Electrospun zinc oxide nanoscaffolds: a targeted and selective anticancer approach DOI
Zafar Said, Haitham S. Mohammed, Sara Ibrahim

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 22

Published: Nov. 7, 2024

This study aims to prepare, characterize, and evaluate zinc oxide nanoscaffolds (ZnO NSs) as a potential anticancer drug that selectively targets malignant cells while remaining non-toxic normal cells. Electrospun NSs were fabricated loaded with varying concentrations of ZnO nanoparticles (NPs). The uniform morphology the samples was confirmed through Field Emission Scanning Electron Microscope (FESEM) imaging. Elemental composition investigated using Energy Dispersive X-ray spectroscopy (EDX), Fourier Transform Infrared (FTIR), diffraction (XRD) analyses. Biocompatibility cytotoxicity assessed (3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay) (MTT) assay flow cytometry. water uptake degradation properties electrospun also examined. Furthermore, cumulative release profile generated assess behavior NSs. prepared demonstrated negligible toxicity toward human dermal Conversely, four used displayed substantial induced apoptosis in various cancer cell lines. observed effects concentration-dependent. Notably, 8% exhibited most significant reduction viability against MCF7 line. findings from this indicate an effective agent, demonstrating pronounced impact. research introduces novel application nanoscaffolds, their capacity for selective activity, particularly breast carcinoma, preserving viability. presents advancement use nanomaterial targeted therapy.

Language: Английский

Hydrogel-based nanoparticles: revolutionizing brain tumor treatment and paving the way for future innovations DOI Creative Commons
Alireza Shadab, Simin Farokhi, Arshia Fakouri

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 4, 2025

Abstract Brain tumor treatment remains a significant challenge due to their high mortality and resistance current therapies. This paper discusses the promising potential of hydrogel-based nanoparticles as innovative drug delivery systems for brain therapy. Extensive characterization techniques reveal ability these Nano-systems demonstrate prolonged blood circulation targeted delivery, leading improved survival rates. Designed with optimized physicochemical characteristics, effectively cross blood–brain barrier, circumventing major impediment brain. By delivering drugs directly bed, enhance therapeutic outcomes minimize adverse effects. In addition, this review investigates characterizing, visualizing, modifying nanoparticles, well standing challenges research avenues clinical application. Further investigations are encouraged by investigate advancements in nanoparticle approaches tumors. includes investigating tailored hydrogels, hybrid systems, computational modeling, integration gene therapy immunotherapy techniques. The study also addresses need enhanced synthesis techniques, stability, scalability, cost-cutting measures overcome obstacles advance use treating Graphical abstract

Language: Английский

Citations

7
Harnessing Electrospun Nanofibers for Comprehensive Oral Disease Management: Current Trends and Future Perspectives DOI

R.S. Gupta,

Giriraj Pandey,

Ajay Kumar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106681 - 106681

Published: Feb. 7, 2025

Language: Английский

Citations

4
Synergistic anticancer effect of Pistacia lentiscus essential oils and 5-Fluorouracil co-loaded onto biodegradable nanofibers against melanoma and breast cancer DOI Creative Commons
Obaydah Abd Alkader Alabrahim, Hassan Mohamed El-Said Azzazy

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Feb. 14, 2024

Abstract Chemoresistance and severe toxicities represent major drawbacks of chemotherapy. Natural extracts, including the essential oils Pistacia lentiscus (PLEO), exhibit substantial anticancer anti-inflammatory activities where different cancers are reported to dramatically recess following targeting with PLEO. PLEO has promising antimicrobial, anticancer, properties. However, therapeutic properties restricted by limited stability, bioavailability, ability. nanoformulation can maximize their physicochemical properties, overcoming shortcomings. Hence, was extracted its chemical composition determined GC–MS. 5-Fluorouracil (5FU) were electrospun into poly-ε-caprolactone nanofibers (PCL-NFs), 290.71 nm 680.95 diameter, investigate potential synergistic against triple-negative breast cancer cells (MDA-MB-231), human adenocarcinoma (MCF-7), skin melanoma cell line (A375). The prepared (NFs) showed enhanced thermal stability remarkable physical integrity tensile strength. Biodegradability studies prolonged over 42 days, supporting NFs use as a localized therapy tissues (postmastectomy) or melanoma. Release revealed sustainable release behaviors 168 h, higher released amounts 5FU at pH 5.4, indicating abilities towards tissues. loaded strong antioxidant Finally, either depicted greater compared free compounds. highest observed co-loaded 5FU. developed 5FU-PLEO-PCL-NFs hold local treatment (post-mastectomy) minimize possible recurrence. Graphical

Language: Английский

Citations

10
Advances in Light-Responsive Smart Multifunctional Nanofibers: Implications for Targeted Drug Delivery and Cancer Therapy DOI Creative Commons
Ahmed M. Agiba, Nihal Mohamed Elmahdy Elsayyad, Hala N. ElShagea

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1017 - 1017

Published: July 31, 2024

Over the last decade, scientists have shifted their focus to development of smart carriers for delivery chemotherapeutics in order overcome problems associated with traditional chemotherapy, such as poor aqueous solubility and bioavailability, low selectivity targeting specificity, off-target drug side effects, damage surrounding healthy tissues. Nanofiber-based systems recently emerged a promising system cancer therapy owing unique structural functional properties, including tunable interconnected porosity, high surface-to-volume ratio entrapment efficiency loading capacity, mass transport which allow controlled targeted delivery. In addition, they are biocompatible, biodegradable, capable surface functionalization, allowing target-specific release. One most common fiber production methods is electrospinning, even though relatively two-dimensional (2D) tightly packed structures rates limited its performance. Forcespinning an alternative spinning technology that generates high-throughput, continuous polymeric nanofibers 3D structures. Unlike forcespinning fibers by centrifugal forces rather than electrostatic forces, resulting significantly higher production. The functionalization nanocarriers on can result anticancer capabilities be activated external stimuli, light. This review addresses current trends potential applications light-responsive dual-stimuli-responsive electro- forcespun therapy, particular emphasis functionalizing nanofiber surfaces developing nano-in-nanofiber emerging dual-controlled release high-precision tumor targeting. progress prospective diagnostic therapeutic discussed context combination therapy.

Language: Английский

Citations

7
Applications of nanofibers drug delivery system in cancer therapy DOI
Nafiu Aminu, Salim Ilyasu, Mohammed Hassan

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 90, P. 105128 - 105128

Published: Nov. 2, 2023

Language: Английский

Citations

16
Injectable self-healing hydrogel as a rising therapeutic strategy for the loco-regional management of cancer DOI

Shruti Srivastav,

Abhilasha Singh, Manjul Pratap Singh

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105913 - 105913

Published: June 26, 2024

Language: Английский

Citations

5
Recent progress in chitosan-based nanofibers as potential drug carriers in cancer therapy DOI
Olivia Sen,

Sougata Jana,

Gouranga Nandi

et al.

International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: May 5, 2024

In the modern healthcare system, therapeutic options of cancer management have gained much attention. Several chemotherapeutic agents and anticancer drugs are in use to combat many them shown promising results. The direct targeting may enhance side effects limit efficacy agents. various drug carriers investigated for successful moieties. Amongst several carriers, nanofibers recently being by researchers due their favorable physicochemical properties, increased surface area, ability control release molecules at target site. Chitosan, a biodegradable marine polysaccharide, offers excellent biocompatibility alongside decreased immunogenicity easy large scale production. Chitosan easily prepared employing electrospinning other techniques. This review focuses on fabrication techniques, suitability chitosan tumor microenvironment recent advancements effective targeting.

Language: Английский

Citations

4
Nanostructured materials for breast cancer therapeutics enhancing drug delivery through nanofibers, nano-mesh, and nanoflowers DOI Creative Commons
Navya Aggarwal, Shreya Gupta,

Shinjini Sen

et al.

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 8, P. 100159 - 100159

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nanofiber Drug Delivery Systems: Recent Advances in Nanofabrication and Their Role in Targeted Therapy in Cancer, Neurodegenerative, and Cardiovascular Diseases DOI

Satyam Yadav,

Amit Sharma, Balak Das Kurmi

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(5)

Published: May 1, 2025

ABSTRACT Nanofiber‐based drug delivery systems show strong potential due to their high surface area‐to‐volume ratio and adjustable structure. Recent studies demonstrated loading efficiencies exceeding 85%, with sustained release kinetics up 96 h. In cancer models, nanofiber‐based carriers improved accumulation at tumor sites by 3–4 fold compared conventional formulations, enhancing therapeutic efficacy minimizing systemic toxicity. This review outlines methods for precise nanofiber shape function control through electrospinning solution blow spinning techniques. advancements in technology have proven promising biomedical applications where they are utilized tissue engineering, neurodegenerative disease management, wound healing, targeted therapy. Nanofibers as an optimal system that improves cellular restoration, together controlled deep penetration capabilities. The recent development of dual‐drug systems, stimuli‐responsive nanofibers, scaffolds composed nanofibers smart materials has expanded usage precision medicine. Research now demonstrates facilitate remodeling functions along angiogenesis promotion, inflammatory response stability improvement. also focuses on the patents a system. addition, this presents new approaches overcome these challenges based interdisciplinary cooperation, AI‐driven design such sophisticated bioinformatics tools. review, advances prospects realizing revolution field improving healthcare outcomes presented detailed overview.

Language: Английский

Citations

0
Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma DOI
Gomaa El Fawal, Marwa M. Abu‐Serie

DARU Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 32(2), P. 573 - 583

Published: July 4, 2024

Language: Английский

Citations

3