Near-infrared photodynamic and photothermal co-therapy based on organic small molecular dyes

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 27, 2023

Abstract Near-infrared (NIR) organic small molecule dyes (OSMDs) are effective photothermal agents for therapy (PTT) due to their advantages of low cost and toxicity, good biodegradation, strong NIR absorption over a wide wavelength range. Nevertheless, OSMDs have limited applicability in PTT conversion efficiency inadequate destruction tumor regions that nonirradiated by light. However, they can also act as photosensitizers (PSs) produce reactive oxygen species (ROS), which be further eradicated using ROS-related therapies address the above limitations PTT. In this review, synergistic mechanism, composition, properties photodynamic (PDT)–PTT nanoplatforms were comprehensively discussed. addition, some specific strategies improving combined PDT based on cancer completely eradicate cells outlined. These include performing image-guided co-therapy, enhancing infiltration, increasing H 2 O or microenvironment, loading anticancer drugs onto enable with phototherapy chemotherapy. Meanwhile, intriguing prospects challenges treatment modality summarized focus future trends its clinical application. Graphical

Language: Английский

---

Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 31, 2025

Language: Английский

---

Nanomaterials: Synthesis and Applications in Theranostics

Nanomaterials, Journal Year: 2021, Volume and Issue: 11(12), P. 3228 - 3228

Published: Nov. 28, 2021

Nanomaterials are endowed with unique features and essential properties suitable for employing in the field of nanomedicine. The nanomaterials can be classified as 0D, 1D, 2D, 3D based on their dimensions. malleable ductile they drawn into wires sheets. Examples quantum dots (0D), nanorods, nanowires (1D), nanosheets (2D), nanocubes (3D). These synthesized using top-down bottom-up approaches. achievements 0D 1D used to detect trace heavy metal (e.g., Pb

Language: Английский

---

Combinatorial Therapeutic Approaches with Nanomaterial-Based Photodynamic Cancer Therapy

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(1), P. 120 - 120

Published: Jan. 4, 2022

Photodynamic therapy (PDT), in which a light source is used combination with photosensitizer to induce local cell death, has shown great promise therapeutically targeting primary tumors negligible toxicity and minimal invasiveness. However, numerous studies have that noninvasive PDT alone not sufficient completely ablate deep tissues, due its inherent shortcomings. Therefore, depending on the characteristics type of tumor, can be combined surgery, radiotherapy, immunomodulators, chemotherapy, and/or targeted therapy, preferably patient-tailored manner. Nanoparticles are attractive delivery vehicles overcome shortcomings traditional photosensitizers, as well enable codelivery multiple therapeutic drugs spatiotemporally controlled Nanotechnology-based strategies provided inspiration improve anticancer effects PDT. Here, we briefly introduce mechanism summarize photosensitizers been tested preclinically for various cancer types clinically approved treatment. Moreover, discuss current challenges facing treatment options, highlight opportunities nanoparticle-based therapies.

Language: Английский

---

In vitro biocompatibility and drug release of collagen-mo-complexes hydrogels for tissue engineering

Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

---

Copper Oxide Nanoparticle-Decorated Carbon Nanoparticle Composite Colloidal Preparation through Laser Ablation for Antimicrobial and Antiproliferative Actions against Breast Cancer Cell Line, MCF-7

BioMed Research International, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 13

Published: March 8, 2022

Copper oxide (CuO) nanoparticle- (NP-) decorated carbon NPs (CNPs) were produced as colloidal suspension through pulsed laser ablation technique in liquid (PLAL) medium. The antimicrobial activity of the was tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), anticancer breast cancer cell line, MCF-7, together with biocompatibility assessment these NPs. X-ray diffraction (XRD) patterns obtained CNPs showed peaks at 26.58° 43.78° (2θ) identical to (002) (111) planes, respectively, phases. It also displayed new 38.5° 48.64° after doping CuO Transmission electron microscope (TEM) images revealed crystalline nature spherical shape prepared 5-40 nm diameter ranges. In addition, NP effects on bacterial walls nucleic acid confirmed using a scanning (SEM) microscopic fluorescence analysis. antibacterial SEM examinations pathogenic microbial species, S. E. coli. cellular material release assay, optical density cells, treated NPs, significant increase time exposure cytotoxicity reached more than 80% level for morphology MCF-7 cells decreased numbers, loss contact surrounding observed. These results that have no observable side can be safely used therapeutic applications. is noteworthy it first report preparation (CuO NPs-CNPs) by PLAL, antiproliferative activities lines, MCF-7. main advantage PLAL synthesizing NPs-CNPs provided two-step, cost-effective, eco-friendly method.

Language: Английский

---

Polyamidoamine-Carbon Nanodot Conjugates with Bioreducible Building Blocks: Smart Theranostic Platforms for Targeted siRNA Delivery

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(2), P. 1191 - 1204

Published: Jan. 5, 2024

This study focuses on designing hybrid theranostic nanosystems, utilizing gadolinium-doped carbon nanodots decorated with bioreducible amphoteric polyamidoamines (PAAs). The objective is to synergize the exceptional properties of (CDs) siRNA complexation capabilities PAAs. Linear copolymeric polyamidoamines, based N,N′-bis(acryloyl)cystamine, arginine, and agmatine, were synthesized, resulting in three distinct copolymers. Notably, sulfur bridges within PAA repeating units confer pronounced susceptibility glutathione-mediated degradation─a key attribute tumor microenvironment. pathway enables controlled stimuli-responsive release, theoretically providing precise spatiotemporal control over therapeutic interventions. selected PAA, conjugated CDs using redox-sensitive spacer cystamine, formed CDs-Cys-PAA conjugate superior complexing capacity. Stable against polyanion exchange, CDs-Cys-PAA/siRNA complex released presence GSH. In vitro studies assessed cytocompatibility, internalization, gene silencing efficacy HeLa, MCF-7, 16HBE cell lines.

Language: Английский

---

Decagram-Scale Synthesis of Multicolor Carbon Nanodots: Self-Tracking Nanoheaters with Inherent and Selective Anticancer Properties

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(2), P. 2551 - 2563

Published: Jan. 5, 2022

Carbon nanodots (CDs) are a new class of carbon-based nanoparticles endowed with photoluminescence, high specific surface area, and good photothermal conversion, which have spearheaded many breakthroughs in medicine, especially drug delivery cancer theranostics. However, the tight control their structural, optical, biological properties synthesis scale-up been very difficult so far. Here, we report for first time an efficient protocol one-step decagram-scale quantities N,S-doped CDs narrow size distribution, along single nanostructure multicolor emission, near-infrared (NIR) conversion efficiency, selective reactive oxygen species (ROS) production cells. This allows achieving targeted multimodal cytotoxic effects (i.e., oxidative stresses) cells by applying biocompatible NIR laser sources that can be remotely controlled under guidance fluorescence imaging. Hence, our findings open up range possibilities real-world biomedical applications, among is In this work, indocyanine green used as bidentate SOx donor has ability to tune groups emission bands obtained solvothermal decomposition citric acid urea N,N-dimethylformamide. The co-doping implies various states providing transitions visible region, thus eliciting tunable from blue red excellent efficiency region useful bioimaging applications image-guided anticancer phototherapy. self-tracking capability SOx-CDs reveals they enter more quickly than healthy cell lines undergo different intracellular fate after internalization. could explain why sulfur doping entails pro-oxidative activities triggering ROS generation when compared lines. We also find stress locally enhanced at moderate power density (2.5 W cm-2). Overall, these suggest inherent drug-independent toward cells, would selectively external light irradiation helpful precision approaches. Also, work opens debate on role CD engineering determining nanotoxicity function metabolism, allowing rational design next-generation nanomaterials properties.

Language: Английский

---

Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(20), P. 3706 - 3706

Published: Oct. 21, 2022

With the urgent need for bio-nanomaterials to improve currently available cancer treatments, gold nanoparticle (GNP) hybrid nanostructures are rapidly rising as promising multimodal candidates therapy. Gold nanoparticles (GNPs) have been hybridized with several nanocarriers, including liposomes and polymers, achieve chemotherapy, photothermal therapy, radiotherapy, imaging using a single composite. The GNP nanohybrids used targeted chemotherapy can be designed respond external stimuli such heat or internal intratumoral pH. Despite their promise there no reviews summarizing current status of nanohybrid use theragnostics. Therefore, this review fulfills gap in literature by providing critical analysis data on treatment specific focus synergistic approaches (i.e., triggered drug release, radiotherapy). It also highlights some challenges that hinder clinical translation from bench bedside. Future studies could expedite progress GNPs, well future possibility improving theragnostics, summarized.

Language: Английский

---

Fluorescence sensing by carbon nanoparticles

Nanoscale Advances, Journal Year: 2022, Volume and Issue: 4(8), P. 1926 - 1948

Published: Jan. 1, 2022

Herein, a summary of the fluorescent sensing applications carbon nanoparticles for detection chemicals and ions is reported.

Language: Английский

---