Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(4), P. 506 - 506
Published: April 15, 2024
Several
biologically
active
compounds
involved
in
the
green
synthesis
of
silver
and
gold
nanoparticles
have
been
isolated
from
snail
mucus
characterized.
This
paper
presents
a
successful
method
for
application
Cornu
aspersum
as
bioreducing
agent
copper
sulfate
biostabilizer
oxide
(CuONPs-Muc)
obtained.
The
at
room
temperature
neutral
pH
yielded
with
spherical
shape
an
average
diameter
150
nm.
structure
properties
CuONPs-Muc
were
characterized
using
various
methods
techniques,
such
ultraviolet–visible
spectroscopy
(UV–vis),
high-performance
liquid
chromatography
(HPLC),
one-dimensional
polyacrylamide
gel
electrophoresis
(1D-PAGE),
up-conversion
infrared
Fourier
transform
(FTIR),
scanning
electron
microscopy
combined
energy
dispersive
(SEM/EDS),
Raman
imaging,
thermogravimetric
analysis
(TG-DSC),
etc.
Mucus
proteins
molecular
weights
30.691
kDa
26.549
identified,
which
are
biogenic
production
CuONPs-Muc.
macromolecular
shell
formed
around
ions
contributes
to
higher
efficiency
synthesized
inhibiting
bacterial
growth
several
Gram-positive
(Bacillus
subtilis
NBIMCC2353,
Bacillus
spizizenii
ATCC
6633,
Staphylococcus
aureus
6538,
Listeria
innocua
NBIMCC8755)
Gram-negative
(Escherichia
coli
ATCC8739,
Salmonella
enteitidis
NBIMCC8691,
typhimurium
14028,
Stenotrophomonas
maltophilia
17666)
bacteria
compared
baseline
mucus.
bioorganic
presented
here
provides
highly
pronounced
antimicrobial
effect.
These
results
will
expand
knowledge
field
natural
nanomaterials
their
role
emerging
dosage
forms.
Biomedical Microdevices,
Journal Year:
2024,
Volume and Issue:
26(1)
Published: Jan. 23, 2024
Abstract
The
rise
in
drug
resistance
pathogenic
bacteria
greatly
endangers
public
health
the
post-antibiotic
era,
and
drug-resistant
currently
pose
a
great
challenge
not
only
to
community
but
also
clinical
procedures,
including
surgery,
stent
implantation,
organ
transplantation,
other
medical
procedures
involving
any
open
wound
compromised
human
immunity.
Biofilm-associated
failure,
as
well
rapid
last-resort
antibiotics,
necessitates
search
for
novel
treatments
against
bacterial
infection.
In
recent
years,
flourishing
development
of
nanotechnology
has
provided
new
insights
exploiting
promising
alternative
therapeutics
bacteria.
Metallic
agents
have
been
applied
antibacterial
usage
several
centuries,
functional
modification
metal-based
biomaterials
using
now
attracted
interest
field,
their
intrinsic
nature
ready
on-demand
functionalization
enhanced
interaction
with
bacteria,
rendering
them
good
potential
further
translation.
However,
possible
toxicity
MNPs
host
cells
tissue
still
hinders
its
application,
current
knowledge
on
cellular
pathways
is
enough.
This
review
will
focus
advances
developing
metallic
nanoparticles
(MNPs),
silver,
gold,
copper,
nanoparticles,
applications,
mechanisms
hosts.
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 21, 2024
Ephedra
alata
leaf
extracts
have
therapeutic
properties
and
contain
various
natural
compounds
known
as
phytochemicals.
This
study
assessed
the
phytochemical
content
antioxidant
effects
of
a
extract,
well
zinc
oxide
(ZnO)
nanoparticle
production.
The
extract
contained
phenolic
acids,
including
vanillic
acid,
chlorogenic
gallic
p-coumaric
vanillin
rutin.
Its
total
flavonoid
were
48.7
±
0.9
mg.g
-1
1.7
0.4
,
respectively.
displayed
DPPH
inhibition
rate
70.5%,
activity
49.5
3.4
significant
antimicrobial
toward
Gram-positive
negative
bacteria.
synthesized
ZnO
nanoparticles
had
spherical
shape,
crystallite
size
25
nm,
particle
between
5
30
bandgap
energy
3.3
eV.
In
specific
conditions
(90
min
contact
time,
pH
7,
25°C),
these
efficiently
photodegraded
87%
methylene
blue,
suggesting
potential
applications
for
sustainable
water
treatment
pollution
control.
