Propolis: Its Role and Efficacy in Human Health and Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(18), P. 6120 - 6120

Published: Sept. 19, 2022

With technological advancements in the medicinal and pharmaceutical industries, numerous research studies have focused on propolis produced by stingless bees (Meliponini tribe) Apis mellifera honeybees as alternative complementary medicines for potential treatment of various acute chronic diseases. Propolis can be found tropical subtropical forests throughout world. The composition phytochemical constituents varies depending bee species, geographical location, botanical source, environmental conditions. Typically, contains lipid, beeswax, essential oils, pollen, organic components. latter include flavonoids, phenolic compounds, polyphenols, terpenes, terpenoids, coumarins, steroids, amino acids, aromatic acids. biologically active propolis, which countless compounds such artepillin C, caffeic acid, acid phenethyl ester, apigenin, chrysin, galangin, kaempferol, luteolin, genistein, naringin, pinocembrin, coumaric quercetin, a broad spectrum biological therapeutic properties antidiabetic, anti-inflammatory, antioxidant, anticancer, rheumatoid arthritis, obstruct pulmonary disorders, cardiovascular diseases, respiratory tract-related gastrointestinal well neuroprotective, immunomodulatory, immuno-inflammatory agents. Therefore, this review aims to provide summary recent role its constituents, their efficacy

Language: Английский

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Targeted therapies for breast and lung cancers by using Propolis loaded albumin protein nanoparticles

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129338 - 129338

Published: Jan. 15, 2024

Language: Английский

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Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10479 - 10479

Published: Sept. 9, 2022

In recent years, interest in natural products such as alternative sources of pharmaceuticals for numerous chronic diseases, including tumors, has been renewed. Propolis, a product collected by honeybees, and polyphenolic/flavonoid propolis-related components modulate all steps the cancer progression process. Anticancer activity propolis its compounds relies on various mechanisms: cell-cycle arrest attenuation cells proliferation, reduction number stem cells, induction apoptosis, modulation oncogene signaling pathways, inhibition matrix metalloproteinases, prevention metastasis, anti-angiogenesis, anti-inflammatory effects accompanied tumor microenvironment (by modifying macrophage activation polarization), epigenetic regulation, antiviral bactericidal activities, gut microbiota, chemotherapy-induced deleterious side effects. Ingredients from also ”sensitize“ to chemotherapeutic agents, likely blocking transcription factor nuclear kappa-light-chain-enhancer activated B (NF-κB). this review, we summarize current knowledge related flavonoids other polyphenolic growth metastasizing ability, discuss possible molecular cellular mechanisms involved inflammatory pathways processes that affect survival, invasion, angiogenesis, metastasis tumor.

Language: Английский

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Propolis and Their Active Constituents for Chronic Diseases

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 259 - 259

Published: Jan. 18, 2023

Propolis is a mass of chemically diverse phytoconstituents with gummy textures that are naturally produced by honeybees upon collection plant resins for utilization in various life processes beehives. Since ancient times, propolis has been unique traditional remedy globally utilized several purposes, and it secured value pharmaceutical nutraceutical areas recent years. The chemical composition comprises constituents deviations the precise honeybee species, source used production bees, climate conditions harvesting season. Over 300 molecular structures have discovered from propolis, important classes include phenolic acids, flavonoids, terpenoids, benzofurans, benzopyrene chalcones. also reported to pharmacological activities, such as antidiabetic, anti-inflammatory, antioxidant, anticancer, immunomodulatory, antibacterial, antiviral, antifungal, anticaries. As chronic diseases risen global health threat, abundant research conducted track its alternative therapies diseases. Several clinical trials revealed potency preventing curing some This review explores beneficial effect active credible mechanisms computational studies on

Language: Английский

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Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 390 - 390

Published: Feb. 24, 2024

Aging populations worldwide are placing age-related diseases at the forefront of research agenda. The therapeutic potential natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular molecular-level changes associated with diseases. With this in mind, scientists have introduced a contextual framework guide future aging research, called hallmarks aging. This encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, altered intercellular communication. Propolis, rich array bioactive compounds, functions as potent functional food, modulating metabolism, gut microbiota, immune response, offering significant health benefits. Studies emphasize propolis' properties, such antitumor, cardioprotective, neuroprotective effects, well ability mitigate oxidative stress, DNA damage, pathogenic bacteria growth. article underscores current scientific evidence supporting role controlling molecular characteristics linked hallmarks, hypothesizing geroscience research. aim is discover novel strategies improve quality life older individuals, addressing existing deficits perspectives area.

Language: Английский

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Current Strategies in Controlling Aspergillus flavus and Aflatoxins in Grains during Storage: A Review

Sustainability, Journal Year: 2024, Volume and Issue: 16(8), P. 3171 - 3171

Published: April 10, 2024

Aspergillus flavus is a ubiquitous pathogen that can infect many foods and grains, it produces large amounts of aflatoxins during their storage. Aflatoxins are considered highly toxic carcinogenic to humans, they cause great damage crop production, food security, human health. Thus, controlling A. in grains presents challenge humans worldwide. Over the past decade, strategies have been demonstrated be useful These methods involve physical agents, chemical biological etc. Some these currently used actual production. In this review, we summarize reported for storage ten years elucidate advantages disadvantages. The discussed include irradiation technology; low oxygen atmospheres; fungicides (benzalkonium chloride, iodine, ammonium bicarbonate, phenolic azole compounds); agents from plants, animals, micro-organisms; aflatoxin elimination methods. We expect review will promote applications current development novel technologies prevent or eliminate feed

Language: Английский

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Combination of Indomethacin with Nanostructured Lipid Carriers for Effective Anticancer Therapy

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7033 - 7048

Published: July 1, 2024

Purpose: The anticancer potential of indomethacin and other nonsteroidal anti-inflammatory drugs (NSAIDs) in vitro, vivo, clinical trials is well known widely reported the literature, along with their side effects, which are mainly observed gastrointestinal tract. Here, we present a strategy for application old drug as an agent by encapsulating it nanostructured lipid carriers (NLC). We describe production method IND-NLC, physicochemical parameters, results antiproliferative activity against selected cancer cell lines, were found to be higher compared free indomethacin. Methods: IND-NLC fabricated using hot high-pressure homogenization method. nanocarriers physicochemically characterized, biopharmaceutical behaviour therapeutic efficacy evaluated vitro. Results: Lipid nanoparticles exhibited particle size 168.1 nm, negative surface charge (– 30.1 mV), low polydispersity index (PDI 0.139), high encapsulation efficiency (over 99%). stable over 60 days retained integrity during storage at 4 °C 25 °C. benefits screened vitro models, where encapsulated effectively inhibited growth breast line MDA-MB-468 dosage 15.7 μM. Conclusion: successfully developed delivery cells confirmed antitumoral studies. suggest that possesses potential. Moreover, presented highly promising may offer new alternative future innovations. Keywords: nanoparticles, indomethacin, activity, tumor-targeting

Language: Английский

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Effect of Propolis on PPP2R1A and Apoptosis in Cancer Cells

Biochemistry Research International, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Recently, it has been shown that protein phosphatase 2A (PP2A) dysfunction was common in many cancer types and mediated by various inactivation mechanisms. Although research studies observed antitumor effect of propolis extracts cancer, the mechanism are still obscure. In this study, we investigated on PPP2R1A expression its relationship with apoptosis SW‐620 (colorectal cancer), DU‐145 PC‐3 (prostate MCF‐7 (breast cancer) cell lines, WI‐38 (healthy fibroblast) cells serving as control. Moreover, aimed to investigate impact analyzing markers such tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL), APAF‐1, caspases‐3, ‐8, ‐9. Propolis samples were extracted, their phenolic compounds quantified using LC‐MS/MS. The RealTime Cell Analysis System‐xCELLigence (RTCA‐SP) device software employed assess viability cytotoxicity samples. IC 50 values for determined (298 μg/mL SW‐620, 185.6 DU‐145, 250.7 PC − 3, 292.9 MCF‐7, 311.2 WI‐38). Subsequently, effects (TRAIL, Apaf‐1, ‐9) analyzed. When compared healthy lines a statistically significant increase caspase‐3 (3.62‐fold) TRAIL (4.38‐fold) line after application propolis. addition, line, 1.4‐fold caspase‐8 which is also significant. Our findings indicated increased levels lines. It suggested high induced treatment might activate pathway. inducible levels, identified new target treatment, demonstrated first time. suggest holds promise potential therapy increasing key molecule treatment.

Language: Английский

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Brazilian Stingless Bee Geopropolis Exhibits Antioxidant Properties and Anticancer Potential Against Hepatocellular Carcinoma Cells

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 141 - 141

Published: Jan. 24, 2025

Hepatocellular carcinoma (HCC) is the third most common cancer in terms of mortality and sixth incidence worldwide. Treatment varies by tumor stage, but low survival rates are across all stages. Due to these poor outcomes, there a critical need for new treatment options lead compounds, prompting an active search. Geopropolis has been identified as source bioactive compounds with various pharmacological activities, including anticancer effects against different types cancer. Since stingless bees may be selective native botanical species, geopropolis they produce can have unusual chemical profile. In this study, we report antioxidant properties potential extracts produced Melipona bicolor, M. marginata, mondury using 2D- 3D- cell culture models. The profile samples UPLC-QTOF HRMS/MS indicated ferreirin dihydrokaempferide main flavonoids, along cupressic acid 15-acetoxyisocupressic abundant diterpenoids. Interestingly, artepillin C, component green propolis, was also detected. showed good viability inhibition selectivity indices comparison cisplatin used HCC option. capacity high correlated cytotoxic effect cells. Investigations into mechanisms show ability induce apoptosis suppress clonogenic lines. We observed spheroid formation, viability, morphology alterations. This first time described panel

Language: Английский

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Antifungal Properties of Chemically Defined Propolis from Various Geographical Regions

Microorganisms, Journal Year: 2022, Volume and Issue: 10(2), P. 364 - 364

Published: Feb. 4, 2022

Long-term fungal infections that are difficult to treat require new substances for their prevention, treatment, or as adjuvants during antibiotic therapy. Propolis is a very promising source of natural show wide range pharmacological properties, including antifungal activity against various strains. The purpose the literature review was summarize recent studies (PubMed, Scopus) on progress in evaluating chemically defined propolis extracts. During selection studies, only those with results expressed minimal inhibitory concentration (MIC) and/or fungicidal (MFC) were analyzed. Moreover, plant, animal and environmental factors influencing chemical composition discussed. Mechanisms extracts research trends aspect developing therapies assessment drug interactions indicated. shows there great definition After comparing MIC/MFC values, it assessed offer not pathogenic Candida strains but also risky molds; however, strength this varied.

Language: Английский

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