International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 13144 - 13144
Published: Dec. 6, 2024
The
efficacy
of
assisted
reproductive
technologies
(ARTs)
in
older
women
remains
constrained,
largely
due
to
an
incomplete
understanding
the
underlying
pathophysiology.
This
review
aims
consolidate
current
knowledge
on
age-associated
mitochondrial
alterations
and
their
implications
for
ovarian
aging,
with
emphasis
causes
DNA
(mtDNA)
mutations,
repair
mechanisms,
future
therapeutic
directions.
Relevant
articles
published
up
30
September
2024
were
identified
through
a
systematic
search
electronic
databases.
free
radical
theory
proposes
that
reactive
oxygen
species
(ROS)
inflict
damage
mtDNA
impair
function
essential
ATP
generation
oocytes.
Oocytes
face
prolonged
pressure
persisting
five
decades.
MtDNA
exhibits
limited
capacity
double-strand
break
repair,
heavily
depending
poly
ADP-ribose
polymerase
1
(PARP1)-mediated
single-strand
breaks.
process
depletes
nicotinamide
adenine
dinucleotide
(NAD⁺)
ATP,
creating
detrimental
cycle
where
continued
further
compromises
oocyte
functionality.
Interventions
interrupt
this
destructive
may
offer
preventive
benefits.
In
conclusion,
cumulative
burden
mutations
demands
can
lead
depletion
elevate
risk
aneuploidy,
ultimately
contributing
ART
failure
women.
Mechanisms of Ageing and Development,
Journal Year:
2024,
Volume and Issue:
222, P. 111995 - 111995
Published: Oct. 9, 2024
Fisetin,
a
flavonoid
naturally
occurring
in
plants,
fruits,
and
vegetables,
has
recently
gained
attention
for
its
potential
role
as
senotherapeutic
agent
the
treatment
of
age-related
chronic
diseases.
Senotherapeutics
target
senescent
cells,
which
accumulate
with
age
disease,
both
circulating
immune
cell
populations
solid
organs
tissues.
Senescent
cells
contribute
to
development
many
diseases,
primarily
by
eliciting
systemic
inflammation
through
their
senescence-associated
secretory
phenotype.
Here,
we
explore
whether
fisetin
can
eliminate
thereby
alleviate
examining
current
evidence
from
vitro
studies
animal
models
that
investigate
fisetin's
impact
on
well
phase
I/II
trials
various
patient
populations.
We
discuss
application
humans,
including
challenges
future
directions.
Our
review
available
data
suggests
targeting
offers
promising
strategy
managing
multiple
potentially
transforming
healthcare
older
multimorbid
patients.
However,
further
are
needed
establish
safety,
pharmacokinetics,
efficacy
senotherapeutic,
identify
relevant
reliable
outcome
measures
human
trials,
optimize
dosing,
better
understand
possible
limitations
agent.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(4), P. 455 - 455
Published: April 2, 2024
In
vitro
oocyte
maturation
(IVM)
technology
is
important
for
assisted
animal
and
human
reproduction.
However,
the
rates
developmental
potential
of
in
vitro-matured
oocytes
are
usually
lower
than
those
vivo-matured
oocytes.
Oxidative
stress
a
main
factor
that
causes
quality
The
purpose
this
study
was
to
investigate
effects
treatment
with
SkQ1,
mitochondria-targeted
antioxidant,
on
mouse
IVM
subsequent
embryonic
development.
results
demonstrated
supplementation
SkQ1
during
improves
competence
vitro-fertilized
embryos.
addition
medium
also
decreased
oxidative
apoptosis,
increased
mitochondrial
membrane
matured
This
provides
new
method
through
which
enhance
oocytes,
thus
promoting
application
development
reproductive
technology.
Sci,
Journal Year:
2024,
Volume and Issue:
6(2), P. 36 - 36
Published: June 13, 2024
Aging
is
a
complex
biological
and
physiological
change
that
leads
to
loss
of
function
in
all
living
organisms.
Although
the
mechanism
behind
aging
process
still
largely
unknown,
scientific
studies
have
shown
oxidative
stress
age-related
low
autophagy,
which
are
associated
with
various
chronic
diseases
such
as
cancer,
diabetes,
cardiovascular
diseases,
neurodegenerative
promote
aging.
Interestingly,
many
medicinal
plants
their
biologically
active
compounds
ability
extend
lifespan
they
can
inhibit
autophagy.
This
review
evaluates
provides
up-to-date
information
on
anti-aging
potential
bioactive
edible
plants.
In
this
study,
seventeen
(17)
from
effects
were
reviewed.
vivo
vitro
showed
these
exhibit
via
mechanisms
activation
increases
antioxidant
enzymes,
reductions
reactive
oxygen
species,
inhibition
inflammatory
markers,
downregulation
senescence
genes.
study
suggests
containing
may
health
lifespan.
However,
exact
mechanisms,
effective
doses,
clinical
trials,
genotoxic
agents
should
be
further
investigated.
Journal of Complementary and Integrative Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Abstract
Fisetin,
a
flavonol
belonging
to
the
flavonoid
subclass,
is
ubiquitous
dietary
present
in
fruits
and
vegetables,
including
fruit
peels,
has
proven
potential
for
anticancer
activity,
especially
lung
cancer
–
leading
cause
of
cancer-related
deaths
globally.
The
current
paper
provides
most
detailed
elaborate
list
various
roles
fisetin
experimentally
induced
cells,
these
include
promotion
apoptosis,
inhibition
cell
proliferation,
migration,
invasion,
as
well
regulation
autophagy.
Among
molecular
targets,
some
identified
pathways,
such
PI3K/Akt,
MAPK,
NF-κB,
that
affects
are
crucial
tumor
formation,
so
it
can
be
considered
chemopreventive
agent.
Moreover,
improves
effectiveness
conventional
treatments
chemo-
radiosensitizer
minimizes
side
effects.
However,
overall
utility
clinical
use
now
somewhat
restricted
by
its
poor
solubility
short
half-life.
It
predicted
future
development
nanotechnologies
drug
delivery,
nanoparticle
encapsulation,
might
help
solve
difficulties.
Further
Preclinical
investigations
required
uniformly
determine
safety,
efficacy,
standard
dosage
consumption
therapy.
PeerJ,
Journal Year:
2025,
Volume and Issue:
13, P. e19198 - e19198
Published: March 28, 2025
Fisetin
is
a
natural
flavonol
with
variety
of
biological
activities,
including
anti-inflammatory
and
antitumor
activities.
However,
the
effect
fisetin
on
mammalian
oocyte
embryo
development
unknown,
so
in
this
study,
we
used
porcine
oocytes
as
an
experimental
model,
added
optimal
concentrations
to
vitro
culture
medium
after
parthenogenetic
activated
investigate
development.
It
was
found
that
0.1
µM
significantly
increased
cleavage
rate
blastocyst
formation
rate,
quality
blastocysts
also
improved.
Staining
results
showed
levels
reactive
oxygen
species
(ROS),
autophagy,
endoplasmic
reticulum
stress
apoptosis
were
reduced,
while
glutathione
mitochondrial
function
fisetin-treated
group
early
embryos
compared
control
group.
Meanwhile,
decreased
expression
level
marker
protein
GRP78
(0.71
±
0.19).
In
addition,
genes
related
pro-apoptosis,
autophagy
antioxidant,
pluripotency
mitochondrial.
According
our
results,
promotes
embryonic
porcine,
may
be
realized
by
down-regulating
GRP78.
