Isolation and identification of the primary toxin in the smoke of the Namibian milk bush, Euphorbia damarana DOI Creative Commons
Mmankeko Petunia Degashu, J.J.M. Meyer, Paul Sewes Frederick Alberts

et al.

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 170, P. 88 - 96

Published: May 17, 2024

Euphorbia damarana L.C.Leach, also known as Damara milk bush, grows only in the north-western desert areas of Namibia and southern Angola. It is often vegetation these regions local inhabitants know very well that it extremely poisonous to humans animals. During 1960s, twenty-seven migrating mineworkers used its dead branches firewood for their barbecue with deadly consequences. They all passed away after consuming meat was infused toxic volatiles smoke. We report this study, on isolation triterpenoid, euphol present high concentrations stems smoke E. damarana. Small compounds phorbol ester skeletons were detected species. The cytotoxicity stem extracts determined by sulfo-rhodamine-B stain (SRB) assay eight human cell lines (A549, PC-3, HeLa, HepG2, MCF-7, MCF-12A, MRC-5 HaCaT). Significant cytotoxic activity observed from purified euphol, IC50 values ranging 1.99 3.99 μg/mL, 5.00 20.00 μg/mL 11.75 40.00 respectively, tested lines. Since primary compound (concentration 10.3 mg/g) extract at a significantly low level, can be considered main toxin responsible deaths miners.

Language: Английский

Anti-Inflammatory and Cytotoxic Compounds Isolated from Plants of Euphorbia Genus DOI Creative Commons

Sarai Rojas-Jiménez,

María Guadalupe Valladares Cisneros, David Osvaldo Salinas-Sánchez

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1083 - 1083

Published: Feb. 29, 2024

Euphorbia is a large genus of the Euphorbiaceae family. Around 250 species have been studied chemically and pharmacologically; different compounds isolated from these species, especially diterpenes triterpenes. Several reports show that several anti-inflammatory activity, which can be attributed to presence diterpenes, such as abietanes, ingenanes, lathyranes. In addition, it was found some anti-cancer activity. this review, we included with or cytotoxic effects published 2018 September 2023. The databases used for review were Science Direct, Scopus, PubMed, Springer, Google Scholar, using keywords 68 studies collected analyzed regarding activities 264 obtained 36 genus. in are terpenes (95%), 68% types triterpenes (approximately 15%).

Language: Английский

Citations

10
Nature’s Green Potential: Anticancer Properties of Plants of the Euphorbiaceae Family DOI Open Access
Víctor Jiménez-González, Tomasz Kowalczyk, Janusz Piekarski

et al.

Cancers, Journal Year: 2023, Volume and Issue: 16(1), P. 114 - 114

Published: Dec. 25, 2023

The number of cancer cases will reach 24 million in 2040, according to the International Agency for Research on Cancer. Current treatments are not effective and selective most patients; this reason, new anticancer drugs need be developed researched enough. There potentially useful isolated from plants that being used clinic. Available information about phytochemistry, traditional uses, vitro vivo experiments with plants, pure compounds Euphorbiaceae family indicates has potential develop drugs. This review examines selected species their bioactive could have against different types cells. It reviews activity crude extracts, compounds, nanoparticles underlying mechanisms action.

Language: Английский

Citations

12
Study on the Chemical Composition and Multidrug Resistance Reversal Activity of Euphorbia uralensis (Euphorbiaceae) DOI Open Access

Yina Ding,

Yuhao Liu, Qiang Dang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 412 - 412

Published: Jan. 6, 2025

Euphorbia uralensis belongs to the family Euphorbiaceae and is widely distributed in northern Xinjiang, making it a characteristic plant of region China. The chemical composition biological activity have not yet been reported, although certain compounds isolated from plants China, demonstrated exceptional multidrug resistance (MDR) reversal. This study aims investigate components present with potential reverse MDR. aerial parts were extracted using organic solvents varying polarities, resulting dichloromethane (Fr-E) petroleum ether (Fr-S) fractions, which exhibited greater MDR reversal than other fractions. constituents Fr-S fraction analyzed GC-MS. Fr-E purified column chromatography. most effective screened out, mechanism was investigated molecular docking, dynamics simulations, Western blotting, rhodamine 123 staining. GC-MS analysis showed that rich triterpenes, fatty acids, phenols, long-chain alkanes, all identified for first time uralensis. Among these, palmitic acid at content level 15.86%. notably unveils discovery new compound 16 previously recorded this plant, main types as steroids, sesquiterpenes, flavonoids. tested cytotoxicity activity. Euphouralosides A, pubinernoid naringenin, punigratine good against MCF-7 MCF-7/ADR cell lines. Punigratine active compound. Moreover, could stably bind ABCB1 protein. blot revealed did affect expression protein cells (p > 0.05). However, following treatment (0.16 μM), there significant increase intracellular accumulation Rh123 < These findings suggest can inhibit efflux protein, thereby overcoming tumors. provides foundation further research on medicinal

Language: Английский

Citations

0
Advances in the Structures, Pharmacological Activities, and Biosynthesis of Plant Diterpenoids DOI
Leilei Li,

Jia Fu,

Nan Liu

et al.

Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 34(8), P. 1563 - 1579

Published: June 17, 2024

Language: Английский

Citations

2
Isolation and identification of the primary toxin in the smoke of the Namibian milk bush, Euphorbia damarana DOI Creative Commons
Mmankeko Petunia Degashu, J.J.M. Meyer, Paul Sewes Frederick Alberts

et al.

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 170, P. 88 - 96

Published: May 17, 2024

Euphorbia damarana L.C.Leach, also known as Damara milk bush, grows only in the north-western desert areas of Namibia and southern Angola. It is often vegetation these regions local inhabitants know very well that it extremely poisonous to humans animals. During 1960s, twenty-seven migrating mineworkers used its dead branches firewood for their barbecue with deadly consequences. They all passed away after consuming meat was infused toxic volatiles smoke. We report this study, on isolation triterpenoid, euphol present high concentrations stems smoke E. damarana. Small compounds phorbol ester skeletons were detected species. The cytotoxicity stem extracts determined by sulfo-rhodamine-B stain (SRB) assay eight human cell lines (A549, PC-3, HeLa, HepG2, MCF-7, MCF-12A, MRC-5 HaCaT). Significant cytotoxic activity observed from purified euphol, IC50 values ranging 1.99 3.99 μg/mL, 5.00 20.00 μg/mL 11.75 40.00 respectively, tested lines. Since primary compound (concentration 10.3 mg/g) extract at a significantly low level, can be considered main toxin responsible deaths miners.

Language: Английский

Citations

1