Omeprazole-Loaded Copper Nanoparticles for Mitochondrial Damage Mediated Synergistic Anticancer Activity against Melanoma Cells DOI
Kalyani Eswar,

Sri Amruthaa Sankaranarayanan,

Rupali Srivastava

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 4795 - 4803

Published: July 3, 2024

Metallic nanoparticles are promising candidates for anticancer therapies. Among the different metallic systems studied, copper is an affordable and biologically available metal with a high redox potential. Copper-based widely used in studies owing to their ability react intracellular glutathione (GSH) induce Fenton-like reaction. However, considering metastatic potential versatility of tumor microenvironment, modalities single therapeutic agent may not be effective. Hence, enhance efficiency chemotherapeutic drugs, repurposing them or conjugating other essential. Omeprazole FDA-approved proton pump inhibitor clinics treatment ulcers. has also been studied its sensitize cancer cells chemotherapy apoptosis. Herein, we report nanosystem comprising encapsulating omeprazole (CuOzL) against B16 melanoma cells. The developed nanoformulation exerted significant synergistic activity when compared either alone by inducing cell death through excessive ROS generation subsequent mitochondrial damage.

Language: Английский

The copper age in cancer treatment: From copper metabolism to cuproptosis DOI
Wensheng Xie, Zhenhu Guo,

Lingyun Zhao

et al.

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 138, P. 101145 - 101145

Published: May 23, 2023

Language: Английский

Citations

47
Latest advances in hepatocellular carcinoma management and prevention through advanced technologies DOI Creative Commons

Tamer A. Addissouky,

Ibrahim El Tantawy El Sayed, Majeed M. A. Ali

et al.

Egyptian Liver Journal, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 2, 2024

Abstract Background Hepatocellular carcinoma (HCC) is a common type of liver cancer, with high mortality rate. cancer that can be effectively managed through early detection and accurate diagnosis, followed by personalized treatment plan may include surgical resection, transplantation, minimally-invasive techniques, immunotherapy, or targeted therapy depending on the stage severity cancer. Main body abstract This paper discusses recent advances in detection, management, prevention HCC. The use newer imaging such as Magnetic resonance (MRI) contrast-enhanced ultrasound, along image segmentation technology deep learning models, have greatly enhanced accuracy HCC diagnosis. Minimally-invasive thermal ablation radiofrequency ablation, allowed for more precise destruction tumors, while Nanoparticles, immunotherapy shown promise management advanced Artificial intelligence (AI) machine has revolutionized research, aiding identification high-risk patients predicting outcomes. Lifestyle modifications, weight alcohol avoidance, hepatitis B vaccinations, play critical role preventing development. Short conclusion Recent improving patient therapy, AI research lifestyle modifications prevention. However, further required to fully understand potential benefits nanoparticles, traditional Chinese medicine herbal medicines treatment. Graphical

Language: Английский

Citations

35
The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm DOI Creative Commons
Thi Thuy Tien Vo, Tzu‐Yu Peng,

Thi Hong Nguyen

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 5, 2024

Abstract Copper is a crucial trace element that plays role in various pathophysiological processes the human body. also acts as transition metal involved redox reactions, contributing to generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated different types regulated cell death. The recent discovery cuproptosis, copper-dependent death pathway distinct from other known forms, raised interest researchers field cancer therapy. Herein, present work aims outline current understanding with an emphasis on its anticancer activities through interplay copper-induced stress, thereby providing new ideas for therapeutic approaches targeting modes future.

Language: Английский

Citations

25
Cuproptosis: Unraveling the Mechanisms of Copper-Induced Cell Death and Its Implication in Cancer Therapy DOI Open Access

Chloe Springer,

Danish Humayun,

Rachid Skouta

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 647 - 647

Published: Feb. 2, 2024

Copper, an essential element for various biological processes, demands precise regulation to avert detrimental health effects and potential cell toxicity. This paper explores the mechanisms of copper-induced death, known as cuproptosis, its disease implications, including cancer therapy. Copper ionophores, such elesclomol disulfiram, increase intracellular copper levels. elevation triggers oxidative stress subsequent offering implications in Additionally, ionophores disrupt mitochondrial respiration protein lipoylation, further contributing toxicity death. Potential targets biomarkers are identified, can be targeted those proteins trigger cuproptosis. The role different cancers is discussed understand therapies using nanomaterials, chelators. Furthermore, explored through diseases Wilson Menkes physiological copper. Exploring cuproptosis presents opportunity improve treatments copper-related disorders cancers, with bring significant advancements modern medicine.

Language: Английский

Citations

24
Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review DOI Creative Commons

Sara Abdolmaleki,

Alireza Aliabadi, Samad Khaksar

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(4)

Published: April 25, 2024

Abstract Copper is a necessary micronutrient for maintaining the well-being of human body. The biological activity organic ligands, especially their anticancer activity, often enhanced when they coordinate with copper(I) and (II) ions. its compounds are capable inducing tumor cell death through various mechanisms action, including activation apoptosis signaling pathways by reactive oxygen species (ROS), inhibition angiogenesis, induction cuproptosis, paraptosis. Some copper complexes currently being evaluated in clinical trials ability to map hypoxia cancers, locally advanced rectal cancer bulky tumors. Several studies have shown that nanoparticles can be used as effective agents chemodynamic therapy, phototherapy, hyperthermia, immunotherapy. Despite promising copper-based compounds, use subject certain limitations. Elevated concentrations may promote growth, metastasis affecting cellular processes.

Language: Английский

Citations

24
Biological structural study of emerging shaped nanoparticles for the blood flow in diverging tapered stenosed arteries to see their application in drug delivery DOI Creative Commons
Noreen Sher Akbar,

Muhammad Bilal Habib,

M. Rafiq

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 17, 2024

Abstract The magnetic force effects and differently shaped nano-particles in diverging tapering arteries having stenoses are being studied current research via blood flow model. There hasn’t been any done on using metallic nanoparticles of different shapes with water as the base fluid. A radially symmetric but axially non-symmetric stenosis is used to depict flow. Another significant aspect our study symmetrical distribution wall shearing stresses connection resistive impedance, well rise these quantities progression stenosis. Shaping accordance understanding offers numerous possibilities for improving drug delivery, targeted therapies, diagnostic imaging context cardiovascular other vascular-related diseases. Exact solutions namely velocity, temperature, resistance boundary shear stress, stress at throat, have assessed. For various parameters relevance Cu-water, graphical results several types tapered (i.e. tapering) explored.

Language: Английский

Citations

16
Biological structural study for the blood casson fluid flow in catheterized diverging tapered stenosed arteries with emerging shaped nanoparticles: application in drug delivery DOI
Noreen Sher Akbar, M. Rafiq, Taseer Muhammad

et al.

Microfluidics and Nanofluidics, Journal Year: 2024, Volume and Issue: 28(6)

Published: May 21, 2024

Language: Английский

Citations

12
Copper-Based Biomaterials for Anti-Tumor Therapy: Recent Advances and Perspectives DOI
Shufang Zhang, Shuping Peng

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Cuproptosis: emerging biomarkers and potential therapeutics in cancers DOI Creative Commons
Min Wang, Lianwen Zheng, Shuai Ma

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Nov. 7, 2023

The sustenance of human life activities depends on copper, which also serves as a crucial factor for vital enzymes. Under typical circumstances, active homeostatic mechanisms keep the intracellular copper ion concentration low. Excess ions cause excessive cellular respiration, causes cytotoxicity and cell death levels steadily rise above threshold. It is novel that mitochondrial ions, regulation. Cuproptosis now understood to play role in several pathogenic processes, including inflammation, oxidative stress, apoptosis. Copper type regulatory death(RCD).Numerous diseases are correlated with development homeostasis imbalances. One most popular areas study field cancer cuproptosis. has been discovered angiogenesis, proliferation, growth, metastasis all accumulation ions. concentrations can serve marker development. In order reference clinical research product, diagnosis, treatment cancer, this paper covers function imbalance malignant cancers related molecular pathways.

Language: Английский

Citations

19
Screening of Cu4O3 NPs efficacy and its anticancer potential against cervical cancer DOI
Torki A. Zughaibi, Nasimudeen R. Jabir,

Azhar U. Khan

et al.

Cell Biochemistry and Function, Journal Year: 2023, Volume and Issue: 41(8), P. 1174 - 1187

Published: Sept. 10, 2023

Cu4 O3 is the least explored copper oxide, and its nanoformulation anticipated to have important therapeutic potential especially against cancer. The current study aimed biosynthesize nanoparticles (NPs) using an aqueous extract of pumpkin seeds evaluate antiproliferative efficacy cervical cells after screening on different cancer cell lines. obtained NPs were characterized by spectroscopic analyses, such as UV-vis, thermogravimetric, energy dispersive X-ray, Fourier-transform infrared spectroscopy (FTIR). In addition, high-resolution transmission electron microscopes (HR-TEM) used observe morphology biosynthesized NPs. UV-vis spectra showed a peak at around 332 nm, confirming formation Moreover, FTIR TAG analyses identified presence various bioactive phytoconstituents that might worked capping stabilization agents comparative stable very high temperatures, respectively. HR-TEM data spherical shape in range 100 nm. was screened three lines viz., Hela, MDA-MB-231, HCT-116 cytotoxicity (MTT) reduction assay. Vero taken normal epithelial (control) cell. responsive line terms IC50 further assessed for anticancer battery biological tests, including morphological alterations, induction apoptosis/ROS generation, regulation mitochondrial membrane (MMP), suppression adhesion/migration. slight decline % viability even highest tested concentration. However, all studied HCT 116, HeLa dose-dependent treatment with calculated value 10, 11, 7.2 µg/mL, Based above data, Hela chosen studies, apoptosis from 3.5 9-folds staining techniques acridine orange/ethidium bromide (AO/EB), 4',6-diamidino-2-phenylindole (DAPI), propidium iodide (PI). enhanced production reactive oxygen species (>3.5-fold), modulation MMP, adhesion/migration observed treated significant line, which needs be confirmed suitable vivo model. our results, we also recommend green-based, eco-friendly, cost-effective alternative method synthesizing novel nanoformulation.

Language: Английский

Citations

18