Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(5), P. 3025 - 3045
Published: Jan. 30, 2024
Abstract
In
the
middle
of
an
ever‐changing
landscape
diabetes
care,
precision
medicine,
and
lifestyle
therapies
are
becoming
increasingly
important.
Dietary
polyphenols
like
hidden
allies
found
in
our
everyday
meals.
These
biomolecules,
commonly
fruits,
vegetables,
various
plant‐based
sources,
hold
revolutionary
potential
within
their
molecular
structure
way
we
approach
its
intimidating
consequences.
There
currently
numerous
types
medications,
but
they
not
appropriate
for
all
patients
due
to
limitations
dosages,
side
effects,
drug
resistance,
a
lack
efficacy,
ethnicity.
Currently,
there
has
been
increased
interest
practicing
herbal
remedies
manage
related
complications.
This
article
aims
summarize
dietary
as
foundation
treatment
associated
We
that
most
inhibit
enzymes
linked
diabetes.
review
outlines
benefits
selected
molecules,
including
kaempferol,
catechins,
rosmarinic
acid,
apigenin,
chlorogenic
caffeic
managing
mellitus
these
compounds
have
exhibited
promising
results
vitro,
vivo,
silico,
some
preclinical
trials
study.
encompassing
exploration
reveals
multifaceted
impact
only
mitigating
also
addressing
conditions
inflammation,
obesity,
even
cancer.
Their
mechanisms
involve
antioxidant
functions,
immune
modulation,
proinflammatory
enzyme
regulation.
Furthermore,
molecules
exhibit
anti‐tumor
activities,
influence
cellular
pathways,
activate
AMPK
offering
less
toxic,
cost‐effective,
sustainable
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(7), P. 836 - 836
Published: July 11, 2024
Polyphenols
are
natural
bioactives
occurring
in
medicinal
and
aromatic
plants
food
beverages
of
plant
origin.
Compared
with
conventional
therapies,
plant-derived
phytochemicals
more
affordable
accessible
have
no
toxic
side
effects.
Thus,
pharmaceutical
research
is
increasingly
inclined
to
discover
study
new
innovative
molecules
for
the
treatment
several
chronic
human
diseases,
like
type
2
diabetes
mellitus
(T2DM)
osteoporosis.
These
pathological
conditions
characterized
by
a
inflammatory
state
persistent
oxidative
stress,
which
interconnected
lead
development
worsening
these
two
health
disorders.
Oral
nano
delivery
strategies
been
used
improve
bioavailability
polyphenols
allow
exert
their
antioxidant,
anti-inflammatory,
anti-diabetic,
pro-osteogenic
biological
activities
vivo
experimental
models
patients.
commonly
formulations
nutraceuticals,
can
counteract
detrimental
effects
T2DM
osteoporosis
pathologies.
This
review
describes
that
protective
against
through
modulation
specific
molecular
markers
pathways.
could
be
as
adjuvants,
combination
synthetic
drugs,
future
develop
therapeutic
Life,
Journal Year:
2023,
Volume and Issue:
13(9), P. 1831 - 1831
Published: Aug. 29, 2023
Diabetes
poses
a
significant
global
health
challenge,
necessitating
innovative
therapeutic
strategies.
Natural
products
and
their
derivatives
have
emerged
as
promising
candidates
for
diabetes
management
due
to
diverse
compositions
pharmacological
effects.
Algae,
in
particular,
garnered
attention
potential
source
of
bioactive
compounds
with
anti-diabetic
properties.
This
review
offers
comprehensive
overview
algae-derived
natural
management,
highlighting
recent
developments
future
prospects.
It
underscores
the
pivotal
role
care
delves
into
diversity
algae,
constituents,
underlying
mechanisms
efficacy.
Noteworthy
algal
substantial
are
briefly
elucidated,
along
specific
contributions
addressing
distinct
aspects
diabetes.
The
challenges
limitations
inherent
utilizing
algae
interventions
examined,
accompanied
by
strategic
recommendations
optimizing
effectiveness.
By
these
considerations,
this
aims
chart
course
research
refining
algae-based
approaches.
Leveraging
multifaceted
activities
chemical
components
holds
promise
pursuit
novel
antidiabetic
treatments.
Through
continued
fine-tuning
interventions,
burden
could
be
mitigated,
ultimately
leading
enhanced
patient
outcomes.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(10), P. 1220 - 1220
Published: Oct. 10, 2024
Polyphenols
are
organic
chemical
compounds
naturally
present
in
plants,
renowned
for
their
anti-inflammatory,
antioxidant,
immunomodulatory,
anticancer,
and
cardiovascular
protective
properties.
Their
bioactivity
bioavailability
can
vary
widely
depending
on
the
methods
of
food
processing
interactions
with
gut
microbiome.
These
factors
induce
changes
polyphenols,
affecting
ability
to
achieve
intended
health
benefits.
Thus,
it
is
essential
develop
apply
that
optimize
polyphenol
content
while
maintaining
bioavailability.
This
review
aims
explore
how
various
techniques
affect
quantity,
bioactivity,
as
well
microbiome,
which
may
ultimately
determine
effects.
Journal of Pharmacy and Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
This
research
studied
two
extracts
from
Treculia
africana
leaves
for
their
potential
against
hyperglycaemia-related
disorders.
The
influence
of
the
on
α-glucosidase
activity
and
albumin
glycation
was
investigated,
cell
viability
estimated
in
HT-29
human
colorectal
cells.
Phenolic
flavonoid
contents
antiradical
were
also
detected.
examined
using
HPLC-DAD
analysis.
methanol
dichloromethane
leaf
showed
a
significant
concentration-dependent
inhibition
(IC50=
3.73
21.28
µg/ml,
respectively).
Both
inhibited
ribose-induced
bovine
serum
250
µg/ml.
Phytochemical
analysis
revealed
presence
chlorogenic
acid
α-mangostin
extracts.
did
not
change
up
to
thus
showing
very
low
cytotoxicity.
extract
T.
manner,
supporting
use
traditional
medicine
control
hyperglycaemia.
Chlorogenic
α-mangostin,
latter
identified
first
time
this
species,
found
leaves.
Further,
vivo
studies
pilot
clinical
trials
should
be
conducted
standardized
evaluate
effectiveness
diabetes
mellitus.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2063 - 2063
Published: Feb. 27, 2025
Arterial
hypertension
and
diabetes
mellitus
are
components
of
the
cardiometabolic
syndrome
that
arises
from
a
sedentary
lifestyle,
excess
calorie
intake,
obesity.
Swietenia
humilis
Zucc
has
been
used
in
traditional
Mexican
medicine
for
treatment
mellitus;
this
work
investigated
antioxidant,
antidiabetic,
vasorelaxant
effects
ethanolic
extract
S.
seeds.
The
phytochemical
composition
was
analyzed
by
high-performance
liquid
chromatography.
To
study
hypoglycemic
effect,
activity
antioxidant
enzymes
(catalase,
superoxide
dismutase,
glutathione
peroxidase)
markers
oxidative
stress
(malondialdehyde
8-hydroxy-2-desoxyguanosine)
were
evaluated
model
induced
nicotinamide
streptozotocin
rats.
vasodilatory
effect
tested
rat
aortic
rings.
seeds
showed
hypoglycemic,
endothelium-independent
effects,
probably
blocking
calcium
transport,
likely
due
to
ursolic
acid
α-amyrin,
compounds
more
abundant
extract.
