A Review on the Research Progress of Mechanism of <em>Panax ginseng C. A. meyer </em>in the Treatment of Alzheimer’s Disease DOI Open Access
Meng Zhang, Ge Meng, Qingqing Li

et al.

Published: June 13, 2023

Panax ginseng C. A. Meyer (P. ginseng), has been widely used in traditional Chinese medicine (TCM). It contains a number of chemical components and possesses variety pharmacological activities. Alzheimer&#039;s disease (AD) is neurodegenerative that creates huge burden on the lives health individuals. In recent years, studies have indicated P. ginseng, especially ginsenosides, play pronounced positive role prevention treatment neurological diseases. This review aimed to summarize currently mechanisms action AD intervention ginsenosides. this review, their respective active effects were first introduced. Then key molecular signaling pathways introduced, its different ingredients disease-related pathogenesis also summarized from Aβ generation aggregation, hyperphosphorylation tau protein，oxidant stress，neuroinflammation，mitochondrial damage，disorder neurotransmitter gut microbiota. Signaling pathway networks related was constructed, which could serve as therapeutic target for disease. addition detailed report improving pathogenesis, application current technology, spatial metabonomics therapeutics diagnostics later discussed. Spatial be applied investigate multi-target Research perspectives study provided further studies.

Language: Английский

Effect of rhizosphere soil microenvironment interaction on ginsenoside content in Panax ginseng: a case study of three-year-old agricultural ginseng DOI

Zhefeng Xu,

Yuqiu Chen, Rui Liu

et al.

Rhizosphere, Journal Year: 2025, Volume and Issue: unknown, P. 101023 - 101023

Published: Feb. 1, 2025

Language: Английский

Citations

2
A comprehensive review on the recent advances for 5-aminolevulinic acid production by the engineered bacteria DOI
Yingying Chen, Jiacong Huang,

Cai-Yun Wu

et al.

Critical Reviews in Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: May 5, 2024

5-Aminolevulinic acid (5-ALA) is a non-proteinogenic amino essential for synthesizing tetrapyrrole compounds, including heme, chlorophyll, cytochrome, and vitamin B12. As plant growth regulator, 5-ALA extensively used in agriculture to enhance crop yield quality. The complexity low of chemical synthesis methods have led significant interest the microbial 5-ALA. Advanced strategies, the: enhancement precursor cofactor supply, compartmentalization key enzymes, product transporters engineering, by-product formation reduction, biosensor-based dynamic regulation, been implemented bacteria production, significantly advancing its industrialization. This article offers comprehensive review recent developments production using engineered presents new insights propel field forward.

Language: Английский

Citations

8
Explore the Driving Factors of Soil Fungal Communities Under Different Land Use Patterns and Speculate on the Influencing Factors of Ginseng Quality DOI

Zhefeng Xu,

Ruixue Yang,

Kemeng Zhang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Endophytic fungi of Panax sokpayensis produce bioactive ginsenoside Compound K in flask fermentation DOI Creative Commons

Subecha Rai,

Laishram Shantikumar Singh, R. Uma Shaanker

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 23, 2024

Abstract Endophytes of Panax have the potential to produce their host plant secondary metabolites, ginsenosides. sokpayensis, an endemic traditional medicinal Sikkim Himalayas was explored for isolation endophytic fungi. In present study, we isolated 35 fungal cultures from rhizome P. sokpayensis and screened ginsenosides production by HPLC comparing peak retention time with that standard The analysis revealed out isolates, mycelial extracts four endophytes (PSRF52, PSRF53, PSRF49 PSRF58) exhibited peaks a similar ginsenoside, Compound K (CK). LC–ESI–MS/MS led confirmation ginsenoside CK which showed compound m/z 639.6278, yield in potato dextrose broth flask fermentation ranging 0.0019 0.0386 mg/g mass dry weight basis. prospective endophyte isolates were identified as Thermothielavioides terrestris PSRF52, Aspergillus sp. PSRF49, Rutstroemiaceae strain Phaeosphaeriaceae PSRF58 based on ITS sequencing. finding highlights need further study growth optimization other culture parameters exploit alternative source production.

Language: Английский

Citations

3
Transformation of Ginsenosides by Lactiplantibacillus plantarum MB11 Fermentation: Minor Ginsenosides Conversion and Enhancement of Anti-Colorectal Cancer Activity DOI Creative Commons
Yunjiao Shen, Yansong Gao, Ge Yang

et al.

Molecules, Journal Year: 2023, Volume and Issue: 29(1), P. 27 - 27

Published: Dec. 20, 2023

The present study aimed to increase the content of minor ginsenosides and enhance anti-colorectal cancer activity via biotransformation by Lactiplantibacillus plantarum MB11 screened from fermented foods. A subcutaneous transplantation tumor model murine colorectal CT26 cells was established in mice anticarcinogenic activities mechanism total (FTGs). results showed that L. fermentation increased decreased major ginsenosides. FTGs reduced weight size compared with group. Immunofluorescence TdT-mediated dUTP nick end labeling (TUNEL) analysis significantly number caspase-3 tissue induce cell apoptosis. Mechanically, activate AMPK/mTOR autophagy pathway regulate JAK2/STAT3 Bax/Bcl-2/caspase-3 apoptosis pathway. Overall, enhanced ginsenosides, induced mice.

Language: Английский

Citations

8
Active Compounds of Panax ginseng in the Improvement of Alzheimer’s Disease and Application of Spatial Metabolomics DOI Creative Commons
Meng Zhang,

Huazhou Niu,

Qingqing Li

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 17(1), P. 38 - 38

Published: Dec. 26, 2023

Panax ginseng C.A. Meyer (P. ginseng) is one of the more common traditional Chinese medicines (TCMs). It contains numerous chemical components and exhibits a range pharmacological effects. An enormous burden placed on people’s health life by Alzheimer’s disease (AD), neurodegenerative condition. Recent research has shown that P. ginseng’s constituents, particularly ginsenosides, have significant beneficial impact prevention management neurological disorders. To understand current status to improve AD, this paper discusses composition ginseng, its mechanism action, clinical application. The pathogenesis AD includes amyloid beta protein (Aβ) generation aggregation, tau hyperphosphorylation, oxidant stress, neuroinflammation, mitochondrial damage, neurotransmitter gut microbiota This review presents key molecular mechanisms signaling pathways active ingredients in involved improving from perspective pathogenesis. A ginseng-related pathway network was constructed provide effective targets for treatment AD. In addition, application spatial metabolomics techniques studying discussed. summary, perspectives study including systematic in-depth action substances evaluates feasibility applying treatment.

Language: Английский

Citations

7
Biosynthetic pathway of prescription cucurbitacin IIa and high-level production of key triterpenoid intermediates in engineered yeast and tobacco DOI Creative Commons
Geng Chen,

Zhaokuan Guo,

Yan-yu Shu

et al.

Plant Communications, Journal Year: 2024, Volume and Issue: unknown, P. 100835 - 100835

Published: Feb. 1, 2024

Cucurbitacin IIa is a triterpenoid isolated exclusively from Hemsleya plants, which non-steroidal anti-inflammatory drug that function as the main ingredient of prescription Hemslecin capsules and tablets in China. Synthetic biology provides new strategies for producing such valuable cucurbitacins large-scale, however, biosynthetic pathway cucurbitacin was still unknown heterologous production galactose medium expensive low-yield. In this study, functions two squalene epoxidases (HcSE1-2), six OSC genes (HcOSC1-6), CYP450 (HcCYP87D20 HcCYP81Q59) acyltransferases (HcAT1) involved biosynthesis were characterised by expression Saccharomyces cerevisiae Nicotiana benthamiana. The high-level yeast key precursor, 11-carbonyl-20β-hydroxy-Cuol, first time constructed glucose via modular engineering mevalonate optimization P450 levels, to produce 46.41 mg/L 11-carbonyl-20β-hydroxy-Cuol 126.47mg/L total shake flasks are highest yield known engineered microbes. Moreover, transient tobacco employed achieve 1.28 mg/g dry weight (dw) leaves. This work uncovered cultivated with high-yield intermediates. We offered low-cost high-efficient platform rapid screening candidate pharmacological triterpenoids.

Language: Английский

Citations

2
Biotransformation approach to produce rare ginsenosides F1, compound Mc1, and Rd2 from major ginsenosides DOI
Mengxue Diao,

Y Chen,

Lijun Meng

et al.

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(4)

Published: March 17, 2024

Language: Английский

Citations

2
Advances in Engineering Nucleotide Sugar Metabolism for Natural Product Glycosylation in Saccharomyces cerevisiae DOI Creative Commons
Samantha A. Crowe, Yuzhong Liu, Xixi Zhao

et al.

ACS Synthetic Biology, Journal Year: 2024, Volume and Issue: 13(6), P. 1589 - 1599

Published: May 31, 2024

Glycosylation is a ubiquitous modification present across all of biology, affecting many things such as physicochemical properties, cellular recognition, subcellular localization, and immunogenicity. Nucleotide sugars are important precursors needed to study glycosylation produce glycosylated products. Saccharomyces cerevisiae potentially powerful platform for producing biomolecules, but it lacks nucleotide sugar diversity. metabolism complex, understanding how engineer will be necessary both access heterologous glycosylations found biology. This review overviews the potential challenges with engineering in yeast from salvage pathways that convert free their associated UDP-sugars de novo synthesis where interconverted through complex metabolic network governing feedback mechanisms. Finally, recent examples small molecules S. explored assessed.

Language: Английский

Citations

2
Phytochemistry, quality control and biosynthesis in ginseng research from 2021 to 2023: A state-of-the-art review concerning advances and challenges DOI Open Access

Mengxiang Ding,

Huizhen Cheng,

Xiaohang Li

et al.

Chinese Herbal Medicines, Journal Year: 2024, Volume and Issue: 16(4), P. 505 - 520

Published: Aug. 23, 2024

L. (Araliaceae) has a long history of medicinal and edible use due to its significant tonifying effects, ginseng research been hot topic in natural products food science. In continuation our recent review, we highlighted the advances from 2021 2023 with 157 citations, which exhibited increasingly systematic, collaborative, intelligent characteristics. this firstly updated progress phytochemistry involving ginsenosides polysaccharides summarized researches on active components. Then, some specific applications by feat multidimensional chromatography, mass spectrometry imaging, DNA barcoding, metabolomics, were analyzed, could provide rich information supporting multi-component characterization, authentication, quality control versatile products. Finally, biosynthesis studies concerning retrospected. Additionally, current challenges future trends respect discussed.

Language: Английский

Citations

2