The probiotic fermented milk of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 alleviates constipation via improving gastrointestinal motility and gut microbiota DOI Creative Commons
Shasha Cheng, Baolei Li, Yixin Ding

et al.

Journal of Dairy Science, Journal Year: 2023, Volume and Issue: 107(4), P. 1857 - 1876

Published: Nov. 2, 2023

Constipation is directly related to the intestinal microenvironment, in which promotion of gastrointestinal (GI) motility and improvement gut microbiota distribution are important for alleviating symptoms. Herein, after intervention probiotic fermented milk (FMMIX) containing Lacticaseibacillus paracasei JY062 Lactobacillus gasseri JM1 14 d Kunming mice with loperamide-induced constipation, results indicated that FMMIX significantly increased secretion serum motilin, gastrin 5-hydroxytryptamine, as well decreased peptide YY, vasoactive peptide, nitric oxide mice. As determined by immunohistochemical analysis, promoted an augmentation quantity Cajal interstitial cells. In addition, mRNA protein expression c-kit stem cell factor (SCF) were upregulated facilitate motility. High-throughput sequencing gas chromatography techniques revealed led increase relative abundance beneficial bacteria (Lactobacillus, Oscillospira, Ruminococcus, Coprococcus, Akkermansia), reduced presence harmful (Prevotella), resulted elevated levels short-chain fatty acids (SCFA) a superior compared unfermented milk. Untargeted metabolomics significant upregulation functional metabolites such l-pipecolinic acid, dl-phenylalanine, naringenin FMMIX, presumably playing potential role constipation relief. Overall, our showed had alleviate symptoms improving GI regulatory peptides neurotransmitters, increasing SCF proteins, modulating structure SCFA levels, may be associated these metabolites. This suggested could promising adjunctive strategy managing contribute development foods aimed at health.

Language: Английский

Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health DOI Creative Commons
Zhijie Wan,

Jianheng Zheng,

Zhigang Zhu

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 13, 2022

Vitamin B consists of a group water-soluble micronutrients that are mainly derived from the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As an integrated part human health, gut microbiota could produce, consume, and even compete for vitamin with host. The interplay between host might be crucial factor affecting absorbing processes B. On other hand, supplementation or deficiency impact growth specific bacteria, resulting changes composition function microbiota. Together, systemically contribute to health. In this review, we summarized interactions tried reveal underlying mechanism so can have better understanding its role

Language: Английский

Citations

99
Fermented foods and gastrointestinal health: underlying mechanisms DOI
Arghya Mukherjee, Samuel Breselge, Eirini Dimidi

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 21(4), P. 248 - 266

Published: Dec. 11, 2023

Language: Английский

Citations

83
Promising bioactivities of postbiotics: A comprehensive review DOI Creative Commons

Nazrana Rafique,

Suhaib Yousuf Jan,

Aamir Hussain Dar

et al.

Journal of Agriculture and Food Research, Journal Year: 2023, Volume and Issue: 14, P. 100708 - 100708

Published: July 11, 2023

Postbiotics are bioactive substances that useful and produced during fermentation in the matrix. under a fragile balance our body, excessive metabolities, may it be from any origin has potential to hamper or interfere number of physiological processes body. As an innovative approach, can used improve immune tolerance treat food allergy particularly infants children. classified on basis structure (peptides, teichoic acis plasmalogens), elemental composition (as carbohydrates), proteins (p40, p75 molecule, lactocepin), vitamins (B-group), lipids (butyrates, acetate, lactate, propionates), organic acids (such as 3-phenyllactic acid propionic) different complex molecules lipoteichoic acids, peptidoglycan-derived muropeptides). Postbiotics, mentioned above have been shown immunological effects by increasing mucin levels encouraging production claudin occluding. Moreover, studies highlight postbiotics promising remedy for prevention gastrointestinal diseases is also considered treatment technique with lesser unfavourable side effects, especially children infants. However, future head-to-head will necessary determine best parent cell strains, postbiotic dosages, inexpensive comparison other medications. The source, origin, extraction, synthesis, bioactivity mechanism all included review. antibacterial mechanisms discussed this review, along their absorption healthy substances, cancer, mental health, therapeutic qualities.

Language: Английский

Citations

75
Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease DOI Open Access

Yoonhwa Shin,

Sunhee Han,

Juhui Kwon

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4466 - 4466

Published: Oct. 21, 2023

The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation dietary fiber. Certain microbes responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance diversity can lead to metabolic disorders inflammation-related diseases. Changes SCFA levels associated microbiota were observed IBD, suggesting an association between disease. affect reactive oxygen species (ROS) with IBD. Gut closely related it study them further.

Language: Английский

Citations

71
Effect of Lactic Acid Bacteria Fermentation on Plant-Based Products DOI Creative Commons
Xiaohua Yang,

Jiaqi Hong,

Linhao Wang

et al.

Fermentation, Journal Year: 2024, Volume and Issue: 10(1), P. 48 - 48

Published: Jan. 9, 2024

Lactic acid bacteria effectively utilize the nutrients and active compounds in plant-based materials via their powerful metabolic pathways enzyme systems, achieving a combination of nutrition, functionality, deliciousness. Currently, majority review articles predominantly concentrate on summarizing fermentation fruits vegetables by lactic bacteria, devoting comparatively less attention to researching other plant species varieties by-products. Furthermore, summary research substances functional properties lacks sufficient depth. This provides comprehensive overview status technological progress various by-products, effects are emphasized. In addition, this emphasizes that give products more functionality. The aim is emphasize significant contribution products, which will assist researchers better comprehending application value domain direct towards interaction mechanisms between product Concurrently, certain theoretical foundation reference for fermented promoting health preventing diseases.

Language: Английский

Citations

26
Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics DOI Open Access
Mónika Fekete,

Andrea Lehoczki,

Dávid Major

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 789 - 789

Published: March 10, 2024

Recent research exploring the relationship between gut and brain suggests that condition of microbiota can influence cognitive health. A well-balanced may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, symbiotics are nutritional supplements functional food components associated with gastrointestinal well-being. The bidirectional communication gut–brain axis essential for maintaining homeostasis, pre-, pro-, potentially affecting various functions such as attention, perception, memory. Numerous studies have consistently shown incorporating into a healthy diet lead improvements in mood. Maintaining support optimal function, crucial disease prevention our fast-paced, Westernized society. Our results indicate benefits older individuals probiotic supplementation but not who good adequate levels physical activity. Additionally, it appears there patients mild impairment Alzheimer’s disease, while mixed seem arise younger healthier individuals. However, important acknowledge individual responses vary, use these dietary should be tailored each individual’s unique health circumstances needs.

Language: Английский

Citations

23
A Comprehensive Review of the Triangular Relationship among Diet–Gut Microbiota–Inflammation DOI Open Access
Nidesha Randeni, Matteo Bordiga, Baojun Xu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9366 - 9366

Published: Aug. 29, 2024

The human gastrointestinal tract hosts a complex and dynamic community of microorganisms known as the gut microbiota, which play pivotal role in numerous physiological processes, including digestion, metabolism, immune function. Recent research has highlighted significant impact diet on microbiota composition functionality, consequential effects host health. Concurrently, there is growing evidence linking to inflammation, key factor many chronic diseases such inflammatory bowel disease (IBD), obesity, diabetes, cardiovascular (CVDs). This review explores how dietary components influence composition, these microbial changes affect pathways, therapeutic implications modulating this axis for prevention management. Beneficial patterns, Mediterranean (MD) plant-based diets, promote diverse balanced supporting anti-inflammatory pathways. Conversely, Western (WD), high saturated fats refined sugars, associated with dysbiosis increased inflammation. With all links between three variables considered, attempts offer thorough examination triangle formed by food.

Language: Английский

Citations

22
Lactic acid bacteria: Nature, Characterization, Mode of action, Products and Applications DOI
Patrick Othuke Akpoghelie, Great Iruoghene Edo,

Ali B.M. Ali

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

3
Mechanisms and Therapeutic Potential of Key Anti-inflammatory Metabiotics: Trans-Vaccenic Acid, Indole-3-Lactic Acid, Thiamine, and Butyric Acid DOI

Mnica Cristina,

Elizabeth Bautista, Renju Jose

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

Citations

2
The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier DOI Open Access
D. Rondinella, Pauline Raoul,

Eleonora Valeriani

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 859 - 859

Published: Feb. 28, 2025

Ultra-processed foods (UPFs) have become a widely consumed food category in modern diets. However, their impact on gut health is raising increasing concerns. This review investigates how UPFs the microbiome and barrier, emphasizing dysbiosis increased permeability. UPFs, characterized by high content of synthetic additives emulsifiers, low fiber content, are associated with decrease microbial diversity, lower levels beneficial bacteria like Akkermansia muciniphila Faecalibacterium prausnitzii, an increase pro-inflammatory microorganisms. These alterations community contribute to persistent inflammation, which various chronic disorders including metabolic syndrome, irritable bowel type 2 diabetes, colorectal cancer. In addition, may alter gut-brain axis, potentially affecting cognitive function mental health. Dietary modifications incorporating fiber, fermented foods, probiotics can help mitigate effects UPFs. Furthermore, public needs stricter regulations for banning along well-defined labels. Further studies necessary elucidate mechanisms connecting systemic illnesses, thereby informing evidence-based dietary guidelines.

Language: Английский

Citations

2