Next-generation probiotics: the upcoming biotherapeutics

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: April 15, 2024

Abstract Recent and continuing advances in gut microbiome research have pointed out the role of microbiota as an unexplored source potentially beneficial probiotic microbes. Along lines these advances, both public awareness acceptance probiotics are increasing. That’s why; academic industrial is dedicated to identifying investigating new microbial strains for development next-generation (NGPs). At this time, there a growing interest NGPs biotherapeutics that alter affect various diseases development. In work, we focused on some emergent promising NGPs, specifically Eubacterium hallii, Faecalibacterium prausnitzii, Roseburia spp., Akkermansia muciniphila , Bacteroides fragilis their presence can impact diseases. Emerging studies point roles open up novel therapeutic options. Interestingly, were found enhance gastrointestinal immunity, immunotherapy efficacy cancer patients, retain intestinal barrier integrity, generate valuable metabolites, especially short-chain fatty acids, decrease complications chemotherapy radiotherapy. Although many considered prevention treatment several chronic diseases, humans still lacking. Therefore, approval microbes from regulatory agencies rare. Besides, issues limit wide use market, such suitable methods culture storage oxygen-sensitive The present review goes over main points related gives viewpoint key hinder application. Furthermore, advancement human healthiness investigations by clarifying limitations traditional microorganisms, discussing characteristics emerging defining management certain ailments. Future should emphasize isolation, mechanisms action probiotics, safety, clinical humans.

Language: Английский

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Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5842 - 5842

Published: May 27, 2024

This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.

Language: Английский

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Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Foods, Journal Year: 2023, Volume and Issue: 13(1), P. 89 - 89

Published: Dec. 26, 2023

Postbiotics are (i) “soluble factors secreted by live bacteria, or released after bacterial lysis, such as enzymes, peptides, teichoic acids, peptidoglycan-derived muropeptides, polysaccharides, cell-surface proteins and organic acids”; (ii) “non-viable metabolites produced microorganisms that exert biological effects on the hosts”; (iii) “compounds microorganisms, from food components microbial constituents, including non-viable cells that, when administered in adequate amounts, promote health wellbeing”. A probiotic- prebiotic-rich diet ensures an supply of these vital nutrients. During anaerobic fermentation nutrients, prebiotics, postbiotics act a benevolent bioactive molecule matrix. can be used functional industry offering number advantages, being added to foods harmful probiotic survival. Postbiotic supplements have grown popularity food, cosmetic, healthcare industries because their numerous advantages. Their classification depends various factors, type microorganism, structural composition, physiological functions. This review offers succinct introduction while discussing salient features classification, production, purification, characterization, functions, applications industry. Furthermore, therapeutic mechanisms antibacterial, antiviral, antioxidant, anticancer, anti-diabetic, anti-inflammatory agents elucidated.

Language: Английский

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Function and therapeutic prospects of next-generation probiotic Akkermansia muciniphila in infectious diseases

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 6, 2024

Akkermansia muciniphila is a gram-negative bacterium that colonizes the human gut, making up 3–5% of microbiome. A. promising next-generation probiotic with clinical application prospects. Emerging studies have reported various beneficial effects including anti-cancer, delaying aging, reducing inflammation, improving immune function, regulating nervous system whereas knowledge on its roles and mechanism in infectious disease currently unclear. In this review, we summarized basic characteristics, genome phenotype diversity, influence derived components diseases, such as sepsis, virus infection, enteric periodontitis foodborne pathogen induced infections. We also provided updates mechanisms how protects intestinal barrier integrity modulate host response. summary, believe therapeutic may be applied for treatment variety diseases.

Language: Английский

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Effects of L-β-Galactoglucan Supplementation on Growth Performance, Palatability, and Intestinal Microbiota in Adult Beagle Dogs

Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 160 - 160

Published: Feb. 28, 2025

Background: This study was conducted to investigate the effects of different levels L-β-galactoglucan on growth performance, palatability, and health condition dogs. Methods: A total 32 healthy beagle dogs (2.0 ± 0.5 yr; 13.2 2.1 kg) were randomly assigned into four treatment groups, with 8 in each group. The fed basal diets supplemented 0 (control), 0.25, 0.5, or 1% L-β-galactoglucan. Results: results showed that feed intake ratio Low_Gal (0.25%) group significantly higher (p < 0.05) as compared control (Con) low-density lipoprotein cholesterol (LDL-C) Mid_Gal (0.5%) a trend toward lower = 0.069). Compared group, alpha diversity bacterial flora Shannon index 0.05). Simpson reduced 0.05), PCoA indicated significant change gut microbiota structure among groups relative abundance Blautia Peptoclostridium Conclusions: These exhibited positive effect improving palatability

Language: Английский

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Evaluation of Potential Probiotic Properties and In Vivo Safety of Lactic Acid Bacteria and Yeast Strains Isolated from Traditional Home-Made Kefir

Foods, Journal Year: 2024, Volume and Issue: 13(7), P. 1013 - 1013

Published: March 26, 2024

Probiotics are known for their health-promoting resources and considered as beneficial microorganisms. The current study focuses on the isolation, a complete in vitro vivo characterization, of yeast lactic acid bacteria acquired from traditional homemade kefir order to assess potentiality probiotic candidates. In particular, isolates Pichia kudriavzevii Y1, Lactococcus lactis subsp. hordniae LAB1 LAB2 were subjected characterization evaluate suitability probiotics. Resistance bile salts, auto-aggregation, co-aggregation, hydrophobicity, biofilm production capability examined, well antioxidant activity. A safety assessment was also conducted confirm non-pathogenic nature isolates, with hemolysis assay antibiotic resistance assessment. Moreover, mortality invertebrate model Galleria mellonella evaluated. Current findings showed that P. exhibited estimable properties, placing them promising candidates functional foods. Both isolated this work could be classified potential probiotics advantageous traits, including antimicrobial activity against enteric pathogens good adhesion ability intestinal cells. This revealed origin different microorganisms may enhance health wellness.

Language: Английский

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Progress of Conjugated Linoleic Acid on Milk Fat Metabolism in Ruminants and Humans

Animals, Journal Year: 2023, Volume and Issue: 13(21), P. 3429 - 3429

Published: Nov. 6, 2023

As a valuable nutrient in milk, fat accounts for significant proportion of the energy requirements ruminants and is largely responsible determining milk quality. Fatty acids (FAs) are pivotal component fat. Conjugated linoleic acid (CLA) one naturally occurring FAs prevalent ruminant dairy products meat. Increasing attention has been given to CLA because its anti-cancer, anti-inflammatory, immune regulation, lipid metabolism regulation properties, these benefits potentially contribute growth health infants. In breast present trace amounts, mainly form cis-9, trans-11 CLA. Notably, improves rate while trans-10, cis-12 inhibits it. Apart from having multiple physiological functions, also factor quality ruminants, especially rate. response growing interest green healthy functional foods, more researchers exploring potential improve production performance animals nutritional value livestock products. Taken together, it novel worthwhile investigate how regulates synthesis. It purpose this review clarify necessity studying

Language: Английский

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Differences among Lactiplantibacillus plantarum strains isolated from different fermented foods in their potential cholesterol-lowering properties

Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 103847 - 103847

Published: March 3, 2024

Language: Английский

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Simultaneously efficient dissolution and structural modification of chrysanthemum pectin: Targeting at proliferation of Bacteroides

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131469 - 131469

Published: April 9, 2024

Language: Английский

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The Role of Microorganisms and Their Antibacterial Compounds in Food Biopreservation

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(13), P. 5557 - 5557

Published: June 26, 2024

The increase in the nutritional awareness of consumers has meant that products with high value, sensory attractiveness, and safety are currently being sought on market. One aspects which innovativeness a food product can be considered is preservation method. Fermentation one oldest methods. In practice, biopreservation primarily method using non-pathogenic microorganisms and/or their metabolites to microbiological extend shelf life. Advances microbiology genetic engineering, taking into account various sources microbiota isolation, have rediscovered fermentation process allowed us obtain innovative functional products. Recently, bacteriocins gained importance. For many years, they been applied as biopreservatives manufacturing, alone or combination other preservatives. most promising perspective seems development combined systems including natural preservatives (i.e., bacteriocin lipopeptides), emerging non-thermal technologies, methods such encapsulation nanotechnology active packaging. this paper, narrative review presented analyze recently published literature regarding role microbial produced antibacterial compounds biopreservation. New technologies an alternative artificial were also discussed.

Language: Английский

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