Cholesteryl ester transfer protein inhibition: a pathway to reducing risk of morbidity and promoting longevity DOI Creative Commons
Michael H. Davidson, Andrew Hsieh, John J.P. Kastelein

et al.

Current Opinion in Lipidology, Journal Year: 2024, Volume and Issue: 35(6), P. 303 - 309

Published: Oct. 17, 2024

Purpose of review To the evidence and describe biological plausibility for benefits inhibiting cholesteryl ester transfer protein (CETP) on multiple organ systems through modification lipoprotein metabolism. Recent findings Results from observational studies, Mendelian randomization analyses, randomized clinical trials support potential CETP inhibition to reduce atherosclerotic cardiovascular disease (ASCVD) risk a reduction apolipoprotein B-containing lipoproteins. In contrast, raising high-density (HDL) particles, as previously hypothesized, did not contribute ASCVD reduction. There is also an expanding body supporting safeguarding against other conditions associated with aging, particularly new-onset type 2 diabetes mellitus dementia, well age-related macular degeneration, septicemia, possibly chronic kidney disease. The latter are likely mediated improved functionality HDL particle, including its role cholesterol efflux antioxidative, anti-inflammatory, antimicrobial activities. Summary At present, there robust reducing activity reduction, exists promotion longevity by risks several conditions. An ongoing large trial program latest potent inhibitor, obicetrapib, expected provide further insight into therapeutic target these various

Language: Английский

Antioxidant and Anti-Inflammatory Functions of High-Density Lipoprotein in Type 1 and Type 2 Diabetes DOI Creative Commons
Damien Denimal

Antioxidants, Journal Year: 2023, Volume and Issue: 13(1), P. 57 - 57

Published: Dec. 28, 2023

(1) Background: high-density lipoproteins (HDLs) exhibit antioxidant and anti-inflammatory properties that play an important role in preventing the development of atherosclerotic lesions possibly also diabetes. In turn, both type 1 diabetes (T1D) 2 (T2D) are susceptible to having deleterious effects on these HDL functions. The objectives present review expound upon functions HDLs setting cardiovascular diseases discuss contributions onset (2) Methods: this narrative is based literature available from PubMed database. (3) Results: several HDLs, such as paraoxonase-1 activity, compromised T2D, thereby facilitating pro-atherogenic oxidized low-density lipoproteins. addition, diminished ability inhibit pro-inflammatory pathways vessels individuals with T2D. Although less extensive, recent evidence suggests defective antiatherogenic particles T1D. Lastly, substantial indicates a by modulating glucose metabolism. (4) Conclusions perspectives: impaired intriguing targets for mitigating risk Further investigations needed clarify influence glycaemic control nephropathy functionality patients Furthermore, exploring novel antidiabetic drugs used management T2D may provide insights future research.

Language: Английский

Citations

22
Research Progress on the Pathogenesis of Aortic Aneurysm and Dissection in Metabolism DOI
Yihong Zhou, Tingyu Wang,

Hongyou Fan

et al.

Current Problems in Cardiology, Journal Year: 2023, Volume and Issue: 49(1), P. 102040 - 102040

Published: Aug. 17, 2023

Language: Английский

Citations

14
Platelet/High-Density Lipoprotein Ratio (PHR) Predicts Type 2 Diabetes in Obese Patients: A Retrospective Study DOI Open Access
Yazeed Alshuweishi,

Arwa Abudawood,

Dalal Alfayez

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(15), P. 1540 - 1540

Published: Aug. 3, 2024

Background: Obesity and type 2 diabetes (T2D) pose global health problems that continue to rise. A chronic low-grade inflammation activation of the immune system are well established in both conditions. The presence these factors can predict disease development progression. Emerging evidence suggests platelet–high density lipoprotein ratio (PHR) is a potential inflammatory marker. purpose this study was investigate relationship between PHR T2D among obese patients. Methods: 203 patients with BMI ≥ 30 kg/m2 participated study. Patients were categorized into two groups: non-diabetic diabetic obese. Comorbidities, baseline characteristics, laboratory data, as levels groups analyzed. Medians, risk assessment, diagnostic performance values examined groups. Results: In patients, median significantly increased compared (p < 0.0001). Furthermore, high had higher FBG HbA1c 0.05). Although weakly yet correlated glycemic markers, ROC curve analysis indicated an AUC 0.700 0.0001) predicting cutoff value 6.96, sensitivity specificity 53.4% 76.1%, respectively. Moreover, (OR = 4.77, p carried for developing individuals. Conclusions: convenient cost-effective marker reliably high-risk population.

Language: Английский

Citations

6
High-Density Lipoprotein Lipid and Protein Cargo and Cholesterol Efflux Capacity Before and After Bariatric Surgery DOI

Sohail Zahid,

Florencia Schlamp,

Michael Gildea

et al.

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

BACKGROUND: Cholesterol efflux capacity (CEC) of HDL (high-density lipoprotein) is inversely associated with incident cardiovascular events, independent cholesterol. Obesity characterized by low cholesterol and impaired function, such as CEC. Bariatric surgery, including Roux-en-Y gastric bypass (RYGB) sleeve gastrectomy (SG), broadly leads to improved outcomes, but impacts on risk factors differ procedure, greater improvements in weight loss, blood pressure, glycemic control after RYGB, CEC levels SG. This study sought determine effects RYGB SG protein lipid cargo investigate associations changes. METHODS: We prospectively studied nondiabetic, premenopausal Hispanic women severe obesity not using medications undergoing (n=31) or (n=36). Anthropometric measurements sampling were obtained before at 6 12 months surgery. was isolated from plasma, quantitative proteomic lipidomic assessments performed LC-MS/MS. assessed ex vivo apoB-depleted serum. RESULTS: Participants experienced similar, significant loss over following bariatric surgery (38.0±10.4 kg) regardless the procedure. Relative quantities 47 proteins (34 increased, 13 decreased) 150 lipids (71 79 carried significantly altered either surgical Proteins similar aggregate response patterns clustered into 15 groups (5 5 decreased, minimal change) responses 25 (7 11 7 change). Network mediation analyses suggested that changes 4 2 clusters mediated ABCA1 (ATP-binding cassette transporter A1) 1 cluster non-ABCA1 The distinct between RYGB. CONCLUSIONS: produces substantial cargo, specific may mediate function Further these mechanisms lead interventions reduce patients obesity.

Language: Английский

Citations

0
A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease DOI Creative Commons
Laura Bonfili,

Francesca Grasselli,

Massimiliano Cuccioloni

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109904 - 109904

Published: March 1, 2025

Language: Английский

Citations

0
Cholesterol and triglyceride concentrations following 12–18 months of clinically prescribed elexacaftor-tezacaftor-ivacaftor—PROMISE sub-study DOI Creative Commons
Rosara Bass, Michael S. Stalvey, George M. Solomon

et al.

Journal of Clinical & Translational Endocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 100391 - 100391

Published: April 1, 2025

Language: Английский

Citations

0
PREVALENCE OF SMALL DENSE LDL IN TYPE 2 DIABETES MELLITUS AND ITS CORRELATION WITH INFLAMMATORY MARKERS: A COMPREHENSIVE STUDY DOI Open Access
N Anush,

SUKHDEEP KUMAR,

Riju Mathew

et al.

Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2025, Volume and Issue: unknown, P. 161 - 166

Published: April 7, 2025

Objectives: This research pursues to determine the incidence of elevated levels sdLDL in T2DM patients and study its association with inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), lipoprotein-associated phospholipase A2 (Lp-PLA2), red cell distribution width (RDW). Methods: The involved 158 participants, comprising both diabetic non-diabetic individuals, recruited from a tertiary care facility. Blood samples underwent analysis for using two-step enzymatic technique. Inflammatory markers were estimated nephelometry chemiluminescent immunoassays. SPSS was employed statistical establish relationships significance levels. Results: Diabetic subjects demonstrated particularly higher than controls (p < 0.001). A robust positive correlation identified between hsCRP, Lp-PLA2, RDW, suggesting connection systemic inflammation. Regression further substantiated that marker linked increased concentrations. Conclusion: outcomes underline crucial role dyslipidemia strong relationship Estimation along biomarkers may improve cardiovascular risk assessment patients. Therapeutic interventions, lipid-lowering anti-inflammatory approaches, could possibly reduce sdLDL-induced atherosclerosis.

Language: Английский

Citations

0
CD8+ Treg cells play a role in the obesity-associated insulin resistance DOI Creative Commons
Pedro Barbosa, Aryane Cruz Oliveira Pinho, André Lázaro

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 336, P. 122306 - 122306

Published: Nov. 27, 2023

Language: Английский

Citations

9
Oxysterols in Vascular Cells and Role in Atherosclerosis DOI
Céline Luquain‐Costaz, Isabelle Delton

Advances in experimental medicine and biology, Journal Year: 2023, Volume and Issue: unknown, P. 213 - 229

Published: Dec. 1, 2023

Language: Английский

Citations

9
Anthropometric and Biochemical Correlations of Insulin Resistance in a Middle-Aged Maltese Caucasian Population DOI Creative Commons
Rachel Agius, Nikolai Paul Pace, Stephen Fava

et al.

Journal of Nutrition and Metabolism, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 10

Published: Feb. 21, 2024

Insulin resistance (IR) is associated with increased cardiovascular disease risk, and all-cause, cardiovascular, cancer mortality. A number of surrogate markers are used in clinical practice to diagnose IR. The aim this study was investigate the discriminatory power a routinely available anthropometric biochemical variables predicting IR determine their optimal cutoffs. We performed cross-sectional cohort middle-aged individuals. receiver operator characteristics (ROC) analyses order parameters interest detecting IR, which defined as homeostatic model assessment-insulin ≥2.5. Both lipid accumulation product (LAP) visceral adiposity index (VAI) exhibited good detect both males females. cutoffs were 42.5 1.44, respectively, 36.2 1.41, Serum triglycerides (TG) waist circumference (WC) similarly demonstrated sexes. for serum TG WC 1.35 mmol/L 96.5 cm, men 1.33 82 women. On other hand, systolic diastolic blood pressure, liver transaminases, high-density lipoprotein cholesterol, uric acid, ferritin, waist-hip ratio, "A" body shape, thigh circumference, weight-adjusted all had poor power. Our data show that LAP, VAI, TG, have lower than those currently recommended Replication studies required different subpopulations ethnicities be able update current cut points ones reflect contemporary population well evaluate longitudinal relationship longer-term cardiometabolic outcomes.

Language: Английский

Citations

3