Journal of Materials Chemistry B,
Journal Year:
2020,
Volume and Issue:
8(31), P. 6517 - 6529
Published: Jan. 1, 2020
Peptides
are
one
of
the
most
important
functional
motifs
for
constructing
smart
drug
delivery
systems
(DDSs).
Functional
peptides
can
be
conjugated
with
drugs
or
carriers
via
covalent
bonds,
assembled
into
DDSs
supramolecular
forces,
which
enables
to
acquire
desired
functions
such
as
targeting
and/or
environmental
responsiveness.
In
this
mini
review,
we
first
introduce
different
types
that
commonly
used
DDSs,
and
highlight
representative
strategies
designing
by
using
in
past
few
years.
We
also
state
challenges
peptide-based
come
up
prospects.
Chemical Reviews,
Journal Year:
2017,
Volume and Issue:
117(10), P. 7132 - 7189
Published: Jan. 26, 2017
Ionic
liquids
are
remarkable
chemical
compounds,
which
find
applications
in
many
areas
of
modern
science.
Because
their
highly
tunable
nature
and
exceptional
properties,
ionic
have
become
essential
players
the
fields
synthesis
catalysis,
extraction,
electrochemistry,
analytics,
biotechnology,
etc.
Apart
from
physical
features
liquids,
high
biological
activity
has
been
attracting
significant
attention
biochemists,
ecologists,
medical
scientists.
This
Review
is
dedicated
to
activities
with
a
special
emphasis
on
potential
employment
pharmaceutics
medicine.
The
accumulated
data
including
antimicrobial
cytotoxic
discussed
view
possible
drug
delivery
systems.
Dedicated
given
novel
active
pharmaceutical
ingredient-ionic
liquid
(API-IL)
concept,
suggests
using
traditional
drugs
form
species.
main
aim
this
attract
broad
audience
chemical,
biological,
scientists
study
advantages
pharmaceutics.
Overall,
highlight
importance
research
direction
defined
as
“Ioliomics”,
studies
ions
chemistry,
biology,
Molecules,
Journal Year:
2017,
Volume and Issue:
22(8), P. 1210 - 1210
Published: July 25, 2017
Medicinal
chemists
continue
to
be
fascinated
by
chalcone
derivatives
because
of
their
simple
chemistry,
ease
hydrogen
atom
manipulation,
straightforward
synthesis,
and
a
variety
promising
biological
activities.
However,
chalcones
have
still
not
garnered
deserved
attention,
especially
considering
high
potential
as
chemical
sources
for
designing
developing
new
effective
drugs.
In
this
review,
we
summarize
current
methodological
developments
towards
the
design
synthesis
state-of-the-art
medicinal
chemistry
strategies
(bioisosterism,
molecular
hybridization,
pro-drug
design).
We
also
highlight
applicability
computer-assisted
drug
approaches
address
how
may
contribute
optimizing
research
outputs
lead
more
successful
cost-effective
discovery
endeavors.
Lastly,
present
examples
use
suggest
possible
solutions
existing
limitations.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(22), P. 12377 - 12449
Published: Jan. 1, 2021
Molecular
photoswitches
are
inherently
lipophilic
and
do
not
spontaneously
dissolve
in
water.
We
describe
the
effect
of
water
on
photochemical
properties
strategies
to
solubilize
organic
apply
them
aqueous
media.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 484 - 484
Published: Feb. 1, 2023
The
oral
route
is
the
most
preferred
for
systemic
and
local
drug
delivery.
However,
delivery
system
faces
harsh
physiological
physicochemical
environment
of
gastrointestinal
tract,
which
limits
bioavailability
targeted
design
system.
Innovative
pharmaceutical
approaches
including
nanoparticulate
formulations,
biomimetic
microfabricated
devices
have
been
explored
to
optimize
targeting
bioavailability.
In
this
review,
anatomical
factors,
biochemical
physiology
factors
that
influence
delivering
via
are
discussed
recent
advance
in
conventional
novel
improving
ability
highlighted.
We
also
address
challenges
opportunities
systems
future.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(17), P. 5436 - 5436
Published: Aug. 25, 2022
In
past
decades,
anticancer
research
has
led
to
remarkable
results
despite
many
of
the
approved
drugs
still
being
characterized
by
high
systemic
toxicity
mainly
due
lack
tumor
selectivity
and
present
pharmacokinetic
drawbacks,
including
low
water
solubility,
that
negatively
affect
drug
circulation
time
bioavailability.
The
stability
studies,
performed
in
mild
conditions
during
their
development
or
under
stressing
exposure
temperature,
hydrolytic
medium
light
source,
have
demonstrated
sensitivity
parameters.
For
this
reason,
formation
degradation
products
is
assessed
both
pharmaceutical
formulations
environment
as
hospital
waste.
To
date,
numerous
been
developed
for
achieving
tissue-specific
targeting
reducing
toxic
side
effects,
well
improving
stability.
prodrugs
represents
a
promising
strategy
targeted
cancer
therapy
selectivity,
efficacy
active
compounds.
Recent
studies
show
incorporation
into
vesicular
systems,
such
polymeric
micelles
cyclodextrins,
use
nanocarriers
containing
chemotherapeutics
conjugate
monoclonal
antibodies
can
improve
pharmacokinetics,
cellular
absorption
study,
we
summarize
latest
advances
knowledge
regarding
effective
highly
stable
formulated
entrapped
nanosystems.
Life,
Journal Year:
2023,
Volume and Issue:
13(5), P. 1099 - 1099
Published: April 27, 2023
A
drug’s
aqueous
solubility
is
defined
as
the
ability
to
dissolve
in
a
particular
solvent,
and
it
currently
major
hurdle
bringing
new
drug
molecules
market.
According
some
estimates,
up
40%
of
commercialized
products
70–90%
candidates
development
stage
are
poorly
soluble,
which
results
low
bioavailability,
diminished
therapeutic
effects,
dosage
escalation.
Because
this,
must
be
taken
into
consideration
when
developing
fabricating
pharmaceutical
products.
To
date,
number
approaches
have
been
investigated
address
problem
poor
solubility.
This
review
article
attempts
summarize
several
conventional
methods
utilized
increase
soluble
drugs.
These
include
principles
physical
chemical
such
particle
size
reduction,
solid
dispersion,
supercritical
fluid
technology,
cryogenic
inclusion
complex
formation
techniques,
floating
granules.
It
includes
structural
modification
(i.e.,
prodrug,
salt
formation,
co-crystallization,
use
co-solvents,
hydrotrophy,
polymorphs,
amorphous
dispersions,
pH
variation).
Various
nanotechnological
liposomes,
nanoparticles,
dendrimers,
micelles,
metal
organic
frameworks,
nanogels,
nanoemulsions,
nanosuspension,
carbon
nanotubes,
so
forth
also
widely
for
enhancement.
All
these
brought
forward
enhancement
bioavailability
orally
administered
drugs
by
improving
water-soluble
However,
issues
not
completely
resolved,
owing
challenges
associated
with
current
approaches,
reproducibility
large
scale
production.
Considering
that
there
no
universal
approach
solving
issues,
more
research
needed
simplify
existing
technologies,
could
commercially
available
employing
techniques.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(8), P. 8687 - 8708
Published: Feb. 13, 2024
The
use
of
carbon
nanotubes
(CNTs),
which
are
nanometric
materials,
in
pathogen
detection,
protection
environments,
food
safety,
and
the
diagnosis
treatment
diseases,
as
efficient
drug
delivery
systems,
is
relevant
for
improvement
advancement
pharmacological
profiles
many
molecules
employed
therapeutics
tissue
bioengineering.
It
has
contributed
to
science
due
development
new
tools
devices
field
medicine.
CNTs
have
versatile
mechanical,
physical,
chemical
properties,
addition
their
great
potential
association
with
other
materials
contribute
applications
different
fields
As,
example,
photothermal
therapy,
ability
convert
infrared
light
into
heat,
engineering,
mechanical
resistance,
flexibility,
elasticity,
low
density,
possible
applications,
biomarkers,
where
electronic
optics
properties
enable
transduction
signals.
This
review
aims
describe
state
art
perspectives
challenges
applying
medical
field.
A
systematic
search
was
carried
out
indexes
Medline,
Lilacs,
SciELO,
Web
Science
using
descriptors
"carbon
nanotubes",
"tissue
regeneration",
"electrical
interface
(biosensors
sensors)",
"photosensitizers",
"photothermal",
"drug
delivery",
"biocompatibility"
"nanotechnology",
"Prodrug
design"
appropriately
grouped.
literature
reviewed
showed
applicability,
but
more
studies
needed
regarding
biocompatibility
CNTs.
data
obtained
point
need
standardized
on
interactions
these
nanostructures
biological
systems.
Chemistry - A European Journal,
Journal Year:
2020,
Volume and Issue:
27(5), P. 1487 - 1513
Published: Sept. 2, 2020
Abstract
Developing
macrocyclic
peptides
that
can
reach
intracellular
targets
is
a
significant
challenge.
This
review
discusses
the
most
recent
strategies
used
to
develop
cell
permeable
cyclic
maintain
binding
their
biological
target
inside
cell.
Macrocyclic
are
unique
from
small
molecules
because
traditional
calculated
physical
properties
unsuccessful
for
predicting
membrane
permeability.
Peptide
synthesis
and
experimental
permeability
only
strategy
effectively
differentiates
between
impermeable
molecules.
Discussed
chemical
strategies,
including
backbone
N‐methylation
stereochemical
changes,
which
have
produced
molecular
scaffolds
with
improved
However,
these
improvements
often
come
at
expense
of
activity
as
modifications
alter
peptide
conformation,
frequently
impacting
compound's
ability
bind
target.
Highlighted
promising
approach,
involves
side‐chain
alterations
improve
without
impact
events.
