Advances in Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(10), P. 16723 - 16730
Published: Jan. 1, 2023
Language: Английский
Diseases, Journal Year: 2025, Volume and Issue: 13(1), P. 18 - 18
Published: Jan. 16, 2025
Cervical intraepithelial neoplasia (CIN) is a premalignant cervical condition closely linked to persistent high-risk HPV infection, major risk factor for cancer. This study aims investigate the relationship between cervicovaginal infections, and CIN development in 94 Romanian women with lesions. Comprehensive assessments included genotyping, cytology, colposcopy, histopathology. In 53.20% of cases, vaginal infections were identified, Candida albicans most frequently associated HPV. Histopathology revealed 48.94% low-grade CIN, 42.55% high-grade 8.51% invasive carcinoma. There was strong correlation types (especially 16 18), colposcopic findings, histopathology, age. emphasizes mutual effect infection increasing developing cancer among women. Persistent types, particularly 18, has been confirmed as primary driver progression.
Language: Английский
Citations
2
Life, Journal Year: 2023, Volume and Issue: 13(7), P. 1486 - 1486
Published: June 30, 2023
This article is intended to deepen our knowledge date regarding the functions of resident microbiota/microbiome in urinary system for human health and disease. First, we sought report general characteristics (composition stability) normal microbiota different anatomical sites relation some factors such as effect age, gender diet, analyzing detail composition light current knowledge. Several pieces evidence suggest importance preserving micro-ecosystem system, cases their relationship with diseases important maintaining well understood. The female male reproductive have mainly been studied over past decade. In past, arrest was thought taken place a sterile environment. Microorganisms form biofilms, three-dimensional structures, that differ organs interact both gametes embryo maternal tissues. These biofilms from also others, gastrointestinal tract. Reduction its diversity intestinal can disrupt estrogen metabolism affect microbiota. It therefore understood quantitative qualitative identification microbiota, but study structures formed by microorganisms. A dysbiosis local or systemic causes lead serious diseases. role probiotics microbial population harmony (eubiosis) preventing certain pathologies investigated. negative variation strains microorganisms (dysbiosis) due even healthy balance microorganism populations (eubiosis), thus prevention has studied.
Language: Английский
Citations
25
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 25, 2024
The vaginal microbiota plays a crucial role in female reproductive health and is considered biomarker for predicting disease outcomes personalized testing. However, its relationship with human papillomavirus (HPV) infection cervical cancer not yet clear. Therefore, this article provides review of the association between microbiota, HPV infection, cancer. We discuss composition dysbiosis, as well potential mechanisms development In addition, we assess feasibility treatment strategies such probiotics transplantation to modulate prevention diseases related future, extensive replication studies are still needed gain deeper understanding complex cancer, clarify outcomes, thus providing theoretical basis
Language: Английский
Citations
9
Medicina, Journal Year: 2025, Volume and Issue: 61(1), P. 84 - 84
Published: Jan. 7, 2025
Background and objectives: Due to the regeneration potential of growth factors (GFs) platelet concentrates (PCs), facial rejuvenation has been a major area attention in esthetic medicine. The effectiveness safety PCs GFs promoting face are examined this systematic review, which is complemented by case series. essential for collagen production dermal matrix remodeling, while PCs, like Platelet-Rich Plasma (PRP), abundant bioactive chemicals that promote tissue healing cellular regeneration. Materials Methods: A comprehensive literature search was performed on PubMed, Web Science, Scopus, focusing human clinical trials published between February 2019 2024 related PRP esthetics. Results: Thirteen studies met inclusion criteria were analyzed. Conclusions: review summarizes most recent data patient outcomes, treatment regimens, possible hazards. series goes with it shows real-world examples how improve skin elasticity, texture, general appearance little negative side effects. These results highlight use as minimally invasive procedures.
Language: Английский
Citations
1
Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(11)
Published: Nov. 1, 2023
Abstract High‐risk human papillomaviruses (HR‐HPVs) cause various malignancies in the anogenital and oropharyngeal regions. About 70% of cervical cancers are caused by HPV types 16 18. Notably, some viruses including herpes simplex virus, Epstein–Barr immunodeficiency virus along with bacteria often interact HPV, potentially impacting its replication, persistence, cancer progression. Thus, infection can be significantly influenced co‐infecting agents that influence dynamics disease Bacterial co‐infections ( e.g., Chlamydia trachomatis ) bacterial vaginosis‐related species also genital tract leading to viral persistence outcomes. Co‐infections involving diverse infectious have significant implications for transmission clinical This review explores multiple facets encompassing co‐infection other pathogens, interaction microbiome, role development.
Language: Английский
Citations
16
Life, Journal Year: 2023, Volume and Issue: 13(7), P. 1531 - 1531
Published: July 9, 2023
The female genital tract (FGT) performs several functions related to reproduction, but due its direct exposure the external environment, it may suffer microbial infections. Both upper (uterus and cervix) lower (vagina) FGT are covered by an epithelium, contain immune cells (macrophages, dendritic cells, T B lymphocytes) that afford a robust protection host. Its part differ in terms of Lactobacillus spp., which dominant vagina. An alteration physiological equilibrium between local microbiota leads condition dysbiosis which, turn, account for outcome infection. Aerobic vaginitis, bacterial vaginosis, Chlamydia trachomatis most frequent infections, can lead severe complications reproduction pregnancy. use natural products, such as probiotics, polyphenols, lactoferrin course infections is issue current investigation. In spite positive results, more research needed define appropriate administration, according type patient.
Language: Английский
Citations
11
Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2790 - 2790
Published: Aug. 21, 2024
Cancer remains a public health concern worldwide, with its incidence increasing worldwide and expected to continue growing during the next decades. The microbiome has emerged as central factor in human disease, demonstrating an intricate relationship between cancer. Although some microbiomes present within local tissues have been shown restrict cancer development, mainly by interacting cells or host immune system, microorganisms are harmful risk factors for development. This review summarizes recent evidence concerning of most common types (i.e., lung, head neck, breast, gastric, colorectal, prostate, cervix cancers), providing general overview future clinical approaches perspectives.
Language: Английский
Citations
4
Microbial Cell Factories, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 30, 2025
Previous studies showed that the female genital tract microbiome plays a crucial role in regulating host's immune defense mechanisms. Our previous research has shown Lactobacillus gasseri LGV03 (L. LGV03) isolated from cervico-vagina of HPV-cleared women contributes to clearance HPV infection and beneficially regulate response. However, mechanisms behind regulation L. response remain unclear. To better understand interaction between function, immunomodulatory activities were investigated zebrafish models neutropenia, macrophage T cells deficiency. higher potent ameliorating vinorelbine-induced deficiency, significantly enhanced mRNA expressions cytokines TNF-α, TNF-β IFN-α. Moreover, transcriptome sequencing results indicated might alleviate immunosuppression zebrafish. Non-targeted detection analysis revealed indole derivatives including phenylacetaldehyde, 3-phenyllactic acid, N-acetylserotonin indole-3-lactic acid increased lysate supernatant LGV03. Meanwhile, ameliorated reduction abundance macrophages, neutrophils cells. alleviating effects or eliminated by aryl hydrocarbon receptor (AHR) antagonist CH-223,191. Furthermore, secretion IFN-α, IFN-β chemokines (MIP-1α, MIP-1β) Ect1/E6E7 cells, meanwhile, these benefits CH-223,191 treatment. In summary, LGV03-derived can activate AHR-mediated
Language: Английский
Citations
0
Open Journal of Pathology, Journal Year: 2025, Volume and Issue: 15(02), P. 29 - 38
Published: Jan. 1, 2025
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 762 - 762
Published: Feb. 21, 2025
Objectives: This systematic review investigates the effectiveness of natural extracts with anti-inflammatory properties for improving oral health, particularly in managing gingivitis and periodontal disease (PD). With PD being a major global health issue, exacerbated by microbial dysbiosis oxidative stress, integration phytochemicals herbal formulations into therapy offers promising avenue adjunctive treatments. Methods: A was conducted following PRISMA guidelines registered under International Prospective Register Systematic Reviews (ID: 641944). Databases, including PubMed, Scopus, Web Science, were searched between 18–24 December 2024, using Boolean keywords combining terms such as “herbal medicine”, “plant extracts”, “anti-inflammatory”, “periodontal therapy”. Studies involving animal models, vitro data, or non-peer-reviewed articles excluded. Results: Seventeen studies met inclusion criteria. Polyherbal single-component (e.g., Camellia sinensis, Punica granatum, Zingiber officinale, Rosmarinus officinalis) demonstrated comparable efficacy to conventional agents like chlorhexidine (CHX). rinses, camellia sinensis gels, granatum reduced inflammation, improved gingival showed antimicrobial properties, offering effective alternatives. Conclusions: Natural products, single polyherbal formulations, provide safe alternatives PD. Their anti-inflammatory, antimicrobial, antioxidant support their role alongside scaling root planning (SRP) therapy. However, further large-scale, long-term are needed standardize establish optimal protocols.
Language: Английский
Citations
0