Journal of Innovative Optical Health Sciences,
Journal Year:
2023,
Volume and Issue:
17(01)
Published: March 31, 2023
Laser
spectroscopic
imaging
techniques
have
received
tremendous
attention
in
the
field
of
cancer
diagnosis
due
to
their
high
sensitivity,
temporal
resolution,
and
short
acquisition
time.
However,
limited
tissue
penetration
laser
is
still
a
challenge
for
vivo
deep-seated
lesions.
Nanomaterials
been
universally
integrated
with
deeper
vivo.
The
components,
morphology,
sizes
nanomaterials
are
delicately
designed,
which
could
realize
or
situ.
Considering
enhanced
signal
emitting
from
nanomaterials,
we
emphasized
combination
diagnosis,
like
surface-enhanced
Raman
scattering
(SERS),
photoacoustic,
fluorescence,
laser-induced
breakdown
spectroscopy
(LIBS).
Applications
above
offer
new
prospects
diagnosis.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(4)
Published: Aug. 29, 2023
Photodynamic
therapy
(PDT),
which
utilizes
type
I
photoreactions,
has
great
potential
as
an
effective
cancer
treatment
because
of
its
hypoxia-tolerant
superiority
over
the
commonly
used
II
pathway.
A
few
photosensitizers
are
exploited;
however,
they
majorly
induce
cytotoxicity
and
possess
poor
tumor
specificity
low-efficient
theranostics.
To
resolve
this
issue,
herein
aminopeptidase
N
(APN)-activated
phototheranostic
probe
(CyA)
is
reported
for
anti-hypoxic
PDT
in
conjunction
with
immunotherapy
treatment.
CyA
can
specifically
activate
near-infrared
fluorescence,
photoacoustic
signals,
phototoxicity
following
APN-induced
substrate
cleavage
subsequent
generation
active
molecules
(such
CyBr).
endows
specific
imaging
capabilities
toward
cells
overexpressing
APN
under
both
normoxia
hypoxia.
In
addition,
locally
activatable
induces
systemic
antitumor
immune
responses.
More
importantly,
integration
localized
activated
evokes
enhanced
therapeutic
effects
improved
inhibition
efficiency
live
mice
compared
individual
treatments.
This
study
aims
to
present
combination
therapy.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Oct. 21, 2023
Liposome
nanoparticles
have
emerged
as
promising
drug
delivery
systems
due
to
their
unique
properties.
Assessing
particle
size
and
polydispersity
index
(PDI)
is
critical
for
evaluating
the
quality
of
these
liposomal
nanoparticles.
However,
optimizing
parameters
in
a
laboratory
setting
both
costly
time-consuming.
This
study
aimed
apply
machine
learning
technique
assess
impact
specific
factors,
including
sonication
time,
extrusion
temperature,
compositions,
on
PDI
Liposomal
solutions
were
prepared
subjected
with
varying
values
parameters.
Two
compositions:
(A)
HSPC:DPPG:Chol:DSPE-mPEG2000
at
55:5:35:5
molar
ratio
(B)
HSPC:Chol:DSPE-mPEG2000
55:40:5
ratio,
made
using
remote
loading
method.
Ensemble
(EL),
technique,
was
employed
Least-squares
boosting
(LSBoost)
algorithm
accurately
model
data.
The
dataset
randomly
split
into
training
testing
sets,
70%
allocated
training.
LSBoost
achieved
mean
absolute
errors
1.652
0.0105
modeling
PDI,
respectively.
Under
conditions
where
temperature
set
approximately
60
°C,
our
EL
predicted
minimum
116.53
nm
composition
time
30
min.
Similarly,
(B),
129.97
times
or
55
In
most
instances,
less
than
0.2
achieved.
These
results
highlight
significant
independent
factors
characteristics
demonstrate
potential
decision
support
system
identifying
best
formulation.
We
recommend
further
studies
explore
effects
other
such
lipid
surfactants,
nanoparticle
characteristics.
Aggregate,
Journal Year:
2024,
Volume and Issue:
5(4)
Published: March 10, 2024
Abstract
Aggregate‐level
photodynamic
therapy
(PDT)
has
attracted
significant
interest
and
driven
substantial
advances
in
multifunction
phototheranostic
platforms.
As
exemplified
by
two
typical
instances
of
aggregation‐caused
quenching
reactive
oxygen
species
(ROS)
aggregation‐induced
generation
ROS,
the
aggregation
effect
plays
a
role
on
ROS
photosensitizers
(PSs),
which
is
worthy
in‐depth
exploration
full
utilization.
However,
contrast
to
well‐developed
researches
luminescence,
studies
concerning
are
currently
relatively
nascent
disjointed
stage,
lacking
guidance
from
firmly
established
research
paradigm.
To
advance
this
regard,
review
aims
at
providing
consolidated
overview
fundamental
principles
status
effects
generation.
Here,
can
be
organized
into
main
facets.
One
involves
comparison
between
isolated
state
aggregated
state,
mainly
conducted
methods
changing
solvent
environments
adding
adjuvants
given
solvent.
The
other
underscores
distinctions
different
aggregate
states,
consisting
three
parts,
namely
within
same
or
categories
based
classification
single‐component
multicomponent
aggregates.
In
endeavor,
we
will
present
our
views
current
methodologies
that
explore
how
affects
highlight
design
strategies
leverage
optimize
PS
regiments.
We
aspire
propel
advancement
platforms
accelerate
clinical
implementation
precision
medicine,
inspire
more
contributions
aggregate‐level
photophysics
photochemistry,
pushing
science
materials
forward.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Sept. 24, 2022
Abstract
Background
Skin
tissue
is
vital
in
protecting
the
body
from
injuries
and
bacterial
infections.
Wound
infection
caused
by
colonization
one
of
main
factors
hindering
wound
healing.
a
large
number
bacteria
can
cause
to
enter
continuous
stage
inflammation,
which
delays
Hydrogel
dressing
composed
natural
synthetic
polymers,
absorb
fluid,
improve
local
microenvironment
wound,
promote
However,
preparation
process
hydrogel,
complex
poor
biological
efficacy
limit
application
hydrogel
environment.
Therefore,
it
particularly
important
develop
prepare
dressings
with
simple
technology,
good
physical
properties
effects
using
polymers.
Results
In
this
study,
gelatin-based
(Tsg-THA&Fe)
was
created
mixing
trivalent
iron
(Fe
3+
)
2,3,4-trihydroxybenzaldehyde
(THA)
form
(THA&Fe),
followed
Schiff
base
reaction
tilapia
skin
gelatin
(Tsg).
The
gel
time
rheological
hydrogels
were
adjusted
controlling
complexes.
dynamic
cross-linking
coordination
bonds
(o-phthalmictriol-Fe
allows
have
self-healing
injectable
properties.
vitro
experiments
confirmed
that
had
biocompatibility
biodegradability
as
well
adhesion,
hemostasis,
antibacterial
feasibility
Tsg-THA&Fe
studied
treating
rat
trauma
model.
results
showed
compared
Comfeel
®
Plus
Transparent
dressing,
could
obvious
reduce
microorganisms,
prevent
colonization,
inflammation
accelerate
Local
distribution
did
not
organ
toxicity.
Conclusions
summary,
simple,
excellent
performance
efficacy.
It
effectively
relieve
control
microbes,
be
used
multi-functional
Graphical
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(26)
Published: July 9, 2023
X-ray
induced
photodynamic
therapy
(X-PDT)
circumvents
the
poor
penetration
depth
of
conventional
PDT
with
minimal
radio-resistance
generation.
However,
X-PDT
typically
requires
inorganic
scintillators
as
energy
transducers
to
excite
neighboring
photosensitizers
(PSs)
generate
reactive
oxygen
species
(ROS).
Herein,
a
pure
organic
aggregation-induced
emission
(AIE)
nanoscintillator
(TBDCR
NPs)
that
can
massively
both
type
I
and
II
ROS
under
direct
irradiation
is
reported
for
hypoxia-tolerant
X-PDT.
Heteroatoms
are
introduced
enhance
harvesting
generation
ability,
AIE-active
TBDCR
exhibits
aggregation-enhanced
especially
less
oxygen-dependent
hydroxyl
radical
(HO
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: May 2, 2024
As
a
new
form
of
regulated
cell
death,
ferroptosis
has
unraveled
the
unsolicited
theory
intrinsic
apoptosis
resistance
by
cancer
cells.
The
molecular
mechanism
depends
on
induction
oxidative
stress
through
excessive
reactive
oxygen
species
accumulation
and
glutathione
depletion
to
damage
structural
integrity
Due
their
high
loading
tunability,
nanocarriers
can
escort
delivery
ferro-therapeutics
desired
site
enhanced
permeation
or
retention
effect
active
targeting.
This
review
shed
light
necessity
iron
in
growth
fascinating
features
regulating
cycle
metastasis.
Additionally,
we
discussed
ferroptosis-mediated
therapy
using
nanoplatforms
chemical
basis
overcoming
barriers
therapy.
Communications Chemistry,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Aug. 13, 2024
Abstract
Mitochondrial
dysregulation
plays
a
significant
role
in
the
carcinogenesis.
On
other
hand,
its
destabilization
strongly
represses
viability
and
metastatic
potential
of
cancer
cells.
Photodynamic
photothermal
therapies
(PDT
PTT)
target
mitochondria
effectively,
providing
innovative
non-invasive
anticancer
therapeutic
modalities.
Cyanine
dyes,
with
strong
mitochondrial
selectivity,
show
enhancing
PDT
PTT.
The
limitations
cyanine
dyes
for
PTT
are
discussed,
along
their
applications
combination
therapies,
theranostic
techniques,
optimal
delivery
systems.
Additionally,
novel
approaches
sonodynamic
therapy
using
photoactive
presented,
highlighting
advances
treatment.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Dec. 7, 2023
Gliomas
are
one
of
the
most
common
primary
malignant
tumours
central
nervous
system
(CNS),
which
glioblastomas
(GBMs)
and
destructive
type.
The
glioma
tumour
microenvironment
(TME)
has
unique
characteristics,
such
as
hypoxia,
blood-brain
barrier
(BBB),
reactive
oxygen
species
(ROS)
neovascularization.
Therefore,
traditional
treatment
effect
is
limited.
As
cellular
oxidative
metabolites,
ROS
not
only
promote
occurrence
development
gliomas
but
also
affect
immune
cells
in
microenvironment.
In
contrast,
either
too
high
or
low
levels
detrimental
to
survival
cells,
indicates
threshold
ROS.
an
in-depth
understanding
mechanisms
production
scavenging,
ROS,
role
TME
can
provide
new
methods
strategies
for
treatment.
Current
increase
include
photodynamic
therapy
(PDT),
sonodynamic
(SDT),
chemodynamic
(CDT),
etc.,
eliminate
ingestion
antioxidants.
Increasing/scavenging
potentially
applicable
treatment,
further
studies
will
help
more
effective
