity detoxify several can be found chain. silico studies revealed genes associated with carbohydrate, protein lipid xenobiotic chelation or degradation, properties. demonstrated high levels total activities, addition activity against Escherichia coli, Salmonella enterica, Staphylococcus aureus, Campylobacter jejuni vitro. metabolic analysis strong enzymatic a release amino acids beneficial short-chain fatty (SCFAs). Moreover, Renuspore® effectively chelated heavy metals, mercury lead, without negatively impacting minerals, iron, magnesium, calcium, degraded contaminants, nitrite, ammonia, 4-Chloro-2-nitrophenol. These findings suggest may play role supporting gut health metabolism eliminating contaminants.

Language: Английский

Degradation of food dyes via biological methods: A state-of-the-art review DOI
Vandana Singh, Chetan Pandit, Arpita Roy

et al.

Bioresource Technology Reports, Journal Year: 2024, Volume and Issue: 25, P. 101780 - 101780

Published: Feb. 1, 2024

Language: Английский

Citations

27
Fungal bioremediation: An overview of the mechanisms, applications and future perspectives DOI Creative Commons
D. Yuvaraj, Gnanasekaran Ramakrishnan, G. Koteswara Reddy

et al.

Environmental Chemistry and Ecotoxicology, Journal Year: 2024, Volume and Issue: 6, P. 293 - 302

Published: Jan. 1, 2024

Fungal bioremediation represents a promising and sustainable approach to addressing environmental pollution by exploiting the natural metabolic capabilities of fungi degrade detoxify wide array pollutants. This review provides comprehensive overview mechanisms, applications, future perspectives fungal bioremediation. Fungi are uniquely equipped with an extensive arsenal enzymes, including laccases, peroxidases, hydrolases, which facilitate breakdown complex organic compounds, heavy metals, xenobiotics into less harmful substances. The versatility enables their application across various contexts, soil, water, air remediation. efficacy is demonstrated in its ability persistent pollutants such as polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), petroleum hydrocarbons, well immobilize transform metals through biosorption bioaccumulation. also discusses challenges limitations associated bioremediation, need for optimized conditions potential ecological impacts. Future research directions highlighted, integration omics technologies elucidation pathways development biotechnological innovations scale up processes. underscores critical role remediation emphasizes continued technological advancements harness full global challenges.

Language: Английский

Citations

26
Recent advancement in the detection of potential cancer biomarkers using the nanomaterial integrated electrochemical sensing technique: a detailed review DOI Creative Commons
Hema Bhardwaj,

ARCHANA ARCHANA,

Ashab Noumani

et al.

Materials Advances, Journal Year: 2024, Volume and Issue: 5(2), P. 475 - 503

Published: Jan. 1, 2024

Graphical representation of the overview lung and oral cancer from detection to medical treatment.

Language: Английский

Citations

17
Biofilm-mediated bioremediation of xenobiotics and heavy metals: a comprehensive review of microbial ecology, molecular mechanisms, and emerging biotechnological applications DOI

Amirhossein Sarkar,

Surajit Bhattacharjee

3 Biotech, Journal Year: 2025, Volume and Issue: 15(4)

Published: March 7, 2025

Language: Английский

Citations

2
Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins DOI Open Access
Amirhossein Malaekeh-Nikouei,

Sina Shokri-Naei,

Sobhan Karbas Foroushan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115263 - 115263

Published: Aug. 2, 2023

In addition to the anti-diabetic effect of metformin, a growing number studies have shown that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer, genomic stability, anti-inflammation, and anti-fibrosis, which potent, can treat other disorders than diabetes mellitus. We aimed describe review protective antidotal efficacy against biologicals, chemicals, natural, medications, pesticides, radiation-induced toxicities. A comprehensive search been performed from Scopus, Web Science, PubMed, Google Scholar databases inception March 8, 2023. All in vitro, vivo, clinical were considered. Many suggest affects diseases diabetes. It is radioprotective chemoprotective drug also viral bacterial diseases. be used inflammation-related apoptosis-related abnormalities toxins lower their effects. Besides lowering blood sugar, attenuate effects on body weight, inflammation, apoptosis, necrosis, caspase-3 activation, cell viability survival rate, reactive oxygen species (ROS), NF-κB, TNF-α, many interleukins, lipid profile, enzymes activity catalase superoxide dismutase. reduce histopathological damages induced by kidneys, liver, colon. However, trials human are needed before using therapeutic agent

Language: Английский

Citations

27
Petroleum Hydrocarbon Catabolic Pathways as Targets for Metabolic Engineering Strategies for Enhanced Bioremediation of Crude-Oil-Contaminated Environments DOI Creative Commons
Nandita Das, Ankita Das, Sandeep Das

et al.

Fermentation, Journal Year: 2023, Volume and Issue: 9(2), P. 196 - 196

Published: Feb. 20, 2023

Anthropogenic activities and industrial effluents are the major sources of petroleum hydrocarbon contamination in different environments. Microbe-based remediation techniques known to be effective, inexpensive, environmentally safe. In this review, metabolic-target-specific pathway engineering processes used for improving bioremediation hydrocarbon-contaminated environments have been described. The microbiomes characterised using environmental genomics approaches that can provide a means determine unique structural, functional, metabolic pathways by microbial community degradation contaminants. bacterial metabolism aromatic hydrocarbons has explained via peripheral catabolic actions enzymes, such as dehydrogenases, hydrolases, oxygenases, isomerases. We proposed microbiome techniques, specific an environment detected manipulated targets. Using combination with synthetic biology, systemic evolutionary approaches, highly efficient strains may utilised facilitate target-dependent bioprocessing hydrocarbons. Moreover, use CRISPR-cas genetic methods editing genes modifying leads selection recombinants improved abilities. idea growing metabolically engineered communities, which play crucial role breaking down range pollutants, also explained. However, limitations in-situ implementation genetically modified organisms pose challenge needs addressed future research.

Language: Английский

Citations

26
Application of Microorganisms in Biotransformation and Bioremediation of Environmental Contaminant: A Review DOI
Moupriya Nag,

Dibyajit Lahiri,

Sreejita Ghosh

et al.

Geomicrobiology Journal, Journal Year: 2023, Volume and Issue: 41(4), P. 374 - 391

Published: Oct. 6, 2023

The increase in population has resulted a rapid waste that is being dumped within the environment. addition of various harmful and contaminating compounds results degradation environment direct impact on human health. Various research studies are taking place recent times help enhancement naturally available microbes to degrade toxic liberated into Although types bioremediation techniques available, microbe-associated remediation proven be best option due its effectiveness, no generation by-products, natural availability with ability take up nutrients from contaminants exist surface earth. Both ex situ can accomplished these microbes. In most cases, this done through biofilm-assisted seclusion pollutants, more precisely by means extracellular polymeric substances (EPSs) biofilm matrix. times, have been implemented like proteomics, genomics, fluxomics transcriptomics for bringing about maximum microbial species. order explore different kinds communities involved bioremediation, strategic approach metagenomic analysis adopted, which brought technological drift remediation, even at genomic level. As chemical mode remediating wastes associated release chemicals those environment, use biological systems potential agent conversion complex materials simpler so it mixes easier manner. Microbes entities easily act bring an effective

Language: Английский

Citations

25
Recent advances in microbial-assisted degradation and remediation of xenobiotic contaminants; challenges and future prospects DOI

A.K. Priya,

M. Muruganandam, Anuj Kumar

et al.

Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 60, P. 105106 - 105106

Published: March 14, 2024

Language: Английский

Citations

16
Aquatic Microbiomes Under Stress: The Role of Gut Microbiota in Detoxification and Adaptation to Environmental Exposures DOI Creative Commons
Ming She See,

Xin Li Ching,

Shing Ching Khoo

et al.

Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100612 - 100612

Published: Jan. 1, 2025

Language: Английский

Citations

1
Microbial Exudates as Biostimulants: Role in Plant Growth Promotion and Stress Mitigation DOI Creative Commons

Mariya Ansari,

Barsha Devi,

Ankita Sarkar

et al.

Journal of Xenobiotics, Journal Year: 2023, Volume and Issue: 13(4), P. 572 - 603

Published: Oct. 1, 2023

Microbes hold immense potential, based on the fact that they are widely acknowledged for their role in mitigating detrimental impacts of chemical fertilizers and pesticides, which were extensively employed during Green Revolution era. The consequence this extensive use has been degradation agricultural land, soil health fertility deterioration, a decline crop quality. Despite existence environmentally friendly sustainable alternatives, microbial bioinoculants encounter numerous challenges real-world settings. These include harsh environmental conditions like unfavorable pH, temperature extremes, nutrient imbalances, as well stiff competition with native species host plant specificity. Moreover, obstacles spanning from large-scale production to commercialization persist. Therefore, substantial efforts underway identify superior solutions can foster eco-conscious system. In context, attention shifted towards utilization cell-free exudates opposed traditional inoculants. Microbial refer diverse array cellular metabolites secreted by cells. enclose wide range compounds, including sugars, organic acids, amino peptides, siderophores, volatiles, more. composition function these compounds vary considerably, depending specific strains prevailing conditions. Remarkably, possess capability modulate influence various physiological processes, thereby inducing tolerance both biotic abiotic stresses. Furthermore, facilitate growth aid remediation pollutants such chemicals heavy metals agroecosystems. Much live microbes, when applied, actively participate phyllosphere rhizosphere, engaging continuous interactions plants plant-associated microbes. Consequently, play pivotal reshaping microbiome. biostimulant properties exhibited position them promising biological components fostering cleaner more systems.

Language: Английский

Citations

22