Egyptian Pharmaceutical Journal,
Journal Year:
2023,
Volume and Issue:
22(4), P. 600 - 603
Published: Oct. 1, 2023
Background
The
disorder
of
the
gut-brain
interaction,
in
adolescence,
is
high
prevalence
worldwide.
Up
till
now
there
no
clear
aetiology
for
this
gastrointestinal
dysfunction.
Objective
To
assess
status
intestinal
barrier
those
having
gut
dysfunction
compared
with
control
group.
Materials
and
methods
A
case-control
study
involved
180
Egyptian
adolescents.
They
were
distributed
into
two
groups,
cases
positive
ROME
criteria
controls
negative
criteria.
Serum
anti-flagellin
antibodies
(IgA
IgG)
fatty
acid
binding
protein
assessed
both
groups.
Results
conclusion
Ninety-nine
adolescents
out
values
equivocal
Therefore,
screening
interaction
disorders
by
worthful
all
positivity
does
not
always
denote
an
underlying
defect.
World Journal of Clinical Pediatrics,
Journal Year:
2025,
Volume and Issue:
14(2)
Published: March 18, 2025
BACKGROUND
Functional
gastrointestinal
disorders
(FGIDs)
in
children
present
with
chronic
symptoms
like
abdominal
pain,
diarrhea,
and
constipation
without
identifiable
structural
abnormalities.
These
are
closely
linked
to
gut-brain
axis
dysfunction,
altered
gut
microbiota,
psychosocial
stress,
leading
psychiatric
comorbidities
such
as
anxiety,
depression,
behavioral
issues.
Understanding
this
bidirectional
relationship
is
crucial
for
developing
effective,
holistic
management
strategies
that
address
physical
mental
health.
AIM
To
examine
the
impacts
of
FGIDs
children,
focusing
on
anxiety
depression
their
association
other
neurodevelopmental
childhood,
attention-deficit/hyperactivity
disorder,
emphasizing
role
axis,
emotional
dysregulation,
stress.
Key
mechanisms
explored
include
neurotransmitter
microbiota
imbalance,
central
sensitization,
heightening
stress
reactivity,
symptom
perception.
The
review
also
evaluates
family
dynamics
coping
exacerbating
FGID
contributing
conditions.
METHODS
A
narrative
was
conducted
using
328
studies
sourced
from
PubMed,
Scopus,
Google
Scholar,
covering
research
published
over
past
20
years.
Inclusion
criteria
focused
examining
diagnosis,
mechanisms,
comorbidities,
factors
pediatric
populations.
commonly
affecting
including
functional
constipation,
irritable
bowel
syndrome,
gastroesophageal
reflux,
cyclic
vomiting
were
analyzed
concerning
psychological
impacts.
RESULTS
highlights
a
strong
connection
between
symptoms,
mediated
by
dysregulated
sensitization.
physiological
disruptions
increase
children’s
vulnerability
while
-
early-life
trauma,
maladaptive
dynamics,
ineffective
intensify
cycle
distress.
CONCLUSION
Effective
requires
biopsychosocial
approach
integrating
medical,
psychological,
dietary
interventions.
Parental
education,
early
intervention,
multidisciplinary
care
coordination
critical
mitigating
long-term
improving
both
health
outcomes
FGIDs.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: March 19, 2025
Introduction
This
study
aims
to
conduct
a
systematic
review
and
meta-analysis
of
randomized
controlled
trials
evaluate
the
efficacy
safety
auricular
acupoint
therapy
(AAT)
for
functional
gastrointestinal
disorders
(FGIDs).
Methods
We
conducted
thorough
search
across
eight
databases,
including
PubMed,
EMBASE,
Web
Science,
Cochrane
Library,
CNKI,
Wanfang,
VIP,
CBM.
The
covered
period
from
inception
each
database
up
June
30,
2024.
authors
independently
reviewed
all
references,
evaluated
risk
bias,
extracted
data.
GRADEpro
software
was
utilized
calculate
overall
strength
evidence.
A
random
effects
or
fixed
model
selected
on
basis
p
-value
I
2
.
RevMan
5.3,
Stata/MP
18.0,
R
4.3.1
Studio
2023.09.0
were
used
data
processing.
TSA
0.9.5.10
beta
stability.
Results
included
19
with
total
1,681
patients
(895
in
treatment
group
886
control
group).
duration
ranged
2–12
weeks.
revealed
that,
compared
control,
AAT
significantly
more
effective
at
treating
FGIDs
(RR:
1.35;
95%
CI:
1.21–1.51;
<
0.001),
reducing
symptom
score
(MD:
−1.94;
−3.06
−0.85;
0.001;
five
trials),
improving
SAS
−12.47;
−13.92
−11.01;
SDS
−4.97;
−9.23
−0.72;
=
0.02;
six
trials).
two
articles
mentioned
relatively
significant
adverse
reactions
2.98;
0.51–17.26;
0.009).
Sensitivity
trial
sequential
analyses
confirmed
stability
these
results.
Discussion
While
our
suggests
that
may
offer
benefits
FGIDs,
results
must
be
interpreted
caution
due
methodological
limitations
trials.
Further
investigations
high-quality
are
warranted.
Systematic
registration
https://clinicaltrials.gov/
,
identifier
CRD42024558786.
Expert Review of Gastroenterology & Hepatology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 19, 2025
Functional
dyspepsia
(FD)
and
irritable
bowel
syndrome
(IBS)
are
the
most
prevalent
disorders
of
gut-brain
interaction
(DGBI),
frequently
overlapping
associated
with
complex
pathophysiological
mechanisms.
Increasing
evidence
implicates
gut
microbiota
alterations
in
driving
symptoms
via
immune
activation,
altered
motility,
vascular
barrier
axis
disruption.
This
review
explores
role
FD
IBS
pathogenesis
symptomatology.
A
comprehensive
literature
search
was
conducted
using
PubMed,
EMBASE,
Google
Scholar
databases,
including
studies
published
between
January
2013
March
2025.
Particular
focus
is
given
to
microbiota-targeted
therapies
such
as
prebiotics,
probiotics,
synbiotics,
postbiotics,
fecal
transplantation
(FMT).
The
also
discusses
multidimensional
treatment
strategies
combining
dietary
lifestyle
modification,
cognitive-behavioral
therapy,
pharmacological
neuromodulation.
Recent
advances
diagnostic
methods,
capsule-based
sampling
digital
tools
for
remote
psychogastroenterology
care,
highlighted.
Despite
scientific
progress,
current
DGBI
management
remains
insufficiently
personalized.
Future
approaches
should
integrate
individualized
profiling
targeted
interventions
utilize
innovative
health
technologies
enhance
clinical
outcomes
IBS.
Brain Behavior and Immunity Integrative,
Journal Year:
2024,
Volume and Issue:
5, P. 100042 - 100042
Published: Jan. 1, 2024
Irritable
bowel
syndrome
(IBS)
is
a
common
functional
disorder
of
the
gut-brain
axis,
characterized
by
abdominal
pain
and
altered
habits.
A
38-year-old
male
patient
with
sedentary
lifestyle,
diagnosed
IBS
based
on
Rome
4
criteria,
was
underwent
Yoga
Naturopathy
(Y&N)
interventions
for
one
month
in
our
outpatient
department.
The
result
showed
reduced
Bowel
Syndrome
Severity
Score
(IBS-SSS)
(315
to
109)
perceived
stress
(PSS)
score
(29
12)
level.
Heart
rate
variability
(HRV)
analysis
increased
SDNN
(35.4
48.3)
RMSSD
(41.3
58.3)
values,
indicative
improved
HRV.
Notably,
parasympathetic
dominance
observed
through
pNN50%
(14.56
18.41)
H.F
(41.92
59.63)
while
LF/HF
Ratio
(1.381
0.675)
decreased,
demonstrating
shift
towards
favourable
autonomic
balance.
This
case
report
suggests
that
lifestyle
change
Naturopathic
intervention
useful
management
psychological
co-morbidities
dysfunction.
Food & Function,
Journal Year:
2023,
Volume and Issue:
14(17), P. 7825 - 7852
Published: Jan. 1, 2023
Under
the
action
of
natural
products,
microorganisms
participate
in
a
complete
cycle
“gut-brain-skin”
axis
linkage
mechanism,
thereby
regulating
development
atopic
dermatitis.
iScience,
Journal Year:
2024,
Volume and Issue:
27(5), P. 109806 - 109806
Published: April 23, 2024
SummaryIn
many
social
mammals,
early
life
and
integration
in
adulthood
largely
predict
individual
health,
lifespan,
reproductive
success.
So
far,
research
has
mainly
focused
on
chronic
stress
as
the
physiological
mediator
between
environment
fitness.
Here,
we
propose
an
alternative,
non-exclusive
mechanism
relying
microbially
mediated
effects:
relationships
with
conspecifics
might
strongly
contribute
to
diversifying
host
microbiomes
transmission
of
beneficial
microbes.
In
turn,
more
diverse
valuable
would
promote
pathogen
resistance
optimal
health
translate
into
lifelong
fitness
benefits.
This
relies
recent
findings
showing
that
are
transmitted
via
routes
play
a
pervasive
role
development,
physiology
susceptibility
pathogens.
We
suggest
microbes
could
explain
sociality-fitness
nexus
similar
or
higher
extent
than
deserves
empirical
studies
mammals.Graphical
abstract
Pharmacopsychiatry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 19, 2024
Abstract
Currently,
it
has
been
stated
that
psychiatric
and
psychological
problems
are
equally
paramount
aspects
of
the
clinical
modulation
manifestation
both
central
nervous
digestive
systems,
which
could
be
used
to
restore
balance.
The
present
narrative
review
aims
provide
an
elaborate
description
bio-psycho-social
facets
refractory
functional
gastrointestinal
disorders,
psychiatrists’
role,
specific
approach,
latest
perspectives
on
practical
therapeutic
management.
In
this
respect,
“psyche,”
“psychiatry,”
“psychology,”
“psychiatrist,”
“psychotropic,”
“refractory
disorders”
(as
keywords)
were
searched
in
relevant
English
publications
from
January
1,
1950,
March
2024,
PubMed,
Web
Science,
Scopus,
EMBASE,
Cochrane
Library,
Google
Scholar
databases.
Eventually,
technique
was
adopted
reach
a
compelling
story
with
high
level
cohesion
through
material
synthesis.
current
literature
recognizes
brain-gut
axis
as
target
for
disorders
model
integrated
framework
explain
disease
pathogenesis.
results
also
reveal
some
evidence
affirm
benefits
psychotropic
medications
therapies
even
when
symptoms
absent.
It
seems
psychiatrists
required
pay
higher
levels
attention
assessment
treatment
patients
accompanied
by
educating
training
practitioners
who
take
care
these
patients.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(10), P. 2600 - 2600
Published: Sept. 22, 2023
The
interplay
between
the
central
nervous
system
and
intestinal
environment
hinges
on
neural,
hormonal,
immune,
metabolic
reactions.
Over
decades,
significant
effort
has
gone
into
exploring
link
digestive
brain.
primary
objective
of
this
study
is
to
assess
catecholamine
levels
in
children
with
neuropsychiatric
disorders.
We
aim
examine
how
these
impact
mental
physical
wellbeing
children,
a
specific
focus
psychoemotional
symptoms
cognitive
performance.
Our
research
seeks
identify
significance
modifying
neurotransmitter
pediatric
medical
interventions,
ultimately
striving
reduce
health
risks
enhance
children’s
future
development.
A
total
135
individuals
were
chosen
partake,
they
engaged
regular
monthly
consultations
according
established
protocols.
Clinical
evaluations
conducted
environment,
encompassing
observation
constipation,
diarrhea,
additional
gastrointestinal
anomalies
not
confined
constipation
or
diarrhea.
This
entailed
assessment
imbalances,
dopamine,
adrenaline,
noradrenaline,
noradrenaline/adrenaline
ratio.
Gastrointestinal
disorders
are
indicative
imbalances
catecholamines,
lower
problems
being
correlated
such
imbalances.
In
subjects
psychiatric
disorders,
more
pronounced
dopamine
ratio
was
observed,
while
elevated
adrenaline
associated
psychoanxiety
Salud Ciencia y Tecnología,
Journal Year:
2023,
Volume and Issue:
3, P. 310 - 310
Published: March 5, 2023
There
is
a
bidirectional
exchange
known
as
the
gut-brain
axis
with
several
connections
including
vagus
nerve,
immune
system,
metabolites,
and
bacterial
products.
During
dysbiosis,
there
an
alteration
of
blood-brain
barrier
permeability
neuroinflammation.
The
objective
this
review
was
to
describe
role
gut
microbiota
its
therapeutic
in
neurodegenerative
diseases.
microbiota-brain
includes
set
microorganisms
common
bacteria
(Lactobacillus
S.
aureus),
fungi,
viruses
that
play
important
function,
such
protection
preventing
passage
or
pathogens
from
outside
gut,
well
metabolizing
carbohydrates
producing
vitamins
K,
B12,
B7.
However,
when
altered
due
stress,
diet,
other
factors,
communication
through
ascending
pathways
can
lead
alterations
immune,
endocrine,
nervous
responses
