Antibacterial Activity of Some Flavonoids and Organic Acids Widely Distributed in Plants

Journal of Clinical Medicine, Journal Year: 2019, Volume and Issue: 9(1), P. 109 - 109

Published: Dec. 31, 2019

Among natural substances widespread in fruits, vegetables, spices, and medicinal plants, flavonoids organic acids belong to the promising groups of bioactive compounds with strong antioxidant anti-inflammatory properties. The aim present work was evaluate antibacterial activity 13 common (flavones, flavonols, flavanones) 6 (aliphatic aromatic acids). minimal inhibitory concentrations (MICs) selected plant were determined by micro-dilution method using clinical strains four species pathogenic bacteria. All tested showed antimicrobial properties, but their biological moderate or relatively low. Bacterial growth most strongly inhibited salicylic acid (MIC = 250–500 μg/mL). These generally more active against Gram-negative bacteria: Escherichia coli Pseudomonas aeruginosa than Gram-positive ones: Enterococcus faecalis Staphylococcus aureus. An analysis effect flavone, chrysin, apigenin, luteolin that presence hydroxyl phenyl rings A B usually did not influence on level activity. significant increase hydroxy derivatives flavone observed only for S. Similarly, position sugar group glycosides had no MIC values.

Language: Английский

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Propolis as a novel antibacterial agent

Saudi Journal of Biological Sciences, Journal Year: 2020, Volume and Issue: 27(11), P. 3079 - 3086

Published: Sept. 14, 2020

Propolis (bee glue) is a bee glue, sticky resinous material released from various plant sources such as bud exudates, flowers, and leaves modified by secretions wax propolis composed of resins, waxes, polyphenols, polysaccharides, volatile materials, secondary metabolites that are responsible for bioactivity antibacterial, anti-angiogenic, antiulcer, anti-inflammatory, antioxidant, anti-viral activities. The physico-chemical characteristics the natural properties kinds have been studied past decade. Novel active anti-microbial compounds identified in propolis. Those positively modulated antimicrobial resistance multidrug resistant bacteria. Published research has indicated its derivatives many with broad spectrum against different types bacteria it enhanced efficacy conventional antibiotics. Besides, combination other honey whereby, combinations synergistic effect bacterial strains Escherichia coli Staphylococcus aureus. activity very much dependent on seasonal regional factors, Middle Eastern shown best antibacterial efficacy. main flavonoids ingredients should not be overlooked evaluated clinical trials to better elucidate their potential application fields medicine. Clinical use new drugs biotechnological products conducted. This review aims at highlighting some recent scientific findings associated components.

Language: Английский

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Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Sept. 6, 2021

Due to the increasing prevalence of life-threatening bacterial, fungal and viral infections ability these human pathogens develop resistance current treatment strategies, there is a great need find new compunds combat them. These molecules must have low toxicity, specific activity high bioavailability. The most suitable compounds for this task are usually derived from natural sources (animal, plant or even microbial). In review article, latest promising used bacteria, filamentous fungi viruses presented evaluated. include extracts, essential oils, small antimicrobial peptides animal origin, bacteriocins various groups (triterpenoids; alkaloids; phenols; flavonoids) with antiviral activity. Data on inhibitory each substance putative mechanism action against bacterial strains. results show that among bioactive studied, triterpenoids significant coronaviruses, but flavonoids also been shown inhibit SARS-COV-2. last chapter devoted nanocarriers improve stability, bioavailability, cellular uptake/internalization, pharmacokinetic profile reduce toxicity compunds. There number such as liposomes, drug delivery microemulsion systems, nanocapsules, solid lipid nanoparticles, polymeric micelles, dendrimers, etc. However, some recent studies focused incorporation substances antimicrobial/antiviral into niosomes silver nanoparticles (which intrinsic activity). antimicrobials isolated animals microorganisms good effect range pathogens, however plants remain prolific source. Even if majority biological evaluation in silico vitro , their internalization optimum represents future “green therapeutics” by work field.

Language: Английский

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A Novel Bilayer Wound Dressing Composed of a Dense Polyurethane/Propolis Membrane and a Biodegradable Polycaprolactone/Gelatin Nanofibrous Scaffold

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Feb. 20, 2020

One-layer wound dressings cannot meet all the clinical needs due to their individual characteristics and shortcomings. Therefore, bilayer which are composed of two layers with different properties have gained lots attention. In present study, polycaprolactone/gelatin (PCL/Gel) scaffold was electrospun on a dense membrane polyurethane ethanolic extract propolis (PU/EEP). The PU/EEP used as top layer protect area from external contamination dehydration, while PCL/Gel sublayer facilitate cells' adhesion proliferation. dressing investigated regarding its microstructure, mechanical properties, surface wettability, anti-bacterial activity, biodegradability, biocompatibility, efficacy in animal model histopathological analyzes. Scanning electron micrographs exhibited uniform morphology bead-free structure average fibers' diameter 237.3 ± 65.1 nm. Significant activity observed against Staphylococcal aureus (5.4 0.3 mm), Escherichia coli (1.9 0.4 mm) Staphylococcus epidermidis (1.0 0.2 according inhibition zone test. high hydrophilicity (51.1 4.9°), biocompatibility. could significantly accelerate closure collagen deposition Wistar rats' skin model. Taking together, PU/EEP-PCL/Gel can be potential candidate for biomedical applications remarkable antibacterial features, healing activities.

Language: Английский

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Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects

Antibiotics, Journal Year: 2022, Volume and Issue: 11(8), P. 1014 - 1014

Published: July 28, 2022

It is accepted that the medicinal use of complex mixtures plant-derived bioactive compounds more effective than purified due to beneficial combination interactions. However, synergy and antagonism are very difficult study in a meticulous fashion since most established methods were designed reduce complexity identify single compounds. This represents critical review current scientific literature on combined effects extracts/bioactive A particular emphasis provided identification antimicrobial synergistic or antagonistic combinations using recent metabolomics elucidation approaches identifying potential mechanisms underlie their Proven examples synergistic/antagonistic activity also discussed. The focus put challenges, difficulties, problems need be overcome future perspectives surrounding effects. utilization from plant extracts as appropriate antimicrobials important needs facilitated by means new technologies discover among them. Understanding nature interactions between will result development therapies.

Language: Английский

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Essential Oils of Lamiaceae Family Plants as Antifungals

Biomolecules, Journal Year: 2020, Volume and Issue: 10(1), P. 103 - 103

Published: Jan. 7, 2020

The incidence of fungal infections has been steadily increasing in recent years. Systemic mycoses are characterized by the highest mortality. At same time, frequency caused drug-resistant strains and new pathogens e.g., Candida auris increases. An alternative to medicines may be essential oils, which can have a broad antimicrobial spectrum. Rich oils plants from Lamiaceae family. In this review presented antifungal activities 72 plants. More than half these good activity (minimum inhibitory concentrations (MICs) < 1000 µg/mL) against fungi. best (MICs 100) some species genera Clinopodium, Lavandula, Mentha, Thymbra, Thymus. cases were observed significant discrepancies between different studies. also shown most important compounds described oils. To chemical components commonly found as main ingredients include β-caryophyllene (41 plants), linalool (27 limonene (26), β-pinene (25), 1,8-cineole (22), carvacrol (21), α-pinene p-cymene (20), γ-terpinene thymol (20).

Language: Английский

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Active packaging films and edible coatings based on polyphenol‐rich propolis extract: A review

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2021, Volume and Issue: 20(2), P. 2106 - 2145

Published: Jan. 23, 2021

Abstract The development of active packaging films and edible coatings based on biopolymers natural bioactive substances has received increasing attention in recent years. Propolis, also called bee glue, is a resin substance collected by worker‐bees from the mucilage, gum, several plants. In food industry, propolis commonly extracted solvents to afford polyphenol‐rich extract with potent antimicrobial antioxidant activities. prepared can be mixed biopolymers, plasticizers, emulsifiers, reinforcing agents develop coatings. functionality closely related type, harvesting method, geographic origin, extraction method conditions propolis, content composition polyphenolic compounds extract, presence other substances. Active impact physical, biochemical, sensory properties (e.g., fruits, vegetables, meat, fish) during storage. This review focuses advances extract. structural characterization, functionality, potential applications summarized.

Language: Английский

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Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review

Foods, Journal Year: 2021, Volume and Issue: 10(6), P. 1360 - 1360

Published: June 11, 2021

Propolis is a complex phytocompound made from resinous and balsamic material harvested by bees flowers, branches, pollen, tree exudates. Humans have used propolis therapeutically for centuries. The aim of this article to provide comprehensive review the antiviral, antibacterial, antifungal, antiparasitic properties propolis. mechanisms action are discussed. There two distinct impacts with regards antimicrobial anti-parasitic propolis, on pathogens host. With pathogens, acts disrupting ability invade host cells forming physical barrier inhibiting enzymes proteins needed invasion into cells. also inhibits replication process pathogens. Moreover, metabolic processes cellular organelles components responsible energy production. regard host, functions as an immunomodulator. It upregulates innate immunity modulates inflammatory signaling pathways. helps maintain host’s antioxidant status. More importantly, small number human clinical trials demonstrated efficacy safety adjuvant therapy pathogenic infections.

Language: Английский

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Anticancer Activity of Propolis and Its Compounds

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2594 - 2594

Published: July 28, 2021

Propolis is a natural material that honey bees (Apis mellifera) produce from various botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Cancer one the major burdens disease worldwide, therefore, numerous studies are being conducted to develop new chemotherapeutic agents treatments for cancer. rich source biologically active compounds, which affect signaling pathways regulating crucial cellular processes. results latest research show propolis can inhibit proliferation, angiogenesis, metastasis cancer cells stimulate apoptosis. Moreover, it may influence tumor microenvironment multidrug resistance cancers. This review briefly summarizes molecular mechanisms anticancer its compounds highlights potential benefits reduce side effects chemotherapy radiotherapy.

Language: Английский

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Propolis Extract and Its Bioactive Compounds—From Traditional to Modern Extraction Technologies

Molecules, Journal Year: 2021, Volume and Issue: 26(10), P. 2930 - 2930

Published: May 14, 2021

Propolis is a honeybee product known for its antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. It rich in bioactive molecules whose content varies depending on the botanical geographical origin of propolis. These have been studied individually as part propolis extracts, they can be used representative markers standardization. Here, we compare pharmacological effects polyphenols whole extracts. Based literature data, extracts act by suppressing similar targets, from pro-inflammatory TNF/NF-κB to pro-proliferative MAPK/ERK pathway. In addition, activate antioxidant mechanisms action, like Nrf2-ARE intracellular pathway, all activity. similarities do not imply that should attribute action solely most compounds. Moreover, will depend efficacy these compounds’ extraction. Thus, also give an overview different extraction technologies, traditional modern ones, which are environmentally friendlier. technologies belong open research area needs further effective solutions terms well-standardized liquid solid would reliable their effects, friendly, sustainable production.

Language: Английский

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