The intersection of frailty and metabolism

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(5), P. 893 - 911

Published: April 12, 2024

Language: Английский

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The association between oxidative balance score and frailty in adults across a wide age spectrum: NHANES 2007–2018

Food & Function, Journal Year: 2024, Volume and Issue: 15(9), P. 5041 - 5049

Published: Jan. 1, 2024

Frailty has been one of the most serious global public health challenges we will ever face.

Language: Английский

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Relationship between changes in the triglyceride glucose-body mass index and frail development trajectory and incidence in middle-aged and elderly individuals: a national cohort study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 16, 2024

Insulin resistance is linked to an increased risk of frailty, yet the comprehensive relationship between triglyceride glucose-body mass index (TyG-BMI), which reflects weight, and remains unclear. This investigated in this study. Data from 9135 participants China Health Retirement Longitudinal Study (2011–2020) were analysed. Baseline TyG-BMI, changes TyG-BMI cumulative baseline 2015, along with frailty (FI) over nine years, calculated. Participants grouped into different categories based on using K-means clustering. FI trajectories assessed a group-based trajectory model. Logistic Cox regression models used analyse associations frail incidence. Nonlinear relationships explored restricted cubic splines, linear mixed-effects model was evaluate development speed. Weighted quantile identify primary contributing factors. Four classes two identified. Individuals third (OR = 1.25, 95% CI: 1.10–1.42) fourth 1.83, 1.61–2.09) quartiles those consistently second highest 1.49, 1.32–1.70) 2.17, 1.84–2.56) changes, 1.20, 1.05–1.36) 1.94, 1.70–2.22) had greater odds experiencing rapid trajectory. Higher noted quartile (HR 1.42, 1.28–1.58), 1.23, 1.12–1.34) 1.58, 1.42–1.77), 1.10, 1.00-1.21) 1.46, 1.33–1.60). persistently second-lowest (β 0.15, 0.38 0.76 respectively) 0.25 0.56, demonstrated accelerated progression. A U-shaped association observed levels both higher risk, BMI being factor. associated risk. However, excessively low also appear contribute development. Maintaining healthy especially BMI, may help prevent or delay onset.

Language: Английский

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Associations Between Frailty and Risk of All-Cause and Cardiovascular Mortality in Patients with Prediabetes: A Population-Based Study

Journal of Multidisciplinary Healthcare, Journal Year: 2025, Volume and Issue: Volume 18, P. 61 - 70

Published: Jan. 1, 2025

Objective: Diabetes is a well-known risk factor for frailty that has been associated with adverse prognosis. However, the association of all-cause and cardiovascular disease (CVD) mortality in patients prediabetes not thoroughly explored. Methods: Participants were derived from 1999– 2018 National Health Nutrition Examination Survey followed up CVD until December 31, 2019. A index calculated using 49-item deficit accumulation model > 0.21 was used to indicate presence frailty. Kaplan-Meier curves weighted Cox proportional hazards regression assess between mortality. Results: The prevalence 28.21% this cohort 7845 prediabetic participants mean age 62.89 years. During median follow-up time 90 months, total 1983 (636 CVD-related) deaths occurred. Each 0.01 score increase 5% 6% increased CVD-related mortality, respectively. hazard ratio 95% confidence interval group 2.28 (1.89– 2.76) 2.84 (2.01– 4.02), respectively, compared those without Restricted cubic spline analysis showed linear or Similar results observed sensitivity analyses. Conclusion: positively prediabetes, highlighting appropriate screening management may help reduce prediabetes. Keywords: disease, frailty,

Language: Английский

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Modulating oxidative stress: a reliable strategy for coping with community-acquired pneumonia in older adults

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Community-acquired pneumonia (CAP) remains one of the leading respiratory diseases worldwide. With aging global population, morbidity, criticality and mortality rates CAP in older adults remain high every year. Modulating signaling pathways that cause inflammatory response improve immune function patients has become focus reducing damage lungs, especially adults. As an important factor causes affects status body, oxidative stress plays role occurrence, development treatment CAP. Furthermore, with CAP, is closely associated senescence, sarcopenia, frailty, aging, multimorbidity, polypharmacy. Therefore, multiple perspectives combined disease characteristics were reviewed to clarify research progress application value modulating Clearly, there no doubt targeted modulation benefits However, many challenges unknowns concerning how modulate for further practical clinical applications exist, more needed. Moreover, limitations are analyzed aim providing references ideas future or

Language: Английский

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Cold atmospheric plasma control metabolic syndromes via targeting fat mass and obesity-associated protein

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107720 - 107720

Published: March 1, 2025

Both obesity and metabolic disorders are global medical problems. Driven by prolonged inflammation, increases the risk of developing syndromes such as fatty liver, diabetes, cardiovascular diseases cancers. The fat mass obesity-associated protein (FTO) is an m6A demethylase, elevated activity which known to promote pathogenesis many disorders, leading establishment various FTO inhibitors. By combing through intrinsic connections among four primary problems, we attribute their shared pathological cause inflammation. reviewing roles in promoting these current status existing inhibitors treating syndromes, underpinned paramount potential resolving clinical issues targeting urgent need establishing novel with maximized efficacy minimized side effect. Cold atmospheric plasma (CAP) fourth state matter demonstrated associated chronic introducing characteristics CAP, proposed it a possible solution unresolved given its anti-inflammation feature safety. We also emphasized intensive investigations exploring feasibility using CAP that might function FTO.

Language: Английский

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Association between brominated flame retardants and obesity: a mediation analysis through markers of oxidative stress and inflammation

Environmental Health and Preventive Medicine, Journal Year: 2025, Volume and Issue: 30(0), P. 35 - 35

Published: Jan. 1, 2025

Recent studies have provided compelling evidence that exposure to brominated flame retardants (BFRs) can adversely affect human health. We aim explore the potential impact of BFRs on adiposity and central obesity. Data from National Health Nutrition Examination Surveys (NHANES) cycles conducted between 2009 2014 was used study connections variables. After filtering, we analyzed a sample 4,110 adults aged 20 years above. Our goal examine association consequences investigate part played by oxidative stress inflammatory markers as intermediaries. To achieve this, advanced statistical methods such weighted quantile sum (WQS) regression, quantile-based g-computation (QGC), Bayesian kernel machine regression (BKMR). The findings showed among examined chemicals, PBDE85 (weight: 41%), PBDE100 (24%), PBB153 (23%) may be dominant contributors general obesity risk. Upon controlling for all variables could results, it found QGC outcomes indicated positive correlation mixtures occurrence abdominal (OR = 1.187, 95% CI: 1.056-1.334, p 0.004). Significant contributions were made (52%), (27%), (21%). Mediation analysis shows lymphatic cells (LC) albumin (ALB) partially mediate link results BKMR are generally consistent with those WQS QGC. At population level, our research has revealed noteworthy However, further investigation is required through prospective cohort in-depth mechanistic exploratory studies.

Language: Английский

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Cross-sectional association between hs-CRP/HDL-C ratio and physical frailty among middle-aged and older adults: findings from a population-based study

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 9, 2025

Background Frailty, characterized by functional decline and disability, is an emerging public health concern in aging populations. Chronic inflammation low high-density lipoprotein cholesterol (HDL-C) levels are key contributors to the progression of frailty. This study aims examine association between ratio high-sensitivity C-reactive protein (hs-CRP) HDL-C frailty among middle-aged older adults United States. Methods Our included participants aged 45 years from 2015–2020 National Health Nutrition Examination Survey (NHANES). Logistic regression restricted cubic spline (RCS) analysis were utilized assess relationship hs-CRP/HDL-C frailty, adjusting for potential confounding covariates. Mediation was performed determine whether plasma proteins mediated this association. Least absolute shrinkage selection operator (LASSO) employed identify variables strongly correlated with a nomogram subsequently developed based on these variables. Results 3,626 participants, whom 787(21.7%) identified as After all covariates, high significant risk factor (OR = 1.736, 95% CI: 1.009–2.988). RCS disclosed nonlinear correlation incidence. Furthermore, mediation suggested that albumin globulin partially association, accounting 37.82% 11.23% indirect effect, respectively. A nomogram, constructed using selected via LASSO regression, exhibited promising discriminative ability, area under curve (AUC) 79.7% (95% 77.7–81.75%). Conclusion findings suggest higher associated increased adults. Albumin mediate relationship. Additionally, our shows strong predictive ability identifying individuals at population.

Language: Английский

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U-shaped relationship between frailty and non-HDL-cholesterol in the elderly: a cross-sectional study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 21, 2025

Background The modulation of lipid metabolism has been explored as a potential treatment for frailty, yet the association between non-high-density lipoprotein-cholesterol (non-HDL-C) and frailty remains unclear. Methods This study utilized data from five cycles National Health Nutrition Examination Survey (NHANES) two China Retirement Longitudinal Study (CHARLS) to investigate this relationship. A 40-item index scale, encompassing various dimensions somatic functioning, psychological evaluation, illness, was developed individually evaluated each participant. variables underwent screening through Least Absolute Shrinkage Selection Operator (LASSO) regression, univariate logistic Light Gradient Boosting Machine (LightGBM), with models multivariate regression LightGBM algorithm. Subsequently, subgroup analyses interaction tests were conducted substantiate correlations. Results U-shaped nonlinear non-HDL-C in older adults validated using Non-HDL cholesterol levels range 117.54–194.64 mg/dL less likely be while likelihood developing higher at 47.99–63.87 or 274.01–259.65 mg/dL. Subgroup confirm these results. Conclusion It is plausible that an intricate elderly exists, though further rigorously designed studies are imperative validate

Language: Английский

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The Effect of Exercise Program Interventions on Frailty, Clinical Outcomes, and Biomarkers in Older Adults: A Systematic Review

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(21), P. 6570 - 6570

Published: Nov. 1, 2024

Frailty is characterized by the decreased ability in older adults to handle daily or acute stressors due age-related declines physiological reserve and organ system performance. This condition results from interaction of multiple pathways changes biomarkers. Exercise programs are currently recommended promote "healthy aging" frail adults.

Language: Английский

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