Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 8, 2022

Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the joints. Microbial infection considered crucial inducer of RA. Alterations in composition intestinal bacteria individuals with preclinical and established RA suggest vital role gut microbiota immune dysfunction characteristic However, mechanisms by which dysbiosis contributes to are not fully understood. Furthermore, multiple therapies commonly used treat may alter diversity, suggesting modulating help prevent or Hence, better understanding changes accompany should aid development novel therapeutic approaches. This mini-review discusses impact pathogenesis RA, selection microbiota-related biomarkers for diagnosing provides examples cross-modulation between some drugs Some suggestions outlooks also raised, guide future research efforts.

Language: Английский

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The Functional Roles of Lactobacillus acidophilus in Different Physiological and Pathological Processes

Journal of Microbiology and Biotechnology, Journal Year: 2022, Volume and Issue: 32(10), P. 1226 - 1233

Published: Aug. 30, 2022

Language: Английский

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Sinomenine ameliorates rheumatoid arthritis by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation

Science Bulletin, Journal Year: 2023, Volume and Issue: 68(14), P. 1540 - 1555

Published: June 28, 2023

Gut microbiota dysbiosis is associated with the development of rheumatoid arthritis (RA). Sinomenine (SIN) an effective immunosuppressive and anti-inflammatory drug used for treating RA, but how SIN regulates gut to alleviate RA remains underexplored. To identify critical microbial species metabolites RA-protective effects SIN, microbiota-dependent anti-RA were assessed by 16S rRNA gene sequencing, antibiotic treatment, fecal transplantation. Metabolomics analysis, transcriptional targeted bacteria/metabolites gavage conducted explore reduce severity RA. could restore intestinal balance mainly modulating abundance Lactobacillus, significantly relieve collagen-induced (CIA) symptoms in a manner. elevated tryptophan indole-3-acrylic acid (IA), indole-3-propionic (IPA), indole-3-acetic (IAA). Tryptophan supplementation activate aryl hydrocarbon receptor (AhR) regulate Th17/Treg CIA rats. Intriguingly, relieved involving enrichment two beneficial anti-CIA Lactobacillus species, L. paracasei casei mono-colonization. The promising therapeutic function was mostly attributed activation AhR explicitly targeting metabolites. bacterium may be CIA.

Language: Английский

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Development of biomedical hydrogels for rheumatoid arthritis treatment

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(1), P. 100887 - 100887

Published: Feb. 1, 2024

Rheumatoid Arthritis (RA) is an autoimmune disorder that hinders the normal functioning of bones and joints reduces quality human life. Every year millions people are diagnosed with RA worldwide which particularly includes elderly women groups. Therefore, this global cause warrants development new biomaterials, medicines, therapeutic methods for treatment. This will improve Healthcare Access Quality Index also relieve administrative financial burdens healthcare service providers at a scale. Hydrogels soft cross-linked polymeric materials can store certain number fluids, drugs biomolecules hydration applications. biocompatible exhibit excellent mechanical properties like providing elastic cushions to articulating by mimicking natural synovial fluid. Hence, hydrogels create biological environment within cavity decrease reactions friction. lubricate joint surfaces prevent degradation cartilage, thus conceiting high potential treat RA. work reviews progress in injectable implantable hydrogels, synthesis methods, types drugs, advantages challenges, discusses role targeted drug delivery, mechanistic behaviour, tribological performance

Language: Английский

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Advances in Synthetic Immunology for Targeted Treatment of Systemic Autoimmune Diseases: Opportunities, Challenges, and Future Directions

Immuno, Journal Year: 2025, Volume and Issue: 5(1), P. 6 - 6

Published: Jan. 25, 2025

Systemic autoimmune diseases (SAIDs) affect millions worldwide, presenting significant clinical challenges due to their complex pathogenesis and limited treatment options. Traditional immunosuppressive therapies, while effective, often lack precision, leading side effects inadequate disease control. Recent advances in synthetic immunology offer promising avenues for precise, targeted interventions SAIDs. This review examines the latest innovations treating diseases, focusing on engineered immune cells, biologics, gene-editing technologies. It explores therapeutic potential of these approaches modulate tolerance, reduce systemic inflammation, enhance patient-specific efficacy. However, despite developments, remain, including system complexity, safety concerns, regulatory hurdles that may hinder translation. aims consolidate current advancements, address existing barriers, outline future directions management, highlighting immunology’s role transforming landscape

Language: Английский

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Targeting Probiotics in Rheumatoid Arthritis

Nutrients, Journal Year: 2021, Volume and Issue: 13(10), P. 3376 - 3376

Published: Sept. 26, 2021

Rheumatoid arthritis (RA) is a progressive inflammatory disorder characterized by swollen joints, discomfort, tightness, bone degeneration and frailty. Genetic, agamogenetic sex-specific variables, Prevotella, diet, oral health gut microbiota imbalance are all likely causes of the onset or development RA, perhaps specific pathways remain unknown. Lactobacillus spp. probiotics often utilized as relief dietary supplements to treat bowel diseases, build strong immune system sustain system. At present, action mechanism towards RA remains Therefore, researchers conclude latest analysis effectively comprehend ultimate pathogenicity rheumatoid arthritis, well functions probiotics, specifically casei acidophilus, in treatment therapeutic diagnostic reports. chronic inflammation immunological illness wherein affected. Probiotics organisms that can regulate microbiota, which may assist relieve manifestations. Over last two decades, there has been surge use probiotics. However, just few research have considered effect probiotic administration on prevention arthritis. Randomized regulated experimental trials shown particular supplement anti-inflammatory benefits, helps people with enhance daily activities alleviates symptoms. As result, utilizing microorganisms therapeutics could be potential possibility for treatment. This review highlights known data preventative effects their interactions.

Language: Английский

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Gut Microbiota and Bone Diseases: A Growing Partnership

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: May 6, 2022

Gut microbiota is key to human health and disease. Convincing studies have demonstrated that dysbiosis in the commensal gut associated with intestinal extra-intestinal diseases. Recent explorations significantly contributed understanding of relationship between bone diseases (osteoporosis, osteoarthritis, rheumatoid arthritis, cancer). its metabolites may become development progression disorders owing their critical role nutrient absorption, immunomodulation, gut-brain-bone axis (regulation hormones). In this work, we review recent developments addressing effect modulation on skeletal explore a feasible preventive approach therapy for

Language: Английский

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Paraprobiotics: definition, manufacturing methods, and functionality

Food Science and Biotechnology, Journal Year: 2023, Volume and Issue: 32(14), P. 1981 - 1991

Published: July 17, 2023

Language: Английский

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Role of the microbiome in regulation of the immune system

Allergology International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Immune health and metabolic functions are intimately connected via diet the microbiota. cells continuously exposed to a wide range of microbes microbial-derived compounds, with important mucosal systemic ramifications. Microbial fermentation dietary components in vivo generates thousands molecules, some which integral molecular circuitry that regulates immune functions. These turn protect against aberrant inflammatory or hyper-reactive processes promote effector responses quickly eliminate pathogens, such as SARS-CoV-2. Potent tolerance mechanisms should ensure these do not over-react non-pathogenic factors (e.g. food proteins), while maintaining ability respond infectious challenges robust, effective well controlled manner. In this review we examine shape microbiota composition interactions host system, their associations mediated disorders strategies for intervention.

Language: Английский

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Probiotic Supplementation for Rheumatoid Arthritis: A Promising Adjuvant Therapy in the Gut Microbiome Era

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: July 23, 2021

Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease that ultimately leads to joint destruction and functional disability. Although the exact etiology of RA not fully understood, it well established gut microbiota (GM) plays vital role in pathogenesis RA, with accumulating evidence suggesting dysbiosis induces response may be linked development. Of interest, patients have significant changes intestinal compared healthy controls, several studies suggested use probiotics as possible adjuvant therapy for RA. Benefits probiotic supplementation were reported animal models human studies, but current regarding effect management remains insufficient make definite recommendations. Several different strains Lactobacillus Bifidobacteria , single species or mixed culture, been investigated, some demonstrated beneficial effects on activity subjects. As now, L.casei bacteria seems strongest candidate application patients. In this review, we highlight GM development progression summarize knowledge potential We also review proposed mechanisms whereby regulate inflammation. Finally, fermented foods discussed alternative supplements since they health benefits.

Language: Английский

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