Panax
ginseng
C.
A.
Meyer
(P.
ginseng),
has
been
widely
used
in
traditional
Chinese
medicine
(TCM).
It
contains
a
number
of
chemical
components
and
possesses
variety
pharmacological
activities.
Alzheimer's
disease
(AD)
is
neurodegenerative
that
creates
huge
burden
on
the
lives
health
individuals.
In
recent
years,
studies
have
indicated
P.
ginseng,
especially
ginsenosides,
play
pronounced
positive
role
prevention
treatment
neurological
diseases.
This
review
aimed
to
summarize
currently
mechanisms
action
AD
intervention
ginsenosides.
this
review,
their
respective
active
effects
were
first
introduced.
Then
key
molecular
signaling
pathways
introduced,
its
different
ingredients
disease-related
pathogenesis
also
summarized
from
Aβ
generation
aggregation,
hyperphosphorylation
tau
protein，oxidant
stress，neuroinflammation，mitochondrial
damage，disorder
neurotransmitter
gut
microbiota.
Signaling
pathway
networks
related
was
constructed,
which
could
serve
as
therapeutic
target
for
disease.
addition
detailed
report
improving
pathogenesis,
application
current
technology,
spatial
metabonomics
therapeutics
diagnostics
later
discussed.
Spatial
be
applied
investigate
multi-target
Research
perspectives
study
provided
further
studies.
Phytochemical Analysis,
Journal Year:
2023,
Volume and Issue:
35(2), P. 220 - 238
Published: Sept. 21, 2023
Abstract
Introduction
Shenlingbaizhu
granule,
a
Traditional
Chinese
Medicine
prescription
comprising
Renshen,
Gancao,
and
Shanyao,
is
widely
consumed
in
China
nowadays.
Objective
The
study
tries
to
propose
pharmacopoeia
quality
markers
(Q‐markers)
prevent
counterfeiting
involving
Shanyao.
Methodology
A
novel
strategy,
that
is,
library‐based
ultra‐high‐performance
liquid
chromatography–quadrupole‐orbitrap
mass
spectrometry,
was
used
analyse
the
lyophilised
aqueous
powder
of
granule.
Subsequently,
quantum
chemistry
calculation
UV‐vis
spectra
scanning
were
also
performed
through
theoretical
or
experimental
approaches.
Result
Thirty‐two
isomers
have
been
strictly
distinguished,
especially
positional
isomeric
isochlorogenic
acid
B
versus
C,
schaftoside
isoschaftoside,
ginsenoside
Rg2
20S
‐ginsenoside
Rg3,
stereoisomeric
Rg3
20R
Rg3.
Seventeen
compounds
unexpectedly
observed,
particularly
scoparone
pectolinarigenin,
while
total
76
bioactive
putatively
identified
study.
results
revealed
glycyrrhizic
acid,
Re,
Rb1,
diosgenin
displayed
different
dipole
moment
values
maximum
absorption
wavelengths
from
each
other.
Conclusion
recommends
as
four
anti‐counterfeiting
Q‐markers
for
pharmacopoeia.
can
be
detected
using
conventional
HPLC.
observation
17
unexpected
updates
our
knowledge
regarding
bioactives
Molecules,
Journal Year:
2024,
Volume and Issue:
29(15), P. 3614 - 3614
Published: July 31, 2024
Identifying
the
catalytic
regioselectivity
of
enzymes
remains
a
challenge.
Compared
to
experimental
trial-and-error
approaches,
computational
methods
like
molecular
dynamics
simulations
provide
valuable
insights
into
enzyme
characteristics.
However,
massive
data
generated
by
these
hinder
extraction
knowledge
about
mechanisms
without
adequate
modeling
techniques.
Here,
we
propose
framework
utilizing
graph-based
active
learning
from
identify
ginsenoside
hydrolases
(GHs),
which
selectively
catalyze
C6
or
C20
positions
obtain
rare
deglycosylated
bioactive
compounds
New Biotechnology,
Journal Year:
2024,
Volume and Issue:
83, P. 219 - 230
Published: Aug. 23, 2024
Ginseng,
a
cornerstone
of
traditional
herbal
medicine
in
Asia,
garnered
significant
attention
for
its
therapeutic
potential.
Central
to
pharmacological
effects
are
ginsenosides,
the
primary
active
metabolites,
many
which
fall
within
dammarane-type
and
share
protopanaxadiol
as
common
precursor.
Challenges
extracting
ginsenosides
from
ginseng
arise
due
their
low
concentrations
roots.
Emerging
solutions
involve
leveraging
microbial
cell
factories
employing
genetically
engineered
yeasts.
Here,
we
optimized
fermentation
conditions
via
Design
Experiment,
realizing
1.2
g/L
simple
shake
flask
cultivations.
Extrapolating
setup
complex
like
compound
K,
achieved
7.3-fold
(0.22
g/L)
titer
improvements.
Our
adaptable
enable
production
high-value
products,
such
sustainable
triterpenoids
synthesis.
Through
synthetic
biology,
engineering,
formulation
studies,
pave
way
scalable
bioactive
compounds
ginseng.
Marine Drugs,
Journal Year:
2023,
Volume and Issue:
22(1), P. 22 - 22
Published: Dec. 28, 2023
Crocin
is
one
of
the
most
valuable
components
Chinese
medicinal
plant
Crocus
sativus
and
widely
used
in
food,
cosmetics,
pharmaceutical
industries.
Traditional
planting
C.
unable
to
fulfill
increasing
demand
for
crocin
global
market,
however,
such
that
researchers
have
turned
their
attention
heterologous
production
a
variety
hosts.
At
present,
there
are
reports
successful
Escherichia
coli,
Saccharomyces
cerevisiae,
microalgae,
plants
do
not
naturally
produce
crocin.
Of
these,
microalga
Dunaliella
salina,
which
produces
high
levels
β-carotene,
substrate
biosynthesis,
worthy
attention.
This
article
describes
biosynthesis
crocin,
compares
features
each
host,
clarifies
requirements
efficient
microalgae.
Authorea (Authorea),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 19, 2023
The
present
study
aimed
to
increase
the
content
of
minor
ginsenosides
and
enhance
anti-colorectal
cancer
activity
via
biotransformation
by
Lactiplantibacillus
plantarum
MB11
screened
from
fermented
foods.
A
subcutaneous
transplantation
tumor
model
murine
colorectal
CT26
cells
was
established
in
mice
anticarcinogenic
activities
mechanism
total
(FTGs).
results
showed
that
L.
fermentation
increased
decreased
major
ginsenosides.
FTGs
reduced
weight
size
compared
group.
Immunofluorescence
TUNEL
analysis
significantly
number
caspase-3
tissue
induce
cell
apoptosis.
Mechanically,
activate
AMPK/
mTOR
autophagy
pathway
regulate
JAK2/
STAT3
Bax/
Bcl-2/
apoptosis
pathway.
Overall,
with
enhanced
ginsenosides,
induced
mice.
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 22, 2024
This
chapter
is
a
revision
of
the
realm
endophytic
fungi,
focusing
on
how
to
approach
study
their
biodiversity
in
relation
distribution,
richness,
host
plant
defense
mechanisms,
chemistry,
and
metabolomic
profiles.
We
will
revise
current
isolation
identification
methods
available
such
as
culture-dependent
techniques
omics
approaches
including
both
targeted
functional
metagenomics,
comparison
give
holistic
view
fungal
biome.
Additionally,
we
discuss
biotechnological
potential
for
production
bioactive
natural
products
be
applied
protection
(against
nematodes,
insect
control),
soil
restoration,
or
disease
control
practices
based
microbial
antagonists.
Authorea (Authorea),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 22, 2023
Shenling
Baizhu
Granule,
a
traditional
Chinese
medicine
prescription
comprising
Renshen,
Gancao,
and
Shanyao,
has
been
widely
consumed
in
China
nowadays.
However,
its
pharmacopoeia
quality-marker
(Q-marker)
not
defined
The
study
thus
used
novel
strategy,
i.e.,
library-based
ultra-high-performance
liquid
chromatography-quadrupole-orbitrap
mass
spectrometry,
to
analyze
lyophilized
aqueous
powder.
strategy
simultaneously
putatively
77
compounds;
Especially,
32
isomeric
compounds
have
strictly
distinguished,
including
ferulic
acid
isoferulic
acid;
liquiritigenin
isoliquiritigenin;
3,4-dicaffeoylquinic
4,5-dicaffeoylquinic
schaftoside
isoschaftoside;
ginsenoside
Re
Rd;
Rc
Rb2;
daidzein
7,4’-dihydroxyflavone;
luteolin
kaempferol;
butin
S-
naringenin;
calycosin
prunetin;
isovitexin
cosmosiin;
orientin
quercitrin;
costunolide
alantolactone;
2’-hydroxydaidzein,
genistein,
apigenin;
Rg2,
20R
-ginsenoside
Rg3,
20S
Rg3.
In
addition,
45
non-isomeric
also
identified.
Combining
with
the
quantum
chemistry
calculation
UV-vis
spectra
scanning
results,
4
are
recommended
as
Q-marker
candidates,
glycyrrhizic
acid,
Re,
Rb1,
diosgenin.
four
can
be
qualitatively
assess
materials
of
prevent
possible
adulterant.
Panax
ginseng
C.
A.
Meyer
(P.
ginseng),
has
been
widely
used
in
traditional
Chinese
medicine
(TCM).
It
contains
a
number
of
chemical
components
and
possesses
variety
pharmacological
activities.
Alzheimer's
disease
(AD)
is
neurodegenerative
that
creates
huge
burden
on
the
lives
health
individuals.
In
recent
years,
studies
have
indicated
P.
ginseng,
especially
ginsenosides,
play
pronounced
positive
role
prevention
treatment
neurological
diseases.
This
review
aimed
to
summarize
currently
mechanisms
action
AD
intervention
ginsenosides.
this
review,
their
respective
active
effects
were
first
introduced.
Then
key
molecular
signaling
pathways
introduced,
its
different
ingredients
disease-related
pathogenesis
also
summarized
from
Aβ
generation
aggregation,
hyperphosphorylation
tau
protein，oxidant
stress，neuroinflammation，mitochondrial
damage，disorder
neurotransmitter
gut
microbiota.
Signaling
pathway
networks
related
was
constructed,
which
could
serve
as
therapeutic
target
for
disease.
addition
detailed
report
improving
pathogenesis,
application
current
technology,
spatial
metabonomics
therapeutics
diagnostics
later
discussed.
Spatial
be
applied
investigate
multi-target
Research
perspectives
study
provided
further
studies.
