Flavonoids and Flavonoid-Based Nanoparticles for Osteoarthritis and Rheumatoid Arthritis Management

BioChem, Journal Year: 2024, Volume and Issue: 4(1), P. 38 - 61

Published: March 13, 2024

Arthritis, a global health burden comprising osteoarthritis and rheumatoid arthritis, demands advanced therapeutic approaches. In this context, flavonoids, diverse group of naturally occurring compounds abundant in fruits, vegetables, medicinal plants, have emerged as promising candidates for mitigating the inflammatory processes associated with arthritic conditions. This review aims, first, to provide comprehensive exploration potential focusing on specific such quercetin, epigallocatechin-3-gallate (EGCG), apigenin, luteolin, fisetin, silibinin, kaempferol, naringenin, myricetin. The second section delves into anti-arthritic activities these drawing insights from clinical trials scientific studies. Each flavonoid is scrutinized individually elucidate its mechanisms action efficacy context both arthritis. third highlights challenges harnessing flavonoids anti-inflammatory purposes. Bioavailability limitations pose significant hurdle, prompting innovative strategies use nanoparticles delivery vehicles. response challenges, fourth focuses emerging field flavonoid-based nanoparticles. includes detailed discussions EGCG, naringenin-based nanoparticles, highlighting formulation preclinical evidence supporting their arthritis management. targeted sites synergistic combinations other are also discussed avenues enhance impact flavonoids. consolidates current knowledge nanoformulations interventions By addressing presenting future research directions, aims contribute advancement effective alleviating

Language: Английский

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Exploring the therapeutic potential of quercetin: A focus on its sirtuin‐mediated benefits

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(5), P. 2361 - 2387

Published: March 1, 2024

Abstract As the global population ages, preventing lifestyle‐ and aging‐related diseases is increasing, necessitating search for safe affordable therapeutic interventions. Among nutraceuticals, quercetin, a flavonoid ubiquitously present in various plants, has garnered considerable interest. This review aimed to collate analyze existing literature on potentials of especially its interactions with SIRTs clinical applicability based bioavailability safety. narrative was survey spanning from 2015 2023 using PUBMED. The keywords MeSH terms used were: “quercetin” AND “bioavailability” OR “metabolism” “metabolites” as well “SIRTuin” “SIRT*” “cellular effects” “pathway” “signaling” “neuroprotective” “cardioprotective” “nephroprotective” “antiatherosclerosis” “diabetes” “antidiabetic” “dyslipidemia” “mice” “rats”. Quercetin demonstrates multiple activities, including neuroprotective, cardioprotective, anti‐atherosclerotic effects. Its antioxidant, anti‐inflammatory, antiviral, immunomodulatory properties are well‐established. At molecular level, it majorly interacts SIRTs, particularly SIRT1 SIRT6, modulates numerous signaling pathways, contributing These pathways play roles reducing oxidative stress, inflammation, autophagy regulation, mitochondrial biogenesis, glucose utilization, fatty acid oxidation, genome stability. However, trials quercetin's effectiveness humans scarce. exhibits wide range SIRT‐mediated Despite compelling preclinical data, more standardized needed fully understand potential. Future research should focus addressing safety concerns.

Language: Английский

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A comprehensive review of the molecular mechanisms driving skin photoaging and the recent advances in therapeutic interventions involving natural polyphenols

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 166, P. 466 - 482

Published: Jan. 31, 2024

Language: Английский

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New UHPLC-Q-Orbitrap MS/MS-based Library-comparison method simultaneously distinguishes 22 phytophenol isomers from Desmodium styracifolium

Microchemical Journal, Journal Year: 2023, Volume and Issue: 191, P. 108938 - 108938

Published: June 3, 2023

Language: Английский

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Natural Autophagy Activators to Fight Age-Related Diseases

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1611 - 1611

Published: Sept. 26, 2024

The constant increase in the elderly population presents significant challenges addressing new social, economic, and health problems concerning this population. With respect to health, aging is a primary risk factor for age-related diseases, which are driven by interconnected molecular hallmarks that influence development of these diseases. One main mechanisms has attracted more attention autophagy, catabolic process removes recycles damaged or dysfunctional cell components preserve viability. autophagy can be induced deregulated response wide range internal external stimuli, such as starvation, oxidative stress, hypoxia, organelles, infectious pathogens, aging. Natural compounds promote stimulation regulatory pathways, mTOR, FoxO1/3, AMPK, Sirt1, lead increased levels essential proteins Beclin-1 LC3, well decrease p62. These changes indicate activation autophagic flux, known decreased cardiovascular neurodegeneration, cataracts. regulated administration natural offers an adjuvant therapeutic alternative diseases; however, experimental evidence needed support confirm benefits. Hence, review aims highlight potential benefits regulating pathways approach combating

Language: Английский

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Anti‐Inflammatory Treatment of Subarachnoid Hemorrhage by Self‐Assembled Silymarin Nanoparticles

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Subarachnoid hemorrhage (SAH) is a common hemorrhagic cerebrovascular disease with high disability rate and mortality. Early brain injury (EBI) the main cause of mortality delayed neurological dysfunction in patients SAH. Neuroinflammation important pathological processes EBI.We prepared Silymarin nanoparticles (SIM NPs) through solvent precipitation method investigated their role combating EBI following SAH mice. We found that SIM NPs diameter 150 nm have strongest ability to cross blood‐brain barrier. are spherical contain irregular particles inside, which may be composed mainly silibinin assembled hydrogen bonding. Further vivo experiments showed improved short‐term mice, reduced cortical neural damage, inflammation Nrf2/STING pathway. Finally, water maze can improve long‐term memory learning Based on above results, we conclude silymarin reduce after by inhibiting pathway, neuroinflammation M1 polarization microglia.

Language: Английский

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Structural characterization and in silico evaluation of bioactive compounds from Rhus cotinus (Syn. Cotinus coggygria) roots as potential EGFR inhibitors for brain Cancer

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102101 - 102101

Published: Feb. 1, 2025

Language: Английский

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Protective Effect of Field Horsetail Polyphenolic Extract on Erythrocytes and Their Membranes

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3213 - 3213

Published: March 30, 2025

Field horsetail (Equisetum arvense L.) is widely utilized in traditional medicine and a rich source of bioactive compounds such as flavonoids, phenolic acids, silica. This study investigates the protective effect polyphenolic extract from field (HLE) on erythrocytes their cell membranes. The content was determined using HPLC-DAD Folin–Ciocalteu methods. extract’s hemolytic activity, toxicity, antioxidant its impact physical properties lipid membrane were investigated. evaluated isolated erythrocyte membranes oxidized by UVC radiation AAPH. ordering fluidity model studied. Furthermore, transmembrane potential, shape dipole potential under influence HLE evaluated. results indicated that exhibited no toxicity to HMEC-1 cells. components effectively protect against oxidation. They interact with outer, polar surface reduce both potential. polyphenols decrease concentration free radicals at membrane, where they are located, serve barrier, preventing penetration into membrane.

Language: Английский

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Exploring Natural Compound Libraries for Breast Cancer Targets: An <i>In Silico</i> Study

Journal of Natural Remedies, Journal Year: 2025, Volume and Issue: unknown, P. 639 - 656

Published: April 4, 2025

Background: Breast cancer is a globally prevalent, heterogenous disease affecting both women and men across all ethnic groups. It complex the second most frequently diagnosed solid tumour in worldwide. The PI3K/AKT/mTOR signalling pathway plays significant role breast progression, survival, drug resistance. dysregulated approximately 20-34% of cases, making it key target for therapeutic intervention. Aim: This study aims to investigate potential natural compounds against using molecular docking studies evaluate their binding affinity interactions with proteins. Methods: Molecular was performed analyse energy, conformational changes, amino acid selected PI3K AKT. Results: Our virtual suggest that ginsenoside (-7.39 kcal/mol), nimbolide (-6.22 pristimerin (-6.28 kcal/mol) exhibit strong affinities toward PI3K, indicating as inhibitors. Additionally, (-5.52 curcumin (-5.63 (-6.07 demonstrated Conclusion: results these AKT, effective favourable may serve promising candidates targeted therapy, especially patients PI3K/Akt dysregulation. Further experimental validation required confirm efficacy. Major Findings: Nimbolide, pristimerin, demonstrate treatment by modulating PI3K/AKT pathway.

Language: Английский

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Silibinin as a promising treatment for diabetes: Insights into behavioral and metabolic changes in an animal model

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(5), P. 3336 - 3345

Published: Feb. 9, 2024

Abstract Diabetes mellitus is causing serious health problems in the chronic period. Silibinin a flavonoid obtained from milk thistle ( Silybum marianum ), which among herbal ethnopharmacological administrations. In studies with silibinin, it has been reported that increases activity of pancreatic beta cells and insulin sensitivity hyperglycemia‐reducing effect. However, behavioral parameters have not evaluated together levels liver function tests. Our aim this study was to examine effects silibinin on secretion, anxiety‐like behaviors, learning streptozotocin (STZ)‐induced rat diabetes model. Wistar albino rats weighing 200–250 g were divided into 4 groups. Control: Saline solution, Diabetes: STZ 45 mg/kg, S 100: mg/kg + 100 200: 200 mg/kg. Administrations continued for 21 days. On 21st day, open field elevated plus maze as unconditional anxiety tests; Barnes memory; rotarod test locomotor conducted. Following tests, blood samples taken under anesthesia. Blood glucose ALT values measured. Insulin measured an ELISA plate reader. shortened time find correct hole. prevented decrease due STZ, exhibited effect decreased elevation ALT.

Language: Английский

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