Advances in multi-omics integrated analysis methods based on the gut microbiome and their applications DOI Creative Commons
Dongdong Duan, Mingyu Wang, Jinyi Han

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

The gut microbiota actually shares the host's physical space and affects physiological functions health indicators through a complex network of interactions with host. However, its role as determinant host disease is often underestimated. With emergence new technologies including next-generation sequencing (NGS) advanced techniques such microbial community sequencing, people have begun to explore interaction mechanisms between microorganisms hosts at various omics levels genomics, transcriptomics, metabolomics, proteomics. enrichment multi-omics integrated analysis methods based on microbiome, an increasing number statistical also been proposed. In this review, we summarized research currently used study microbiome We analyzed advantages limitations briefly introduced their application progress.

Language: Английский

Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis DOI Creative Commons
Najeeha Talat Iqbal,

Hana Khan,

Aqsa Khalid

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 23, 2025

Language: Английский

Citations

1
The Role of Bacteriophages in the Gut Microbiota: Implications for Human Health DOI Creative Commons
Stephen Chijioke Emencheta, Chinasa Valerie Olovo, Osita C. Eze

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2416 - 2416

Published: Oct. 3, 2023

Bacteriophages (phages) are nano-sized viruses characterized by their inherent ability to live off bacteria. They utilize diverse mechanisms absorb and gain entry into the bacterial cell wall via release of viral genetic material, which uses replication host bacteria produce daughter progeny virions that attack surrounding cells. possess specific characteristics, including specificity for particular or closely related species. have many applications, as potential alternatives antibiotics against multi-resistant pathogens control agents in bacteria-contaminated environments. ubiquitously abundant nature biota, gut. Gut microbiota describes community interactions microorganisms within intestine. As with bacteria, parasitic bacteriophages constantly interact cells gut system obvious implications human health. However, it is imperative understand these they open up possible applicable techniques gut-implicated diseases. Thus, this review aims explore communities current impacts on

Language: Английский

Citations

22
Recent insights of obesity-induced gut and adipose tissue dysbiosis in type 2 diabetes DOI Creative Commons
Debarun Patra, Dipanjan Banerjee, Palla Ramprasad

et al.

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 28, 2023

An imbalance in microbial homeostasis, referred to as dysbiosis, is critically associated with the progression of obesity-induced metabolic disorders including type 2 diabetes (T2D). Alteration gut diversity and abundance pathogenic bacteria disrupt homeostasis potentiate chronic inflammation, due intestinal leakage or release a diverse range metabolites. The obesity-associated shifts worsen triglyceride cholesterol level that regulates adipogenesis, lipolysis, fatty acid oxidation. Moreover, an intricate interaction gut-brain axis coupled altered microbiome profile microbiome-derived metabolites bidirectional communication for instigating insulin resistance. Furthermore, distinct community within visceral adipose tissue its dysfunction obese T2D individuals. specific bacterial signature was found mesenteric patients. Recently, it has been shown Crohn's disease, gut-derived bacterium Clostridium innocuum translocated modulates function by inducing M2 macrophage polarization, increasing promoting surveillance. Considering these facts, modulation microbiota could serve one contemporary approaches manage using prebiotics, probiotics, faecal transplantation. Altogether, this review consolidates current knowledge on dysbiosis role development T2D. It emphasizes significance well alteration dysfunction, identifying novel therapeutic strategies, providing valuable insights directions future research potential clinical interventions.

Language: Английский

Citations

21
Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.) DOI Creative Commons
Henrique Silvano Arruda, Felipe Tecchio Borsoi, Amanda Cristina Andrade

et al.

Plants, Journal Year: 2023, Volume and Issue: 12(7), P. 1536 - 1536

Published: April 3, 2023

Araticum (Annona crassiflora Mart.) is a native and endemic species to Brazilian Cerrado whose fruits have high sensorial, nutritional, bioactive, economic potential. Its use in local folk medicine, associated with recent scientific findings, has attracted growing interest from different industrial sectors. Therefore, understanding the advances achieved so far identifying gaps be filled essential direct future studies transform accumulated knowledge into innovative technologies products. In this review, we summarize phytochemical composition, bioactivities, food products araticum fruit that been reported literature over past 10 years. The compiled data showed parts contain wide range of bioactive compounds, particularly phenolic alkaloids, annonaceous acetogenins, carotenoids, phytosterols, tocols. These phytochemicals contribute biological activities verified extracts/fractions, including antioxidant, anti-inflammatory, anti-Alzheimer, anticancer, antidiabetic, anti-obesity, antidyslipidemic, antinociceptive, hepatoprotective, healing cutaneous wound, antibacterial, insecticide effects. Despite promising further studies—particularly toxicological (especially, byproducts), pre-clinical, clinical trials—must conducted confirm these effects humans assure safety well-being consumers.

Language: Английский

Citations

18
Endotoxemia and Gastrointestinal Cancers: Insight into the Mechanisms Underlying a Dangerous Relationship DOI Creative Commons

Vittoria Manilla,

Natalia Di Tommaso,

Francesco Santopaolo

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(2), P. 267 - 267

Published: Jan. 19, 2023

Lipopolysaccharide (LPS), also known as endotoxin, is a component of the membrane gram-negative bacteria and well-recognized marker sepsis. In case disruption intestinal barrier, occurs with unhealthy diets, alcohol consumption, or during chronic diseases, microbiota residing in gastrointestinal tract becomes crucial factor amplifying systemic inflammatory response. Indeed, translocation LPS into bloodstream its interaction toll-like receptors (TLRs) triggers molecular pathways involved cytokine release immune dysregulation. This critical step exacerbation many including metabolic disorders cancer. role cancer development widely recognized, examples include gastric tumor related to Helicobacter pylori infection hepatocellular carcinoma, both which are preceded by prolonged injury; addition, risk recurrence metastasis appears be associated endotoxemia. Here, we review mechanisms that link promotion progression tumorigenesis endotoxemia, possible therapeutic interventions can deployed counteract these events.

Language: Английский

Citations

17
The Role of Fecal Microbiota Transplantation (FMT) in the Management of Metabolic Diseases in Humans: A Narrative Review DOI Creative Commons
Eva Zikou, Chrysi Koliaki, Konstantinos Makrilakis

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1871 - 1871

Published: Aug. 16, 2024

The gut microbiota represents a complex ecosystem of trillions microorganisms residing in the human gastrointestinal tract, which is known to interact with host physiology and regulate multiple functions. Alterations microbial composition, diversity, function are referred as dysbiosis. Dysbiosis has been associated variety chronic diseases, including

Language: Английский

Citations

8
Microbiome-driven IBS metabotypes influence response to the low FODMAP diet: insights from the faecal volatome DOI Creative Commons
Thomas Conley, Rachael Slater, Stephen Moss

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 107, P. 105282 - 105282

Published: Aug. 23, 2024

Language: Английский

Citations

7
Foundational Nutrition: Implications for Human Health DOI Open Access
Jeremy R. Townsend, Trevor O. Kirby,

Tess M. Marshall

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(13), P. 2837 - 2837

Published: June 22, 2023

Human nutrition, and what can be considered “ideal” is a complex, multi-faceted topic which many researchers practitioners deliberate. While some attest that basic human nutrition relatively understood, it undeniable global nutritional problem persists. Many countries struggle with malnutrition or caloric deficits, while others encounter difficulties overconsumption micronutrient deficiencies. A multitude of factors contribute to this problem. Limitations the current scope recommended daily allowances (RDAs) dietary reference intakes (DRIs), changes in soil quality, reductions nutrient density are just few these factors. In article, we propose new, working approach towards designated “Foundational Nutrition”. This lens combines whole food conjunction micronutrients other nutrients critical for optimal health special consideration given gut microbiome overall health. Together, synergistic addresses vital components enhances bioavailability potentiate bioactive effect.

Language: Английский

Citations

15
Acetaminophen-Induced Hepatotoxicity in Obesity and Nonalcoholic Fatty Liver Disease: A Critical Review DOI Creative Commons
Karima Begriche,

Clémence Penhoat,

Pénélope Bernabeu-Gentey

et al.

Livers, Journal Year: 2023, Volume and Issue: 3(1), P. 33 - 53

Published: Jan. 12, 2023

The epidemic of obesity, type 2 diabetes and nonalcoholic liver disease (NAFLD) favors drug consumption, which augments the risk adverse events including injury. For more than 30 years, a series experimental clinical investigations reported or suggested that common pain reliever acetaminophen (APAP) could be hepatotoxic in obesity related metabolic diseases, at least after an overdose. Nonetheless, several did not reproduce these data. This discrepancy might come from extent steatosis, accumulation specific lipid species, mitochondrial dysfunction diabetes-related parameters such as ketonemia hyperglycemia. Among factors, some them seem pivotal for induction cytochrome P450 2E1 (CYP2E1), conversion APAP to toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI). In contrast, other factors explain why NAFLD are always associated with frequent severe APAP-induced acute hepatotoxicity, increased volume distribution body, higher hepatic glucuronidation reduced CYP3A4 activity. Accordingly, occurrence outcome injury obese individual would depend on delicate balance between augment generation NAPQI others can mitigate hepatotoxicity.

Language: Английский

Citations

14
The Influence of the Protozoan Giardia lamblia on the Modulation of the Immune System and Alterations in Host Glucose and Lipid Metabolism DOI Open Access
Sylwia Klimczak, Kacper Packi,

Alicja Rudek

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8627 - 8627

Published: Aug. 7, 2024

Giardia lamblia, the cause of giardiasis, significantly impacts patients with metabolic disorders related to insulin resistance (IR). Both giardiasis and share elements such as chronic inflammation intestinal dysbiosis, which substantially affect cytokine profiles patients. This review discusses mechanisms virulence G. its influence on immune system, association disorders. The aims show how lamblia invasion acts system glucose lipid metabolism. Key findings reveal that infection, by disrupting permeability, alters microbiota composition responses, potentially impairing status. Future research should focus elucidating specific influences metabolism, exploring long-term consequences developing targeted therapeutic strategies include both parasitic aspects. These insights underscore need for a multidisciplinary approach treatment in

Language: Английский

Citations

5