Network Pharmacology Exploration Reveals Gut Microbiota Modulation as a Common Therapeutic Mechanism for Anti-Fatigue Effect Treated with Maca Compounds Prescription

Nutrients, Journal Year: 2022, Volume and Issue: 14(8), P. 1533 - 1533

Published: April 7, 2022

Maca compounds prescription (MCP) is a common botanical used in dietary supplements, primarily to treat exercise-induced fatigue. The aim of this study elucidate the multi-target mechanism MCP on fatigue management via network pharmacology and gut microbiota analysis. Databases literature were screen chemical targets MCP. Subsequently, 120 active ingredients 116 fatigue-related played cooperative role managing fatigue, where several intestine-specific indicated anti-fatigue might be closely related its prebiotics intestinal bacteria. Thus, forced swimming tests (FSTs) carried mice fecal samples collected analyzed by 16S rRNA sequencing. Gut beneficially regulated MCP-treated group phylum, genus OTU levels, respectively, that with critical correlation included Lactobacillus Candidatus Planktophila. results systematically reveal acts against multi-targets different reshapes microbial ecosystem.

Language: Английский

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Gut microbiota in muscular atrophy development, progression, and treatment: New therapeutic targets and opportunities

The Innovation, Journal Year: 2023, Volume and Issue: 4(5), P. 100479 - 100479

Published: July 11, 2023

Skeletal muscle atrophy is a debilitating condition that significantly affects quality of life and often lacks effective treatment options. Muscle can have various causes, including myogenic, neurogenic, other factors. Recent investigation has underscored compelling link between the gut microbiota skeletal muscle. Discerning potential differences in associated with atrophy-related diseases, understanding their influence on disease development, recognizing as intervention targets are paramount importance. This review aims to provide comprehensive overview role diseases. We summarize clinical pre-clinical studies investigate for modulation enhance performance promote recovery. Furthermore, we delve into intricate interplay drawing from an array studies. Emerging evidence suggests significant composition individuals diseases compared healthy individuals. It conceivable these alterations contribute pathogenesis disorders through bacterium-related metabolites or inflammatory signals. Additionally, interventions targeting demonstrated promising results mitigating progression animal models, underscoring therapeutic modulating conditions. By analyzing available literature, this sheds light involvement The findings our underlying mechanisms open avenues development novel strategies gut-muscle axis.

Language: Английский

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Effects of Probiotic Supplementation on Exercise and the Underlying Mechanisms

Foods, Journal Year: 2023, Volume and Issue: 12(9), P. 1787 - 1787

Published: April 25, 2023

Long-term, high-intensity exercise can trigger stress response pathways in multiple organs, including the heart and lungs, gastrointestinal tract, skeletal muscle, neuroendocrine system, thus affecting their material energy metabolism, immunity, oxidative stress, endocrine function, reducing function. As a natural, safe, convenient nutritional supplement, probiotics have been hot research topic field of biomedical health recent years. Numerous studies shown that probiotic supplementation improves body through gut-brain axis gut-muscle axis, may also improve motor function body. This paper reviews progress on role intestinal barrier status body, as well underlying mechanisms.

Language: Английский

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Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8061 - 8061

Published: April 29, 2023

It has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and its perturbation implicated development progression of a growing list diseases. The number studies evaluating how interacts with influences other organs systems body vice versa constantly increasing several ‘gut–organ axes’ have already defined. Recently, view on link between (GM) peripheral nervous system (PNS) become broader by exceeding fact PNS can serve as systemic carrier GM-derived metabolites products to organs. communication network central periphery internal rather be affected itself GM perturbation. In this review, we summarize current knowledge about impact PNS, regard somatic autonomic divisions, physiological, regenerative pathological conditions.

Language: Английский

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Reshaped Gut Microbial Composition and Functions Associated with the Antifatigue Effect of Salidroside in Exercise Mice

Molecular Nutrition & Food Research, Journal Year: 2023, Volume and Issue: 67(12)

Published: April 21, 2023

Salidroside (SA) is an active compound derived from Rhodiola rosea and widely used in healthcare foods. However, the underlying mechanism its specific role regulating gut microbial community during exercise (Ex) remains unknown.Mice are subjected to a weight-loaded swimming test (WST) Ex determine how microbiota affects antifatigue activity of SA. The SA-treated group mice (100 mg kg-1 .bw.) display significant increase time compared control (26.2 versus 10.5 min, p < 0.01), as well respiratory enzymatic activities after swimming. significantly higher than RS (regular rest) bacteria profiles + SA change with species diversity abundance. Receiver operating characteristic (ROC) curves Alistipes, Rikenellaceae, Parabacteroides, Candidatus Arthromitus, Lactobacillus indicate high diagnostic utility distinguish treatment. Microbial function analysis shows that may improve Ex-induced fatigue by modulating energy metabolism-related processes.SA demonstrates effects on various levels metabolism composition, providing insights into mechanisms natural prebiotic.

Language: Английский

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