Synthesis of Lobeglitazone intermediates seeking for continuous drug production in flow capillary microreactor DOI
Renan Rodrigues de Oliveira Silva, Paulo Victor Cuesta Calvo,

Christian Adrian Merfels

et al.

Journal of Industrial and Engineering Chemistry, Journal Year: 2022, Volume and Issue: 116, P. 239 - 249

Published: Sept. 16, 2022

Language: Английский

Oscillatory flow reactors for synthetic chemistry applications DOI Creative Commons
Pauline Bianchi, Jason D. Williams, C. Oliver Kappe

et al.

Journal of Flow Chemistry, Journal Year: 2020, Volume and Issue: 10(3), P. 475 - 490

Published: July 28, 2020

Abstract Oscillatory flow reactors (OFRs) superimpose an oscillatory to the net movement through a reactor. OFRs have been engineered enable improved mixing, excellent heat- and mass transfer good plug character under broad range of operating conditions. Such features render these appealing, since they are suitable for reactions that require long residence times, (such as in biphasic liquid-liquid systems) or homogeneously suspend solid particles. Various OFR configurations, offering specific features, developed over past two decades, with significant progress still being made. This review outlines principles recent advances technology overviews synthetic applications solid-liquid systems.

Language: Английский

Citations

94

Synthesis of cyclic carbonates from CO2 cycloaddition to bio-based epoxides and glycerol: an overview of recent development DOI Creative Commons

Muhammad Usman,

Abdul Rehman, Faisal Saleem

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(33), P. 22717 - 22743

Published: Jan. 1, 2023

Anthropogenic carbon dioxide (CO 2 ) emissions contribute significantly to global warming and deplete fossil resources, prompting a shift bio-based raw materials.

Language: Английский

Citations

32

Towards Industrially Important Applications of Enhanced Organic Reactions by Microfluidic Systems DOI Creative Commons
Ayesha Zafar,

China Takeda,

Asif Manzoor

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(2), P. 398 - 398

Published: Jan. 13, 2024

This review presents a comprehensive evaluation for the manufacture of organic molecules via efficient microfluidic synthesis. Microfluidic systems provide considerably higher control over growth, nucleation, and reaction conditions compared with traditional large-scale synthetic methods. synthesis has become crucial technique quick, affordable, organometallic compounds complicated characteristics functions. Therefore, unique, straightforward flow methodology can be developed to conduct syntheses improve their efficiency.

Language: Английский

Citations

12

Influence of fluid rheology on multistability in the unstable flow of polymer solutions through pore constriction arrays DOI

Emily Y. Chen,

Sujit S. Datta

Journal of Rheology, Journal Year: 2025, Volume and Issue: 69(2), P. 235 - 249

Published: March 1, 2025

Diverse chemical, energy, environmental, and industrial processes involve the flow of polymer solutions in porous media. The accumulation dissipation elastic stresses as polymers are transported through tortuous, confined pore space can lead to development an instability above a threshold rate, producing transition from steady unsteady characterized by strong spatiotemporal fluctuations, despite low Reynolds number (Re≪1). Furthermore, 1D ordered arrays constrictions, this undergo second multistability, where distinct pores simultaneously exhibit states. Here, we examine how multistability is influenced fluid rheology. Through experiments using diverse having systematic variations shear-thinning or elasticity, constriction varying geometries, show that onset be described single dimensionless parameter, given sufficient elasticity. This streamwise Deborah number, compares stress relaxation time solution required for advected between constrictions. Our work thus helps deepen understanding influence rheology on instabilities, helping establish guidelines rational design polymeric fluids with desirable behaviors.

Language: Английский

Citations

1

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries DOI Creative Commons
Guido Gambacorta,

James S. Sharley,

Ian R. Baxendale

et al.

Beilstein Journal of Organic Chemistry, Journal Year: 2021, Volume and Issue: 17, P. 1181 - 1312

Published: May 18, 2021

Due to their intrinsic physical properties, which includes being able perform as volatile liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal candidates for continuous-flow manufacturing. This review highlights the potential crossover between a multibillion dollar industry flourishing sub-field of flow chemistry evolving within discipline organic synthesis. is illustrated through selected examples industrially important transformations specific fragrances flavours by highlighting advantages conducting these using approach. designed be compendium techniques apparatus already published in chemical engineering literature would constitute known solution or inspiration commonly encountered procedures manufacture flavour chemicals.

Language: Английский

Citations

53

Harnessing elastic instabilities for enhanced mixing and reaction kinetics in porous media DOI Creative Commons
Christopher Browne, Sujit S. Datta

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(29)

Published: July 9, 2024

Turbulent flows have been used for millennia to mix solutes; a familiar example is stirring cream into coffee. However, many energy, environmental, and industrial processes rely on the mixing of solutes in porous media where confinement suppresses inertial turbulence. As result, drastically hindered, requiring fluid permeate long distances appreciable introducing additional steps drive that can be expensive environmentally harmful. Here, we demonstrate this limitation overcome just by adding dilute amounts flexible polymers fluid. Flow-driven stretching generates an elastic instability, driving turbulent-like chaotic flow fluctuations, despite pore-scale prohibits typical Using situ imaging, show these fluctuations stretch fold within pores along thin layers (“lamellae”) characterized sharp solute concentration gradients, diffusion pores. This process results 3 × reduction required length, 6 increase transverse dispersivity, harnessed rate at which chemical compounds react 5 —enhancements rationalize using turbulence-inspired modeling underlying transport processes. Our work thereby establishes simple, robust, versatile, predictive way media, with potential applications ranging from large-scale production environmental remediation.

Language: Английский

Citations

8

From circular synthesis to material manufacturing: advances, challenges, and future steps for using flow chemistry in novel application area DOI
Alessandra Sivo, Renan Galaverna, Gustavo Gomes

et al.

Reaction Chemistry & Engineering, Journal Year: 2020, Volume and Issue: 6(5), P. 756 - 786

Published: Dec. 16, 2020

We review the emerging use of flow technologies for circular chemistry and material manufacturing, highlighting advances, challenges, future directions.

Language: Английский

Citations

45

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients DOI
Cloudius R. Sagandira,

Sinazo Nqeketo,

Kanyisile Mhlana

et al.

Reaction Chemistry & Engineering, Journal Year: 2021, Volume and Issue: 7(2), P. 214 - 244

Published: Dec. 30, 2021

The convergence of end-to-end continuous flow synthesis with downstream processing, process analytical technology (PAT), artificial intelligence (AI), machine learning and automation in ensuring improved accessibility quality medicines on demand.

Language: Английский

Citations

38

Modern advancements in continuous-flow aided kinetic analysis DOI
Connor J. Taylor, Jamie A. Manson,

Graeme Clemens

et al.

Reaction Chemistry & Engineering, Journal Year: 2022, Volume and Issue: 7(5), P. 1037 - 1046

Published: Jan. 1, 2022

Although kinetic analysis has traditionally been conducted in a batch vessel, continuous-flow aided continues to swell popularity.

Language: Английский

Citations

27

Flow-Injection Methods in Water Analysis—Recent Developments DOI Creative Commons
Marek Trojanowicz, Marta Pyszynska

Molecules, Journal Year: 2022, Volume and Issue: 27(4), P. 1410 - 1410

Published: Feb. 19, 2022

Widespread demand for the analysis and control of water quality supply human activity ecosystem sustainability has necessitated continuous improvement methods in terms their reliability, efficiency, costs. To satisfy these requirements, flow-injection using different detection successfully been developed recent decades. This review, based on about 100 original research papers, presents achievements this field over past ten years. Various methodologies establishing measurements are reviewed, together with microfluidics portable systems. The applications mostly concern not only determination inorganic analytes but also speciation elements, several total indices quality. Examples organic residues (e.g., pesticides, phenolic compounds, surfactants) natural surface waters, seawater, groundwater, drinking have identified. Usually, changes format manual procedures results various operational parameters, such as limits detection, sampling rate, or selectivity matrices.

Language: Английский

Citations

26