Advances in multi-omics integrated analysis methods based on the gut microbiome and their applications DOI Creative Commons
Dongdong Duan, Mingyu Wang, Jinyi Han

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

The gut microbiota actually shares the host's physical space and affects physiological functions health indicators through a complex network of interactions with host. However, its role as determinant host disease is often underestimated. With emergence new technologies including next-generation sequencing (NGS) advanced techniques such microbial community sequencing, people have begun to explore interaction mechanisms between microorganisms hosts at various omics levels genomics, transcriptomics, metabolomics, proteomics. enrichment multi-omics integrated analysis methods based on microbiome, an increasing number statistical also been proposed. In this review, we summarized research currently used study microbiome We analyzed advantages limitations briefly introduced their application progress.

Language: Английский

Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease DOI Open Access

Yoonhwa Shin,

Sunhee Han,

Juhui Kwon

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4466 - 4466

Published: Oct. 21, 2023

The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation dietary fiber. Certain microbes responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance diversity can lead to metabolic disorders inflammation-related diseases. Changes SCFA levels associated microbiota were observed IBD, suggesting an association between disease. affect reactive oxygen species (ROS) with IBD. Gut closely related it study them further.

Language: Английский

Citations

71
Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives DOI Creative Commons
Mohamed E. Abouelela, Yosra A. Helmy

Microorganisms, Journal Year: 2024, Volume and Issue: 12(3), P. 430 - 430

Published: Feb. 20, 2024

Next-generation probiotics (NGPs) represent an innovative group of beneficial bacteria that are currently undergoing research and development. NGPs designed not only for conventional use as foods or dietary supplements but also tailored pharmaceutical applications. Research indicates show therapeutic promise in addressing various chronic ailments. Offering multiple advantages over probiotics, present opportunities personalized probiotic therapies, involvement synthetic biology gene editing, participation combination targeted delivery methods, application settings. Our review discusses the potential effect NGPs, covering diverse trajectories including their identification, characterization, delivery. Furthermore, this elucidates influence on critical aspects human health, specifically, gut immune function, broader health outcomes. Mechanistic insights encompass production bioactive compounds, competitive interactions with pathogenic bacteria, modulation cell activity, reinforcement barrier. What is noteworthy current points out prevalent NGP strains sources, providing a highlight comprehensive framework understanding applications future benefits domain advanced therapeutics.

Language: Английский

Citations

51
The complex relationship between obesity and neurodegenerative diseases: an updated review DOI Creative Commons
Alexandre Neto, Adelaide Fernandes, Andreia Barateiro

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Nov. 9, 2023

Obesity is a global epidemic, affecting roughly 30% of the world’s population and predicted to rise. This disease results from genetic, behavioral, societal, environmental factors, leading excessive fat accumulation, due insufficient energy expenditure. The adipose tissue, once seen as simple storage depot, now recognized complex organ with various functions, including hormone regulation modulation metabolism, inflammation, homeostasis. associated low-grade inflammatory state has been linked neurodegenerative diseases like multiple sclerosis (MS), Alzheimer’s (AD), Parkinson’s (PD). Mechanistically, reduced expandability leads hypertrophic adipocytes, triggering insulin leptin resistance, blood-brain barrier disruption, altered brain neuronal atrophy, cognitive decline. impacts disorders through shared underlying mechanisms, underscoring its potential modifiable risk factor for these diseases. Nevertheless, further research needed fully grasp intricate connections between obesity neurodegeneration. Collaborative efforts in this field hold promise innovative strategies address relationship develop effective prevention treatment methods, which also includes specific diets physical activities, ultimately improving quality life health.

Language: Английский

Citations

43
Multi-omic approaches for host-microbiome data integration DOI Creative Commons
Ashwin Chetty, Ran Blekhman

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 2, 2024

The gut microbiome interacts with the host through complex networks that affect physiology and health outcomes. It is becoming clear these interactions can be measured across many different omics layers, including genome, transcriptome, epigenome, metabolome, proteome, among others. Multi-omic studies of provide insight into mechanisms underlying host-microbe interactions. As more layers are considered, increasingly sophisticated statistical methods required to integrate them. In this review, we an overview approaches currently used characterize multi-omic between data. While a large number have generated deeper understanding host-microbiome interactions, there still need for standardization approaches. Furthermore, would also benefit from collection curation large, publicly available multi-omics datasets.

Language: Английский

Citations

21
Implication of Obesity and Gut Microbiome Dysbiosis in the Etiology of Colorectal Cancer DOI Open Access
Samradhi Singh, Poonam Sharma, Devojit Kumar Sarma

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(6), P. 1913 - 1913

Published: March 22, 2023

The complexity and variety of gut microbiomes within among individuals have been extensively studied in recent years connection to human health diseases. Our growing understanding the bidirectional communication between metabolic diseases microbiome has also highlighted significance dysbiosis genesis development obesity-related cancers. Therefore, it is crucial comprehend possible role microbiota crosstalk obesity colorectal cancer (CRC). Through induction microbial dysbiosis, epithelial barrier impairment, metabolomic dysregulation, chronic inflammation, or dysregulation energy harvesting, may promote tumors. It well known that strategies for prevention treatment are most effective when combined with a healthy diet, physical activity, active lifestyle choices. Recent studies suggest an improved complex linkages various cancers as can potentially improve treatments overall outcomes. In this context, we herein review summarize clinical experimental evidence supporting functional pathogenesis progression CRC concerning its correlates, which pave way novel prognostic tools prevention. Therapeutic approaches restoring homeostasis conjunction discussed herein.

Language: Английский

Citations

36
Non-alcoholic fatty liver disease and gut microbial dysbiosis- underlying mechanisms and gut microbiota mediated treatment strategies DOI
Muthukumaran Jayachandran, Shen Qu

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2023, Volume and Issue: 24(6), P. 1189 - 1204

Published: Oct. 16, 2023

Language: Английский

Citations

31
Exploring the Potential Impact of GLP-1 Receptor Agonists on Substance Use, Compulsive Behavior, and Libido: Insights from Social Media Using a Mixed-Methods Approach DOI Creative Commons
Davide Arillotta, Giuseppe Floresta,

Guy Pelletier

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 617 - 617

Published: June 20, 2024

Glucagon-like peptide-1 (GLP-1) is involved in a range of central and peripheral pathways related to appetitive behavior. Hence, this study explored the effects glucagon-like receptor agonists (GLP-1 RAs) on substance behavioral addictions, including alcohol, caffeine, nicotine, cannabis, psychostimulants, compulsive shopping, sex drive/libido. Data were collected from various social platforms. Keywords GLP-1 RAs substance/behavioral addiction used extract relevant comments. The employed mixed-methods approach analyze online discussions posted December 2019 June 2023 using specialized web application. Reddit entries focus here due limited data other platforms, such as TikTok YouTube. A total 5859 threads comments extracted six subreddits, which included about drugs associated brand names. To obtain posts, keywords potential use behavior selected. Further analysis two main steps: (1) manually coding posts based users’ references impact non-substance habits, excluding irrelevant or unclear comments; (2) performing thematic dataset keywords, AI-assisted techniques followed by manual revision generated themes. Second, was performed keyword-related dataset, In total, 29.75% alcohol-related; 22.22% caffeine-related; 23.08% nicotine-related clearly stated cessation intake these substances following start prescription. Conversely, mixed results found for cannabis intake, only limited, anecdotal made available cocaine, entactogens, dissociative drugs’ misuse. Regarding 21.35% reported shopping interruption, whilst sexual drive/libido elements reportedly increased several users. current appeared be useful tool gaining insight into complex topics addiction-related disorders; some RA-related mental health benefits could also inferred here. Overall, it that may show target both craving maladaptive/addictive behaviors, although further empirical research needed.

Language: Английский

Citations

15
The Role of Gut Microbiota and the Potential Effects of Probiotics in Heart Failure DOI Creative Commons
Carmine Petruzziello, Angela Saviano, Luca Manetti

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(2), P. 271 - 271

Published: Feb. 4, 2024

Heart failure (HF) remains a significant global health challenge, affecting millions of individuals worldwide and posing substantial burden on healthcare systems. HF is syndrome intricate pathophysiology, involving systemic inflammation, oxidative stress, metabolic perturbations, maladaptive structural changes in the heart. It influenced by complex interactions between cardiac function, physiology, environmental factors. Among these factors, gut microbiota has emerged as novel intriguing player landscape pathophysiology. The microbiota, beyond its role digestion nutrient absorption, impacts immune responses, processes, and, suggested evidence literature, development progression HF. There bidirectional communication heart, often known gut–heart axis, through which microbiota-derived metabolites, signals, microbial products exert profound effects cardiovascular health. This review aims to provide comprehensive overview relationship Additionally, we explore potential using probiotics therapeutic strategy modulate microbiota’s composition attenuate adverse observed Conventional approaches targeting hemodynamic neurohormonal dysregulation have substantially improved management HF, but emerging research exploring implications harnessing for innovative treatment.

Language: Английский

Citations

9
Roles of Traditional and Next-Generation Probiotics on Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Systematic Review and Network Meta-Analysis DOI Creative Commons
Yuezhi Zhu, Jen Kit Tan, Jia Liu

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 329 - 329

Published: March 7, 2024

Non-alcoholic fatty liver disease (NAFLD) and its progressive stage, non-alcoholic steatohepatitis (NASH), are becoming one of the most common chronic diseases globally. Lifestyle interventions such as weight reduction, increased physical activity, maintaining healthy diets play a pivotal role in managing NAFLD/NASH. Recent studies suggest that gut microbiome is associated with pathogenesis NAFLD/NASH, prompting microbiome-targeted therapy to emerge new therapeutic option for We conducted systematic review based on PRISMA statement employed network meta-analysis investigate effects traditional probiotics next-generation (NGPs) Comparative analysis reveals primarily reduce fat deposition inflammation by improving microbiota composition, enhancing intestinal barrier function, modulating immune responses. In contrast, NGPs demonstrate more significant potential, attributed their direct inhibiting oxidative stress ability enhance production short-chain acids (SCFAs), appear potential strategy management NAFLD/NASH through dual action directly SCFA production, highlighting importance understanding utilizing indirect regulatory mechanisms

Language: Английский

Citations

9
New Molecules in Type 2 Diabetes: Advancements, Challenges and Future Directions DOI Open Access
Kyriazoula Chatzianagnostou, Melania Gaggini,

Adrian Suman Florentin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6218 - 6218

Published: June 5, 2024

Although good glycemic control in patients with type 2 diabetes (T2D) can prevent cardiovascular complications, many diabetic still have poor optimal control. A new class of antidiabetic drugs (e.g., glucagon-like peptide-1-GLP-1 receptor agonists, sodium-glucose co-transporters-SGLT2 inhibitors), addition to the low hypoglycemic effect, exert multiple beneficial effects at a metabolic and level, through mechanisms other than antihyperglycemic agents. This review aims discuss these drugs, highlighting benefits, description their action as well available data by preclinical clinical studies. Moreover, innovative tools T2D field will be described which may help advance towards better targeted personalized care future.

Language: Английский

Citations

9