Hyperglycaemia and Its Prognostic Value in Patients with COVID-19 Admitted to the Hospital in Lithuania DOI Creative Commons
Lina Zabulienė, Ieva Kubiliute,

Mykolas Urbonas

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 12(1), P. 55 - 55

Published: Dec. 25, 2023

Background and objectives: Increased blood glucose levels atadmission are frequently observed in COVID-19 patients, even those without pre-existing diabetes. Hyperglycaemia is associated with an increased incidence of severe infection. The aim this study was to evaluate the association between hyperglycaemia at admission need for invasive mechanical ventilation (IMV) in-hospital mortality patients diabetes who were hospitalized Materials methods: This retrospective observational conducted Vilnius University Hospital Santaros Clinics, Lithuania adult tested positive acute respiratory syndrome coronavirus 2 SARS-CoV-2 March 2020 May 2021. Depersonalized data retrieved from electronic medical records. Based on day admission, divided into 4 groups: hypoglycaemia (blood below 4.0 mmol/L), normoglycaemia ≥4.0 mmol/L <6.1 mild ≥6.1 <7.8 intermittent ≥7.8 <11.1 mmol/L). A multivariable binary logistic regression model created determine IMV. Survival analysis performed assess effect outcome within 30 days hospitalization. Results: Among 1945 1078 (55.4%) had normal levels, 651 (33.5%) hyperglycaemia, 196 (10.1%) 20 (1.0%) hypoglycaemia. oddsratio (OR) IMV 4.82 (95% CI 2.70–8.61, p < 0.001), OR 2.00 1.21–3.31, = 0.007) compared presenting levels. hazardratio (HR) 30-day 1.62 1.10–2.39, 0.015), while HR 3.04 2.01–4.60, 0.001) admission. Conclusions: In diabetes, presence indicative COVID-19-induced alterations metabolism stress hyperglycaemia. risk mortality. finding highlights importance clinicians carefully consider select optimal support treatment strategies these patients. Further studies long-term consequences specific population warranted.

Language: Английский

The influence of diabetes and hyperglycemia on short and long-term mortality after the first-ever known COVID-19 infection DOI

B. Soto,

Ana C Varella, Marcos Rafael Nogueira Cavalcante

et al.

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 112100 - 112100

Published: March 1, 2025

Language: Английский

Citations

0
Glycemic Dysregulation, Inflammation and Disease Outcomes in Patients Hospitalized with COVID-19: Beyond Diabetes and Obesity DOI Creative Commons
Angelos Liontos, Dimitrios Biros,

Aikaterini Kavakli

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(7), P. 1468 - 1468

Published: June 28, 2023

Introduction: During the COVID-19 pandemic, diabetes mellitus (DM) and obesity were associated with high rates of morbidity mortality. The aim this study was to investigate relationship between markers inflammation, disease severity, insulin resistance, hyperglycemia, outcomes in patients without obesity. Materials Methods: Epidemiological, clinical, laboratory data collected from University Hospital Ioannina Registry included hospitalized March 2020 December 2022. cohort divided into three subgroups based on presence DM, obesity, or absence both. Results: In diabetic patients, elevated CRP, IL-6, TRG/HDL-C ratio, TyG index, severe pneumonia, hyperglycemia extended hospitalization. Increased NLR, decreased PFR a higher risk death. obese subgroup, lower levels longer hospitalization death, while lung DM resistance indices, during Conclusion: Inflammatory severity indices strongly across all subgroups.

Language: Английский

Citations

6
Diabetes and bacterial co-infection are two independent risk factors for respiratory syncytial virus disease severity DOI Creative Commons
Hakan Şıvgın, Şirin ÇETİN, Ayşe Ülgen

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Nov. 1, 2023

Diabetes mellitus (DM) is common among older adults hospitalized with lower respiratory tract infection, yet information on the impact of DM disease severity limited. This study retrospectively analyzed 46 Turkish patients infected syncytial virus (RSV), their comorbidities, co-infection status, and symptoms. Patients are grouped into four levels from mild to severe, according lung parenchymal infiltration status oxygen level. Similar previously published studies, we found that comorbidities diabetes, heart failure, hypertension, any type, bacterial co-infection, age associated severity. Cough most symptom (89%) followed by fever (26%) myalgia, dyspnea, weakness (around 20%). Using a second-order analysis (two-variable regression), identified two independent risks for severity, first represented second co-infection. We observed whose more severe symptoms were not an age, but combination diabetes To confirm true causality statistical correlation, further studies needed.

Language: Английский

Citations

6
Insulin Resistance in Long COVID-19 Syndrome DOI Open Access
Dana Emilia Man, Minodora Andor, Valentina Buda

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(9), P. 911 - 911

Published: Aug. 28, 2024

The COVID-19 pandemic has caused severe health issues worldwide and contributed to huge financial losses. Key comorbidities linked an increased risk of higher mortality rates include cardio-metabolic disorders such as type 1 2 diabetes mellitus (T1DM T2DM), atherosclerotic cardiovascular disease, chronic kidney hypertension, heart failure, obesity. persistence symptoms even after the acute phase is over termed long syndrome. This study aimed evaluate relationship between syndrome development insulin resistance in previously non-diabetic patients.

Language: Английский

Citations

1
Impact of the peak period of coronavirus disease 2019 on 28‐day mortality, emergency department visits and length of hospital stay of emergency admissions: A single center retrospective observational study in Hong Kong DOI
R. Li, Alex Kwok-Keung Law, Colin A. Graham

et al.

Hong Kong Journal of Emergency Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Abstract Background During the fifth wave of COVID‐19, accident and emergency departments in Hong Kong experienced significant overcrowding yet there was limited evidence available regarding services patients' clinical outcomes. The aim this study to compare 28‐day mortality, department (ED) visits, length stay (LOS) between peak period COVID‐19 a control 2019. Method This retrospective case‐control comparing (7 Feb 2022 23 Apr 2022) with 2019 2019). Patients' characteristics, ED diagnoses, LOS were compared. Results 35,429 patients included. in‐hospital mortality significantly higher risk ratio 3.91 (95% CI: 3.38–4.53). There 36% reduction visits during while 53.7% increase critical cases at triage. average admissions increased from 3.8 days (Median = 2.0; IQR 1.0–3.0) 5.1 1.0–6.0) especially subgroups chronic kidney disease, influenza pneumonia, diabetes, mental disorders. Conclusion Increased all‐cause deaths observed along overall lengthened LOS.

Language: Английский

Citations

0
Hyperglycaemia and Its Prognostic Value in Patients with COVID-19 Admitted to the Hospital in Lithuania DOI Creative Commons
Lina Zabulienė, Ieva Kubiliute,

Mykolas Urbonas

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 12(1), P. 55 - 55

Published: Dec. 25, 2023

Background and objectives: Increased blood glucose levels atadmission are frequently observed in COVID-19 patients, even those without pre-existing diabetes. Hyperglycaemia is associated with an increased incidence of severe infection. The aim this study was to evaluate the association between hyperglycaemia at admission need for invasive mechanical ventilation (IMV) in-hospital mortality patients diabetes who were hospitalized Materials methods: This retrospective observational conducted Vilnius University Hospital Santaros Clinics, Lithuania adult tested positive acute respiratory syndrome coronavirus 2 SARS-CoV-2 March 2020 May 2021. Depersonalized data retrieved from electronic medical records. Based on day admission, divided into 4 groups: hypoglycaemia (blood below 4.0 mmol/L), normoglycaemia ≥4.0 mmol/L <6.1 mild ≥6.1 <7.8 intermittent ≥7.8 <11.1 mmol/L). A multivariable binary logistic regression model created determine IMV. Survival analysis performed assess effect outcome within 30 days hospitalization. Results: Among 1945 1078 (55.4%) had normal levels, 651 (33.5%) hyperglycaemia, 196 (10.1%) 20 (1.0%) hypoglycaemia. oddsratio (OR) IMV 4.82 (95% CI 2.70–8.61, p < 0.001), OR 2.00 1.21–3.31, = 0.007) compared presenting levels. hazardratio (HR) 30-day 1.62 1.10–2.39, 0.015), while HR 3.04 2.01–4.60, 0.001) admission. Conclusions: In diabetes, presence indicative COVID-19-induced alterations metabolism stress hyperglycaemia. risk mortality. finding highlights importance clinicians carefully consider select optimal support treatment strategies these patients. Further studies long-term consequences specific population warranted.

Language: Английский

Citations

0