Emergent Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
Language: Английский
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: April 5, 2024
Pseudomonas aeruginosa , a Gram-negative bacterium, is recognized for its adaptability and opportunistic nature. It poses substantial challenge in clinical settings due to complicated antibiotic resistance mechanisms, biofilm formation, capacity persistent infections both animal human hosts. Recent studies revealed potential zoonotic transmission of P. between animals, the environment, populations which highlights awareness this microbe. Implementation One Health approach, underscores connection human, animal, environmental health, we aim offer comprehensive perspective on current landscape management. This review presents innovative strategies designed counteract infections. Traditional antibiotics, while effective many cases, are increasingly compromised by development multidrug-resistant strains. Non-antibiotic avenues, such as quorum sensing inhibition, phage therapy, nanoparticle-based treatments, emerging promising alternatives. However, their application encounters obstacles like cost, side effects, safety concerns. Effectively addressing necessitates research efforts, advancements development, comprehension host-pathogen interactions deal with resilient pathogen.
Language: Английский
Citations
57
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2655 - 2655
Published: Feb. 24, 2024
One of the key mechanisms enabling bacterial cells to create biofilms and regulate crucial life functions in a global highly synchronized way is communication system called quorum sensing (QS). QS cell-to-cell process that depends on population density mediated by small signalling molecules autoinducers (AIs). In bacteria, controls biofilm formation through regulation gene expression involved extracellular polymeric matrix (EPS) synthesis, virulence factor production, stress tolerance metabolic adaptation. Forming one antimicrobial resistance (AMR). A common feature human pathogens ability form biofilm, which poses serious medical issue due their high susceptibility traditional antibiotics. Because associated with formation, there belief inhibition activity quenching (QQ) may provide alternative therapeutic methods for treating microbial infections. This review summarises recent progress research, focusing biofilms, especially those formed pathogenic become resistant antibiotic treatment. Subsequently, potential approach highlighting innovative non-antibiotic strategies control AMR bacteria has been discussed.
Language: Английский
Citations
32
Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 623 - 623
Published: July 4, 2024
Hospital-acquired infections, also known as nosocomial include bloodstream surgical site skin and soft tissue respiratory tract urinary infections. According to reports, Gram-positive Gram-negative pathogenic bacteria account for up 70% of infections in intensive care unit (ICU) patients. Biofilm production is a main virulence mechanism distinguishing feature bacterial pathogens. Most pathogens develop biofilms at the solid-liquid air-liquid interfaces. An essential requirement biofilm presence conditioning film. A film provides first surface on which can adhere fosters growth by creating favorable environment. The improves microbial adherence delivering chemical signals or generating microenvironments. Microorganisms use this coating nutrient source. gathers both inorganic organic substances from its surroundings, these are generated microbes These nutrients boost initial adhering facilitate formation acting food Coatings with combined antibacterial efficacy antifouling properties provide further benefits preventing dead cells debris surfaces. In present review, we address numerous that form surfaces biomedical devices. addition, explore several efficient smart antiadhesive coatings device-relevant materials manage caused biofilm-forming
Language: Английский
Citations
31
Journal of Chemical Technology & Biotechnology, Journal Year: 2024, Volume and Issue: 99(8), P. 1707 - 1733
Published: March 8, 2024
Abstract Biodegradation of pollutants is one the most economical methods for their removal and usually accompanied by no production toxic by‐products. In general, this approach favored over others because it offers reduced expenses potential complete mineralization. order to enhance viability longevity bioremediation agents within polluted areas, becomes necessary immobilize cells. Cell immobilization refers procedure confining intact cells specific areas a device or material, without compromising essential biological functions. A wide variety carriers approaches have been used restriction various Immobilization techniques, such as microencapsulation, opened up new possibilities in biotechnology facilitating development artificial organs, cell therapies drug delivery systems. Researchers found promising outcomes applications through microorganisms. This enhances stability, reusability catalytic efficiency, making valuable strategy biocatalysis, other biotechnological processes. Notably, use immobilized microorganisms has led significant improvements pollutants, with some studies achieving 100% efficiency. When comparing degradation between free same time period, results demonstrated that achieved efficiency >21% more than microbial consortia. The primary objective review give an overview key scientific aspects related using cells, particular focus on techniques entrap © 2024 Society Chemical Industry (SCI).
Language: Английский
Citations
19
Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 207 - 207
Published: Feb. 18, 2025
The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering unique physicochemical properties that enhance efficacy, overcome mechanisms, and provide alternative therapeutic approaches. This review explores diverse nanomaterial-based used resistance, focusing on their mechanisms action practical applications. such metal nanoparticles, carbon-based nanomaterials, polymeric nanostructures exhibit antibacterial through various pathways, including generation reactive oxygen species (ROS), disruption bacterial membranes, enhancement delivery. Additionally, ability nanomaterials bypass traditional biofilm formation efflux pumps, been demonstrated numerous studies. also discusses synergistic effects observed when are combined with conventional antibiotics, leading increased susceptibility reduced required dosages. By highlighting recent advancements clinical applications nanomaterial-antibiotic combinations, paper provides comprehensive overview how reshaping future therapies. Future research directions challenges, toxicity scalability, addressed guide safer, more effective treatments.
Language: Английский
Citations
6
Life, Journal Year: 2025, Volume and Issue: 15(1), P. 49 - 49
Published: Jan. 2, 2025
Biofilms, composed of structured communities bacteria embedded in a self-produced extracellular matrix, pose significant challenge due to their heightened resistance antibiotics and immune responses. This review highlights the mechanisms underpinning antibiotic within bacterial biofilms, elucidating adaptive strategies employed by microorganisms withstand conventional antimicrobial agents. encompasses role altered gene expression, formation persister cells, contributing recalcitrance biofilms eradication. A comprehensive understanding these provides for exploring innovative therapeutic interventions. study explores promising avenues future research, emphasizing necessity uncovering specific genetic phenotypic adaptations occurring biofilms. The identification vulnerabilities biofilm architecture elucidation key biofilm-specific targets emerge as crucial focal points development targeted strategies. In addressing limitations traditional antibiotics, this discusses approaches. Nanomaterials with inherent properties, quorum-sensing inhibitors disrupting communication, bacteriophages viral agents are highlighted potential alternatives. exploration combination therapies, involving agents, biofilm-disrupting enzymes, immunomodulators, is emphasized enhance efficacy existing treatments overcome resilience.
Language: Английский
Citations
5
Nanoscale, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Biofilms play a pivotal role in bacterial pathogenicity and antibiotic resistance, representing major challenge the treatment of infections. The limited diffusion inactivation efficacy antibiotics within biofilms hinder their clearance, while increasing dosage may enhance effectiveness, it also promotes resistance. Nano-delivery systems that target antimicrobial agents directly to offer promising strategy overcome this challenge. This review summarizes resistance mechanisms therapeutic challenges associated with biofilms, focus on recent advances nano-delivery such as liposomes, nanoemulsions, cell membrane vesicles (CMVs), polymers, dendrimers, nanogels, inorganic nanoparticles, metal-organic frameworks (MOFs). Furthermore, explores potential applications biofilm provides recommendations guide future research development field.
Language: Английский
Citations
4
Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: 57, P. 105780 - 105780
Published: Jan. 1, 2025
Language: Английский
Citations
3
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 267 - 267
Published: Feb. 18, 2025
Medicinal aromatic plants (MAPs) are a rich and diverse source of traditional modern medicines. Aromatic contain valuable essential oils that exhibit numerous biological activities. Essential used in pharmaceutical production, cosmetics, food preservation to ensure the microbiological stability products. Plants from Lamiaceae family, including Origanum vulgare L., raw materials with antimicrobial antioxidant properties, they can be utilized production new drugs other bioproducts. Oregano is an example plant great potential, known for its health-related culinary applications growing significance medicines, antiseptics, preservatives. This work aims consolidate current research results on occurrence, acquisition, use, medicinal dietary value common oregano oil. The obtained indicate plant, serving as natural antiseptics protective agents. oil, thymol carvacrol, has number health-promoting properties. These compounds (also present extracts) significant antioxidant, anti-inflammatory, antiangiogenic, anticancer, findings highlight promising role these potential structures search antibiofilm
Language: Английский
Citations
3
International Journal of Microbiology, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
The escalating threat of infectious diseases, exacerbated by antimicrobial resistance (AMR) and biofilm formation, necessitates innovative therapeutic strategies. This review presents a comprehensive exploration the potential nanoparticles synthesized from natural sources, including plant extracts, microbial products, marine compounds, as agents. These naturally derived demonstrated significant antibiofilm antivirulence effects, with specific examples revealing their capacity to reduce mass up 78% inhibit bacterial quorum sensing 65%. integration bioactive such polyphenols chitosan, facilitates nanoparticle stability enhances efficacy, while green synthesis protocols environmental risks. Notably, identifies silver using tea achieving 85% inhibition polymicrobial growth in vitro. Despite these promising results, challenges standardization scalability persist. study underscores transformative leveraging sourced sustainable alternatives conventional antimicrobials, offering quantitative insights for future application combating mono- infections.
Language: Английский
Citations
3