International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 6022 - 6022
Published: May 30, 2024
The
role
of
probiotics
in
regulating
intestinal
flora
to
enhance
host
immunity
has
recently
received
widespread
attention.
Altering
the
human
gut
microbiota
may
increase
predisposition
several
disease
phenotypes
such
as
inflammation
and
metabolic
disorders.
converts
dietary
nutrients
into
metabolites
that
serve
biologically
active
molecules
modulating
regulatory
functions
host.
Probiotics,
which
are
microorganisms,
play
a
versatile
restoring
composition
microbiota,
helping
improve
prevent
phenotypes.
This
comprehensive
review
provides
firsthand
information
on
their
influence
health,
effects
diet
how
alter
function
along
with
corresponding
building
healthy
intestine.
We
also
discuss
implications
some
most
important
diseases.
In
summary,
significant
boosting
overall
immunity,
increasing
abundance
beneficial
bacteria,
ameliorate
symptoms
multiple
Immunology,
Journal Year:
2024,
Volume and Issue:
172(1), P. 1 - 20
Published: Jan. 4, 2024
Irritable
bowel
syndrome
(IBS),
one
of
the
most
prevalent
functional
gastrointestinal
disorders,
is
characterized
by
recurrent
abdominal
pain
and
abnormal
defecation
habits,
resulting
in
a
severe
healthcare
burden
worldwide.
The
pathophysiological
mechanisms
IBS
are
multi-factorially
involved,
including
food
antigens,
visceral
hypersensitivity
reactions,
brain–gut
axis.
Numerous
studies
have
found
that
gut
microbiota
intestinal
mucosal
immunity
play
an
important
role
development
crosstalk
with
multiple
mechanisms.
Therefore,
based
on
existing
evidence,
this
paper
elaborates
damage
activation
disturbance
closely
related
to
progression
IBS.
Combined
application
prospect,
it
also
provides
references
for
further
in-depth
exploration
clinical
practice.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
174, P. 116567 - 116567
Published: April 6, 2024
Bile
acid
(BA)
receptors
(e.g.,
farnesoid
X-activated
receptor,
muscarinic
receptor)
are
expressed
in
cardiomyocytes,
endothelial
cells,
and
vascular
smooth
muscle
indicating
the
relevance
of
BAs
to
cardiovascular
disease
(CVD).
Hydrophobic
cardiotoxic,
while
hydrophilic
cardioprotective.
For
example,
fetal
cardiac
insufficiency
maternal
intrahepatic
cholestasis
during
pregnancy,
degree
abnormality,
is
closely
related
level
hydrophobic
blood
infant
blood.
However,
ursodeoxycholic
(the
most
BA)
can
reverse/prevent
these
detrimental
effects
increased
levels
on
heart.
The
gut
microbiota
(GM)
GM
metabolites
(especially
secondary
BAs)
have
crucial
roles
hypertension,
atherosclerosis,
unstable
angina,
heart
failure.
Herein,
we
describe
relationship
between
CVD
at
BA
level.
We
combine
concept
"microbiota-gut-heart
axis"
(MGHA)
postulate
role
mechanism
development.
In
addition,
strategies
for
treating
with
under
MGHA
proposed.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 522 - 522
Published: Feb. 4, 2023
For
many
decades,
the
proper
functioning
of
human
body
has
become
a
leading
scientific
topic.
In
course
numerous
experiments,
striking
impact
probiotics
on
been
documented,
including
maintaining
physiological
balance
endogenous
microorganisms,
regulating
immune
system,
enhancing
digestive
properties
host,
and
preventing
or
alleviating
diseases.
Recent
research,
especially
from
last
decade,
shows
that
this
health-benefiting
activity
is
largely
conditioned
by
production
extracellular
vesicles.
Although
importance
vesicles
in
virulence
live-threatening
pathogens
widely
described
literature,
much
less
known
with
respect
to
health-promoting
effect
secreted
non-pathogenic
probiotics.
Based
this,
current
review
article,
we
decided
collect
latest
literature
data
health-inducing
The
characteristics
probiotics’
will
be
extended
description
their
physicochemical
proteome
connection
biological
activities
exhibited
these
structures.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2023,
Volume and Issue:
13
Published: Feb. 16, 2023
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
disease,
accompanied
by
itching
and
swelling.
The
main
pathological
mechanism
of
AD
related
to
the
imbalance
between
Type
2
helper
cells
(Th2
cells)
1
(Th1
cells).
Currently,
no
safe
effective
means
treat
prevent
are
available;
moreover,
some
treatments
have
side
effects.
Probiotics,
such
as
strains
Lactobacillus
,
can
address
these
concerns
via
various
pathways:
i)
facilitating
high
patient
compliance;
ii)
regulating
Th1/Th2
balance,
increasing
IL-10
secretion,
reducing
cytokines;
iii)
accelerating
maturation
immune
system,
maintaining
intestinal
homeostasis,
improving
gut
microbiota;
iv)
symptoms
AD.
This
review
describes
treatment
prevention
using
13
species
.
commonly
observed
in
children.
Therefore,
includes
higher
proportion
studies
on
children
fewer
adolescents
adults.
However,
there
also
that
do
not
improve
even
worsen
allergies
In
addition,
subset
genus
relieve
has
been
identified
vitro
future
should
include
more
vivo
randomized
controlled
clinical
trials.
Given
advantages
disadvantages
mentioned
above,
further
research
this
area
urgently
required.
Life,
Journal Year:
2023,
Volume and Issue:
13(10), P. 2023 - 2023
Published: Oct. 8, 2023
The
human
gut
microbiota
(GM)
is
a
complex
microbial
ecosystem
that
colonises
the
gastrointestinal
tract
(GIT)
and
comprised
of
bacteria,
viruses,
fungi,
protozoa.
GM
has
symbiotic
relationship
with
its
host
fundamental
for
body
homeostasis.
not
limited
to
scope
GIT,
but
there
are
bidirectional
interactions
between
other
organs,
highlighting
concept
"gut-organ
axis".
Any
deviation
from
normal
composition
GM,
termed
"microbial
dysbiosis",
implicated
in
pathogenesis
various
diseases.
Only
few
studies
have
demonstrated
modifications
disease
phenotypes,
it
still
unknown
whether
an
altered
contributes
or
simply
reflects
status.
Restoration
probiotics
prebiotics
been
postulated,
evidence
effects
limited.
Prebiotics
substrates
"selectively
utilized
by
microorganisms,
conferring
health
benefit".
This
study
highlights
vital
organs
demonstrates
dysbiosis
emergence
certain
representative
Finally,
this
article
focuses
on
potential
as
target
therapy
manipulate
presents
gaps
literature
research.
Frontiers in Psychiatry,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 9, 2024
Depression
is
considered
a
multifaceted
and
intricate
mental
disorder
of
growing
concern
due
to
its
significant
impact
on
global
health
issues.
The
human
gut
microbiota,
also
known
as
the
“second
brain,”
has
an
important
role
in
CNS
by
regulating
it
through
chemical,
immunological,
hormonal,
neurological
processes.
Various
studies
have
found
bidirectional
link
between
brain
gut,
emphasizing
onset
depression
therapies.
biological
molecular
processes
underlying
microbiota
are
required,
association
may
represent
novel
study.
However,
profound
insights
into
stratification
diversity
still
uncommon.
This
article
investigates
emerging
evidence
bacterial
relationship
brain’s
system
potential
pathogenicity
relevance.
interplay
immune
system,
nervous
neurotransmitter
synthesis,
neuroplasticity
transitions
widely
studied.
consequences
stress,
dietary
fibers,
probiotics,
prebiotics,
antibiotics
GB
axis
being
Multiple
revealed
this
led
development
effective
microbiota-based
drugs
for
both
prevention
treatment.
Therefore,
results
support
hypothesis
that
influences
provide
promising
area
research
improved
knowledge
etiology
disease
future
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 20, 2024
Various
microbial
communities
reside
in
the
gastrointestinal
tract
of
humans
and
play
an
important
role
immunity,
digestion,
drug
metabolism,
intestinal
integrity,
protection
from
pathogens.
Recent
studies
have
revealed
that
gut
microbiota
(GM)
is
involved
communication
with
brain,
through
a
bidirectional
network
known
as
gut-brain
axis.
This
involves
humoral,
immunological,
endocrine,
neural
pathways.
Gut
dysbiosis
negatively
impacts
these
pathways,
leading
to
neurological
complications
cognitive
deficits.
Both
pre-clinical
clinical
demonstrated
probiotics
can
restore
healthy
GM,
reduce
pH,
inflammation
pathogenic
microbes
gut.
Additionally,
improve
cell-to-cell
signaling
increase
blood-brain-derived
neurotrophic
factors.
Probiotics
emerge
potential
approach
for
preventing
managing
Despite
promising
findings,
safety
concerns
possible
risks
probiotic
usage
must
be
closely
monitored
addressed.
review
article
provides
brief
overview
significance
health.
