Antibiotic use at the Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin: a point prevalence survey DOI Creative Commons

Morelle Sèssiwèdé Gnimavo,

Bawa Boya, Steward Mudenda

et al.

JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 7(1)

Published: Dec. 26, 2024

Abstract Background Antimicrobial stewardship promotes the appropriate use of antibiotics to prevent emergence and spread antimicrobial resistance. This study evaluated using a point prevalence survey at Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin. Methods cross-sectional utilized WHO methodology for monitoring antibiotic among inpatients hospitals. The was conducted from 11 January 2022 19 hospitalized patients before 8:00 a.m. on day survey. Results Of 111 inpatient medical files reviewed, 82.9%. number received per patient ranged 1 5, with mean 2.45 ± 1.11 median 2. most commonly prescribed class beta-lactams (46.7%), aminoglycosides (20.6%) nitroimidazoles (19.7%). According AWaRe classification, 30.4% Access group 44% combination Watch antibiotics; treatment empiric 94.5% encounters. Only 22.7% were treated based microbiological examination/culture sensitivity testing. Conclusions found high CHUZ/AS Tertiary Care Hospital ampicillin, metronidazole ceftriaxone. Consequently, low culture testing guide treatment, particularly paediatric surgical population, preference broad-spectrum suggests that is not optimal. Therefore, programmes, policies guidelines must be instigated strengthened address these gaps promote rational antibiotics.

Language: Английский

Antibiotic use and adherence to the WHO AWaRe guidelines across 16 hospitals in Zambia: a point prevalence survey DOI Creative Commons
Joseph Yamweka Chizimu, Steward Mudenda, Kaunda Yamba

et al.

JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 6(5)

Published: Sept. 3, 2024

The inappropriate use of antibiotics in hospitals contributes to the development and spread antimicrobial resistance (AMR). This study evaluated prevalence antibiotic adherence World Health Organization (WHO) Access, Watch Reserve (AWaRe) classification across 16 Zambia.

Language: Английский

Citations

7
The Burden of Antimicrobial Resistance in Zambia, a Sub-Saharan African Country: A One Health Review of the Current Situation, Risk Factors, and Solutions DOI Open Access
Steward Mudenda, Webrod Mufwambi,

Shafiq Mohamed

et al.

Pharmacology &amp Pharmacy, Journal Year: 2024, Volume and Issue: 15(12), P. 403 - 465

Published: Jan. 1, 2024

Language: Английский

Citations

7
Point Prevalence Survey of Antibiotic Use in Level 1 hospitals in Zambia: Future Prospects for Antimicrobial Stewardship Programs DOI Creative Commons
Steward Mudenda, Adriano Focus Lubanga, Shazia Jamshed

et al.

Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 887 - 902

Published: Feb. 1, 2025

The inappropriate prescribing and use of antibiotics have contributed to the emergence spread antimicrobial resistance (AMR). In Zambia, there is a paucity information on patterns among hospitalized patients in level 1 hospitals. This study investigated antibiotic five hospitals Lusaka, Zambia. cross-sectional utilized World Health Organization (WHO) Point Prevalence Survey (PPS) methodology in-patients admitted before 08:00 a.m. survey day August 2024. Data were analysed using IBM SPSS version 23.0. prevalence inpatients was 59.0%, with ceftriaxone being most prescribed. Antibiotics prescribed mainly for paediatrics male inpatients. found that 53.0% from Access group while 38.2% Watch Access, Watch, Reserve (AWaRe) classification. Adherence national treatment guidelines 36.0%, empirically without evidence culture sensitivity tests. high low adherence findings this demonstrate need establish strengthen stewardship programs laboratory capacity aid clinicians diagnosing, treating, managing across

Language: Английский

Citations

1
Antimicrobial stewardship situation analysis in selected hospitals in Zambia: findings and implications from a national survey DOI Creative Commons
Joseph Yamweka Chizimu, Steward Mudenda, Kaunda Yamba

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 27, 2024

Background Antimicrobial stewardship (AMS) programs are critical in combating antimicrobial resistance (AMR). In Zambia, there is little information regarding the capacity of hospitals to establish and implement AMS programs. The objective this study was conduct a baseline assessment WHO core elements for an program implementation eight Zambia. Materials methods We conducted exploratory cross-sectional from September 2023 December using self-scoring Periodic National Healthcare Facility Assessment Tool World Health Organization (WHO) policy guidance on integrated activities human health. Eight public were surveyed across five provinces Data analyzed tool thematic analysis. Results Overall, 62.5% (6/8) facilities scored low (below 60%) implementing Most had challenges with reporting feedback within hospital (average score = 46%), Drugs Therapeutics Committee (DTC) functionality 49%), actions 50%), education training 54%), leadership commitment 56%). overall all average (56%). All (100%) did not have allocated budget Finally, neither antibiograms guide utilization nor AMS-trained staff more than 50% surveyed. Conclusion This found these hospitals, especially where DTCs non-functional. identified gaps require urgent attention sustainable multidisciplinary

Language: Английский

Citations

6
The Effect of Educational Intervention on Healthcare Workers’ Awareness and Knowledge of Antimicrobial Resistance, Stewardship, and Surveillance: Opportunities for Antimicrobial and Diagnostic Stewardship DOI Open Access
Steward Mudenda, Victor Daka,

Mapeesho Kamayani

et al.

Pharmacology &amp Pharmacy, Journal Year: 2025, Volume and Issue: 16(05), P. 125 - 149

Published: Jan. 1, 2025

Language: Английский

Citations

0
Antibiotic use at the Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin: a point prevalence survey DOI Creative Commons

Morelle Sèssiwèdé Gnimavo,

Bawa Boya, Steward Mudenda

et al.

JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 7(1)

Published: Dec. 26, 2024

Abstract Background Antimicrobial stewardship promotes the appropriate use of antibiotics to prevent emergence and spread antimicrobial resistance. This study evaluated using a point prevalence survey at Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin. Methods cross-sectional utilized WHO methodology for monitoring antibiotic among inpatients hospitals. The was conducted from 11 January 2022 19 hospitalized patients before 8:00 a.m. on day survey. Results Of 111 inpatient medical files reviewed, 82.9%. number received per patient ranged 1 5, with mean 2.45 ± 1.11 median 2. most commonly prescribed class beta-lactams (46.7%), aminoglycosides (20.6%) nitroimidazoles (19.7%). According AWaRe classification, 30.4% Access group 44% combination Watch antibiotics; treatment empiric 94.5% encounters. Only 22.7% were treated based microbiological examination/culture sensitivity testing. Conclusions found high CHUZ/AS Tertiary Care Hospital ampicillin, metronidazole ceftriaxone. Consequently, low culture testing guide treatment, particularly paediatric surgical population, preference broad-spectrum suggests that is not optimal. Therefore, programmes, policies guidelines must be instigated strengthened address these gaps promote rational antibiotics.

Language: Английский

Citations

2