Fucoidan Supplementation Improves Antioxidant Capacity via Regulating the Keap1/Nrf2 Signaling Pathway and Mitochondrial Function in Low-Weaning Weight Piglets

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 407 - 407

Published: March 28, 2024

Fucoidan (FC) is known for its antioxidant properties, but it has unclear effects and mechanisms on weaned piglets. Two experiments were conducted to determine the optimal FC dosage in piglet diets protective effect against lipopolysaccharide (LPS)-induced oxidative stress. In experiment one, 24 low weight piglets randomly assigned four dietary treatments: a basal diet (FC 0), or supplemented with 150 150), 300 300), 600 mg/kg 600). two, 72 low-weaning allocated into (CON), of fucoidan added challenged LPS (100 µg LPS/kg body weight) not. The results showed that treatments increased G:F ratio, reduced diarrhea incidence plasma IGF-1 concentrations. addition, supplementation SOD activity MDA concentration. challenge triggered strong systemic redox imbalance mitochondrial dysfunction. However, (300 mg/kg) enzymes, including SOD, decreased concentration liver, down-regulated Keap1 gene expression, up-regulated Nrf2, CAT, MFN2, SDHA, UQCRB expression liver. These indicated improved growth performance capacity piglets, which might be attributed modulation Keap1/Nrf2 signaling pathway function

Language: Английский

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Control of Neonatal Diarrhea in Piglets with Reduced Antibiotic Use by Application of a Complementary Feed—A Randomized Controlled Farm Trial

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(1), P. 42 - 42

Published: Jan. 10, 2025

The objective of this farm trial was to investigate if the consumption antibiotics could be reduced when piglets showing early signs neonatal diarrhea were treated with an oral dose tannin extract derived from sweet chestnut wood. had a very high incidence among gilt litters. Gilts randomized into test or control groups in 1:1 ratio compare used for and piglet mortality during four-week period. Control litters antibiotic paromomycin, while complementary feed O-Nella-Protect. included 18 comprising 254 piglets. In group, 100% received treatment. against by 84% (p = 0.001) other illnesses 45% 0.045). both groups, six died. Microbiological analysis identified potential bacterial viral pathogens. conclusion, indicates that even under challenge potentially serious pathogens, complimentary containing can support health reduce consumption.

Language: Английский

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Effect of Neonatal Interventions with Specific Micronutrients and Bovine Colostrum on Micronutrient and Oxidative Statuses and on Gut Microbiota in Piglets from Birth to Post-Weaning Period

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(2), P. 151 - 151

Published: Feb. 10, 2025

This study aimed to determine the impact of supplementations copper, vitamins A and D (ADCU), a bovine colostrum extract (BC) on micronutrient status, antioxidant intestinal microbiota piglets until post-weaning period. Twenty-three sows were fed conventional gestation lactation diets, twenty-four diets supplemented with ADCU. For each litter, all received one four treatments during lactation: no supplementation; ADCU; BC; ADCU + BC. Within low (LW) high birth weight (HW) piglet euthanized before after weaning collect liver samples. Serum vitamin D, retinol, Cu greater in (p < 0.01), mostly weaning. After weaning, decreased markedly drop 75% treatments, despite levels their diets. The status was not globally altered by > 0.05). composition, sow supplementation increased 0.01) richness bacterial species colon, either or shortly Short-chain fatty acids caecal digesta LW at 16 days age In conclusion, oral postnatal statuses lactation, but this did generally persist Treatments improve response oxidative stress, favoured gut diversity, particularly piglets.

Language: Английский

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Effect of Benzoic Acid supplementation on growth performance and early development of gastrointestinal tract function and immune system in artificially reared suckling piglets.

Livestock Science, Journal Year: 2025, Volume and Issue: unknown, P. 105655 - 105655

Published: Feb. 1, 2025

Language: Английский

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Maternal and/or direct feeding of organic acid-preserved cereal grains improves performance and digestive health of pigs from birth to slaughter

Animal Feed Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 116295 - 116295

Published: March 1, 2025

Language: Английский

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Chlorogenic Acid Enhances the Intestinal Health of Weaned Piglets by Inhibiting the TLR4/NF-κB Pathway and Activating the Nrf2 Pathway

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9954 - 9954

Published: Sept. 15, 2024

Chlorogenic acid (CGA) is a natural polyphenol with potent antioxidant and anti-inflammatory activities. However, the exact role of it in regulating intestinal health under oxidative stress not fully understood. This study aims to investigate effects dietary CGA supplementation on weaned piglets stress, explore its regulatory mechanism. Twenty-four were randomly divided into two groups fed either basal diet (CON) or supplemented 200 mg/kg (CGA). reduced diarrhea rate, increased villus height jejunum, decreased crypt depth duodenum, ileum (

Language: Английский

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Dose-Dependent Effects of Supplementing a Two-Strain Bacillus subtilis Probiotic on Growth Performance, Blood Parameters, Fecal Metabolites, and Microbiome in Nursery Pigs

Animals, Journal Year: 2023, Volume and Issue: 14(1), P. 109 - 109

Published: Dec. 28, 2023

This experiment was conducted to evaluate the effects of dietary supplementation level a two-strain Bacillus subtilis probiotic on growth performance, blood parameters, fecal metabolites, and microbiome in nursery pigs. A total 54 weaned piglets were allotted three treatments replicate pens with six pigs/pen for 28 d feeding trial. The as follows: control: no supplementation; Pro1x: B. at 1.875 × 105 CFU/g diet; Pro10x: 106 diet. Body weight 14 postweaning (p = 0.06) average daily gain 0 < 0.05) greater Pro1x treatment than other treatments. Blood glucose levels both control 0.05). In short-chain fatty acid (SCFA) concentrations, butyrate concentrations 0.05), acetate, propionate, SCFA Pro10x beta diversity composition based Unweighted Unifrac analysis dissimilar between conclusion, two strains selected reduce pathogenic Escherichia coli diets diet improved rate early period, increased altered microbial community composition. higher dose did not improve performance parameters over those piglets.

Language: Английский

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Novel Antioxidants for Animal Nutrition

MDPI eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

It am enthused to announce that the printed version of our successful Special Issue, which delves into realm innovative antioxidants for animal nutrition, is now available.Our journey this fascinating field novel nutrition has been marked by insights, discoveries, and collective efforts important researchers.As we navigate intricate pathways it becomes increasingly evident play a pivotal role in shaping health well-being both humans animals.In design functional diets, their importance cannot be neglected.I would like take opportunity extend my sincerest gratitude Prof. Luciana Rossi her unwavering dedication unparalleled expertise.Prof. Rossi's invaluable awareness fundamental trajectory guidance beacon light throughout journey.

Language: Английский

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Dietary Triple-Strain Bacillus- Based Probiotic Supplementation Improves Performance, Immune Function, Intestinal Morphology, and Microbial Community in Weaned Pigs

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

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Disease resilience in farm animals

Published: Jan. 1, 2024

To diminish the detrimental impact of diseases and to improve farm animal health, it has been suggested enhance disease resilience animals.Good can be described as ability animals minimally affected by challenges that cause and, if affected, recover quickly.At this moment, knowledge is limited on how operationalise into management, in favour health.Knowledge required whether influenced even predicted, so we know will respond they may encounter.The aim thesis was investigate potential influencing factors possible predictive indicators typical multifactorial production related livestock animals.Disease quantified pigs measuring duration, recovery severity symptoms after a challenge with respiratory co-infection model Porcine Respiratory Reproductive Syndrome Virus (PRRSV) Actinobacillus pleuropneumoniae (A.pleuropneumoniae).The effect housing condition studied introduction social environmental enrichment one study group comparison were conventionally housed.The application benefitted coinfection, an accelerated viral clearance reduction risk lung lesions.In dairy cows calving seen period transition dry lactation phase used monitor various clinical deviations proxies resilience, because time when become most susceptible diseases.To test (dynamic aspects of) variables could predict outcome, number physiological, immunological behavioural measured prior tested (dynamic) ((D)IORs).The found consist single measurements, average values multiple measurements (IORs), or dynamic features continuous (DIORs).In higher level lymphocytes, naïve T helper cells, memory cells relative levels granulocytes raised concentrations natural (auto-) antibodies (N(A)Abs) predicting IORs for co-infection.In cows, high eating time, variance ear temperature strict regularity behaviour including rumination activity, (D)IORs duration post-partum diseases, summarised Total Deficit Score.This shows improves are kept under conditions better meet their needs.Subsequently, challenges.These provide insight upon perturbations.As consequence, help assess farms form basis future development management studies.

Language: Английский

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