Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 360 - 360
Published: March 12, 2025
Background/Objectives:
This
study
aimed
to
develop
and
evaluate
an
anti-pollution
film-forming
spray
(FFS)
containing
coffee
cherry
pulp
extract
(FFS-CCS).
The
formulation
was
designed
create
a
protective
skin
barrier,
improving
health
while
defending
against
environmental
pollutants.
Its
physical
properties,
dust
resistance,
stability,
penetration,
clinical
effectiveness
were
assessed
ensure
optimal
performance
safety.
Methods:
Various
polymers
ternary
solvent
system
used
enhance
the
stability
solubility
of
bioactive
compounds
from
extract.
formulations
characterized
based
on
appearance,
film
formation,
viscosity,
pH,
uniformity,
pattern,
angle,
thickness,
particle
adhesion.
Stability
testing
conducted
under
different
storage
conditions.
Skin
penetration
using
Franz
diffusion
cells
with
Strat-M®
membranes
simulate
human
skin.
A
single-blind,
placebo-controlled
trial
42
participants
over
60
days
effects
FFS-CCS
hydration,
tone,
wrinkle
reduction.
Clinical
assessments
performed
Corneometer,
Mexameter,
Visioscan.
Results:
FFS1-CCS
formulation,
incorporating
PVP
K90
system,
significantly
improved
solubility,
bioavailability
key
(chlorogenic
acid,
caffeine,
theophylline).
Physical
characterization
confirmed
uniform,
transparent
films
viscosity
sprayability.
showed
minimal
degradation.
retention
studies
revealed
enhanced
systemic
absorption.
K90,
along
ethanol
propylene
glycol,
extended
compounds’
residence
time
skin,
ensuring
localized
delivery.
Clinically,
reduced
roughness,
lightened
decreased
erythema.
Conclusions:
utilizing
bioavailability,
extract,
resulting
in
reduction,
tone
enhancement.
These
findings
highlight
potential
as
multifunctional,
sustainable
cosmeceutical
ingredient,
offering
both
anti-aging
protection
benefits,
making
it
promising
solution
for
skincare
applications.
Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
8, P. 101559 - 101559
Published: May 24, 2024
This
comprehensive
review
examines
the
diverse
range
of
uses
gold
nanoparticles
across
numerous
disciplines,
focusing
on
their
distinctive
characteristics
in
catalysis,
thermal
conductivity,
optical
properties,
electrical
and
biological
interactions.
work
emphasizes
crucial
significance
progression
cancer
treatment,
demonstrating
multifunctionality
areas
drug
transport,
photothermal
therapy,
bioimaging,
diagnostic
applications.
Gold
have
demonstrated
utility
improving
accuracy
effectiveness
treatments,
presenting
innovative
approaches
to
address
clinical
obstacles.
Nevertheless,
research
also
discusses
notable
challenges,
including
apprehensions
over
toxicity,
influence
nanoparticle
size,
potential
environmental
repercussions.
These
issues
emphasize
necessity
responsible
administration
fully
exploit
capabilities
context
therapy.
Notwithstanding
these
obstacles,
ultimately
underscores
profound
domains
such
as
monitoring,
renewable
energy,
healthcare,
cosmetics,
biotechnology.
highlights
capacity
mold
future
through
inventive
adaptable
means
ADMET & DMPK,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 26, 2024
Background
and
purpose:
Scientific
research
is
crucial
to
develop
therapies
for
various
disease
severity
levels,
as
modern
drugs
cause
side
effects
are
difficult
predict.
Researchers
exploring
herbal
alternatives
with
fewer
effects,
particularly
propolis,
which
has
been
validated
through
in
vitro,
vivo,
clinical
studies.
This
will
focus
on
scientific
evidence
its
supporting
technology
developing
new
bioactive
compounds
chronic
diseases.
Nanotechnology
can
improve
the
delivery
absorption
of
medicines,
often
have
poor
bioavailability
due
their
high
molecular
weight
solubility
water,
oral
medicines.
enhance
propolis's
multi-target
therapy
reduce
effects.
Experimental
approach:
All
publications
related
each
section
this
review
were
discovered
using
search
engines
Google
Scholar,
Scopus,
Pubmed.
was
only
available
publication
between
2013
2023.
The
selected
used
references
after
being
thoroughly
studied.
Key
results:
Evaluation
propolis
active
compounds,
classification
nano
formulations,
design
concepts,
mechanisms
action
formulation.
Additionally,
challenges
prospects
how
these
insights
be
translated
into
benefits
discussed.
Conclusion:
In
last
ten
years,
a
list
nanoformulation
reported.
concludes
difficulties
encountered
large-scale
nanoformulations.
To
commercialize
them,
improvements
carrier
synthesis,
standardized
evaluation
methodology
within
framework
strategy
process
improvement,
Good
Manufacturing
Practices
would
required.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 3461 - 3473
Published: April 1, 2024
Purpose:
Ivosidenib
(IVO),
an
isocitrate
dehydrogenase-1
(IDH1)
used
for
treatment
of
acute
myeloid
leukemia
(AML)
and
cholangiocarcinoma.However,
poor
solubility,
low
bioavailability,
high
dose
side
effects
limit
clinical
application
IVO.Methods:
Ivosidenib-loaded
PLGA
nanoparticles
(IVO-PLGA-NPs)
chitosan
coated
(IVO-CS-PLGA-NPs)
were
prepared
using
emulsification
solvent
evaporation
method
the
liver
cancer.
Results:The
developed
IVO-PLGA-NPs
evaluated
their
particle
size
(171.7±4.9
nm),
PDI
(0.333),
ZP
(-23.0±5.8
mV),
EE
(96.3±4.3%),
DL
(9.66±1.1%);similarly,
IVO-CS-PLGA-NPs
(177.3±5.2
(0.311),
+25.9±5.7
mV,
(90.8±5.7%),
(9.42±0.7%).The
coating
was
evidenced
by
increase
in
mean
positive
value.Because
coating,
showed
a
more
stable
prolonged
release
IVO
than
IVO-PLGA-NPs.In
comparison
to
pure-IVO,
found
be
effective
against
HepG2
cells,
with
IC
50
values
MTT
assay
being
approximately
half
those
pure-IVO.In
expressions
caspase-3,
caspase-9,
p53
significantly
(p
<
0.05)
elevated.Conclusion:
Overall,
these
findings
suggest
that
improves
delivery
efficacy
ivosidenib
cancer
treatment.
