Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110802 - 110802
Published: Dec. 1, 2024
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)
Published: Jan. 15, 2024
Abstract Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad vital functions across diverse cellular processes. Dysfunctions within mitochondria serve catalysts for various diseases, prompting widespread demise. Mounting research on remedying damaged indicates that constitute valuable target therapeutic intervention against diseases. But less clinical practice and lower recovery rate imply limitation traditional drugs, which need further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution high efficacy by capitalizing excellent nanomaterials targeting drug delivery. Mitochondria‐remedying nanodrugs achieved ideal effects. This review elucidates significance in cells organs, while also compiling mortality data related Correspondingly, nanodrug‐mediate strategies applicable mitochondria‐remedying disease are detailed, with full understanding roles dysfunction advantages nanodrugs. In addition, future challenges directions discussed. conclusion, this provides comprehensive insights into design development nanodrugs, aiming to help scientists who desire extend their fields engage interdisciplinary subject.
Language: Английский
Citations
30
Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(3), P. 344 - 379
Published: Jan. 1, 2024
Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.
Language: Английский
Citations
12
Advanced Science, Journal Year: 2024, Volume and Issue: 11(25)
Published: April 22, 2024
Abstract Deep penetration and downregulation of heat shock protein (HSP) expression in multimodal synergistic therapy are promising approaches for curing cancer clinical trials. However, free small‐molecule drugs most drug vehicles have a low delivery efficiency deep into the tumor owing to poor hypoxic conditions at site. In this study, objective is use reactive oxygen species (ROS)‐responsive supramolecular gels co‐loaded with photosensitizer Zn(II) phthalocyanine tetrasulfonic acid (ZnPCS 4 ) functionalized tetrahedral DNA (TGSAs) (G@P/TGSAs) enhance tissue cell block HSP90 pathway chemo‐ photodynamic (PDT) ‐ photothermal (PTT) trimodal therapy. The injected situ release ZnPCS TGSAs under high ROS concentrations originating from both PDT. penetrate deeply tissues augment by inhibiting pathway. Proteomics show that HSP‐related proteins molecular chaperones inhibited/activated, Simultaneously, TGSA‐regulated apoptotic activated. vivo study demonstrates efficient excellent (45% growth inhibition).
Language: Английский
Citations
8
Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)
Published: Aug. 9, 2024
Acute kidney injury (AKI) is the sudden decrease in renal function that can be attributed to dysregulated reactive oxygen species (ROS) production and impaired mitochondrial function. Irisin, a type I membrane protein secreted by skeletal muscles response physical activity, has been reported alleviate damage through regulation of biogenesis oxidative metabolism. In this study, macrophage membrane-coated metal-organic framework (MCM@MOF) developed as nanocarrier for encapsulating irisin overcome inherent characteristics irisin, including short circulation time, limited kidney-targeting ability, low permeability. The engineered irisin-mediated biomimetic nanotherapeutics have extended time enhanced targeting capability toward injured kidneys due preservation proteins. irisin-encapsulated effectively mitigate acute ischemia-reperfusion protecting modulating SOD2 levels tubular epithelial cells. present study provides novel insights advance development potential therapeutic approach AKI.
Language: Английский
Citations
8
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 22, 2024
Abstract There remains a lack of effective drugs to alleviate the kidney stones caused by oxidative stress and inflammatory damage. The MOF‐818 nanozyme is utilized lessen generation reactive oxygen species (ROS) effectively, restore membrane potential mitochondria, regulate cell cycle, decrease death, hinder recruitment macrophages, mitigate release factors in macrophages. These effects are attributed nanozyme's ability mimic enzyme properties catalase (CAT) superoxide dismutase (SOD). It demonstrated that this can reduce calcium oxalate crystal deposition reducing renal injury high concentration oxalate, upregulate expression levels SOD CAT tissues, downregulate adhesion proteins factor IL‐6 TNF‐α, promote polarization macrophages from M1 M2 phenotype rat model induced ethylene glycol. Overall, has effectively suppress harm hence lowering likelihood stone formation. also expected be used as an alternative drug for treatment provide experimental theoretical basis development new nanomedicines.
Language: Английский
Citations
6
Theranostics, Journal Year: 2016, Volume and Issue: 6(8), P. 1105 - 1118
Published: Jan. 1, 2016
Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.
Language: Английский
Citations
46
Kidney360, Journal Year: 2024, Volume and Issue: 5(4), P. 618 - 630
Published: Feb. 28, 2024
Kidney diseases, both acute and chronic, are a substantial burden on individual public health, they continue to increase in frequency. Despite this an intense focus the study of disease mechanisms, few new therapeutic approaches have extended clinic. This is part due poor pharmacology many, if not most, therapeutics with respect sites kidney within glomerulus or nephron. Considering this, past decade, more pointedly over 2 years, there been developments nanoparticle systems deliver disease. Here, we provide broad overview various classes nanomaterials that developed improve development for strategy used accumulation, briefly models focused on, any. We then one specific system, polymeric mesoscale nanoparticles, which has broadly 13 publications, demonstrating targeting tubular epithelium 26-fold specificity compared other organs. While several nanomedicines advanced clinic decades, including mRNA-based coronavirus vaccines others, none diseases specifically. In total, confident rapid advancement nanoscale-based concerted by clinicians, scientists, engineers, stakeholders will push these technologies into clinical trials next decade.
Language: Английский
Citations
4
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216570 - 216570
Published: Feb. 27, 2025
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Selective drug delivery to podocytes remains a challenge. Aptamers, nucleic acids that bind specific cells, offer potential solution, though podocyte-targeting aptamers have not yet been developed. Podocytes stimulated with adriamycin, puromycin aminonucleoside, and high glucose are used screen an single-stranded DNA (ssDNA) library (10¹⁵ sequences). High-throughput sequencing identifies nucleotide sequences, the aptamer's affinity, stability, cytotoxicity, uptake, biodistribution (especially podocyte), target protein ability deliver siRNA evaluated. After 11-14 rounds of selection, high-affinity pools identified. Sequencing reveals 23,848 unique narrowed down 12 candidates. Aptamer S7 is specifically bound podocytes, its truncated version, RLS-2, demonstrates superior affinity (50-70 nM) improved stability phosphorothioate modifications. RLS-2 exhibits no significant internalized by localized lysosomes. In adriamycin-induced diabetic nephropathy mice, preferentially accumulates within glomeruli. Its specificity podocyte verified colocalization examination quantitated via flowcytometry. EPB41L5 identified as protein. Aptamer-siRNA chimeras based on successfully downregulate gene expression without need for transfection reagents in vitro. These findings underscore promising agent development podocyte-targeted systems.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 5, 2024
Non-invasive imaging in the near-infrared region (NIR) offers enhanced tissue penetration, reduced spontaneous fluorescence of biological tissues, and improved signal-to-noise ratio (SNR), rendering it more suitable for vivo deep imaging. In recent years, a plethora NIR photoresponsive materials have been employed disease diagnosis, particularly acute kidney injury (AKI). These encompass inorganic nonmetallic such as carbon (C), silicon (Si), phosphorus (P), upconversion nanoparticles (UCNPs); precious metal like gold silver; well small molecule organic semiconductor polymer with near infrared responsiveness. enable effective therapy triggered by light serve valuable tools monitoring AKI living systems. The review provides concise overview current state pathological characteristics AKI, followed an exploration application nanomaterials AKI. Finally, presents design challenges prospects associated
Language: Английский
Citations
3