The Emerging Development of Multicolor Carbon Dots

Small, Journal Year: 2022, Volume and Issue: 18(51)

Published: Nov. 3, 2022

Abstract As a relatively new type of fluorescent carbon‐based nanomaterials, multicolor carbon dots (MCDs) have attracted much attention because their excellent biocompatibility, tunable photoluminescence (PL), high quantum yield, and unique electronic physicochemical properties. The emission characteristics (CDs) obviously depend on the source precursor, reaction conditions, environment, which directly or indirectly determines CDs. Therefore, this review is first systematic classification summary multiple regulation methods synthetic MCDs reviews recent research progress in synthesis from variety precursor materials such as aromatic molecules, small organic natural biomass, focusing how different produce corresponding MCDs. This also introduces innovative applications fields biological imaging, light‐emitting diodes (LEDs), sensing, anti‐counterfeiting due to PL It hoped that by selecting appropriate adjustment methods, can inspire guide future design tailored MCDs, provide help for development multifunctional

Language: Английский

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Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities

ACS Omega, Journal Year: 2023, Volume and Issue: 8(16), P. 14290 - 14320

Published: April 10, 2023

Cancer is ranked as the second leading cause of death globally. Traditional cancer therapies including chemotherapy are flawed, with off-target and on-target toxicities on normal cells, requiring newer strategies to improve cell selective targeting. The application nanomaterial has been extensively studied explored chemical biology tools in theranostics. It shows greater applications toward stability, biocompatibility, increased permeability, resulting precise targeting, mitigating shortcomings traditional therapies. nanoplatform offers an exciting opportunity gain targeting multifunctionality. advent nanotechnology, particular development smart nanomaterials, transformed diagnosis treatment. large surface area nanoparticles enough encapsulate many molecules ability functionalize various biosubstrates such DNA, RNA, aptamers, antibodies, which helps theranostic action. Comparatively, biologically derived nanomaterials perceive advantages over produced by conventional methods terms economy, ease production, reduced toxicity. present review summarizes techniques theranostics emphasizes (such organic (NPs), inorganic NPs, carbon-based NPs). We also critically discussed challenges impeding their translation treatment diagnostic applications. This concludes that use could significantly will facilitate new dimensions for tumor detection therapy.

Language: Английский

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Lignin-based carbon quantum dots with high fluorescence performance prepared by supercritical catalysis and solvothermal treatment for tumor-targeted labeling

Advanced Composites and Hybrid Materials, Journal Year: 2023, Volume and Issue: 6(2)

Published: March 23, 2023

Language: Английский

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The emerging development of nitrogen and sulfur co-doped carbon dots: Synthesis methods, influencing factors and applications

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 37, P. 102032 - 102032

Published: March 29, 2024

Language: Английский

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Reduction of Tumor Burden Via Precise Photothermal Release of Sirolimus by Carbon Nanodots in 3D Plexiform Neurofibroma-in-a-Dish Models

Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 105978 - 105978

Published: Feb. 1, 2025

Language: Английский

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Sequential Drug Delivery in Targeted Cancer Therapy

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(3), P. 573 - 573

Published: March 5, 2022

Cancer is a major public health problem and one of the leading causes death. However, traditional cancer therapy may damage normal cells cause side effects. Many targeted drug delivery platforms have been developed to overcome limitations free form therapeutics biological barriers. The commonly used cell surface targets are CD44, matrix metalloproteinase-2, folate receptors, etc. Once enters cell, active molecule its final destination still preferred. subcellular targeting strategies include using glucocorticoid receptors for nuclear targeting, negative mitochondrial membrane potential N-acetylgalactosaminyltransferase Golgi apparatus Therefore, most effective way deliver therapeutic agents through sequential system that simultaneously achieves cellular- subcellular-level targeting. dual-targeting holds great promise improving effects overcoming resistance. This review classifies systems based on organelles. We summarize different mechanisms gave examples each case.

Language: Английский

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Gadolinium-Doped Carbon Nanodots as Potential Anticancer Tools for Multimodal Image-Guided Photothermal Therapy and Tumor Monitoring

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(18), P. 17206 - 17217

Published: Sept. 5, 2023

This study focuses on the synthesis and characterization of gadolinium-doped carbon nanodots (CDs-Gd) their potential applications in multimodal imaging precision cancer therapy. CDs-Gd were synthesized through a solvothermal decomposition method combining citric acid, GdCl3, urea. The incorporation Gd3+ ions within carbonaceous structure resulted stable with peculiar architecture that retained optical paramagnetic properties. Combined techniques confirmed presence pH-sensitive COOH functions surface along unique lattice induced by doping. properties exhibited tunable emission spectrum displaying blue-green pH-dependent behavior. Additionally, contrast-enhancing T1-weighted magnetic resonance (MRI) experiments. MRI acquisitions at different concentrations pH values demonstrated as contrast agents for monitoring changes an aqueous environment. We found relaxivity 5.5 (tumor, 11.3 mM-1 s-1) is roughly 3-fold higher than observed 7.4 (physiological, 5.0 outperformed clinical standards such γ-butyrol (3.3 s-1). Monitoring tumor microenvironment (TME) crucial evaluating effectiveness anticancer treatments understanding progression. Furthermore, concentration-dependent photothermal conversion ability near-infrared (NIR) region, allowing efficient heat generation under laser irradiation. indicates application image-guided therapy (IG-PTT) treatment. vitro studies MCF-7 (breast cancer) 16-HBE (healthy bronchial epithelium) cell lines high biocompatibility (cell viability >80%). However, upon NIR activation, they showed potent effects inhibiting proliferation inducing apoptosis selectively cells. In conclusion, nanoparticles possess optical, photothermal, properties, making them promising candidates imaging-guided applications.

Language: Английский

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Mercaptosuccinic Acid-Based Carbon Quantum Dots as Peroxidase-like Nanozymes Inducing Cell Pyroptosis for Tumor-Specific Therapy

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 10699 - 10710

Published: May 2, 2024

Nonspecific targeting and low efficiency are challenges to face in tumor treatment. By utilizing the unique microenvironment (TME) of acidic condition overexpressed H2O2, nanozyme with peroxidase (POD)-like activity for decomposing H2O2 into extremely toxic hydroxyl radicals (•OH) destroy cancer cells situ is promisingly addressed tumor-specific However, catalytic therapeutic most current POD-like nanozymes usually counteracted by weak acidity (pH 6.0–6.7) insufficient (∼50–100 μM) TME. Herein, we report a mercaptosuccinic acid-derived carbon quantum dot (MA-CQD) nanozyme, which highly biocompatible possesses superior (Km = 0.58 mM) under TME, therefore efficiently convert trace amounts endogenous treatment, while posing minimal nonspecific damage normal tissues neutral 7.4). MA-CQDs confirmed cause an intensive caspase-1/gasdermin D-mediated cell pyroptosis through produced reactive oxygen species, providing effective way therapy. Our nanocatalyst demonstrates desirable suppression rate. This work offers prospective mode therapy inspires development cancer-specific pyroptotic nanomedicine.

Language: Английский

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Imaging-guided precision oncotherapy mediated by nanoprobes: From seeing to curing

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(1), P. 108460 - 108460

Published: April 15, 2023

Language: Английский

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Harnessing sulfur-doped carbon nanodots conjugated with IDO inhibitors act as a dual-mode breast cancer immunotherapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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