Nutrients,
Journal Year:
2023,
Volume and Issue:
15(21), P. 4663 - 4663
Published: Nov. 3, 2023
The
role
of
probiotic
supplementation
in
type
2
diabetes
(T2D)
treatment
is
controversial.
present
study
aimed
to
assess
the
effects
a
multi-strain
supplement
(LactoLevureR
(containing
Lactobacillus
acidophilus,
plantarum,
Bifidobacterium
lactis,
and
Saccharomyces
boulardii))
over
6
months,
primarily
on
glycemic
control
as
well
lipid
levels
alterations
gut
microbiome,
among
individuals
with
T2D
residing
Greece.
A
total
91
adults
(mean
age
[±SD]
65.12
±
10.92
years,
62.6%
males)
were
randomized
receive
or
matching
placebo
capsule,
once
daily,
for
months.
Blood
chemistries
anthropometric
parameters
conducted
every
3
stool
samples
collected
at
baseline
Significant
reductions
HbA1c,
fasting
blood
glucose,
cholesterol
observed
participants
treated
(n
=
46)
compared
controls
45),
even
after
adjustment
greater
decrease
adiposity
(waist
circumference).
Although
there
no
statistically
significant
differences
diversity
microbiome
(α
β
diversity),
administration
probiotics
did
influence
several
genera,
metabolites,
key
enzymes
associated
diabetes.
Overall,
LactoLevureR
6-month
period
was
well-tolerated
had
positive
impact
metabolic
parameters,
alongside
improvements
indices
adiposity.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Dec. 19, 2023
Postbiotics,
which
are
bioactive
substances
derived
from
the
metabolic
processes
of
beneficial
microbes,
have
received
considerable
attention
in
field
microbiome
science
recent
years,
presenting
a
promising
path
for
exploration
and
innovation.
This
comprehensive
analysis
looks
into
multidimensional
terrain
postbiotic
production,
including
an
extensive
examination
diverse
classes,
revealing
their
sophisticated
mechanisms
action
highlighting
future
applications
that
might
significantly
affect
human
health.
The
authors
thoroughly
investigate
various
support
ranging
conventional
fermentation
procedures
to
cutting-edge
enzyme
conversion
synthetic
biology
approaches.
review,
as
acknowledgment
field’s
developing
nature,
not
only
highlights
current
achievements
but
also
navigates
through
problems
inherent
production.
In
order
successfully
include
postbiotics
therapeutic
interventions
production
functional
food
ingredients,
emphasis
is
given
critical
elements,
improving
yields,
bolstering
stability,
assuring
safety.
knowledge
presented
herein
sheds
light
on
expanding
potential
revolutionize
development
novel
therapeutics
ingredients.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
161, P. 114468 - 114468
Published: March 1, 2023
Probiotics
are
frequently
consumed
as
functional
food
and
widely
used
dietary
supplements,
but
also
recommended
in
treating
or
preventing
various
gastrointestinal
diseases.
Therefore,
their
co-administration
with
other
drugs
is
sometimes
unavoidable
even
compulsory.
Recent
technological
developments
the
pharmaceutical
industry
permitted
development
of
novel
drug-delivery
systems
for
probiotics,
allowing
addition
to
therapy
severely
ill
patients.
Literature
data
regarding
changes
that
probiotics
could
impose
on
efficacy
safety
chronic
medication
scarce.
In
this
context,
present
paper
aims
review
currently
by
international
medical
community,
evaluate
relationship
between
gut
microbiota
pathologies
high
impact
worldwide
and,
most
importantly,
assess
literature
reports
concerning
ability
influence
pharmacokinetics/pharmacodynamics
some
drugs,
especially
those
narrow
therapeutic
indexes.
A
better
understanding
potential
drug
metabolism,
contribute
improving
management,
facilitating
individualized
updating
treatment
guidelines.
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(7), P. 1714 - 1714
Published: June 30, 2023
Recently,
probiotics
are
increasingly
being
used
for
human
health.
So
far,
only
lactic
acid
bacteria
isolated
from
the
gastrointestinal
tract
were
recommended
use
as
probiotics.
However,
more
authors
suggest
that
can
be
also
unconventional
sources,
such
fermented
food
products
of
animal
and
plant
origin.
Traditional
a
rich
source
microorganisms,
some
which
may
have
probiotic
properties.
A
novel
category
recently
microorganisms
with
great
potential
health
benefits
next-generation
(NGPs).
In
this
review,
general
information
"beneficial
microbes",
including
NGPs
acetic
bacteria,
presented
well
essential
mechanisms
microbe
host
interactions.
Many
reports
showed
NGP
selected
strains
sources
exhibit
positive
properties
when
it
comes
to
(i.e.,
they
effect
on
metabolic,
gastrointestinal,
neurological,
cardiovascular,
immune
system
diseases).
Here
we
briefly
present
current
regulatory
framework
requirements
should
followed
introduce
new
use.
The
term
"probiotic"
herein
is
not
limited
conventional
Innovation
will
undoubtedly
result
in
isolation
fascinating
advantages
hitherto
unforeseen
functionalities.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(21), P. 4663 - 4663
Published: Nov. 3, 2023
The
role
of
probiotic
supplementation
in
type
2
diabetes
(T2D)
treatment
is
controversial.
present
study
aimed
to
assess
the
effects
a
multi-strain
supplement
(LactoLevureR
(containing
Lactobacillus
acidophilus,
plantarum,
Bifidobacterium
lactis,
and
Saccharomyces
boulardii))
over
6
months,
primarily
on
glycemic
control
as
well
lipid
levels
alterations
gut
microbiome,
among
individuals
with
T2D
residing
Greece.
A
total
91
adults
(mean
age
[±SD]
65.12
±
10.92
years,
62.6%
males)
were
randomized
receive
or
matching
placebo
capsule,
once
daily,
for
months.
Blood
chemistries
anthropometric
parameters
conducted
every
3
stool
samples
collected
at
baseline
Significant
reductions
HbA1c,
fasting
blood
glucose,
cholesterol
observed
participants
treated
(n
=
46)
compared
controls
45),
even
after
adjustment
greater
decrease
adiposity
(waist
circumference).
Although
there
no
statistically
significant
differences
diversity
microbiome
(α
β
diversity),
administration
probiotics
did
influence
several
genera,
metabolites,
key
enzymes
associated
diabetes.
Overall,
LactoLevureR
6-month
period
was
well-tolerated
had
positive
impact
metabolic
parameters,
alongside
improvements
indices
adiposity.
