
EBioMedicine, Journal Year: 2024, Volume and Issue: 110, P. 105450 - 105450
Published: Nov. 21, 2024
Language: Английский
EBioMedicine, Journal Year: 2024, Volume and Issue: 110, P. 105450 - 105450
Published: Nov. 21, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6178 - 6178
Published: June 4, 2024
The respiratory system is constantly exposed to viral infections that are responsible for mild severe diseases. In this narrative review, we focalized the attention on syncytial virus (RSV), influenza virus, and acute syndrome-coronavirus-2 (SARS-CoV-2) infections, high morbidity mortality in last decades. We reviewed human innate adaptive immune responses airways following infection, focusing a particular population: newborns pregnant women. recent Coronavirus disease-2019 (COVID-19) pandemic has highlighted how our interest pathologies must not decrease. Furthermore, increase knowledge of infection mechanisms improve future defense strategies.
Language: Английский
Citations
19Pathogens, Journal Year: 2024, Volume and Issue: 13(7), P. 561 - 561
Published: July 3, 2024
Influenza virus possesses an RNA genome of single-stranded, negative-sensed, and segmented configuration. causes acute respiratory disease, commonly known as the "flu" in humans. In some individuals, flu can lead to pneumonia distress syndrome. A (IAV) is most significant because it recurring seasonal epidemics, occasional pandemics, zoonotic outbreaks human populations, globally. The host innate immune response IAV infection plays a critical role sensing, preventing, clearing well disease pathology. Host cells sense through multiple receptors mechanisms, which culminate induction concerted antiviral creation state, inhibits clears from cells. However, antagonizes escapes many steps by different mechanisms. Herein, we review those viral This covers aspects response, i.e., (1) sensing incoming particles, (2) activation downstream signaling pathways, (3) expression interferon-stimulated genes, (4) antagonism escape.
Language: Английский
Citations
7Progress in molecular biology and translational science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119527 - 119527
Published: Feb. 1, 2025
Language: Английский
Citations
0Viral Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Respiratory syncytial virus (RSV) is a significant cause of disease in the young and old. Recently, pre-fusion F protein vaccines for RSV have received food drug administration (FDA) approval to protect adults aged 60 years older; however, evaluated against typically do not elicit complete or durable protective immunity. We previously showed that an G central conserved domain (CCD) nanoparticle vaccine containing S177Q mutation (NP-S177Q) induced favorable immunogenicity RSV-neutralizing antibodies compared with vaccination alone mice. Boosting BALB/c mice NP-S177Q improved correlates protection reduced markers immunopathology following challenge. This study examined microparticle (MP) displaying CCD (MP-S177Q) adjuvanted monophosphoryl lipid A (MPLA) Our findings show MP-S177Q develop effective viral neutralization MP-WT bronchoalveolar Th1-type cytokine responses challenge vehicle-vaccinated shows rationally mutated MP safe, effective, can advance precision vaccines.
Language: Английский
Citations
0Published: July 11, 2024
Respiratory Syncytial Virus is a common respiratory pathogen known for causing illnesses, ranging from mild symptoms to severe lower tract infections in infants and the elderly. This virus responsible one-third of pneumonia deaths pediatric population, but there are currently only few effective vaccines pharmacological treatments. The frac-talkine (CX3CL1) receptor (CX3CR1) co-receptor RSV expressed by airway epithelial cells diversity immune cells. Recent research has highlighted role CX3CR1 host response infection, its potential development an efficient vaccine novel
Language: Английский
Citations
2Microorganisms, Journal Year: 2023, Volume and Issue: 11(11), P. 2810 - 2810
Published: Nov. 19, 2023
Many studies have focused on SARS-CoV-2 and Mycobacterium tuberculosis (Mtb) co-infection consequences. However, after a vaccination plan against COVID-19, the cases of severe disease death are consistently controlled, although asymptomatic mild COVID-19 still happen together with (TB) cases. Thus, in this context, we sought to compare T cell response COVID-19-non-vaccinated -vaccinated patients active exposed antigens. Flow cytometry was used analyze activation markers (i.e., CD69 CD137) cytokines (IFN-γ, TNFα, IL-17, IL-10) levels CD4+ CD8+ cells upon exposure peptides. The data obtained showed that from non-vaccinated TB present high frequency TNF-α viral challenge compared vaccinated donors. Conversely, show IL-10 spike peptide stimulus patients. No differences were observed other parameters analyzed. results suggest reduced immune balance coinfected individuals may consequences for pathogen control, necessitating further research understand its impact clinical outcomes those concurrent Mtb infections.
Language: Английский
Citations
2Journal of Theoretical Biology, Journal Year: 2024, Volume and Issue: 594, P. 111928 - 111928
Published: Aug. 22, 2024
Language: Английский
Citations
0International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9800 - 9800
Published: Sept. 11, 2024
Respiratory syncytial virus (RSV) is a common respiratory pathogen that causes illnesses, ranging from mild symptoms to severe lower tract infections in infants and older adults. This responsible for one-third of pneumonia deaths the pediatric population; however, there are currently only few effective vaccines. A better understanding RSV–host relationship at molecular level may lead more management RSV-related symptoms. The fractalkine (CX3CL1) receptor (CX3CR1) co-receptor RSV expressed by airway epithelial cells diverse immune cells. G protein binds CX3CR1 via highly conserved amino acid motif (CX3C motif), which also present CX3CL1. CX3CL1-CX3CR1 axis involved activation infiltration into infected lung. presence alters natural functions CX3CR1-CX3CL1 modifies host’s response, an aspects need be considered development efficient vaccine specific pharmacological treatment.
Language: Английский
Citations
0EBioMedicine, Journal Year: 2024, Volume and Issue: 110, P. 105450 - 105450
Published: Nov. 21, 2024
Language: Английский
Citations
0